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Entry version 66 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Latrophilin-like protein 1

Gene

lat-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding.

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latrophilin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lat-1Imported
ORF Names:B0457.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
B0457.1a ; CE02945 ; WBGene00002251 ; lat-1
B0457.1b ; CE32789 ; WBGene00002251 ; lat-1
B0457.1c ; CE36086 ; WBGene00002251 ; lat-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 555ExtracellularSequence analysisAdd BLAST528
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei556 – 576Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini577 – 584CytoplasmicSequence analysis8
Transmembranei585 – 605Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini606 – 613ExtracellularSequence analysis8
Transmembranei614 – 634Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini635 – 653CytoplasmicSequence analysisAdd BLAST19
Transmembranei654 – 674Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini675 – 692ExtracellularSequence analysisAdd BLAST18
Transmembranei693 – 713Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini714 – 745CytoplasmicSequence analysisAdd BLAST32
Transmembranei746 – 766Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini767 – 770ExtracellularSequence analysis4
Transmembranei771 – 791Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini792 – 1014CytoplasmicSequence analysisAdd BLAST223

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Approximately 17% arrest during embryogenesis and 56% arrest at the L1 developmental stage. Defects present in seam cell positioning and division plane. Unfertilized oocytes in hermaphrodites. Five-fold less sensitive to the inhibitory effects of emodepside or imipramine on pharyngeal pumping. Irregular defecation.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi528H → A: Abolishes autocatalytic cleavage activity. 1 Publication1
Mutagenesisi530T → A: Abolishes autocatalytic cleavage activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042198128 – 1014Latrophilin-like protein 1Add BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EDW2

PeptideAtlas

More...
PeptideAtlasi
G5EDW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epidermal precursor cells and pharyngeal primordium. In adults expression is seen in pharyngeal muscle cells and nervous system, the nerve ring, the gonad, and the vulva.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during oogenesis, embryogenesis, and organogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002251, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
39746, 2 interactors

Protein interaction database and analysis system

More...
IntActi
G5EDW2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.B0457.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EDW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 134SUEL-type lectinPROSITE-ProRule annotationAdd BLAST92
Domaini494 – 541GPSPROSITE-ProRule annotation1 PublicationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni814 – 833DisorderedSequence analysisAdd BLAST20
Regioni932 – 994DisorderedSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi939 – 954Pro residuesSequence analysisAdd BLAST16
Compositional biasi955 – 994Polar residuesSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GPS domain is required for signaling.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193, Eukaryota
KOG4729, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_293252_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EDW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLYNTND

Database of Orthologous Groups

More...
OrthoDBi
388923at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EDW2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111418, SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50228, SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a3 Publications (identifier: G5EDW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRNKTTYSL LQTILVACLL TVTPTFASNK PTTDESGTIS HTICDGEAAE
60 70 80 90 100
LSCPAGKVIS IVLGNYGRFS VAVCLPDNDI VPSNINCQNH KTKSILEKKC
110 120 130 140 150
NGDSMCYFTV DKKTFTEDPC PNTPKYLEVK YNCVVPATTT TTTTTTSTTT
160 170 180 190 200
TDSSLIVDEE EEAQKDALNS DVIKPVKKKE DVFCSATNRR GVNWQNTKSG
210 220 230 240 250
TTSSAPCPEG SSGKQLWACT EEGQWLTEFP NSAGCESNWI SSRNSVLSGV
260 270 280 290 300
ISSEDVSGLP EFLRNLGSET RRPMVGGDLP KVLHLLEKTV NVIAEESWAY
310 320 330 340 350
QHLPLSNKGA VEVMNYMLRN QEIWGSWDVT KRKEFASRFI LAAEKAMVAS
360 370 380 390 400
AKGMMTSAES NVIVQPAITV EISHKIKMSS QPTDYILFPS AALWNGQNVD
410 420 430 440 450
NVNIPRDAIL KINKDETQVF FSSFDNLGAQ MTPSDVTVAI AGTDQTEVRK
460 470 480 490 500
RRVVSRIVGA SLIENGKERR VENLTQPVRI TFYHKESSVR HLSNPTCVWW
510 520 530 540 550
NHHELKWKPS GCKLSYHNKT MTSCDCTHLT HFAVLMDVRG HDLNEIDQTL
560 570 580 590 600
LTLLTYVGCI ISIICLLLTF FAYLIFSRNG GDRVFIHENL CLSLAIAEIT
610 620 630 640 650
FLAGITRTED SLQCGIIAVA LMYMFLSALT WMLLEGYHIH RMLTEVFPSD
660 670 680 690 700
PRRFTYLLVG YIPPAIITLV AYLYNSDGFG TPDHCWLSTQ NNFIWFFAGP
710 720 730 740 750
ACFIFCANSL VLVKTLCTVY QHTSGGYLPC RHDVDSGRSI RNWVKGSLAL
760 770 780 790 800
ASLLGVTWIF GLFWVEDSRS IVMAYVFTIS NSLQGLFIFL FHVVFAEKMR
810 820 830 840 850
KDVGHWMYRR GCGGSSNSSP NHKRHNVQRD LMSPGVNSST GSDFLYNTND
860 870 880 890 900
KYLTNSDTTN RLVYNGIMNH PNQMSVYQQH PHHQIYEQQP GTYDYATIAY
910 920 930 940 950
GDMMPGHRVA APPAYQRLAV AEGRYGSQHQ LYQGWHHRPP PEFSPPPPPL
960 970 980 990 1000
STGPPNSRHY GTGSSGRRPP SSKMSDDSAY SDGSSSMLTT EVTPQGQTVL
1010
RIDLNKPSMY CQDL
Length:1,014
Mass (Da):113,025
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74CC38DE6D82FB40
GO
Isoform b2 Publications (identifier: G5EDW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-124: DSMCYFTVDKKTFTEDPCPNTP → KQTCRFFVDTFLFDDACPMMS
     130-136: KYNCVVP → QHECHE

