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Entry version 63 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

cand-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-6798695, Neutrophil degranulation
R-CEL-8951664, Neddylation
R-CEL-917937, Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 1
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cand-1
ORF Names:Y102A5A.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
Y102A5A.1 ; CE20378 ; WBGene00013606 ; cand-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms show impenetrant phenotypes, including developmental arrest, morphological defects of the vulva and tail and reduced fecundity. Worms also display supernumerary seam cell divisions, defective alae formation, and the accumulation of the SCF(lin-23) target, the glutamate receptor glr-1. Increased levels of the neddylated isoforms of Cul-2 and cul-4.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004222401 – 1274Cullin-associated NEDD8-dissociated protein 1Add BLAST1274

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5ED41

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5ED41

PeptideAtlas

More...
PeptideAtlasi
G5ED41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In early embryos, expressed in all cells. Expression is higher during early stages and is reduced in late-stage embryos. Present in the one-cell stage zygote, indicating it is provided as a maternal product by the hermaphrodite parent. During larval stages, expressed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. Also observed in a subset of non-proliferative tissues, including hypodermal cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00013606, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cul-1, cul-2, cul-3, cul-4, cul-5 and cul-6.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
45111, 7 interactors

Protein interaction database and analysis system

More...
IntActi
G5ED41, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.Y102A5A.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 79HEAT 1Add BLAST39
Repeati127 – 167HEAT 2Add BLAST41
Repeati375 – 413HEAT 3Add BLAST39
Repeati500 – 540HEAT 4Add BLAST41
Repeati617 – 655HEAT 5Add BLAST39
Repeati671 – 709HEAT 6Add BLAST39
Repeati1000 – 1038HEAT 7Add BLAST39
Repeati1041 – 1078HEAT 8Add BLAST38
Repeati1079 – 1117HEAT 9Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni320 – 349DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi322 – 348Acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAND family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1824, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017740

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007157_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5ED41

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNLAIKC

Database of Orthologous Groups

More...
OrthoDBi
194023at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5ED41

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR039852, CAND1/CAND2
IPR013932, TATA-bd_TIP120

The PANTHER Classification System

More...
PANTHERi
PTHR12696, PTHR12696, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08623, TIP120, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5ED41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAYHVGQLV DKMSNPDKDF RFMACNDLMK DLQTGTIALE DDSTAKVIRA
60 70 80 90 100
LIKLLSDSNG EVQNLAIKCI GLLAQPSKIK THHLEYLVEE LTPHVFSKAE
110 120 130 140 150
QSRDIHSLTL KAMILNLAPS ASSNATTTVV KRMLPKFVDS LSLCAPDDAA
160 170 180 190 200
RVDVLDLIGE VLLRFGDVVP EMHKGSLKVM VDHLYSFRSA IRKKAITGIG
210 220 230 240 250
HLASVINGEL YDELVQDLLK ELAQRSPPSS AAQNVQLRTL VIALSTVARA
260 270 280 290 300
SGSRFSKHTP KVVPFLLQYL QIDPGTESEH DDLREASIQG LEVFLYRNPQ
310 320 330 340 350
EVVAFEKEVI QQLTDALAYD PNYEYGDDDE DEQMEDDEDD DEDEYSDDED
360 370 380 390 400
VTWKVRRAAA KAIEAMISSH RESLLNLSQK IGPVVIGRFK EREETVRTEI
410 420 430 440 450
ISVYIALLNQ ISILVPDLQK AVVAADEDSI ETDDIVVIGG TKFSTNYLSR
460 470 480 490 500
SQLAIIQSLA DQKDVLLRTI TKSMKKHPKT GPKCIELLSA LIRTYPSGLE
510 520 530 540 550
DSLDDIIPAV SNILTDKNAS AQGKMTVLSF ISNALTLNNP KRFKNLLSPL
560 570 580 590 600
TTIMTHSISE PFYKVSAEGL AVCCKYIDVL RELSACGGNE EAKKLLVVVE
610 620 630 640 650
KKFMANDTDQ EVRERAISAI SMLLAAFKDV LKNETPAILE KMTERIGRDM
660 670 680 690 700
TCLVAFRAST HIVEAGIIFS SAQLQSILRH VVDYVKKIAR SLRMTCLNFV
710 720 730 740 750
EKLMKHSPAG SIPVEELTCV LGEMSNLISE TDLQITNQAF CCLTYAFLNF
760 770 780 790 800
PTCVSLHMQP ILDSIIRLLT SPLIQGLALN SLLNLFTAIV KTDFPEKPTF
810 820 830 840 850
ESLLDSVTSP VYDNVALSRH AHMAIASCAA VITESTQNLE KSRSLAKKLA
860 870 880 890 900
QQLQTANMSD SIRLFAMITL GELGRRVPDT YSPDFPVKPE DLAIKAFNHH
910 920 930 940 950
HEDLKSAAAQ ALGALAVGNL NVYLPFILEQ IRTQPKKQYL LLHALKEVIV
960 970 980 990 1000
WESSSEESTK STDLFRSAIV DIWGMLMANA GGNEDGTRSV VAECLGRLCS
1010 1020 1030 1040 1050
FDPESLLPKL KESMRSSDPA IRSSAVSAIK YMINDEKRIV DITLQKQIGD
1060 1070 1080 1090 1100
FLAAVRDEDL KVRRVALVVL NSAAHNKPAL VRDLLPDLLP AVYEETKLRK
1110 1120 1130 1140 1150
ELIKEVEMGP FKHQVDEGLD LRKCAFECMF TLLESCVDKI DITQFSSVME
1160 1170 1180 1190 1200
VGLSDQNHDV KLLNYLTLQR VANLAPGQVL QRIDRVCEPL KTQLNVRPRG
1210 1220 1230 1240 1250
NAVKQEVEKL EELKKAVIRV VYGLKLKLPE VERNPQFLDL YNTIKHTKEL
1260 1270
EALANDVLKE SQRAVVYDTP META
Length:1,274
Mass (Da):141,726
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D0D62BAD14B83D2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL023822, Z81593 Genomic DNA Translation: CAA19440.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T25024

NCBI Reference Sequences

More...
RefSeqi
NP_507244.1, NM_074843.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y102A5A.1.1; Y102A5A.1.1; WBGene00013606

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y102A5A.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023822, Z81593 Genomic DNA Translation: CAA19440.1
PIRiT25024
RefSeqiNP_507244.1, NM_074843.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi45111, 7 interactors
IntActiG5ED41, 1 interactor
STRINGi6239.Y102A5A.1

Proteomic databases

EPDiG5ED41
PaxDbiG5ED41
PeptideAtlasiG5ED41

Genome annotation databases

EnsemblMetazoaiY102A5A.1.1; Y102A5A.1.1; WBGene00013606
GeneIDi180125
KEGGicel:CELE_Y102A5A.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180125
WormBaseiY102A5A.1 ; CE20378 ; WBGene00013606 ; cand-1

Phylogenomic databases

eggNOGiKOG1824, Eukaryota
GeneTreeiENSGT00390000017740
HOGENOMiCLU_007157_0_0_1
InParanoidiG5ED41
OMAiQNLAIKC
OrthoDBi194023at2759
PhylomeDBiG5ED41

Enzyme and pathway databases

ReactomeiR-CEL-6798695, Neutrophil degranulation
R-CEL-8951664, Neddylation
R-CEL-917937, Iron uptake and transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5ED41

Gene expression databases

BgeeiWBGene00013606, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR039852, CAND1/CAND2
IPR013932, TATA-bd_TIP120
PANTHERiPTHR12696, PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623, TIP120, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAND1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ED41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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