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Entry version 67 (10 Apr 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

vab-10

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: WormBase
  • microtubule binding Source: InterPro
  • structural molecule activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vab-10Imported
ORF Names:CELE_ZK1151.1Imported, ZK1151.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
ZK1151.1c ; CE35152 ; WBGene00006876 ; vab-10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDD3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EDD3

PeptideAtlas

More...
PeptideAtlasi
G5EDD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006876 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5EDD3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZK1151.1c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
G5EDD3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EDD3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 142Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini179 – 286Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini817 – 874SH3InterPro annotationAdd BLAST58
Domaini4729 – 4801GARInterPro annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili23 – 43Sequence analysisAdd BLAST21
Coiled coili782 – 802Sequence analysisAdd BLAST21
Coiled coili1029 – 1049Sequence analysisAdd BLAST21
Coiled coili1182 – 1202Sequence analysisAdd BLAST21
Coiled coili1406 – 1426Sequence analysisAdd BLAST21
Coiled coili1649 – 1669Sequence analysisAdd BLAST21
Coiled coili1705 – 1725Sequence analysisAdd BLAST21
Coiled coili1796 – 1816Sequence analysisAdd BLAST21
Coiled coili1850 – 1877Sequence analysisAdd BLAST28
Coiled coili1942 – 1962Sequence analysisAdd BLAST21
Coiled coili2094 – 2114Sequence analysisAdd BLAST21
Coiled coili2198 – 2218Sequence analysisAdd BLAST21
Coiled coili2233 – 2267Sequence analysisAdd BLAST35
Coiled coili2313 – 2368Sequence analysisAdd BLAST56
Coiled coili2379 – 2399Sequence analysisAdd BLAST21
Coiled coili2454 – 2481Sequence analysisAdd BLAST28
Coiled coili2526 – 2546Sequence analysisAdd BLAST21
Coiled coili2644 – 2678Sequence analysisAdd BLAST35
Coiled coili2755 – 2782Sequence analysisAdd BLAST28
Coiled coili2960 – 2980Sequence analysisAdd BLAST21
Coiled coili3026 – 3049Sequence analysisAdd BLAST24
Coiled coili3349 – 3369Sequence analysisAdd BLAST21
Coiled coili3430 – 3450Sequence analysisAdd BLAST21
Coiled coili3545 – 3565Sequence analysisAdd BLAST21
Coiled coili3589 – 3609Sequence analysisAdd BLAST21
Coiled coili3617 – 3637Sequence analysisAdd BLAST21
Coiled coili3790 – 3810Sequence analysisAdd BLAST21
Coiled coili4231 – 4251Sequence analysisAdd BLAST21
Coiled coili4285 – 4305Sequence analysisAdd BLAST21
Coiled coili4448 – 4468Sequence analysisAdd BLAST21
Coiled coili4509 – 4543Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164812

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EDD3

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSQVWYI

Database of Orthologous Groups

More...
OrthoDBi
24858at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EDD3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF02187 GAS2, 1 hit
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00243 GAS2, 1 hit
SM00150 SPEC, 26 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

