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UniProtKB - G5EDJ3 (G5EDJ3_CAEEL)

Entry version 89 (25 May 2022)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Equilibrative Nucleoside Transporter

Gene

ent-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportARBA annotation

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.57.1.15, the equilibrative nucleoside transporter (ent) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Equilibrative Nucleoside TransporterImported
Submitted name:
Equilibrative nucleoside transporter 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ent-1Imported
ORF Names:CELE_ZK809.4Imported, ZK809.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...WormBasei		ZK809.4a ; CE31754 ; WBGene00001320 ; ent-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 51HelicalSequence analysisAdd BLAST23
Transmembranei117 – 136HelicalSequence analysisAdd BLAST20
Transmembranei142 – 160HelicalSequence analysisAdd BLAST19
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei277 – 295HelicalSequence analysisAdd BLAST19
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei347 – 368HelicalSequence analysisAdd BLAST22
Transmembranei380 – 404HelicalSequence analysisAdd BLAST25
Transmembranei416 – 439HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00001320, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		6239.ZK809.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1479, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182898

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021611_0_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		RFYQYYS

Database of Orthologous Groups

More...OrthoDBi		559763at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002259, Eqnu_transpt
IPR036259, MFS_trans_sf

The PANTHER Classification System

More...PANTHERi		PTHR10332, PTHR10332, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01733, Nucleoside_tran, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF016379, ENT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01130, DERENTRNSPRT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G5EDJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAVELQPL NKTKKVEEES PEPEDKGNLV FYIILLHGIG TLMPWNMLIT 
        60         70         80         90        100
ISYDYFESYK MLANSTIDMD TGVVTGYPTV YSSNFQSFQT IASQVPNLLL 
       110        120        130        140        150
NLLNIFIVVK GGLASRITVG LSIVAVCVIT TMMFIYVETS TWLTGFFTLT 
       160        170        180        190        200
IITIIVLNGA NGVYQNSIFG LASELPFKYT NAVIIGNNLC GTFVTLLSMS 
       210        220        230        240        250
TKAVTRNILD RSFAYFSIAL ITLVFCFISF HILKKQRFYQ YYSTRAERQR 
       260        270        280        290        300
NKNDEAVDSE GKVANYIATF KEAFPQLINV FLVFFVTLSI FPGVMMYVKD 
       310        320        330        340        350
EKKGGVYDFP LPQKYFMDVT TFLQFNVFAF IGSIVAGRKQ WPAPNKLWIP 
       360        370        380        390        400
VYLRLLYIPF FIFCNYLPET RSLPVFFEST WLFVIIAASM SFGSGYFSGL 
       410        420        430        440 
AMMYTSKTVD PSKAQVAGMM AGFFLISGIV SGLIFTMVIK MVVTA
Length:445
Mass (Da):50,030
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6537CC199D87A51A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GU99F5GU99_CAEEL
Equilibrative Nucleoside Transporte...
ent-1 CELE_ZK809.4, ZK809.4
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF435979 mRNA Translation: AAM46663.1
BX284604 Genomic DNA Translation: CAA92642.2

Protein sequence database of the Protein Information Resource

More...PIRi		T28006

NCBI Reference Sequences

More...RefSeqi		NP_001255573.1, NM_001268644.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		ZK809.4a.1; ZK809.4a.1; WBGene00001320

Database of genes from NCBI RefSeq genomes

More...GeneIDi		178097

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_ZK809.4

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435979 mRNA Translation: AAM46663.1
BX284604 Genomic DNA Translation: CAA92642.2
PIRiT28006
RefSeqiNP_001255573.1, NM_001268644.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.ZK809.4a

Protein family/group databases

TCDBi2.A.57.1.15, the equilibrative nucleoside transporter (ent) family

Genome annotation databases

EnsemblMetazoaiZK809.4a.1; ZK809.4a.1; WBGene00001320
GeneIDi178097
KEGGicel:CELE_ZK809.4

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		178097
WormBaseiZK809.4a ; CE31754 ; WBGene00001320 ; ent-1

Phylogenomic databases

eggNOGiKOG1479, Eukaryota
GeneTreeiENSGT00950000182898
HOGENOMiCLU_021611_0_1_1
OMAiRFYQYYS
OrthoDBi559763at2759

Gene expression databases

BgeeiWBGene00001320, Expressed in adult organism and 5 other tissues

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR002259, Eqnu_transpt
IPR036259, MFS_trans_sf
PANTHERiPTHR10332, PTHR10332, 1 hit
PfamiView protein in Pfam
PF01733, Nucleoside_tran, 1 hit
PIRSFiPIRSF016379, ENT, 1 hit
PRINTSiPR01130, DERENTRNSPRT
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EDJ3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 25, 2022
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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