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Entry version 76 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1

Gene

nrfl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity).

Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis (PubMed:22916205).

May play a role in promoting fertility (PubMed:30560135).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1Curated
Short name:
NHERF-1Curated
Alternative name(s):
Regulatory cofactor of Na(+)/H(+) exchangerCurated
Sodium-hydrogen exchanger regulatory factor 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nrfl-1Imported
Synonyms:mpz-2Imported, tag-60Imported
ORF Names:C01F6.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C01F6.6a ; CE30847 ; WBGene00006438 ; nrfl-1
C01F6.6b ; CE30848 ; WBGene00006438 ; nrfl-1
C01F6.6c ; CE39888 ; WBGene00006438 ; nrfl-1
C01F6.6d ; CE39889 ; WBGene00006438 ; nrfl-1
C01F6.6e ; CE39890 ; WBGene00006438 ; nrfl-1
C01F6.6f ; CE47486 ; WBGene00006438 ; nrfl-1
C01F6.6g ; CE47559 ; WBGene00006438 ; nrfl-1
C01F6.6h ; CE49694 ; WBGene00006438 ; nrfl-1
C01F6.6i ; CE49735 ; WBGene00006438 ; nrfl-1
C01F6.6j ; CE49636 ; WBGene00006438 ; nrfl-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable, with no gross anatomy or growth defects observed (PubMed:22916205). Localization of aat-6 at the intestinal apical cell membrane diminishes as animals age, and eventually aat-6 becomes diffusely dispersed in the cytoplasm (PubMed:22916205). RNAi-mediated knockdown in a pept-1 (lg601) mutant background results in a reduced number of progeny (PubMed:30560135).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi26 – 27GY → AA: Does not impair binding to aat-6. Abolishes binding to aat-6; when associated with A-154 and A-155. 1 Publication2
Mutagenesisi154 – 155EF → AA: Highly reduces binding to aat-6. Abolishes binding to aat-6; when associated with A-26 and A-27. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004482951 – 467Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1Add BLAST467

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDM4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EDM4

PeptideAtlas

More...
PeptideAtlasi
G5EDM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the excretory canal and intestine (PubMed:22916205). Expressed on the apical cell membrane of intestinal cells (at protein level) (PubMed:22916205).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in larval and adult stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00006438, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
G5EDM4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PDZ 2 domain) with aat-6 (via PDZ-binding motif); the interaction sequesters aat-6 to the apical cell membrane of intestinal cells.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4311, nrfl-1-aat-6 complex

Protein interaction database and analysis system

More...
IntActi
G5EDM4, 10 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EDM4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 94PDZ 1PROSITE-ProRule annotationAdd BLAST83
Domaini143 – 225PDZ 2PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni344 – 429DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi344 – 371Polar residuesSequence analysisAdd BLAST28
Compositional biasi406 – 422Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ 2 domain is required for the interaction with the amino acid transporter protein aat-6.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000182849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_057921_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EC64

Identification of Orthologs from Complete Genome Data

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OMAi
ENEYGYN

Database of Orthologous Groups

More...
OrthoDBi
880632at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF17820, PDZ_6, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: G5EDM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHIPSDVTP PRLCVVEKLN GENEYGYNLH AEKGRGQFVG TVDPDSPAER
60 70 80 90 100
GGLITGDRIF AVNGHSIIGE NHKKVVERIK ANPNRCEMLV ISEEGAKWYN
110 120 130 140 150
ENNVQITLDL PNIERVSPMS KETPVFVPPP PPPTDAMPYL PRLAELNKGT
160 170 180 190 200
PDQEFGFNLH AERGRGHFIG TVDAGGIGEK AGLEAGQRIV GVNGQLIYPT
210 220 230 240 250
TGHKEVVALI KKDTMKTTLL VASEDVDKYH KDHNIAYSWD NVERVDTRPV
260 270 280 290 300
INVETHHHHE EVSVPKSNGY DVPPLNPHSI QVNEEREISK MTTTTRTETI
310 320 330 340 350
TNSNSAYQYK ESSTAYDAYA TPPVDSNDLM DEVFGRVNLP GVTMSSHTEV
360 370 380 390 400
LPPTDDISSV SSLSSHRESA VDVPVSHQYV PSYATESHQK HEQHSQTHHH
410 420 430 440 450
HHQHQQPSPL SNGSSHGYAA SSTSGYDDDD IYHLSAREAR ERLRMKNRKH
460
HLHEMSLNEK YQLVSNM
Length:467
Mass (Da):52,066
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68FCB98A33515930
GO
Isoform bImported (identifier: G5EDM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: MVHIPSDVTP...LPNIERVSPM → MDRNPSEPER...SIESLESRSR

