Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 77 (12 Aug 2020)
Sequence version 1 (14 Dec 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18

Gene

daf-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate (PubMed:15637588). By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance (PubMed:9885576, PubMed:10209098, PubMed:10377431, PubMed:16950159, PubMed:19249087, PubMed:23995781, PubMed:10077613, PubMed:20207731). Similarly, promotes apoptosis during embryonic development by suppressing the recruitment of the prosurvival kinases akt-1/2 to the plasma membrane (PubMed:25383666). In addition, regulates Z2/Z3 germline precursor cell cycle by maintaining them arrested at the G2 stage and by controlling their growth during L1 diapause (PubMed:16631584). After sperm depletion in larvae and adult hermaphrodites, promotes germline stem cell quiescence and oocyte accumulation (PubMed:26552888). By dephosphorylating ephrin-like receptor vab-1 on tyrosine residues, negatively regulates oocyte maturation downstream of vab-1 and upstream of mpk-1, independently of daf-2 (PubMed:19853560). Plays a role in postembryonic muscle arm extensions (PubMed:18436204). Required for neurite outgrowth during AIY interneuron embryonic development (PubMed:22069193). Mainly independently of daf-2, negatively regulates vulva induction probably by inhibiting mpk-1 phosphorylation (PubMed:22916028). Both lipid and protein phosphatase activities are required for the regulation of vulva induction (PubMed:22916028).1 PublicationBy similarity15 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei169Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid metabolism
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1660499, Synthesis of PIPs at the plasma membrane
R-CEL-1855204, Synthesis of IP3 and IP4 in the cytosol
R-CEL-199418, Negative regulation of the PI3K/AKT network
R-CEL-202424, Downstream TCR signaling
R-CEL-5689880, Ub-specific processing proteases
R-CEL-5689896, Ovarian tumor domain proteases
R-CEL-8948747, Regulation of PTEN localization
R-CEL-8948751, Regulation of PTEN stability and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
G5EE01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18Curated (EC:3.1.3.16By similarity, EC:3.1.3.481 Publication, EC:3.1.3.671 Publication)
Alternative name(s):
Abnormal dauer formation protein 18Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:daf-18Imported
ORF Names:T07A9.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
T07A9.6 ; CE26385 ; WBGene00000913 ; daf-18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants are viable but with a shorter lifespan. They also fail to enter dauer stage under starvation conditions and 17 percent of mutants display vulval bursting (PubMed:10209098, PubMed:10377431, PubMed:20207731). Unlike in wild-type animals, germline stem cell proliferation continues following sperm depletion and Z2/Z3 germline precursors continue to proliferate during L1 diapause (PubMed:16631584, PubMed:26552888). The number of unfertilized eggs laid after sperm depletion is also increased (PubMed:26552888). Prevents constitutive dauer entry and pharynx remodeling and restores normal brood size in a daf-2 mutant background (PubMed:10209098, PubMed:10377431). Prevents increase in lifespan in an arr-1 (ok401) mutant background or in mpz-1 RNAi-mediated knockdown animals (PubMed:20207731). Suppresses the increase in ovulation rate and mpk-1 phosphorylation in distal oocytes in a vab-1 (dx31) mutant background. Restores normal axon extension of PLM neurons in a daf-2 (e1370) mutant background (PubMed:23995781). RNAi-mediated knockdown prevents arrest at the dauer larval stage in a daf-2 or age-1 mutant background (PubMed:9885576, PubMed:10077613). In addition, suppresses increased thermotolerance and fat storage and reduces daf-16 nuclear localization in a daf-2 mutant background (PubMed:19249087).9 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi137D → A: Probable loss of phosphatase activity. Stabilizes the interaction with vab-1. 1 Publication1
Mutagenesisi169C → S: Loss of tyrosine phosphatase activity. 1 Publication1
Mutagenesisi174G → E: Probable loss of lipid phosphatase activity without affecting protein phosphatase activity. Fails to prevent both constitutive dauer formation and increased lifespan in a daf-2 (e1370) mutant background. Partially increases the percentage of animals lacking a vulva in a let-23 mutant background and partially reduces the number of animals with multiple vulva in a gain-of-function let-60 mutant background. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004378721 – 962Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18CuratedAdd BLAST962

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by vab-1 on tyrosine residues which may promote daf-18 degradation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EE01

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EE01

PeptideAtlas

More...
PeptideAtlasi
G5EE01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryo, larvae and in adult germline (at protein level) (PubMed:16481471, PubMed:22916028, PubMed:19853560). Expressed at equal levels in the 6 vulva precursor cells (VPCs) of L2 larvae and in the descendant cells of the induced VPCs (at protein level) (PubMed:22916028). Expressed in the uterus (at protein level) (PubMed:22916028). Expressed in the Z2/Z3 germline precursors, oocytes, several amphid neurons and weakly in the nerve cord (at protein level) (PubMed:19853560).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000913, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with vab-1 (via kinase domain); the interaction is independent of vab-1 kinase activity (PubMed:19853560).

Interacts with arr-1 and mpz-1; the interaction may inhibit daf-18 (PubMed:20207731).

