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Entry version 75 (05 Jun 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Phosphatidylinositol 3-kinase piki-1

Gene

piki-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phagocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1660499 Synthesis of PIPs at the plasma membrane
R-CEL-1660514 Synthesis of PIPs at the Golgi membrane
R-CEL-1660516 Synthesis of PIPs at the early endosome membrane
R-CEL-432722 Golgi Associated Vesicle Biogenesis
R-CEL-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
G5EDY0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase piki-11 Publication (EC:2.7.1.1371 Publication)
Alternative name(s):
Phosphoinositide-3-kinase class 21 Publication
Short name:
PI3-kinase class 21 Publication
Short name:
PI3K class 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:piki-1Imported
ORF Names:F39B1.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F39B1.1 ; CE05832 ; WBGene00009552 ; piki-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1059K → A: May disrupt ATP binding. Severe defect in apoptotic cell corpse clearance in gonads. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004362661 – 1607Phosphatidylinositol 3-kinase piki-1CuratedAdd BLAST1607

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDY0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EDY0

PeptideAtlas

More...
PeptideAtlasi
G5EDY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009552 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_R02F2.5Q216483EBI-321433,EBI-314179

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5EDY0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F39B1.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 21UIMPROSITE-ProRule annotationAdd BLAST20
Domaini362 – 453PI3K-RBDPROSITE-ProRule annotationAdd BLAST92
Domaini598 – 766C2 PI3K-typePROSITE-ProRule annotationAdd BLAST169
Domaini776 – 953PIK helicalPROSITE-ProRule annotationAdd BLAST178
Domaini1054 – 1317PI3K/PI4KPROSITE-ProRule annotationAdd BLAST264
Domaini1344 – 1458PXPROSITE-ProRule annotationAdd BLAST115
Domaini1485 – 1576C2PROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 172Pro-richPROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0905 Eukaryota
COG5032 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169868

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EDY0

KEGG Orthology (KO)