Show »
Length:608
Mass (Da):68,197
Checksum:i23E509FA59708DFB
GO
Isoform cImported (identifier: G5EDM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: M → MRNSCHPSNNSPPPSSWYAPTSYSQ
     311-378: Missing.

Show »
Length:423
Mass (Da):47,498
Checksum:i80477F9AF7C7AFC1
GO
Isoform dImported (identifier: G5EDM4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: M → MRNSCHPSNNSPPPSSWYAPTSYSQ
     311-378: ESSTAYDAYA...SAVDVPVSHQ → VSQNNENYGDNQTIVITTCSFLK

Show »
Length:446
Mass (Da):50,068
Checksum:iC9E9A39C880F28EA
GO
Isoform eImported (identifier: G5EDM4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Show »
Length:331
Mass (Da):37,091
Checksum:iEAF7F950F1807D7B
GO
Isoform fImported (identifier: G5EDM4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: MVHIPSDVTP...LPNIERVSPM → MHFIDK

Show »
Length:354
Mass (Da):39,621
Checksum:iEB3076C0930848AF
GO
Isoform gImported (identifier: G5EDM4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: MVHIPSDVTP...LPNIERVSPM → MRRNFCSLLIQGCSKSCK

Show »
Length:366
Mass (Da):40,905
Checksum:i4348595BAEBE1483
GO
Isoform hImported (identifier: G5EDM4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: M → MRNSCHPSNNSPPPSSWYAPTSYSQ

Show »
Length:491
Mass (Da):54,712
Checksum:i76B4C73CEF2DD7DF
GO
Isoform iImported (identifier: G5EDM4-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-378: Missing.

Show »
Length:399
Mass (Da):44,851
Checksum:i83DC17926106C346
GO
Isoform jImported (identifier: G5EDM4-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     311-378: Missing.

Show »
Length:263
Mass (Da):29,876
Checksum:i60D02394B8EB1CC5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0603791 – 136Missing in isoform e and isoform j. CuratedAdd BLAST136
Alternative sequenceiVSP_0603801 – 119MVHIP…RVSPM → MDRNPSEPERIDWKNPITWI SYLYTSFVYYLWLISSHLPH LPQPQRITDDKSTEQITRDA GIPRTEIVTRGDATQTVRQV AGLGDPAPKDSSLLPPSSSF VYCNNCLTPHSSQRTCSPAY VSTLSRQKSLTLLKKLKKPS SSASSTTTTTSSTVSFRAPS RASSTISDASTIRPSELIAI VPSGSHVLLRVPKLDWKTES IRIKRTRMSDWMDAEQRDVM RQFDEVIRSEEEDERTSRKR NGIFKDGSVRSIESLESRSR in isoform b. CuratedAdd BLAST119
Alternative sequenceiVSP_0603811 – 119MVHIP…RVSPM → MHFIDK in isoform f. CuratedAdd BLAST119
Alternative sequenceiVSP_0603821 – 119MVHIP…RVSPM → MRRNFCSLLIQGCSKSCK in isoform g. CuratedAdd BLAST119
Alternative sequenceiVSP_060383119M → MRNSCHPSNNSPPPSSWYAP TSYSQ in isoform c, isoform d and isoform h. Curated1
Alternative sequenceiVSP_060384311 – 378Missing in isoform c, isoform i and isoform j. CuratedAdd BLAST68
Alternative sequenceiVSP_060385311 – 378ESSTA…PVSHQ → VSQNNENYGDNQTIVITTCS FLK in isoform d. CuratedAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92439.3
BX284604 Genomic DNA Translation: CAD37352.1
BX284604 Genomic DNA Translation: CAJ80811.1
BX284604 Genomic DNA Translation: CAJ80816.1
BX284604 Genomic DNA Translation: CAJ80817.1
BX284604 Genomic DNA Translation: CCH63894.1
BX284604 Genomic DNA Translation: CCH63914.1
BX284604 Genomic DNA Translation: CDO41140.1
BX284604 Genomic DNA Translation: CDO41141.1
BX284604 Genomic DNA Translation: CDO50111.1