Interacts (via C-terminus) with daf-2 (via kinase domain) (PubMed:23995781).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3881, arr-1-mpz-1-daf-18 complex

Protein interaction database and analysis system

More...
IntActi
G5EE01, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T07A9.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EE01

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 230Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST173
Domaini234 – 530C2 tensin-typePROSITE-ProRule annotationAdd BLAST297

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PTEN phosphatase protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2283, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163053

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_307414_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EE01

KEGG Orthology (KO)

More...
KOi
K01110

Database of Orthologous Groups

More...
OrthoDBi
1195490at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10409, PTEN_C2, 1 hit
PF00102, Y_phosphatase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01326, PTEN_C2, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51181, PPASE_TENSIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EE01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTPPPDVPS TSTRSMARDL QENPNRQPGE PRVSEPYHNS IVERIRHIFR
60 70 80 90 100
TAVSSNRCRT EYQNIDLDCA YITDRIIAIG YPATGIEANF RNSKVQTQQF
110 120 130 140 150
LTRRHGKGNV KVFNLRGGYY YDADNFDGNV ICFDMTDHHP PSLELMAPFC
160 170 180 190 200
REAKEWLEAD DKHVIAVHCK AGKGRTGVMI CALLIYINFY PSPRQILDYY
210 220 230 240 250
SIIRTKNNKG VTIPSQRRYI YYYHKLRERE LNYLPLRMQL IGVYVERPPK
260 270 280 290 300
TWGGGSKIKV EVGNGSTILF KPDPLIISKS NHQRERATWL NNCDTPNEFD
310 320 330 340 350
TGEQKYHGFV SKRAYCFMVP EDAPVFVEGD VRIDIREIGF LKKFSDGKIG
360 370 380 390 400
HVWFNTMFAC DGGLNGGHFE YVDKTQPYIG DDTSIGRKNG MRRNETPMRK
410 420 430 440 450
IDPETGNEFE SPWQIVNPPG LEKHITEEQA MENYTNYGMI PPRYTISKIL
460 470 480 490 500
HEKHEKGIVK DDYNDRKLPM GDKSYTESGK SGDIRGVGGP FEIPYKAEEH
510 520 530 540 550
VLTFPVYEMD RALKSKDLNN GMKLHVVLRC VDTRDSKMME KSEVFGNLAF
560 570 580 590 600
HNESTRRLQA LTQMNPKWRP EPCAFGSKGA EMHYPPSVRY SSNDGKYNGA
610 620 630 640 650
CSENLVSDFF EHRNIAVLNR YCRYFYKQRS TSRSRYPRKF RYCPLIKKHF
660 670 680 690 700
YIPADTDDVD ENGQPFFHSP EHYIKEQEKI DAEKAAKGIE NTGPSTSGSS
710 720 730 740 750
APGTIKKTEA SQSDKVKPAT EDELPPARLP DNVRRFPVVG VDFENPEEES
760 770 780 790 800
CEHKTVESIA GFEPLEHLFH ESYHPNTAGN MLRQDYHTDS EVKIAEQEAK
810 820 830 840 850
AFVDQLLNGQ GVLQEFMKQF KVPSDNSFAD YVTGQAEVFK AQIALLEQSE
860 870 880 890 900
DFQRVQANAE EVDLEHTLGE AFERFGHVVE ESNGSSKNPK ALKTREQMVK
910 920 930 940 950
ETGKDTQKTR NHVLLHLEAN HRVQIERRET CPELHPEDKI PRIAHFSENS
960
FSDSNFDQAI YL
Length:962
Mass (Da):110,329
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79212EF05C959837
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ131181 mRNA Translation: CAA10315.1
AF098286 mRNA Translation: AAD03420.1
AF126286 mRNA Translation: AAD21620.1
BX284604 Genomic DNA Translation: CCD73977.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T51924

NCBI Reference Sequences

More...
RefSeqi
NP_499926.1, NM_067525.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T07A9.6.1; T07A9.6.1; WBGene00000913

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T07A9.6

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131181 mRNA Translation: CAA10315.1
AF098286 mRNA Translation: AAD03420.1
AF126286 mRNA Translation: AAD21620.1
BX284604 Genomic DNA Translation: CCD73977.1
PIRiT51924
RefSeqiNP_499926.1, NM_067525.5

3D structure databases

SMRiG5EE01
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3881, arr-1-mpz-1-daf-18 complex
IntActiG5EE01, 3 interactors
STRINGi6239.T07A9.6

Proteomic databases

EPDiG5EE01
PaxDbiG5EE01
PeptideAtlasiG5EE01

Genome annotation databases

EnsemblMetazoaiT07A9.6.1; T07A9.6.1; WBGene00000913
GeneIDi176869
KEGGicel:CELE_T07A9.6

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176869
WormBaseiT07A9.6 ; CE26385 ; WBGene00000913 ; daf-18

Phylogenomic databases

eggNOGiKOG2283, Eukaryota
GeneTreeiENSGT00940000163053
HOGENOMiCLU_307414_0_0_1
InParanoidiG5EE01
KOiK01110
OrthoDBi1195490at2759

Enzyme and pathway databases

ReactomeiR-CEL-1660499, Synthesis of PIPs at the plasma membrane
R-CEL-1855204, Synthesis of IP3 and IP4 in the cytosol
R-CEL-199418, Negative regulation of the PI3K/AKT network
R-CEL-202424, Downstream TCR signaling
R-CEL-5689880, Ub-specific processing proteases
R-CEL-5689896, Ovarian tumor domain proteases
R-CEL-8948747, Regulation of PTEN localization
R-CEL-8948751, Regulation of PTEN stability and activity
SignaLinkiG5EE01

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EE01

Gene expression databases

BgeeiWBGene00000913, Expressed in adult organism and 5 other tissues

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
PfamiView protein in Pfam
PF10409, PTEN_C2, 1 hit
PF00102, Y_phosphatase, 1 hit
SMARTiView protein in SMART
SM01326, PTEN_C2, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51181, PPASE_TENSIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTEN_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EE01
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: December 14, 2011
Last modified: August 12, 2020
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again