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Protein

Receptor-type guanylate cyclase gcy-23

Gene

gcy-23

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369).By similarity1 Publication

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi883Magnesium 1PROSITE-ProRule annotation1
Metal bindingi883Magnesium 2PROSITE-ProRule annotation1
Metal bindingi884Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi927Magnesium 1PROSITE-ProRule annotation1
Metal bindingi927Magnesium 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: InterPro

GO - Biological processi

  • cGMP biosynthetic process Source: GO_Central
  • detection of temperature stimulus Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • receptor guanylyl cyclase signaling pathway Source: WormBase
  • signal transduction Source: GO_Central
  • thermosensory behavior Source: UniProtKB
  • thermotaxis Source: UniProtKB

Keywordsi

Molecular functionLyase, Receptor
Biological processcGMP biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type guanylate cyclase gcy-23Curated (EC:4.6.1.2By similarity)
Gene namesi
Name:gcy-23Imported
ORF Names:T26C12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT26C12.4 ; CE41702 ; WBGene00001548 ; gcy-23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 458ExtracellularSequence analysisAdd BLAST443
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Topological domaini480 – 1073CytoplasmicSequence analysisAdd BLAST594

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000043329216 – 1073Receptor-type guanylate cyclase gcy-23Sequence analysisAdd BLAST1058

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi336N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiG5EEE9
PaxDbiG5EEE9

Expressioni

Tissue specificityi

Expressed specifically in AFD sensory neurons.1 Publication

Gene expression databases

BgeeiWBGene00001548

Interactioni

Protein-protein interaction databases

STRINGi6239.T26C12.4

Structurei

3D structure databases

ProteinModelPortaliG5EEE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini508 – 808Protein kinasePROSITE-ProRule annotationAdd BLAST301
Domaini878 – 1008Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili813 – 844Sequence analysisAdd BLAST32

Domaini

The protein kinase domain is predicted to be catalytically inactive.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
KOiK01769
OMAiINKHSAY
OrthoDBiEOG091G00ZD
PhylomeDBiG5EEE9

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

G5EEE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRELFIFLL LLGECANVKV KVGHIGAVGS MRNAEKILQL SKEQLTQEGV
60 70 80 90 100
LGNDFDIEIL NQMGCGESYE GVAVGADMYH VQGVRAFIGP YCNAELDAVA
110 120 130 140 150
KMATFWNIPV VGYMASSNSF ADKTIFKTLA RVSLRTTNSL AEAAAALIKH
160 170 180 190 200
YGWNKVAIAT NTGAVAFERV QSFEEVFHQR GINVVRKIML EEYTNAKAIM
210 220 230 240 250
NSGLLQELEN SARVVVCAFS STRDMNKEFM QAVTLSGMNN ANYAWILPWL
260 270 280 290 300
QLETKDMAPW LGENGEYQQN VKDHFANSFI IDDVNGFDNT LVTPFKERLE
310 320 330 340 350
ASGYSTDDLE MKNIYGYIHL YDALRLYALA VRATMNETGN ENSYLNGKEV
360 370 380 390 400
WNHMRRITFP GLVSNAGVTS GTVMMDDIAE RAPVYAAFYV PPNSDTVRKV
410 420 430 440 450
CELEPVMLTN CDGTKTGNGC YELQVTDLST GFWPSIDGSL PADEPACGFR
460 470 480 490 500
NEKCDYTTLI IGGCIVLLII LLIICFFILS RVCENRALAN TPWRIYRDDF
510 520 530 540 550
RTIQENEMKS MLSIGSSKTK MSNMSMFVKH HAVVGTNTHA SFHLYPQRRP
560 570 580 590 600
IVFNRQDLQL LNQMKQAVHD NLNPFLGMSF NEKEEMVVLW KFCSRGTIQD
610 620 630 640 650
MIYNQEVSLD SKFHGAFIRD ITLGLEYLHS SIIGYHGSLT PWSCLIDRNW
660 670 680 690 700
MIKLTDYGIA NPLERWEKLG LISTETLKEG DDKSGSAQKT SLLYQPPEML
710 720 730 740 750
KNKESNRTRR MDQSWVKQSQ ARRQMGDIYA FGMVMHEILF RALPFPNGTN
760 770 780 790 800
VSEVMDYIRD GTKTFRPTVH DRTQIHPDLV ALLLDCWNEN PEVRPSIRRV
810 820 830 840 850
RLNTENYLKV KGSLVDQMMR MMEQYANNLE KLVAERTGML EEANVRADKL
860 870 880 890 900
LGQLLPKYVA NELKMGRSVP AKTFDMATVM FSDIVGFTTI CSSSTPLEVV
910 920 930 940 950
SMLNSIYSKF DDAINKHGSY KVETIGDAYM IVSGIPEENG NEHIRNICNT
960 970 980 990 1000
ALELMLLLKT YEIPHRRNVK LRIRLGIHTG TVAAGVVGLT APRYCLFGDT
1010 1020 1030 1040 1050
VNVASRMEST SEPEKIQMSQ EARDFCVRYY SEFQITLRGT VEAKGKGPVT
1060 1070
SYWLLGKQSE SQMQQQNFSQ LGI
Length:1,073
Mass (Da):121,128
Last modified:December 14, 2011 - v1
Checksum:i8B7DD98D84D3A46C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB201390 mRNA Translation: BAE78830.1
FO081749 Genomic DNA Translation: CCD74008.1
RefSeqiNP_500309.3, NM_067908.4
UniGeneiCel.12776

Genome annotation databases

EnsemblMetazoaiT26C12.4; T26C12.4; WBGene00001548
GeneIDi191652
KEGGicel:CELE_T26C12.4

Similar proteinsi

Entry informationi

Entry nameiGCY23_CAEEL
AccessioniPrimary (citable) accession number: G5EEE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: December 14, 2011
Last modified: April 25, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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