G5EDD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGERYRSHH AVDPSDAQEK EVLDHYELNR EKYNDERDNV QKKTFTKWVN
60 70 80 90 100
KHLSKTDHKI DDLFVDLRDG YALIALLEAL TGERIQKENG YTRFHRIQNV
110 120 130 140 150
QYCLDFLKKK NIKLVNIRPE DIVEGNGKLT LGLIWTIILN FQVSVIRQRL
160 170 180 190 200
LLESSQHEQM SAKHTTTNSQ VSLHGSDATS ARDALLQWAR RVTAGYPRVN
210 220 230 240 250
VNNFSSSWRD GLAFNAILHR YRSSAIDWNK ISSDSVSNTE RLNNAFAAAD
260 270 280 290 300
REFGVERLLD AEDVDTNNPD EKSIITYVSS LYNALPHEPE MSRLQKVQEE
310 320 330 340 350
YIEEAYEWRE WVVRAIQLVD DRHLQGTASE LIYELQRFRE DDLPPREEQK
360 370 380 390 400
RRLTLVYEHL EKVMRSTELF AIPHELSAPE LQRVWNELQN SIDRRFDVLE
410 420 430 440 450
RHRIQEGNSN DLLSRLARGI GITNEKLDLI LKRIEDVEAR VDTSPPAAVE
460 470 480 490 500
RTVSEIVDDL NALESPIARF FEDVEELKSM QHPEANDFYK QVYGLHQRRT
510 520 530 540 550
TYLDRLTNQI LVRLGVRTDS LHKENQQRLE NMRKTSFSRV EECIEWVRVR
560 570 580 590 600
MEKLTTMEFL EDLETLEHVF EQHKFDNRDI QDFRQNVDEC IARQAEVSAE
610 620 630 640 650
DTYEYCELLR VLESEYQQLR DLSAGRMLDL DSLIAFVRAA QLELIWVSER
660 670 680 690 700
ESIEVTRNWS DIKQLDLPML TNYYKQLLHE MELREKQYND VHNQGAALLN
710 720 730 740 750
QGHPAIRVIE VYLRQMQSQW DWLLALSKCL EEHLRDALNL KSFMEEASDA
760 770 780 790 800
EAWIQEQSVR LENNYNRTDF SLEEGERFLR ELDEIKEILN KYHQVLMALT
810 820 830 840 850
ERCASISPLW QRGERIPHPI KVTALCDYSD ENVTIKAGDD VYLLDNSDLI
860 870 880 890 900
KWTIRDISGA EGQVPSVVFR IPPTDARLTA LLNRLLQQFE KLKKLWDKKH
910 920 930 940 950
RMVRFNMVLN TMRTIQGWDL DTFNSIDPDQ RDAIMKALND DANKLLSELD
960 970 980 990 1000
PNDPLALRLR EELRRTNEHF WNLLNASQKP PEPDWASQYD QKMAELLKKL
1010 1020 1030 1040 1050
EEAWRELNDA VGKPISRSPE DLERVIHAHK RFEDALQALD SDVANVKELF
1060 1070 1080 1090 1100
RQLPNPTPTQ RVNHDRLNGL WDDLWDLSRM YVERIKVLES VLNGMVEVAD
1110 1120 1130 1140 1150
IVRQHEITLN SFDDLPAALD KLRGHHSQLL EINMVLKVSK LGAQNEHFSQ
1160 1170 1180 1190 1200
QQTVIDQLNR NVALLRQHVS RTRINEGHHP DVDAIEDEVQ KLNVRWENVN
1210 1220 1230 1240 1250
SQIASRLLAV ESALQIQMVY RSEYETEMSW LDTVEETINR LRKPEELRPE
1260 1270 1280 1290 1300
QYQQQLDMLI AEYTNLQEHT QAIEHVNKEG GRFIHEAKIF DAKLGQYSDG
1310 1320 1330 1340 1350
IVGIHGPGIK SEFRRTKPQP KNGSQIVTEE LELLNRRFAQ LSSLILERRN
1360 1370 1380 1390 1400
TMQVLIQNWK RQKQENVTQV VSFREAEVSG MMTDLTRFRQ EIFTTHLTFN
1410 1420 1430 1440 1450
SNPESIDAAT KNVQNVKQSL DSWRDRIKER LDEIDRLCTE EGDSLTPEQY
1460 1470 1480 1490 1500
SALREMRRQL ADEYDTVLRT VEGIHTRLNI LSALLIEFSS VTSSMQSWMT
1510 1520 1530 1540 1550
DRTRLAGDIR HKSGDPMRID EARFEAKSLM DEVIREESRL KTIGASVLKI
1560 1570 1580 1590 1600
EQEISAMRDD VRASGSTDDV GISVDEVYET RRRVEDDYMQ LLRQCQDLIS
1610 1620 1630 1640 1650
FQNRLHAMND EHSEQARRAD EWLQMLQNDV EDVDQDPRFQ RDEDRIQRIE
1660 1670 1680 1690 1700
