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Protein
Submitted name:

DNA-binding protein LAG-1

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
DNA-binding protein LAG-1Imported
Submitted name:
Lag-1 proteinImported
Submitted name:
Lin-12 And Glp-1 phenotypeImported
Gene namesi
Name:lag-1Imported
ORF Names:CELE_K08B4.1Imported, K08B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08B4.1a ; CE28839 ; WBGene00002245 ; lag-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiWBGene00002245 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3152 CSL-Notch-Mastermind transcription factor complex
IntActiG5EDU7, 15 interactors
MINTiG5EDU7
STRINGi6239.K08B4.1a

Structurei

3D structure databases

SMRiG5EDU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 380LAG1_DNAbindInterPro annotationAdd BLAST165
Domaini384 – 536BTDInterPro annotationAdd BLAST153

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
KOiK06053
OMAiFRSEEMM

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 2 hits
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G5EDU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIVPEAMFQS
60 70 80 90 100
VSPLAGVAAA PSQIAALQQI QALMTFQMQQ NNLFPKIDTI SKSPTPELAS
110 120 130 140 150
PSAKRMRLSP STSSHSDVAS TSKGTNGQDQ SKNSPTNSDP FYTIGQSTPN
160 170 180 190 200
TSSFLDTSNS SFGAPSTVVA NPMTNYQLAF QAKLGSLHSL IGDSVQSLTS
210 220 230 240 250
DRMIDFLSNK EKYECVISIF HAKVAQKSYG NEKRFFCPPP CIYLIGQGWK
260 270 280 290 300
LKKDRVAQLY KTLKASAQKD AAIENDPIHE QQATELVAYI GIGSDTSERQ
310 320 330 340 350
QLDFSTGKVR HPGDQRQDPN IYDYCAAKTL YISDSDKRKY FDLNAQFFYG
360 370 380 390 400
CGMEIGGFVS QRIKVISKPS KKKQSMKNTD CKYLCIASGT KVALFNRLRS
410 420 430 440 450
QTVSTRYLHV EGNAFHASST KWGAFTIHLF DDERGLQETD NFAVRDGFVY
460 470 480 490 500
YGSVVKLVDS VTGIALPRLR IRKVDKQQVI LDASCSEEPV SQLHKCAFQM
510 520 530 540 550
IDNELVYLCL SHDKIIQHQA TAINEHRHQI NDGAAWTIIS TDKAEYRFFE
560 570 580 590 600
AMGQVANPIS PCPVVGSLEV DGHGEASRVE LHGRDFKPNL KVWFGATPVE
610 620 630 640 650
TTFRSEESLH CSIPPVSQVR NEQTHWMFTN RTTGDVEVPI SLVRDDGVVY
660 670
SSGLTFSYKS LERHGPCRIV SNY
Length:673
Mass (Da):74,947
Last modified:December 14, 2011 - v1
Checksum:i72B236C29ECAE0B6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8MXE7Q8MXE7_CAEEL
Lin-12 And Glp-1 phenotype
lag-1 CELE_K08B4.1, K08B4.1
671Annotation score:
V6CK60V6CK60_CAEEL
Lin-12 And Glp-1 phenotype
lag-1 CELE_K08B4.1, K08B4.1
627Annotation score:
V6CLJ5V6CLJ5_CAEEL
Lin-12 And Glp-1 phenotype
lag-1 CELE_K08B4.1, K08B4.1
790Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49794 mRNA Translation: AAB03858.1
U49795 Genomic DNA Translation: AAB03859.1
BX284604 Genomic DNA Translation: CCD72375.1
PIRiT33741
RefSeqiNP_741410.1, NM_171350.4
UniGeneiCel.18193

Genome annotation databases

EnsemblMetazoaiK08B4.1a; K08B4.1a; WBGene00002245
GeneIDi177373
KEGGicel:CELE_K08B4.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49794 mRNA Translation: AAB03858.1
U49795 Genomic DNA Translation: AAB03859.1
BX284604 Genomic DNA Translation: CCD72375.1
PIRiT33741
RefSeqiNP_741410.1, NM_171350.4
UniGeneiCel.18193

3D structure databases

SMRiG5EDU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3152 CSL-Notch-Mastermind transcription factor complex
IntActiG5EDU7, 15 interactors
MINTiG5EDU7
STRINGi6239.K08B4.1a

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08B4.1a; K08B4.1a; WBGene00002245
GeneIDi177373
KEGGicel:CELE_K08B4.1

Organism-specific databases

CTDi177373
WormBaseiK08B4.1a ; CE28839 ; WBGene00002245 ; lag-1

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
KOiK06053
OMAiFRSEEMM

Gene expression databases

BgeeiWBGene00002245 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 2 hits
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5EDU7_CAEEL
AccessioniPrimary (citable) accession number: G5EDU7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 10, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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