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Entry version 63 (26 Feb 2020)
Sequence version 1 (14 Dec 2011)
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Protein

Reticulon-like protein

Gene

ret-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-193634 Axonal growth inhibition (RHOA activation)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulon-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ret-1Imported
ORF Names:CELE_W06A7.3Imported, W06A7.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
W06A7.3f ; CE41710 ; WBGene00004336 ; ret-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3117 – 3135HelicalUniRule annotationAdd BLAST19
Transmembranei3141 – 3160HelicalUniRule annotationAdd BLAST20
Transmembranei3226 – 3252HelicalUniRule annotationAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDI2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EDI2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00004336 Expressed in pharyngeal muscle cell (C elegans) and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
G5EDI2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.W06A7.3f

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3104 – 3303ReticulonInterPro annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 76DisorderedSequence analysisAdd BLAST46
Regioni342 – 365DisorderedSequence analysisAdd BLAST24
Regioni406 – 427DisorderedSequence analysisAdd BLAST22
Regioni509 – 536DisorderedSequence analysisAdd BLAST28
Regioni587 – 606DisorderedSequence analysisAdd BLAST20
Regioni620 – 660DisorderedSequence analysisAdd BLAST41
Regioni750 – 908DisorderedSequence analysisAdd BLAST159
Regioni925 – 964DisorderedSequence analysisAdd BLAST40
Regioni1358 – 1388DisorderedSequence analysisAdd BLAST31
Regioni1403 – 1444DisorderedSequence analysisAdd BLAST42
Regioni1461 – 1608DisorderedSequence analysisAdd BLAST148
Regioni1651 – 1671DisorderedSequence analysisAdd BLAST21
Regioni1694 – 1752DisorderedSequence analysisAdd BLAST59
Regioni1783 – 1804DisorderedSequence analysisAdd BLAST22
Regioni1843 – 1882DisorderedSequence analysisAdd BLAST40
Regioni1896 – 1936DisorderedSequence analysisAdd BLAST41
Regioni1953 – 2030DisorderedSequence analysisAdd BLAST78
Regioni2053 – 2129DisorderedSequence analysisAdd BLAST77
Regioni2162 – 2181DisorderedSequence analysisAdd BLAST20
Regioni2250 – 2272DisorderedSequence analysisAdd BLAST23
Regioni2502 – 2525DisorderedSequence analysisAdd BLAST24
Regioni2562 – 2588DisorderedSequence analysisAdd BLAST27
Regioni2606 – 2628DisorderedSequence analysisAdd BLAST23
Regioni2728 – 2785DisorderedSequence analysisAdd BLAST58
Regioni2946 – 2985DisorderedSequence analysisAdd BLAST40
Regioni3041 – 3085DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2834 – 2854Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 46PolarSequence analysisAdd BLAST16
Compositional biasi53 – 75PolarSequence analysisAdd BLAST23
Compositional biasi755 – 778PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1408 – 1434PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1467 – 1486PolarSequence analysisAdd BLAST20
Compositional biasi1496 – 1513PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1527 – 1551PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1557 – 1571PolarSequence analysisAdd BLAST15
Compositional biasi1702 – 1735PolyampholyteSequence analysisAdd BLAST34
Compositional biasi1912 – 1931PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1953 – 1969PolarSequence analysisAdd BLAST17
Compositional biasi1971 – 2030PolyampholyteSequence analysisAdd BLAST60
Compositional biasi2057 – 2072PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2562 – 2586PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2743 – 2757PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2946 – 2964PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1792 Eukaryota
ENOG410XPKH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173112

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_226433_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EDI2

Identification of Orthologs from Complete Genome Data

More...
OMAi
EVQDNVE

Database of Orthologous Groups

More...
OrthoDBi
1121487at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003388 Reticulon

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02453 Reticulon, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50845 RETICULON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