ELNRMAAGGS SQLDDAEQAS RRLLTALEGT NVANDVRARH EELANLRRGK
1710 1720 1730 1740 1750
HQKVIDRLSQ NMMEAASRKA EAEGVKQAVE NLRQWSEQTA QRTRQPVQLP
1760 1770 1780 1790 1800
LTELDLHEAR KDEQVLHGEI ENRLALIEEL EKKAADVGDH ASLAELQECK
1810 1820 1830 1840 1850
MKLKRSNSDL KGLRDNIFDA INGLQTVNSE GETLSRAVDS AGAKIRSARL
1860 1870 1880 1890 1900
PEAQSEVEAL QDQADNLERI TNNLCNIPNV TRTEPVIQKS KDLRKRVDSC
1910 1920 1930 1940 1950
AQELDARMGK LAELESLDAE FDGAKNKLSS FIGAFDDELK GLEKVSIDKE
1960 1970 1980 1990 2000
KLAEQRRQTQ DLVDKHSEGN AILDDVEAIA QKVTAEDPSK TGSAQKSVGE
2010 2020 2030 2040 2050
LGARLQRQAS ELKARGDKIN KLDSKATSFA ESEAAVLGYI EKQKDQLSTG
2060 2070 2080 2090 2100
FPVPATKEGV KSQLLDLERM NKTGKEEQRR VDDARHSARE LAREASVEKE
2110 2120 2130 2140 2150
VQDMNQREKK LLDEWEDLAD QFDAVRSRAN KAEQVLNECA QMEKYIGAKK
2160 2170 2180 2190 2200
NMLEGIGAPS TEPGVAKANR AQIQSMKAET EGEKSALEHV NSLANELIAD
2210 2220 2230 2240 2250
GGANVEELMK KMDRLNRKWH SLESGLDENA GRVEEAAKLG QELKDIQKEL
2260 2270 2280 2290 2300
RKELGELESN VEKASAMSSN DIGDQLATLD SLKSRFGGVD KALEKLKGIL
2310 2320 2330 2340 2350
EATEELEVDA TNRAEIQEQL ETTQKKADEL ERKIENVKKA ALNAQNEGLE
2360 2370 2380 2390 2400
LEKKLDELIG TVNSAENELE LAAPIAAESL KLADELKRAE ELFQKLIENE
2410 2420 2430 2440 2450
GDVSLIRAKV AEELKKKPDA ELKKKLELLY QKWPKALGAA RDRKDLVSKA
2460 2470 2480 2490 2500
GDLVKQFGDQ VQALEQRLQG DQAELDELLA SDKAHDPEVC DALKLVELTM
2510 2520 2530 2540 2550
ARRLADVDAL NAVMNRIESS APGPDANRLR RRADTLSDDA KGMAKKARTA
2560 2570 2580 2590 2600
ADLAQRKQGL AKKFERLCDE VSQFTENQKA EIQDAIEKDL LNAERVQSKL
2610 2620 2630 2640 2650
NKIDDFWSSN SRELKNVGDE IKIDATPEDA QAVDTKLAEL QAGIDGLLAT
2660 2670 2680 2690 2700
LQEQNVHLEE KREQANRVQS ESQKAAGKIN SLVAEIADLD PIGRSRDELQ
2710 2720 2730 2740 2750
KQKKEVVELA GDLGSAQTKM LELGAEWEAA LGAGIVAQPV FEMNRAATDE
2760 2770 2780 2790 2800
LNKLAARAGK RLAQREKKIT ETEDEIDKLH ADADQIVGAL EAIAKDEALQ
2810 2820 2830 2840 2850
GAPSQLLDPK QVSEKVRQLK ESLKPVGEKM DAFNTDCKLL IKTAGPESDT
2860 2870 2880 2890 2900
KELDSLLKKV GDAYSDVVGK VSDKEMSVDA AVQQQGKVED AYRALLNWLE
2910 2920 2930 2940 2950
ETEEMMENRK KPSADAKVAK AQLHDYEVLM KHVEDKKPSV DGFKAMIEKI
2960 2970 2980 2990 3000
VAEASSDEEK KALGNKNAQI EDRYKDLLNS AVDRQRKLLD AVDLAERLQE
3010 3020 3030 3040 3050
VTIPLDSWLQ SADKRLQALA KVPITVEKAE EMIGEQEALQ DELEHKSDDL
3060 3070 3080 3090 3100
KDVLEIAPML ASLVSVEDAN SISGQVNQLE ARARALDAGI TNMRPLLESF
3110 3120 3130 3140 3150
LQQIQDFTLD AEDMTQFVGE TEVKLGELDE LPIEPDDLVE QTNILAEIAV
3160 3170 3180 3190 3200
SIADRDEMMA NIFEVGKQLA IQGEPEEALI AQKKLDDLKF RYADLMTSAD
3210 3220 3230 3240 3250
EKIALLAKAI PLSEGFHEGF DTVMQVLEDM DRDLQTIDEE DPETQAELIF
3260 3270 3280 3290 3300
LLEEDISQKM RPSVDELTAL SNQLQVLCSA DKADELQTNT IAMNKLVNSV
3310 3320 3330 3340 3350
