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Entry version 63 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Rap guanine nucleotide exchange factor

Gene

pxf-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi347 – 463cNMPAdd BLAST117

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5673001 RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor
Short name:
RA-GEF
Alternative name(s):
PDZ-domain-containing exchange factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pxf-1
Synonyms:ra-gef
ORF Names:T14G10.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
T14G10.2a ; CE28080 ; WBGene00004254 ; pxf-1
T14G10.2b ; CE28081 ; WBGene00004254 ; pxf-1
T14G10.2d ; CE46125 ; WBGene00004254 ; pxf-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Beginning in the L2 stage, onward, animals display striking and progressive defects in morphology of the epidermis. Worms show molting defect and exhibit a trail of old cuticle that remains attached to the posterior part of the body. Longitudinal ridges termed alae, which are cuticular structures secreted by lateral hypodermal seam cells, are poorly distinct or interrupted. Sensory rays in males are malformed. Developed a fairly normal gonad but have a strongly reduced fertility. Show uncoordinated movement and an enlarged gut lumen. Died as a 'bag of worms', or alternatively, as a result of a burst vulva.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004238761 – 1470Rap guanine nucleotide exchange factorAdd BLAST1470

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EDB9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EDB9

PeptideAtlas

More...
PeptideAtlasi
G5EDB9

PRoteomics IDEntifications database

More...
PRIDEi
G5EDB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hermaphrodite-specific neurons (HSNs), oviduct sheath cells and lateral seam cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at the comma stage in endodermal precursor and hypodermal cells of the embryo. Expressed in the hypodermis and gut during elongation and larval stages. Expressed in neuronal precursor cells at the comma stage. Expressed in neuronal cells in the head and tail, in cells of the ventral nerve cord and of the pharynx at the L1 hatched larvae stage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004254 Expressed in 5 organ(s), highest expression level in adult organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5EDB9 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
R06F6.12Q6BEV52EBI-2918010,EBI-2002318

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
G5EDB9, 5 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T14G10.2a.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini478 – 592N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST115
Domaini597 – 679PDZPROSITE-ProRule annotationAdd BLAST83
Domaini782 – 869Ras-associatingPROSITE-ProRule annotationAdd BLAST88
Domaini894 – 1124Ras-GEFPROSITE-ProRule annotationAdd BLAST231

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi130 – 214Pro-richAdd BLAST85

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RAPGEF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3542 Eukaryota
ENOG410XS6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168958

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EDB9

KEGG Orthology (KO)

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KOi
K08018

Identification of Orthologs from Complete Genome Data

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OMAi
EVCSEHN

Database of Orthologous Groups

More...
OrthoDBi
31139at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EDB9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038 CAP_ED, 2 hits
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