Show »
Length:1,012
Mass (Da):112,948
Checksum:i8F007AD4FD6D215B
GO
Isoform c1 Publication (identifier: G5EDW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-114: KCNGDSMCYFTVDKKT → NYHDDYNHNYINYYNR
     115-1014: Missing.

Show »
Length:114
Mass (Da):12,700
Checksum:i92F67B6E94B6278E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04629299 – 114KCNGD…VDKKT → NYHDDYNHNYINYYNR in isoform c. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_046293103 – 124DSMCY…CPNTP → KQTCRFFVDTFLFDDACPMM S in isoform b. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_046294115 – 1014Missing in isoform c. 1 PublicationAdd BLAST900
Alternative sequenceiVSP_046295130 – 136KYNCVVP → QHECHE in isoform b. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY314770 mRNA Translation: AAQ84877.1
AY314771 mRNA Translation: AAQ84878.1
Z54306 Genomic DNA Translation: CAA91091.1
Z54306 Genomic DNA Translation: CAD59141.1
Z54306 Genomic DNA Translation: CAE54881.1

Protein sequence database of the Protein Information Resource

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PIRi
T18759

NCBI Reference Sequences

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RefSeqi
NP_001021897.1, NM_001026726.3
NP_495894.1, NM_063493.3
NP_871949.1, NM_182149.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0457.1a.1; B0457.1a.1; WBGene00002251 [G5EDW2-1]
B0457.1b.1; B0457.1b.1; WBGene00002251 [G5EDW2-2]
B0457.1c.1; B0457.1c.1; WBGene00002251 [G5EDW2-3]

UCSC genome browser

More...
UCSCi
B0457.1a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314770 mRNA Translation: AAQ84877.1
AY314771 mRNA Translation: AAQ84878.1
Z54306 Genomic DNA Translation: CAA91091.1
Z54306 Genomic DNA Translation: CAD59141.1
Z54306 Genomic DNA Translation: CAE54881.1
PIRiT18759
RefSeqiNP_001021897.1, NM_001026726.3
NP_495894.1, NM_063493.3
NP_871949.1, NM_182149.4

3D structure databases

SMRiG5EDW2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi39746, 2 interactors
IntActiG5EDW2, 1 interactor
STRINGi6239.B0457.1a

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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Proteomic databases

EPDiG5EDW2
PaxDbiG5EDW2
PeptideAtlasiG5EDW2

Genome annotation databases

EnsemblMetazoaiB0457.1a.1; B0457.1a.1; WBGene00002251 [G5EDW2-1]
B0457.1b.1; B0457.1b.1; WBGene00002251 [G5EDW2-2]
B0457.1c.1; B0457.1c.1; WBGene00002251 [G5EDW2-3]
UCSCiB0457.1a, c. elegans

Organism-specific databases

WormBaseiB0457.1a ; CE02945 ; WBGene00002251 ; lat-1
B0457.1b ; CE32789 ; WBGene00002251 ; lat-1
B0457.1c ; CE36086 ; WBGene00002251 ; lat-1

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
KOG4729, Eukaryota
HOGENOMiCLU_293252_0_0_1
InParanoidiG5EDW2
OMAiFLYNTND
OrthoDBi388923at2759
PhylomeDBiG5EDW2

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EDW2

Gene expression databases

BgeeiWBGene00002251, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

Family and domain databases

Gene3Di2.60.120.740, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PRINTSiPR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SUPFAMiSSF111418, SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50228, SUEL_LECTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPLT1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDW2
Secondary accession number(s): G5EEH7, Q7JM97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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