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Entry version 65 (17 Jun 2020)
Sequence version 1 (14 Dec 2011)
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Protein

Nuclear transcription factor Y subunit nfya-1

Gene

nfya-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the components in the nfya-1-NF-Y complex, represses the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues (PubMed:23933492). May act to repress txb-2 expression in conjunction with tbx-2 itself, which has an autoregulatory role (Probable). With the components in this complex, negatively regulates the expression of the homeobox protein egl-5 to spatially restrict its expression in tissues such as the head (PubMed:17574230). May regulate egl-5 expression in association with the mes-2-mes-3-mes-6 complex (PubMed:17574230).1 Publication2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi336 – 361NFYA/HAP2-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear transcription factor Y subunit nfya-1Curated
Alternative name(s):
CAAT box DNA-binding protein subunit nfya-1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nfya-1Imported
ORF Names:T08D10.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T08D10.1 ; CE03642 ; WBGene00011614 ; nfya-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region of hermaphrodites (PubMed:17574230). RNAi-mediated knockdown results in morphological defects in the male tail due to cell transformation defects whereby anterior seam cells adopt a posterior seam cell fate, which is indicated by ectopic expression of the ray-specific protein pkd-2 in the anterior mid-body region (PubMed:17574230). This leads to impaired cell identities of the rays derived from seam cells (PubMed:17574230). These animals also have defective cell transformations in the ventral cord and generate two extra serotonergic CP neurons (PubMed:17574230). RNAi-mediated knockdown results in ectopic expression of tbx-2 in the gut and seam cells of L4 stage larvae and adults (PubMed:23933492).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi102 – 482Missing in bp4; ectopic expression of the homeobox protein egl-5 in the head and mid-body regions. 1 PublicationAdd BLAST381
Mutagenesisi107Q → K in bp5; ectopic expression of the homeobox protein egl-5 in the head and mid-body regions. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004503321 – 482Nuclear transcription factor Y subunit nfya-1Add BLAST482

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EEG1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EEG1

PeptideAtlas

More...
PeptideAtlasi
G5EEG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in certain parts of the gonads with high expression in fertilized oocytes in the uterus and mature oocytes from the distal to the proximal arm of the gonad, but weak expression in the syncytial ovaries and immature oocytes at the beginning of the proximal arm of the gonad (PubMed:15704008). Highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail (PubMed:17574230). Weakly expressed in most somatic cells (PubMed:17574230). Not expressed in the intestine, the hypodermis, body wall muscle surrounding the pseudocoelomic space, secretory cells in the pharyngeal terminal bulb wall, in the small ganglia surrounding the pharynx and in the neurons running anteriorly to the sensory organs in the head (PubMed:15704008).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at all developmental stages (PubMed:15704008, PubMed:17574230). In larvae, highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail, while expression in most somatic cells is weak (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011614 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterotrimeric transcription factor complex (nfya-1-NF-Y complex) composed of nfya-1, nfyb-1 and nfyc-1, which binds to 5'-CCAAT-3' box motif in the promoters of its target genes (PubMed:17574230).

Interacts with the nfyb-1 and nfyc-1 dimer; the interaction is required for subsequent binding to the 5'-CCAAT-3' box motif in DNA (PubMed:17574230). Does not interact with either nfyb-1 or nfyc-1 in their monomeric form (PubMed:17574230).

Interacts with mes-3 (PubMed:17574230).

1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5666 CCAAT-binding factor complex, nfya-1 variant

Protein interaction database and analysis system

More...
IntActi
G5EEG1, 3 interactors

Molecular INTeraction database

More...
MINTi
G5EEG1

STRING: functional protein association networks

More...
STRINGi
6239.T08D10.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EEG1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi306 – 329Subunit association domain (SAD)PROSITE-ProRule annotationAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFYA/HAP2 subunit family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1561 Eukaryota
COG5224 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015714

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_483342_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EEG1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCKLFQY

Database of Orthologous Groups

More...
OrthoDBi
1269806at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001289 NFYA

The PANTHER Classification System

More...
PANTHERi
PTHR12632 PTHR12632, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02045 CBFB_NFYA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00616 CCAATSUBUNTB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00521 CBF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51152 NFYA_HAP2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EEG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGASRGDVQ RPTPVQAPAK RPIPPTVFRF EKASKIGTSL DTTPKELPIR
60 70 80 90 100
RPVPLPGPRF VKDVNPSPPA TSSPNVQTQC HQPPVVRSQT HQASVSQTTP
110 120 130 140 150
TQTTPSQYTP ASVSTARAPQ FHRSSHVTPS QQQRIEQAFG PAPVSQSQPQ
160 170 180 190 200
NGSYIQYNEP STSVASTTTS FYSPNESEPV FTHAISFKPN EPENGQKARE
210 220 230 240 250
QLELLDSGKI NEINQSKVPT TIELPPNCKL FQYSWVLDGI PRTLLVPMPM
260 270 280 290 300
DATEEDVKAM LPKTLEMDSN LFNNARPRDE LPVLSFPNGT VPNVEMIGPK
310 320 330 340 350
VQQPMLVNPK QFNRIMRRRE MRQQLEASGR LPLARQKYLH ESRHLHALKR
360 370 380 390 400
KRGLDGRFDN TKTAESSSMV SSTTSPRKLK RRNRLPGEET SDSSSIVLPS
410 420 430 440 450
PVEIQPKGGI VNSSMPSTST GYINNGMDHQ TDYIEHQQPM STYDQYHDHV
460 470 480
QYIAPDGNVN YHNNHDNGVD LTGSDGQSFT NL
Length:482
Mass (Da):53,591
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D582B6B8EC95C2D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA90639.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T22754

NCBI Reference Sequences

More...
RefSeqi
NP_509999.1, NM_077598.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T08D10.1.1; T08D10.1.1; WBGene00011614

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181368

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T08D10.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA90639.1
PIRiT22754
RefSeqiNP_509999.1, NM_077598.3

3D structure databases

SMRiG5EEG1
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-5666 CCAAT-binding factor complex, nfya-1 variant
IntActiG5EEG1, 3 interactors
MINTiG5EEG1
STRINGi6239.T08D10.1

Proteomic databases

EPDiG5EEG1
PaxDbiG5EEG1
PeptideAtlasiG5EEG1

Genome annotation databases

EnsemblMetazoaiT08D10.1.1; T08D10.1.1; WBGene00011614
GeneIDi181368
KEGGicel:CELE_T08D10.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181368
WormBaseiT08D10.1 ; CE03642 ; WBGene00011614 ; nfya-1

Phylogenomic databases

eggNOGiKOG1561 Eukaryota
COG5224 LUCA
GeneTreeiENSGT00390000015714
HOGENOMiCLU_483342_0_0_1
InParanoidiG5EEG1
OMAiNCKLFQY
OrthoDBi1269806at2759

Gene expression databases

BgeeiWBGene00011614 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001289 NFYA
PANTHERiPTHR12632 PTHR12632, 1 hit
PfamiView protein in Pfam
PF02045 CBFB_NFYA, 1 hit
PRINTSiPR00616 CCAATSUBUNTB
SMARTiView protein in SMART
SM00521 CBF, 1 hit
PROSITEiView protein in PROSITE
PS51152 NFYA_HAP2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFYA1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EEG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 17, 2020
Last sequence update: December 14, 2011
Last modified: June 17, 2020
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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