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Entry version 80 (12 Aug 2020)
Sequence version 1 (14 Dec 2011)
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Protein

Retinoblastoma-like protein homolog lin-35

Gene

lin-35

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated (PubMed:11684669, PubMed:12062054, PubMed:16287966, PubMed:17466069, PubMed:25562820). When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development (PubMed:11684669, PubMed:12062054, PubMed:15238519, PubMed:17466069, PubMed:25562820). May furthermore act with cell cycle regulator cki-1 to negatively regulate cell cycle progression (PubMed:11684669). Acts redundantly with lin-53, fzr-1 and lin-23 to control cell cycle progression by regulating the expression of G1 phase cyclins (PubMed:11850412, PubMed:25562820). In particular, negatively regulates the expression of the cyclin E homolog cye-1, which is essential for the G1/S phase transition (PubMed:16287966, PubMed:17466069). Regulates cell division in the intestinal lineage, repressing the expression of genes such as cdc-25.2, which are required for intestinal cells to transition from the karyokinesis cell cycle (also known as nuclear division) to endoreplication, a specific growth pathway in the intestinal epithelium required for feeding and gut development in growing larvae during the L1 stage molt (PubMed:17466069, PubMed:27104746). Its role as a transcriptional repressor in the regulation of intestinal cell division during postembryonic development is most likely in complex with an E2F cell cycle regulatory transcription factor efl-1 and its binding partner the synthetic multivulva class B protein dpl-1 (PubMed:17466069). Synthetic multivulva (synMuv) class B protein (PubMed:9875852, PubMed:11850412). SynMuv proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:9875852, PubMed:17075059). Together with synMuv class B protein lin-53, and redundantly with synMuv class A protein lin-15A, represses transcription to control vulval development, most likely through antagonization of the Ras-signaling pathway in the major hypodermal syncytium hyp7 (PubMed:9875852, PubMed:15621535, PubMed:16624904, PubMed:26100681). Acts redundantly with the transcriptional corepressor spr-1 and the zinc finger protein zfp-2 to play a role in vulval morphogenesis, promote germline proliferation and somatic gonad development (PubMed:17417969, PubMed:17070797). Acts redundantly with ubc-18 in the regulation of pharyngeal morphogenesis during embryonic develpment by negatively regulating the expression of proteins such as sup-35 (PubMed:12783801, PubMed:19521497, PubMed:24214340). Functions with the SWI/SNF complex and proteins such as pha-1 to regulate larval development (PubMed:15196946, PubMed:15280233). Functions redundantly with xnp-1 to regulate somatic gonad development (PubMed:15328017, PubMed:15649460). Acts redundantly with slr-2 to regulate the expression of intestinal genes required for nutrient utilization (PubMed:18437219, PubMed:22542970). Regulates transcription in response to starvation (PubMed:23664972). Furthermore, in response to starvation, promotes germ cell programmed cell death by negatively regulating the expression of the anti-apoptotic protein ced-9 (PubMed:17881492, PubMed:24752899). Conversely, in conjunction with mcd-1, efl-1 and the synthetic multivulva class B proteins dpl-1, lin-37 and lin-52, may also regulate transcription to promote programmed cell death independently of ced-1, ced-8 and ced-9 cell death pathways (PubMed:17237514). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:23347407). In particular, negatively regulates the expression of mes-4, a histone methyltransferase that controls the expression of germline specific genes (PubMed:23347407). May play a role in double strand break formation during meiosis (PubMed:15315757). May suppress sensitivity to RNAi (PubMed:16507136, PubMed:17417969). May play a role in the response to endoplasmic reticulum (ER) stress (PubMed:24715729).3 Publications28 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-CEL-1538133, G0 and Early G1
R-CEL-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-CEL-2299718, Condensation of Prophase Chromosomes
R-CEL-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-CEL-69231, Cyclin D associated events in G1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinoblastoma-like protein homolog lin-35Curated
Alternative name(s):
Abnormal cell lineage protein 35Imported
Synthetic multivulva protein lin-35Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lin-35Imported
ORF Names:C32F10.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C32F10.2 ; CE24823 ; WBGene00003020 ; lin-35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable, but with a reduced fertility and brood size (PubMed:11684669, PubMed:15328017, PubMed:15280233, PubMed:17417969). Low penetrance defects including reduced integrity of the proximal gonad, a low percentage of endomitotic oocytes, distal tip cell migration defects and abnormalities in vulval morphology (PubMed:17417969). Some studies demonstrate aberrant intestinal nuclear divisions, with increased intestinal nuclei in growing larvae (PubMed:17466069). In addition there is increased sensitivity to RNA-induced gene silencing by RNAi (PubMed:16507136, PubMed:17417969). RNAi-mediated knockdown results in increased survival in response to ER stress inducer tunicamycin as compared to wild-type animals (PubMed:24715729). RNAi-mediated knockdown results in larval arrest at 25 degrees Celsius in an xpn-1 mutant background (PubMed:15649460). RNAi-mediated knockdown in a ced-1 mutant background results in reduced somatic cell apoptosis (PubMed:27650246). Double knockout with the synthetic multivulva class B protein lin-15A results in a multiple vulva (Muv) phenotype (PubMed:16624904, PubMed:26100681). Double knockout with either cdk-4 or cyd-1 rescues the cell cycle progression defect in the single cdk-4 and cyd-1 mutants (PubMed:11684669, PubMed:25562820). Double knockout with xnp-1 results in 43% embryonic lethality (PubMed:15328017). Surviving animals develop slowly, are small, sterile and display male and female gonad developmental defects characterized by shorter gonadal arms, fewer germ cells, an everted vulva phenotype, and failed formation of sheath and spermathecal cells (PubMed:15328017). Double knockout with spr-1 or zfp-2 results in defects in growth, vulval morphogenesis, somatic gonad development and fertility (PubMed:17417969, PubMed:17070797). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514). Programmed cell death defect in a ced-3 n2427 mutant background (PubMed:17237514). Knockout with RNAi-mediated knockdown of psa-1, ham-3, swsn-2.2, swsn-3 or swsn-6 (components of the SWI/SNF complex) results in larval arrest during larval development (PubMed:15280233). Knockout with RNAi-mediated knockdown of pha-1 (developmental protein), snfc-5 or swsn-8 (additional SWI/SNF complex components) results in sterility and/or a protruding vulva phenotype (PubMed:15196946, PubMed:15280233). Double knockout with slr-2 results in early larval arrest due to mis-regulation of intestinal specific gene expression, which results in starvation-induced growth arrest (PubMed:18437219, PubMed:22542970).17 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004410231 – 961Retinoblastoma-like protein homolog lin-35CuratedAdd BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei714Phosphoserine; by CDK41 Publication1
Modified residuei719Phosphothreonine; by CDK41 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by the cyclin dependent kinase cdk-4. Phosphorylation inhibits the transcriptional repressor activity of lin-35 and allows for progression through the G1 phase of the cell cycle during postembryonic development.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDT1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
G5EDT1