Protein sequence database of the Protein Information Resource

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PIRi
T18808
T21299

NCBI Reference Sequences

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RefSeqi
NP_001040908.1, NM_001047443.3 [G5EDM4-3]
NP_001040909.1, NM_001047444.4 [G5EDM4-4]
NP_001040910.1, NM_001047445.4 [G5EDM4-5]
NP_001263761.1, NM_001276832.1 [G5EDM4-6]
NP_001263762.1, NM_001276833.1 [G5EDM4-7]
NP_001294067.1, NM_001307138.1
NP_001294068.1, NM_001307139.1 [G5EDM4-9]
NP_001294128.1, NM_001307199.1
NP_741478.1, NM_171410.4 [G5EDM4-1]
NP_741479.1, NM_171411.5 [G5EDM4-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C01F6.6a.1; C01F6.6a.1; WBGene00006438 [G5EDM4-1]
C01F6.6b.1; C01F6.6b.1; WBGene00006438 [G5EDM4-2]
C01F6.6c.1; C01F6.6c.1; WBGene00006438 [G5EDM4-3]
C01F6.6d.1; C01F6.6d.1; WBGene00006438 [G5EDM4-4]
C01F6.6e.1; C01F6.6e.1; WBGene00006438 [G5EDM4-5]
C01F6.6e.2; C01F6.6e.2; WBGene00006438 [G5EDM4-5]
C01F6.6e.3; C01F6.6e.3; WBGene00006438 [G5EDM4-5]
C01F6.6e.4; C01F6.6e.4; WBGene00006438 [G5EDM4-5]
C01F6.6f.1; C01F6.6f.1; WBGene00006438 [G5EDM4-6]
C01F6.6g.1; C01F6.6g.1; WBGene00006438 [G5EDM4-7]
C01F6.6h.1; C01F6.6h.1; WBGene00006438 [G5EDM4-8]
C01F6.6i.1; C01F6.6i.1; WBGene00006438 [G5EDM4-9]
C01F6.6j.1; C01F6.6j.1; WBGene00006438 [G5EDM4-10]
C01F6.6j.2; C01F6.6j.2; WBGene00006438 [G5EDM4-10]
C01F6.6j.3; C01F6.6j.3; WBGene00006438 [G5EDM4-10]

Database of genes from NCBI RefSeq genomes

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GeneIDi
177736

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_C01F6.6

UCSC genome browser

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UCSCi
C01F6.6a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92439.3
BX284604 Genomic DNA Translation: CAD37352.1
BX284604 Genomic DNA Translation: CAJ80811.1
BX284604 Genomic DNA Translation: CAJ80816.1
BX284604 Genomic DNA Translation: CAJ80817.1
BX284604 Genomic DNA Translation: CCH63894.1
BX284604 Genomic DNA Translation: CCH63914.1
BX284604 Genomic DNA Translation: CDO41140.1
BX284604 Genomic DNA Translation: CDO41141.1
BX284604 Genomic DNA Translation: CDO50111.1
PIRiT18808
T21299
RefSeqiNP_001040908.1, NM_001047443.3 [G5EDM4-3]
NP_001040909.1, NM_001047444.4 [G5EDM4-4]
NP_001040910.1, NM_001047445.4 [G5EDM4-5]
NP_001263761.1, NM_001276832.1 [G5EDM4-6]
NP_001263762.1, NM_001276833.1 [G5EDM4-7]
NP_001294067.1, NM_001307138.1
NP_001294068.1, NM_001307139.1 [G5EDM4-9]
NP_001294128.1, NM_001307199.1
NP_741478.1, NM_171410.4 [G5EDM4-1]
NP_741479.1, NM_171411.5 [G5EDM4-2]