G5EDI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAENVDVEL FFRKPPEITN FELVKTIWID PKEETNSTNE PTSEHEPKSL
60 70 80 90 100
QPLALQPLQT PESESGGSSC SHSEVEQLPD DILNEPLDDE VFEEEEENVQ
110 120 130 140 150
TDLLFRQPKN SEMELAYTIS KSAEINLDEL EFEDEEVEVD LLFREPTDRR
160 170 180 190 200
FELVYTIPMM EDVSIDSQET ITFEDIPPSE ELDNVVEEVT DVAELTEFTF
210 220 230 240 250
KPVEKDEQTE TESFTTVLEA NAGEGARDFI ERVKLTSNDT LDDLDDDPEE
260 270 280 290 300
ETFQNSFVKS VDSKTPTPTG DNYEIEDSSV SDVLKDAAEK LQIIRNYSAD
310 320 330 340 350
LESEKDTINT DVQHVFIGLE DEGGVIPIIQ ETQEYVAEIG PTQDNQEYDS
360 370 380 390 400
TSKSDLEPQS SADGVVETST FEAPAVFGLE DSEDIINKHA LETASNQEFS
410 420 430 440 450
KIKEPEVTEV SENTAENLNE EVGESKNPEA IDLVESGENA GIEQNAGAEQ
460 470 480 490 500
SQKEAVEETS SFKAPAVIGL EESRDILKDP LLETAPDQEN FNNKESEMTE
510 520 530 540 550
IAEITTPIRL ESSGDNFIGT DPEKGTEQIK GSESSELVTQ EVIGLEESGD
560 570 580 590 600
ILKEPALETV TNQELSENKV SEVTEIAENI TPIGLECSGD NFIGTDPEQQ
610 620 630 640 650
PEPIKGIESS ELDVIGLEDS GDEVKQSQLK SSEDQEFSEL KEHDASGNVD
660 670 680 690 700
ETGESADIKQ DDVTEIVQRE TIGLEDSGLA EIVAAHEKNL TSSDIDSSVI
710 720 730 740 750
PEDAENASPE AIGLESSGDN FIGTDLEHEE GQIDNCESYV LETAAVIGLE
760 770 780 790 800
DSGENLKDSV QEDPPEKEFS ENKESEVTGD VENTTAIGLE SSGEHFIGLE
810 820 830 840 850
QGQQAASIEA NENSEMEAPA VIGLEDSGDN LNRPALETAS DQESSENKEP
860 870 880 890 900
DASENVEETE PVSSAKVIAL ESSGDCEEGN IKISANENSV EPDGADKPAH
910 920 930 940 950
TEQEIPTIIL PSETTVTQLE DHLSETEEKQ NEVESSIKSE KNVIGLEDSG
960 970 980 990 1000
DTFRDTSGLA PAEDNEAEAT ITTDFVPLES AGDIPSENEI KEVASAPDVV
1010 1020 1030 1040 1050
GLEEYIIGNI PNAPVVNDDI PNVFTPEVAN DETVETFSVT AEEASIPVVV
1060 1070 1080 1090 1100
ELEPIGDEYE FQRPVENFSE PSDNINLEES GAEQVLLENN MFTPLDELEP
1110 1120 1130 1140 1150
QQKILNEKAE HIEIEASGDE FIKDHPFPVE NEQNVNEQSS RVETVHSFIG
1160 1170 1180 1190 1200
LESSGVGLTG AVSDSVANNV KENTESPDII SLEASGDELS KLVEAREIIT
1210 1220 1230 1240 1250
ESKDAYSTDV PESRKTVSDV IGLEEAGDKI VSNNVSNVMG NPDESQLALE
1260 1270 1280 1290 1300
QADNVPELPI ENSEQETVAV KATESCDHVV DSQKTLERAS SLEEDIMSPE
1310 1320 1330 1340 1350
VLGITSSQTL SDYLPVISED QDSIPVPVTE VEETSEKLVK ASSLEEDVVS
1360 1370 1380 1390 1400
PEVLELDDRV QNKNPESEVT AVDASKTEGD FSDSPDSRAT ETFMEKLVTV
1410 1420 1430 1440 1450
TENLLPAGDK LSEERIQEIR ENETISQPGK EEDDLENAND PDDETIVEKI
1460 1470 1480 1490 1500
VSMAESSLPI EAVISTEDGG TSDQPAQNAI PDSEETTVDD SQTEEIFTDD
1510 1520 1530 1540 1550
NVKKSKENTP KAENDTEINY LPGGEEGPED NAEKRNEAVS PNDETSEIKQ
1560 1570 1580 1590 1600
DLENLENGAS GPDNNVQVDE AAQEDPTDPE TVDETTSKIS ENMPKAPDTE
1610 1620 1630 1640 1650
DDNATEFIEA GLETTEAFGD AEHVSYLDAN IEKLVAMADE PLPVDELVSI
1660 1670 1680 1690 1700