PeptideAtlas

More...
PeptideAtlasi
G5EDT1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G5EDT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos and newly hatched L1 larvae (PubMed:9875852). In older larvae and adults expressed in P3-8.p vulval precursor cells and its descendents (PubMed:9875852). Expressed in the major hypodermal syncytium hyp7 during the L3 stage of larval development (PubMed:15621535).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003020, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54, dpl-1 and efl-1 (PubMed:17075059).

Interacts with lin-53 (PubMed:9875852).

Interacts (via C-terminus) with dpl-1 (via C-terminus) and efl-1 (via C-terminus) (PubMed:11463372).

Interacts (via C-terminus) with lin-8 (PubMed:16020796).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1100, DRM complex
CPX-1138, RB1-E2F1-TFDP1 transcription repressor complex

Protein interaction database and analysis system

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IntActi
G5EDT1, 9 interactors

Molecular INTeraction database

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MINTi
G5EDT1

STRING: functional protein association networks

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STRINGi
6239.C32F10.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the retinoblastoma protein (RB) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1010, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183202

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_312900_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EDT1

KEGG Orthology (KO)

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KOi
K04681

Identification of Orthologs from Complete Genome Data

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OMAi
DYIRFGW

Database of Orthologous Groups

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OrthoDBi
113612at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
G5EDT1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036915, Cyclin-like_sf
IPR002720, RB_A
IPR002719, RB_B
IPR028309, RB_fam
IPR024599, RB_N