3D structure databases

SMRiG5EDM4
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-4311, nrfl-1-aat-6 complex
IntActiG5EDM4, 10 interactors

Proteomic databases

EPDiG5EDM4
PaxDbiG5EDM4
PeptideAtlasiG5EDM4

Genome annotation databases

EnsemblMetazoaiC01F6.6a.1; C01F6.6a.1; WBGene00006438 [G5EDM4-1]
C01F6.6b.1; C01F6.6b.1; WBGene00006438 [G5EDM4-2]
C01F6.6c.1; C01F6.6c.1; WBGene00006438 [G5EDM4-3]
C01F6.6d.1; C01F6.6d.1; WBGene00006438 [G5EDM4-4]
C01F6.6e.1; C01F6.6e.1; WBGene00006438 [G5EDM4-5]
C01F6.6e.2; C01F6.6e.2; WBGene00006438 [G5EDM4-5]
C01F6.6e.3; C01F6.6e.3; WBGene00006438 [G5EDM4-5]
C01F6.6e.4; C01F6.6e.4; WBGene00006438 [G5EDM4-5]
C01F6.6f.1; C01F6.6f.1; WBGene00006438 [G5EDM4-6]
C01F6.6g.1; C01F6.6g.1; WBGene00006438 [G5EDM4-7]
C01F6.6h.1; C01F6.6h.1; WBGene00006438 [G5EDM4-8]
C01F6.6i.1; C01F6.6i.1; WBGene00006438 [G5EDM4-9]
C01F6.6j.1; C01F6.6j.1; WBGene00006438 [G5EDM4-10]
C01F6.6j.2; C01F6.6j.2; WBGene00006438 [G5EDM4-10]
C01F6.6j.3; C01F6.6j.3; WBGene00006438 [G5EDM4-10]
GeneIDi177736
KEGGicel:CELE_C01F6.6
UCSCiC01F6.6a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
177736
WormBaseiC01F6.6a ; CE30847 ; WBGene00006438 ; nrfl-1
C01F6.6b ; CE30848 ; WBGene00006438 ; nrfl-1
C01F6.6c ; CE39888 ; WBGene00006438 ; nrfl-1
C01F6.6d ; CE39889 ; WBGene00006438 ; nrfl-1
C01F6.6e ; CE39890 ; WBGene00006438 ; nrfl-1
C01F6.6f ; CE47486 ; WBGene00006438 ; nrfl-1
C01F6.6g ; CE47559 ; WBGene00006438 ; nrfl-1
C01F6.6h ; CE49694 ; WBGene00006438 ; nrfl-1
C01F6.6i ; CE49735 ; WBGene00006438 ; nrfl-1
C01F6.6j ; CE49636 ; WBGene00006438 ; nrfl-1

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00950000182849
HOGENOMiCLU_057921_0_0_1
InParanoidiG5EC64
OMAiENEYGYN
OrthoDBi880632at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EDM4

Gene expression databases

BgeeiWBGene00006438, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiG5EDM4, baseline and differential

Family and domain databases

Gene3Di2.30.42.10, 2 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF17820, PDZ_6, 2 hits
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SUPFAMiSSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHRF1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDM4
Secondary accession number(s): G5EC64
, G5EE55, G5EFP7, I2HAG6, I2HAI6, Q27GP2, X5LQ26, X5LVA5, X5MBG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2019
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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