ADRVARRAER IEMASKQSRA VLDDLQYLIE WFSAARERIL EGAPPSLDLE
3360 3370 3380 3390 3400
VLKSQLKHQR ITNEEASANK VQFRNVAGEA KKVARQLGME GNEANEKISD
3410 3420 3430 3440 3450
TVDEGKELVE EVMALCADRT ETLERALALM EQLTSQFDEL NKWLDQMDAE
3460 3470 3480 3490 3500
LQASPSVTTA TPAAELREMH DHNEELARMV AAYRPIIEGF KSDVGSLHEV
3510 3520 3530 3540 3550
LAEDQAPLLE SVAGELVQGY EEVREAVRAR GHAIDNMMGA TIGFGERLET
3560 3570 3580 3590 3600
LVANLQGAAD RLRENEGISA DPSVLESRLA ENRSIVESLR DKQNAYDALK
3610 3620 3630 3640 3650
QTASELLASA PEGDAAAGDV ENKLNRLEKL WKEIEREAVD RGVLLEDVLD
3660 3670 3680 3690 3700
KAKHFWSELD SCQKAVDDLR NRLELVEPAT GHPEQLADQQ EIMAQVASEM
3710 3720 3730 3740 3750
ERARPRIEAL SIAGKQLADY VPDDEKAVIE NQVANVRGGF STITGLFAEK
3760 3770 3780 3790 3800
KRDLIAAMEE AMTFHGDLQE LLKWLDMAEQ KLLKMSPVEH AKHMTEIEQL
3810 3820 3830 3840 3850
LKELHTFKDE VHERGVAKEQ VVATALQLAA DAPPHLAATV RQPVADLNTR
3860 3870 3880 3890 3900
WSRLNAALAE REHKLENLML QMGKLASTIA QLTAWMDKTR ATLKDIAPPK
3910 3920 3930 3940 3950
NAVNLRDIEI AQCKLVVLSN DIHAHQDSVN AVNRAAQKYI QTSGALDAET
3960 3970 3980 3990 4000
SDSLKSMNLK WEDIQKVLES LAFDMEVAKK EAENVGGEVE KWQRWLEETE
4010 4020 4030 4040 4050
SALLSTKPTG GLPETAEFQL DEFKALKLDV EHNASPLEAH LHATEQHLKE
4060 4070 4080 4090 4100
EPQDADTWLS KTHGAMKTKW NKVKELLVDR EKKLQVAYEQ AVALESALND
4110 4120 4130 4140 4150
MEDWIIAAER KLTDQPSISR LPDVIEKQLA EHESWMEEVA GRKMAMTKHQ
4160 4170 4180 4190 4200
ASGVHMQYYC EKKDAIPIKN RLVSLKHRVE KISGRTAERA KQLAVTRDEV
4210 4220 4230 4240 4250
ATWQDGLHDL EHFISDVLVK IAPEPNTTSS LEKLKAKLEE VKEAQRDVTA
4260 4270 4280 4290 4300
KQTLFDVTRK RGIGLAERAT RSEYKQISMT NEKMSKKWAE MLKKLRDRLR
4310 4320 4330 4340 4350
EAEQAVLEGG AFEESMNDLE SWVDDELERY QKAEHEPVFA DIDGVRALVD
4360 4370 4380 4390 4400
EESRRSAERK TKENGVKTVV KKADALMASG VDEKDSIAQA KERLVEKWNQ
4410 4420 4430 4440 4450
VEEAARHRGN SIKEAEQAAE EFDAKTHALL DWLAVEEQKL KASGLDEVEG
4460 4470 4480 4490 4500
VKQEMDEAKG RYQECLKKGE EILSKCQPAA EPILRNWMRV VEARWKEVSE
4510 4520 4530 4540 4550
KVDEREFTLL EQEQKAKEQN EQIEKLAKFA AQKREELNRM IEQPPAQDLD
4560 4570 4580 4590 4600
TMEQNICDFA NLDSELREQQ PEVDAACKSA KKGARNPAAE MLSTEWKKLW
4610 4620 4630 4640 4650
LDAMGLQSSL DNQKALLEEM KRLEGWKWED WKERYVEWND HAKARVNDLF
4660 4670 4680 4690 4700
RRIDRLHTGN VPRQVFIDGI IGSNYVPNST IVYSKFPTSR LEMAKVADRF
4710 4720 4730 4740 4750
DKGDGMINAK EFINALRFDA SNRNAKPQTD TEKITHEIEL QKKTCSCCTP
4760 4770 4780 4790 4800
YQIEKISENH YRFGDTHIKR MVRILRSTVM VRVGGGWESL DEFLHKHDPC
4810 4820 4830 4840 4850
RAKGRLNINM FPEARPIHAL DSMRSFTKNR HGKQLPTTGT PGPIMKIREK
4860 4870 4880 4890 4900
TDRSVPMSGG LGGTAGYTVT TDSHRHTDAR PSRIPRAPSD MSAGRLSRVG
4910 4920 4930 4940 4950
SVSNSKNSIV DSSTPSRPES RASSDAGDRQ TRIPSLRARK GQRYIPQGPS