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PANTHERi
PTHR23113 PTHR23113, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366 SSF48366, 1 hit
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 2 hits
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: G5EDB9-1) [UniParc]FASTAAdd to basket
Also known as: PXF-1-A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPRKPRQDP VNDARFYESL IKPPHLRTPD DIRNVYEQLR QLDTFSNLFI
60 70 80 90 100
GPLKALCKTA RYERHPAQYI LFRDGDVARS WYILLSGSVF IENQIYMPYG
110 120 130 140 150
CFGKRTGQNH RRTHNCLLLQ ESEMIVIDYP TEPQSNGMSP RTPPRGIHHS
160 170 180 190 200
GEPVHQKTPR KSAPNMSVDS IAMPPPPVPP RPLRLPQTAA KGPAPLPPRG
210 220 230 240 250
LPRTYPLDFP VDIPTTSSSS SNTSYNDQHR SQVYLNGLSA DEDTLVRVKH
260 270 280 290 300
RREKSNSVGG QAQNGISTAR RLRGRSTASS TTTEGETASN EGADSDEDEG
310 320 330 340 350
SMPSQESSSG GFMDLRDSVR ECLEKEPSER NSEDLAVLLD FMQHMSAFAA
360 370 380 390 400
LPMSIKRQLC LKMVFAVVND AGTVVLAHNE KLDSWSVIVN GCVEVVKPSG
410 420 430 440 450
ERVEYKLGDS FGAEPTPATQ IHIGEMRTMV DDCEFVLVEH RDFCSIMSTI
460 470 480 490 500
GDHIEKDRDG LTGEVVSEVE RRTVGTHCGQ VLIKGKPDKL IHHLVDERDH
510 520 530 540 550
NVDPHYVDDF LLTYRVFIRD PTTIFEKLML WFADSIYRDK VARLVLLWVN
560 570 580 590 600
NHFNDFETND EMWNLLERFE GALERDGMHS QLSLLNIACS VKAKPRQVIL
610 620 630 640 650
TRRKDDKMMM RLVGGQESGN SVYVAEVFPD TSAAREGVKR ADEMLEVNQQ
660 670 680 690 700
SAKYLSAKKA EDLLTGSLSL TLMLKNNVLG YKETIGKIEH NKPKNGTSRS
710 720 730 740 750
GAGIPMVIPV HKTSITGKKS STTSSKSGMM EKLMTILKSS KEDSMDFTDE
760 770 780 790 800
AKISSADLRP SRSNPDITSI SQYYGPVRSE CPEHVLKIYR NDQTFKYLPV
810 820 830 840 850
YKETSAQNVV QLALQEFNMT AEGSPEWSLC ECTVTIDGVI KQRRLPPQME
860 870 880 890 900
NLAERIALNS RYYLKNNSRS EPLVPDELAP ELLKEAQTQL LSLNAQVVAA
910 920 930 940 950
QLTLQDFSVF SAIEPTEFLD NLFKLDSKYG SPKLEEFEQL FNREMWWVAT
960 970 980 990 1000
EICTERHVQK RAKLIKKFIK VARYCRDLRN FNSMFAIMSG LDKPAVRRLH
1010 1020 1030 1040 1050
SSWERVSSKY IRMLDEIHQL VDPSRNMSKY RQHLAEVAQE PPVVPIYPVI
1060 1070 1080 1090 1100
KKDLTFAHDG NATYSEKLIN FEKLRLIAKS IRGVMKLSSA PYEIASMAER
1110 1120 1130 1140 1150
SGGVVMDALL HMNSFENSNV ATMRKGMSGK QNQPRKKVYE QALMVRKVKS
1160 1170 1180 1190 1200
YLEGLHVVDN EMELDSMSYD IEPQVQTAHR GANSSSTANI RRVPSPTPSS
1210 1220 1230 1240 1250
LSSQSAGSAD QSSRHRLLFN GTGSISSAGG GSKFGVESPQ AVQKMLSLVQ
1260 1270 1280 1290 1300
NSKVKGAPPQ ITSPSTSARS SLQRNMPRVT GRQATSSAQG PVQLNEETST
1310 1320 1330 1340 1350
VTTYYQSDNG RRQRSGSEGR FDNIPPSTFY LTSDGLTVSP RQSLSVVIPT
1360 1370 1380 1390 1400
HPHGHSPTSP RCRSRSPASS GCSSFSTIAS IAATSMAAAP SAFVSNPYQH
1410 1420 1430 1440 1450
HQTVRGHVIG HRPMPIVTSG SATLPNHVSP RGLPPKSRPT ILPGSHTNSS
1460 1470
SRMGTIKEAT FLTSEQVSRV
Length:1,470
Mass (Da):163,808
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59404704C1346BC8
GO
Isoform b (identifier: G5EDB9-2) [UniParc]FASTAAdd to basket
Also known as: PXF-1-B

The sequence of this isoform differs from the canonical sequence as follows:
     1309-1311: NGR → VLI
     1312-1470: Missing.