More...
KOi
K00923

Identification of Orthologs from Complete Genome Data

More...
OMAi
IQRGQWP

Database of Orthologous Groups

More...
OrthoDBi
204282at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EDY0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR036871 PX_dom_sf
IPR003903 UIM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit
PS50330 UIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EDY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDEELQLA IEISKKTFKD EQKLRSNDLD LIRFESPDEP ARQRKINQIK
60 70 80 90 100
QLYEANSPGP SSYSGSLATS PIDFRPVYNE PRAGPIPHSQ SYPRNYFQDW
110 120 130 140 150
SAIASTSQPP AFPPPPRPPK PEQYKFPPAP SVPLLHDRYF VPPPPPVPPR
160 170 180 190 200
HSRVQQSPPV PIHPTPPVSS TPLRHSAPSF ASDSQQFLSP IKPFEISFNS
210 220 230 240 250
TVDTSSNQTG SHDHSIQYQP LTHLYVPYVM HSLNSSYGAL LNGDLIDLSA
260 270 280 290 300
FEDSSNASQD EIRKEFDPLF ISTYSTDTPS PDNSMPAVNA YFSKPIDEPE
310 320 330 340 350
CVGGAKLIQE NIEFPSSSFC LIDCPNGIEE QVKKLCKRNL IRKDMTPDFF
360 370 380 390 400
IAPTVDYMVT TASTVKVVVY KDHSWKANKS NGKAMICAID EKMDIITTQA
410 420 430 440 450
LSLFDSELPT DKEYGLKIYG LNQFLSSDSL LGSNLYTGHC LLNGDDVKLD
460 470 480 490 500
LGVFAPNSRI YEQTLESWNL MKSQVKYSTV VDKEDVENTL GHLASEMSQY
510 520 530 540 550
EIAFNDGSTL KLSSSSQRVK QVIMLLCKCL HGIVPEKLYN EMQKYLASTT
560 570 580 590 600
EDQLVHHRND FLREIHSFLE LYCRCTVSRY NIPPLQIITK PKVEVLSKMD
610 620 630 640 650
FLQIMLNSVH SIPEHWQSQY SEFYMSLDLY HGTQVLDGFS NKVPKTIKND
660 670 680 690 700
HFFPRIPLDL YAKFKRLNLC QYPRETRIVV SISGTVRNSA QAANEYNPDI
710 720 730 740 750
VMLGYCSVPL YDENLFMRQG PLFLPLTLLK KQPMLKPFGP YPYIKDARDP
760 770 780 790 800
ILIMSFKIWD TEIYFPNVVI DMQCIPQDFA TLDIETQEYL LELIENQDTS
810 820 830 840 850
TLETDDQDLI WQKRLHLTNQ PEALPLVLSS LQDWSFGFVM RVYQILEEWA
860 870 880 890 900
PLRPEIAMEF LLPKYPDERI RAHAVQSLAR GSTDFLYHTI PQFIEALRFE
910 920 930 940 950
LYEKSALADF ILELSFVSLD FTFEIYWQLQ QRVDHCAVDD LPYAIRCQNL
960 970 980 990 1000
QQKMIDEHEN PNLKTDIKLQ HELLNELDSI QDDLRSKSGD SEIERLHRLR
1010 1020 1030 1040 1050
TRLGILDSKL LQNKVRLPIC PAFDCTGVRI EECSVFNSNA KPLKIVFRGL
1060 1070 1080 1090 1100
NMNYSIIHKR DDDMRQDAFV MKMLNEMDRI WKSNGLDLRM ITFRIMPVGY
1110 1120 1130 1140 1150
RRGMGELVLN CATLMEIQKE EGLRGVLNDE ILRKWLMKHN SDEFAYKEAQ
1160 1170 1180 1190 1200
ENFIRSCAGW CIVTYVLGIG DRHNDNILFT KNGHVFHIDF GKYMGDWQMA
1210 1220 1230 1240 1250
AGFRRDRVPF VFTTEMFHVI NNGRAPTQYN QKFIDYCCKA FNHLRRNKNT
1260 1270 1280 1290 1300
LTNLLRIMAC SDIPGINMDS LAFVENNLML DLSDTDATVQ FTAMIQNSLG
1310 1320 1330 1340 1350
SAFVRLNFVA HTVAQFISSR PSFSKQDPNK LSFVPELYTE NSDGRISRVT
1360 1370 1380 1390 1400
VLKFEKHCIP NKIYMYKVEV HRKNVAVSSF IYRSFAEFEE LHTKLRARFP
1410 1420 1430 1440 1450
MMAVSLNTIS NLRSNVRAVA QKRIIHVQKF LIYLFNQVDE ICHCDLVYTF
1460 1470 1480 1490 1500
FHSILRDNKC DTYIDESLDM PSQCQIYLKI EYNSVKETLS VFIGHAKYLA
1510 1520 1530 1540 1550
LLQNNQQPDP YVKTYVRPDL RNQSKQKTQV VRGTRHPTFN QDLNYTEFPI
1560 1570 1580 1590 1600
EILSTRVLEV SIWNNGGYLV KHKMYMLCIP LLKVKKLAES RKNCRTLEGW

FNCEKCV
Length:1,607
Mass (Da):185,305
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77153B9F760C8DC1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA93489.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21982

NCBI Reference Sequences

More...
RefSeqi
NP_510529.1, NM_078128.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F39B1.1; F39B1.1; WBGene00009552

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181618

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F39B1.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA93489.1
PIRiT21982
RefSeqiNP_510529.1, NM_078128.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5EDY0, 2 interactors
STRINGi6239.F39B1.1

Proteomic databases

EPDiG5EDY0
PaxDbiG5EDY0
PeptideAtlasiG5EDY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF39B1.1; F39B1.1; WBGene00009552
GeneIDi181618
KEGGicel:CELE_F39B1.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181618
WormBaseiF39B1.1 ; CE05832 ; WBGene00009552 ; piki-1

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00940000169868
InParanoidiG5EDY0
KOiK00923
OMAiIQRGQWP
OrthoDBi204282at2759
PhylomeDBiG5EDY0

Enzyme and pathway databases

ReactomeiR-CEL-1660499 Synthesis of PIPs at the plasma membrane
R-CEL-1660514 Synthesis of PIPs at the Golgi membrane
R-CEL-1660516 Synthesis of PIPs at the early endosome membrane
R-CEL-432722 Golgi Associated Vesicle Biogenesis
R-CEL-8856828 Clathrin-mediated endocytosis
SignaLinkiG5EDY0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EDY0

Gene expression databases

BgeeiWBGene00009552 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR036871 PX_dom_sf
IPR003903 UIM_dom
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit
PS50330 UIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIKI1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: December 14, 2011
Last modified: June 5, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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