EERPEEVAPA ESTGEDEDIF RRDRRTVSLT GTGDQNAPIQ VIFVGDGDEN
1710 1720 1730 1740 1750
PDANADQERT SEHNELIESD KESEEAITKN EEDVDQDPIQ SEEPLTSQEG
1760 1770 1780 1790 1800
ESSIGNKIVA VVGSVLLGGA VIPYGVLASN ENEDAHADRE VEETGDSTRD
1810 1820 1830 1840 1850
RPEEETFVSK LTSMVENILP STNDENPEAV SMVENVLPVN TEGLDESKED
1860 1870 1880 1890 1900
NPDAPTAEAH SGEKNLRNDK TTDTRERDPE EETILNKLVE NALPTGVTGS
1910 1920 1930 1940 1950
FTEVSAPDAQ ELDETVVDHA GQNDTSEVED APEKSAGGTV IEKFTSMIES
1960 1970 1980 1990 2000
ILPVQAPTQP ENAESHIDQE TGGASEIKDD QNQPEEFSAE HQGKFEVSAE
2010 2020 2030 2040 2050
PDQESAEFQL EAKKDQDKET IENSEDAKKE TVMEKLVSLV ENILPVEAVL
2060 2070 2080 2090 2100
PSDSTVTKNS EDKKELETQE LSSKEIKTSG QPEYVPETSE AFVSDPEIFQ
2110 2120 2130 2140 2150
RVKRASSTEP KTQKTEPHAP IFIVGQSTED DEQSIANVID ELVHEDDEKK
2160 2170 2180 2190 2200
VPEVTANISV SASENIDDST TANAVPKTEV SSEQLQVATV EFELESAPEE
2210 2220 2230 2240 2250
ESAAIPEVQE PLEKVEVQPD LSQNSPAPHK IIDLHFNIPK DHEDYGNDYV
2260 2270 2280 2290 2300
PFGTESSEES QKADGNQENQ EEEDVVAELN FHPIRQWRDE DVISLQSLKS
2310 2320 2330 2340 2350
LVAEVGCITD VDASDVNEQD EESTLKILKV VPSEPSLLEL DFTNDPKVIH
2360 2370 2380 2390 2400
VPIPLMEPAT MYLEEMVEWI IADAVKEVSE MEVVTESEIS EMAPQVSEST
2410 2420 2430 2440 2450
CPIPEPLADL KLPVEDDEKT PEPEPVVPGQ VQERIIPIEV EQAPTIPQRP
2460 2470 2480 2490 2500
PRAPKSELPK VAKPLDDSKS RVRFAPLNIK LGRTYSEEQQ KELVESLERP
2510 2520 2530 2540 2550
LTIITQQKPP EKPTEDIGAL SPLSPNTLAE YEEVPMMDMQ SVPHSPQEKQ
2560 2570 2580 2590 2600
EEIEALSEII EEPQAMKEVE KPVESAPEKD NESLEAPEII NEPIRRVLVE
2610 2620 2630 2640 2650
TKIMGPGKSL NEDNDDDDDG SECLDSIGDL SERTIQRFNT SIDDPSIRRD
2660 2670 2680 2690 2700
SFSSISSFGD RQKFRTAIEN IRQDLLPFQS SVSQYLRSSP NPSQQLLVTN
2710 2720 2730 2740 2750
LSMDSPSDLS PNAPPVGFEN TAQFLEKLQQ EDRPSAEGSI DSSGFEKVDH
2760 2770 2780 2790 2800
EGLDEFAAPP VHDPMQKSVF GSLGSDDMKP GSQDDGFVFI ERNEANEATL
2810 2820 2830 2840 2850
KKNQKMSSHH NDVIEKNYFN DNAPTAALLE SPIAEEARKL VQDAVESASE
2860 2870 2880 2890 2900
YKKQAVDSGD EIGRELLDNV EQKIEQVKEP IVDSLHKAYD GVGDFVHETV
2910 2920 2930 2940 2950
PNAVDDFVRE AEKQLPESPV PEKIETPEPL VDIHDTVDKV HDEVDNFLRR
2960 2970 2980 2990 3000
EPTPPFETDD VAPLSDDKPQ FGNQTPEEDE TTFDRKGPLT IPEEVEKAAA
3010 3020 3030 3040 3050
AQNNDLDDFD PLVTSNTGAA FGAAVGAAAA VESLTEEEMF GHQKFETVPR
3060 3070 3080 3090 3100
PPTPPKDISD EDVKPSTVNL GPSHHHSHPS SPHHSILKHH GDAWIDFKTV
3110 3120 3130 3140 3150
PPCVLDVIYW RDAKKSAIVL SLALLVLFVL AKYPLLTVVT YSLLLALGAA
3160 3170 3180 3190 3200
AGFRSIFSVF KKVEAQIKKT DSEHPFSEIL AQDLTLPQEK VHAQADVFVE
3210 3220 3230 3240 3250
HATCIANKLK KLVFVESPLE SIKFGLVLWS LTYIASWFSG FTLAILGLLG
3260 3270 3280 3290 3300
VFSVPKVYES NQEAIDPHLA TISGHLKNVQ NIIDEKLPFL RSAPVAAEEK