Show »
Length:1,311
Mass (Da):147,004
Checksum:iA4870F07DC201F97
GO
Isoform d (identifier: G5EDB9-3) [UniParc]FASTAAdd to basket
Also known as: PXF-1-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:1,347
Mass (Da):149,268
Checksum:i19708909E535BC0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5ECB8G5ECB8_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EEE0G5EEE0_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,305Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECE2G5ECE2_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GUA2F5GUA2_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
85Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL09435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0532711 – 123Missing in isoform d. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0532691309 – 1311NGR → VLI in isoform b. 1 Publication3
Alternative sequenceiVSP_0532701312 – 1470Missing in isoform b. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF170796 mRNA Translation: AAF22963.1
AF308447 mRNA Translation: AAL09433.1
AF308448 mRNA Translation: AAL09434.1
AF308449 mRNA Translation: AAL09435.1 Different initiation.
Z68880, Z69664 Genomic DNA Translation: CAA93100.2
Z68880 Genomic DNA Translation: CAC42342.1
Z68880 Genomic DNA Translation: CCD31121.1

Protein sequence database of the Protein Information Resource

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PIRi
T23314

NCBI Reference Sequences

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RefSeqi
NP_001023389.1, NM_001028218.4 [G5EDB9-1]
NP_001023390.1, NM_001028219.2 [G5EDB9-2]
NP_001255465.1, NM_001268536.1 [G5EDB9-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T14G10.2a.1; T14G10.2a.1; WBGene00004254 [G5EDB9-1]
T14G10.2a.2; T14G10.2a.2; WBGene00004254 [G5EDB9-1]
T14G10.2b.1; T14G10.2b.1; WBGene00004254 [G5EDB9-2]
T14G10.2b.2; T14G10.2b.2; WBGene00004254 [G5EDB9-2]
T14G10.2d.1; T14G10.2d.1; WBGene00004254 [G5EDB9-3]
T14G10.2d.2; T14G10.2d.2; WBGene00004254 [G5EDB9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
177894

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T14G10.2

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170796 mRNA Translation: AAF22963.1
AF308447 mRNA Translation: AAL09433.1
AF308448 mRNA Translation: AAL09434.1
AF308449 mRNA Translation: AAL09435.1 Different initiation.
Z68880, Z69664 Genomic DNA Translation: CAA93100.2
Z68880 Genomic DNA Translation: CAC42342.1
Z68880 Genomic DNA Translation: CCD31121.1
PIRiT23314
RefSeqiNP_001023389.1, NM_001028218.4 [G5EDB9-1]
NP_001023390.1, NM_001028219.2 [G5EDB9-2]
NP_001255465.1, NM_001268536.1 [G5EDB9-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5EDB9, 5 interactors
STRINGi6239.T14G10.2a.1

Proteomic databases

EPDiG5EDB9
PaxDbiG5EDB9
PeptideAtlasiG5EDB9
PRIDEiG5EDB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT14G10.2a.1; T14G10.2a.1; WBGene00004254 [G5EDB9-1]
T14G10.2a.2; T14G10.2a.2; WBGene00004254 [G5EDB9-1]
T14G10.2b.1; T14G10.2b.1; WBGene00004254 [G5EDB9-2]
T14G10.2b.2; T14G10.2b.2; WBGene00004254 [G5EDB9-2]
T14G10.2d.1; T14G10.2d.1; WBGene00004254 [G5EDB9-3]
T14G10.2d.2; T14G10.2d.2; WBGene00004254 [G5EDB9-3]
GeneIDi177894
KEGGicel:CELE_T14G10.2

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
177894
WormBaseiT14G10.2a ; CE28080 ; WBGene00004254 ; pxf-1
T14G10.2b ; CE28081 ; WBGene00004254 ; pxf-1
T14G10.2d ; CE46125 ; WBGene00004254 ; pxf-1

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00940000168958
InParanoidiG5EDB9
KOiK08018
OMAiEVCSEHN
OrthoDBi31139at2759
PhylomeDBiG5EDB9

Enzyme and pathway databases

ReactomeiR-CEL-5673001 RAF/MAP kinase cascade

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EDB9

Gene expression databases

BgeeiWBGene00004254 Expressed in 5 organ(s), highest expression level in adult organism
ExpressionAtlasiG5EDB9 baseline and differential

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPGF_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EDB9
Secondary accession number(s): G5EBY1, G5EEX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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