SSSSK
Length:4,955
Mass (Da):562,959
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A7EE8BBD570D9F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EFK7G5EFK7_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,322Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECG8G5ECG8_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,323Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFD1G5EFD1_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
1,497Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECP9G5ECP9_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,424Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECG5G5ECG5_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,410Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFW2G5EFW2_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,405Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EEC4G5EEC4_CAEEL
VAB-10A protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,436Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFM4G5EFM4_CAEEL
VAB-10B protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,944Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYR7A0A1N7SYR7_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,819Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYN7A0A1N7SYN7_CAEEL
Uncharacterized protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,946Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAD90188.2

NCBI Reference Sequences

More...
RefSeqi
NP_001021855.1, NM_001026684.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.16101

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK1151.1c; ZK1151.1c; WBGene00006876

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173058

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAD90188.2
RefSeqiNP_001021855.1, NM_001026684.3
UniGeneiCel.16101

3D structure databases

ProteinModelPortaliG5EDD3
SMRiG5EDD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK1151.1c

Proteomic databases

EPDiG5EDD3
PaxDbiG5EDD3
PeptideAtlasiG5EDD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1151.1c; ZK1151.1c; WBGene00006876
GeneIDi173058

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173058
WormBaseiZK1151.1c ; CE35152 ; WBGene00006876 ; vab-10

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000164812
InParanoidiG5EDD3
OMAiSSQVWYI
OrthoDBi24858at2759
PhylomeDBiG5EDD3

Enzyme and pathway databases

ReactomeiR-CEL-6809371 Formation of the cornified envelope

Gene expression databases

BgeeiWBGene00006876 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiG5EDD3 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF02187 GAS2, 1 hit
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 5 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00243 GAS2, 1 hit
SM00150 SPEC, 26 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EDD3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 10, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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