KDQ
Length:3,303
Mass (Da):362,480
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6352E20BB576B4AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5U8N2B5U8N2_CAEEL
Reticulon-like protein
ret-1 CELE_W06A7.3, W06A7.3
494Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7JLB1Q7JLB1_CAEEL
Reticulon-like protein
ret-1 CELE_W06A7.3, W06A7.3
570Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECZ2G5ECZ2_CAEEL
Reticulon-like protein
ret-1 CELE_W06A7.3, W06A7.3
3,299Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q23187Q23187_CAEEL
Reticulon-like protein
ret-1 CELE_W06A7.3, W06A7.3
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q23188Q23188_CAEEL
Reticulon-like protein
ret-1 CELE_W06A7.3, W06A7.3
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7JLB0Q7JLB0_CAEEL
Reticulon-like protein
ret-1 CELE_W06A7.3, W06A7.3
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAN86643.2

NCBI Reference Sequences

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RefSeqi
NP_001123026.1, NM_001129554.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
W06A7.3f.1; W06A7.3f.1; WBGene00004336

Database of genes from NCBI RefSeq genomes

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GeneIDi
179981

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAN86643.2
RefSeqiNP_001123026.1, NM_001129554.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5EDI2, 4 interactors
STRINGi6239.W06A7.3f

Proteomic databases

EPDiG5EDI2
PaxDbiG5EDI2

Genome annotation databases

EnsemblMetazoaiW06A7.3f.1; W06A7.3f.1; WBGene00004336
GeneIDi179981

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
179981
WormBaseiW06A7.3f ; CE41710 ; WBGene00004336 ; ret-1

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00940000173112
HOGENOMiCLU_226433_0_0_1
InParanoidiG5EDI2
OMAiEVQDNVE
OrthoDBi1121487at2759

Enzyme and pathway databases

ReactomeiR-CEL-193634 Axonal growth inhibition (RHOA activation)

Gene expression databases

BgeeiWBGene00004336 Expressed in pharyngeal muscle cell (C elegans) and 6 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EDI2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 26, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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