The PANTHER Classification System

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PANTHERi
PTHR13742, PTHR13742, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11934, DUF3452, 1 hit
PF01858, RB_A, 1 hit
PF01857, RB_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01367, DUF3452, 1 hit
SM01368, RB_A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EDT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRAADEPG TSTTDPFHEQ SPFDAVLAGT ETTDTICEEP PAKRIDLDIK
60 70 80 90 100
QEFNGGVQSG GLIKNESELT QMTIKQETEG NINEARREEE DEEQDEDSRT
110 120 130 140 150
SMPPALGEDD DYEEDDADSF IDKTNTPPPS QSFLEGCRAA NLPNDIVTGA
160 170 180 190 200
WETYNHAVQR VSLEGSESAW QLSAIYYYLL SKGIKRRGKT IRILIQPFPV
210 220 230 240 250
SILTIANSFD ISVAEMLDKT ARFVEIIHSR KIRRYQEYIR RIQEGLAVSC
260 270 280 290 300
VIFKKFCRIF CKIFEEIKVG SENCPSSHEL FTVLWTSFLV MKSRMTVDDL
310 320 330 340 350
ISNYQLLFSI LDQVYTEMCS MKEGIVHHLN QKFVEDLLEN DCTIIRALCT
360 370 380 390 400
QFGGSVLDAR HFSDHTFKKM EKTGIPSTWN FQEFRDLIMN VPKTAYENYL
410 420 430 440 450
LQRGSIDERI FIPSVEDFSK IFQSPDTYSV ADILKVSYSG RRFRDAEFLT
460 470 480 490 500
KISNNHCLEK LALGGKVASE KLVTQSKEQP RVPCVEYNLE LGNYPDDLES
510 520 530 540 550
NNQSLYNRLT KIIGSWKLEN SKLEEVCGTM SDSPMATILL KSDEMTNKFE
560 570 580 590 600
RTLSAELGET INENIPKYHY NVRKELELVF LIFMEKIIVA ELKKKVREED
610 620 630 640 650
LLNVIRREEF LDSVFCFCVE LILVSNGYDR PFPWSAELCG VHPFMFHKVI
660 670 680 690 700
DLMITHEKQL SRQMVQHFSR IEETVIEYFS WKSDSPLWPM VVRCPFAHFQ
710 720 730 740 750
EFGEDWADKL NSYSPIKFTP IKKPDDLRDE LGRPIVPQNQ TSRTLRIFLK
760 770 780 790 800
RTYFTAARRL QDLTDRVSMG ARAKSQCWSL FDYLLRNDTL IFMDRHLDQI
810 820 830 840 850
LLCCVFVIMK INESSMLFTE IMAQYRRQSA NSLLVYRSVT VFQEQLNPEN
860 870 880 890 900
PQAVNTKETI LERLEGPQKE KTTVDIIKYY NIEFRDRIKY IIGQIDSASD
910 920 930 940 950
EDLMEMPVAT ESGLMPVRVY LTHKLSIQTL PKTKHGESKQ ERAIANLEKS
960
GITIAMERSG D
Length:961
Mass (Da):110,903
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i712475505E527DF1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF116529 mRNA Translation: AAD05570.1
BX284601 Genomic DNA Translation: CCD61908.1

Protein sequence database of the Protein Information Resource

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PIRi
T34024

NCBI Reference Sequences

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RefSeqi
NP_491686.1, NM_059285.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
C32F10.2.1; C32F10.2.1; WBGene00003020

Database of genes from NCBI RefSeq genomes

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GeneIDi
172249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C32F10.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116529 mRNA Translation: AAD05570.1
BX284601 Genomic DNA Translation: CCD61908.1
PIRiT34024
RefSeqiNP_491686.1, NM_059285.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-1100, DRM complex
CPX-1138, RB1-E2F1-TFDP1 transcription repressor complex
IntActiG5EDT1, 9 interactors
MINTiG5EDT1
STRINGi6239.C32F10.2

PTM databases

iPTMnetiG5EDT1

Proteomic databases

EPDiG5EDT1
PaxDbiG5EDT1
PeptideAtlasiG5EDT1

Genome annotation databases

EnsemblMetazoaiC32F10.2.1; C32F10.2.1; WBGene00003020
GeneIDi172249
KEGGicel:CELE_C32F10.2

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172249
WormBaseiC32F10.2 ; CE24823 ; WBGene00003020 ; lin-35

Phylogenomic databases

eggNOGiKOG1010, Eukaryota
GeneTreeiENSGT00950000183202
HOGENOMiCLU_312900_0_0_1
InParanoidiG5EDT1
KOiK04681
OMAiDYIRFGW
OrthoDBi113612at2759
PhylomeDBiG5EDT1

Enzyme and pathway databases

ReactomeiR-CEL-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-CEL-1538133, G0 and Early G1
R-CEL-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-CEL-2299718, Condensation of Prophase Chromosomes
R-CEL-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-CEL-69231, Cyclin D associated events in G1

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EDT1

Gene expression databases

BgeeiWBGene00003020, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036915, Cyclin-like_sf
IPR002720, RB_A
IPR002719, RB_B
IPR028309, RB_fam
IPR024599, RB_N
PANTHERiPTHR13742, PTHR13742, 1 hit
PfamiView protein in Pfam
PF11934, DUF3452, 1 hit
PF01858, RB_A, 1 hit
PF01857, RB_B, 1 hit
SMARTiView protein in SMART
SM01367, DUF3452, 1 hit
SM01368, RB_A, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIN35_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDT1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: December 14, 2011
Last modified: August 12, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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