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Entry version 88 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Ion_trans_2 domain-containing protein

Gene

slo-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channelARBA annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.3.8, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ion_trans_2 domain-containing proteinImported
Submitted name:
SLO-2 potassium channelImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slo-2Imported
ORF Names:CELE_F08B12.3Imported, F08B12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F08B12.3b ; CE18570 ; WBGene00004831 ; slo-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei124 – 147HelicalSequence analysisAdd BLAST24
Transmembranei215 – 236HelicalSequence analysisAdd BLAST22
Transmembranei248 – 267HelicalSequence analysisAdd BLAST20
Transmembranei273 – 291HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004831, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 292Ion_trans_2InterPro annotationAdd BLAST59
Domaini445 – 546BK_channel_aInterPro annotationAdd BLAST102

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172581

Identification of Orthologs from Complete Genome Data

More...
OMAi
LICEDEF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003929, K_chnl_BK_asu
IPR013099, K_chnl_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03493, BK_channel_a, 1 hit
PF07885, Ion_trans_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

G5EDJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDTNNRTD RCTMKHRERR VDSCHSLPSD YRIPNKHVAR MQYGEKKNIK
60 70 80 90 100
HKLQQWFIEN PSISARIRSC NVLIKLLTCI LYCIRVVNDE RSYPDDFPFS
110 120 130 140 150
EEEAGKQDVT LYKYLLWVDF DFKIWFLQTM FACISMVYTI LVFYLSYSGS
160 170 180 190 200
VVRLLINIHF LLELITSFPF IISIFIPSLT YLYVPVFLNC WLAKGALQAM
210 220 230 240 250
MNDLNRKSFI SSSALFRQLL LLFSVLACLI FTGMCSIEHL QRARGKRIDL
260 270 280 290 300
FTSFYFVMVT FSTVGYGDWY PDYWASQLCV VILICVALGL IPKQLDELGQ
310 320 330 340 350
TWSERQKSGT DFSSWNGVES HVVVTITTLE VEFIRDFLEE FYAHPENQRI
360 370 380 390 400
QIVLLSPAEL DNQTRMLLKI PLWNNRVHYV RGSSLRDEDL ERANVATSKA
410 420 430 440 450
CFILSARHVN RKVATDEHTI LRSWAIKDFA PNVKQYVQIF RAETKMHIEH
460 470 480 490 500
AEVLICEDEF KYALLANNCI CPGISTFITL LMHTSRGEEG QKSTEPWHKV
510 520 530 540 550
YGFHSGNEMY QIKVQDSKFF CEYVGKSFSS TSFHAHKEYG IGLIAVSPDG
560 570 580 590 600
DTSRMKLNPG SSHIIQPTDT VYYMGLTNEE SLTDFRKGIR SQQKRANVAS
610 620 630 640 650
TIANIGTVAV DVPRSDKTEL VGRKKKKRKE KAADEIHLIE VGEHVQSSRR
660 670 680 690 700
PSIAMVTEGK IDSSSDSDQE EICDKCRGPC IQHKLQRTYP QVRTYIGTSN
710 720 730 740 750
TVCHMMKERR SLCCLKLDEK CAHKSATSAH EYQWRNRPII LAADRTSSGM
760 770 780 790 800
YNLVIPLRAY YRPVHDLHPI IILLELEEQD SLNDAFLDAI SYFPDVYWMK
810 820 830 840 850
GKVGNLDCLL RAGVSSAEHV VVVKETAVMA EEHTADCNTI ITVQKIHRMF
860 870 880 890 900
PRLRMITELT HATNMRFVQF NPHNAYSLAQ SRFEKKERKR GSHMPFMFRL
910 920 930 940 950
PFAQGGVFSA NMLDRLLYQA IIKPFVVDLV RLLLGIDQHS DGGYLTSFVI
960 970 980 990 1000
TSDDLWIRNY GRLYQKLCSS VADIPIGIFR TKKMDTKTVS LDLQEQCKDF
1010 1020 1030 1040 1050
ENTEMGRNKD MYDHVKNRMR LLNIKDTHTL LEGSDEKSQI SYVIINPAQD
1060 1070 1080 1090 1100
LELESGDIVY VIRSPIRKDA TNARINPRRG LRRSKNVSET IDSTNQVPTI

VIDENNL
Length:1,107
Mass (Da):127,393
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i650648E86CC26805
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9G2R4H9G2R4_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q565B7Q565B7_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,086Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2MZB8B2MZB8_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2R6H9G2R6_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2R7H9G2R7_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2R3H9G2R3_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECD1G5ECD1_CAEEL
Ion_trans_2 domain-containing prote...
slo-2 CELE_F08B12.3, F08B12.3
1,119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF232770 mRNA Translation: AAF37866.1
BX284606 Genomic DNA Translation: CAA92116.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20577
T20578

NCBI Reference Sequences

More...
RefSeqi
NP_001024528.1, NM_001029357.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F08B12.3b.1; F08B12.3b.1; WBGene00004831

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181332

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232770 mRNA Translation: AAF37866.1
BX284606 Genomic DNA Translation: CAA92116.1
PIRiT20577
T20578
RefSeqiNP_001024528.1, NM_001029357.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.1.3.8, the voltage-gated ion channel (vic) superfamily

Genome annotation databases

EnsemblMetazoaiF08B12.3b.1; F08B12.3b.1; WBGene00004831
GeneIDi181332

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181332
WormBaseiF08B12.3b ; CE18570 ; WBGene00004831 ; slo-2

Phylogenomic databases

GeneTreeiENSGT00940000172581
OMAiLICEDEF

Gene expression databases

BgeeiWBGene00004831, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003929, K_chnl_BK_asu
IPR013099, K_chnl_dom
PfamiView protein in Pfam
PF03493, BK_channel_a, 1 hit
PF07885, Ion_trans_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EDJ1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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