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Entry version 75 (02 Jun 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Ataxin-2 homolog

Gene

atx-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable RNA-binding protein that negatively regulates the translation of targets (PubMed:15342467, PubMed:27689799).

Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation (PubMed:27689799).

Required for gonad development, germ cell proliferation and for the production of oocytes (PubMed:15514056, PubMed:11303786, PubMed:15342467).

Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1 (PubMed:27457958).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processCell cycle, Cell division

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ataxin-2 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atx-21 PublicationImported
ORF Names:D2045.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
D2045.1a ; CE37889 ; WBGene00000231 ; atx-2
D2045.1b ; CE37967 ; WBGene00000231 ; atx-2
D2045.1c ; CE42488 ; WBGene00000231 ; atx-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Sterile, however growth rate, size and fat accumulation are not altered in response to a restricted diet in contrast to wild-type animals under the same conditions (PubMed:27457958). RNAi-mediated knockdown results in embryonic lethality as a result of cell division defects at the one-cell stage (PubMed:27689799). Cell division defects include polar body extrusion failure, abnormal spindle positioning, chromosome missegregation and cytokinesis failure (PubMed:27689799). One-cell embryos also have enlarged centrosomes and microtubule growth defects characterized by increased microtubule nucleation, short astral microtubules and elevated expression levels of zyg-1, which is involved in centriole duplication, and tbg-1, a pericentriolar materials factor involved in microtubule nucleation (PubMed:27689799). In other contrasting studies, RNAi-mediated knockdown at the L4 stage of larval development, results in the initial production of viable progeny, that with continued RNAi exposure, grow into sterile adults in which germ cells have a proliferation defect that leads to a reduced sized gonad containing large quantities of sperm and no oocytes (PubMed:15514056, PubMed:15342467). The masculinization of the germline phenotype (also called the Mog phenotype) is likely due to altered activity of the translational repressor gld-1 in these mutants and the translational repression of 'feminizing' genes including tra-2 and rme-2 (PubMed:15342467). RNAi-mediated knockdown in both arms of the syncytial gonad of adult hermaphrodites results in the production of 95% fewer eggs than wild-type and of the eggs produced, all arrest during embryogenesis possibly due to cell division defcts (PubMed:11303786).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004392581 – 959Ataxin-2 homologCuratedAdd BLAST959

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5ED29

PeptideAtlas

More...
PeptideAtlasi
G5ED29

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the central nervous system, dorsal and ventral nerve chord, intestinal lining and body-wall muscle (PubMed:11303786). Expressed in the gonad (PubMed:15342467).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in 4-cell stage embryos and during larval stages L3 and L4.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000231, Expressed in multi-cellular organism and 6 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5ED29, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with szy-20 (via C-terminus); the interaction is RNA independent (PubMed:27689799).

Interacts with pab-1 (PubMed:15342467).

Interacts with gdi-1 (PubMed:27457958).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5ED29, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.D2045.1d

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni203 – 378DisorderedSequence analysisAdd BLAST176
Regioni392 – 484DisorderedSequence analysisAdd BLAST93
Regioni501 – 528DisorderedSequence analysisAdd BLAST28
Regioni697 – 831DisorderedSequence analysisAdd BLAST135
Regioni867 – 959DisorderedSequence analysisAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi217 – 241Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi242 – 265Polar residuesSequence analysisAdd BLAST24
Compositional biasi279 – 315Polar residuesSequence analysisAdd BLAST37
Compositional biasi336 – 351Polar residuesSequence analysisAdd BLAST16
Compositional biasi358 – 374Polar residuesSequence analysisAdd BLAST17
Compositional biasi409 – 435Polar residuesSequence analysisAdd BLAST27
Compositional biasi508 – 528Polar residuesSequence analysisAdd BLAST21
Compositional biasi718 – 745Polar residuesSequence analysisAdd BLAST28
Compositional biasi756 – 786Polar residuesSequence analysisAdd BLAST31
Compositional biasi787 – 802Pro residuesSequence analysisAdd BLAST16
Compositional biasi867 – 884Polar residuesSequence analysisAdd BLAST18
Compositional biasi895 – 932Polar residuesSequence analysisAdd BLAST38
Compositional biasi933 – 947Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal part is necessary for interaction with szy-20.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ataxin-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2375, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174882

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSNPRMM

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009604, LsmAD_domain
IPR025852, SM_dom_ATX

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14438, SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01272, LsmAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform aImported (identifier: G5ED29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTPTGLPAL NGDVLSAIND MIGRVIIINT TDKKRYSGVL GAVSQDFDFG
60 70 80 90 100
MQCVVEITKE NENNLLRTES ECRDKMVFHY SDIVDFAYVT QEIKKQHAVS
110 120 130 140 150
KFVTDRQYHG DTPIEGEELQ EWNGGEEDGL GGSIEDDVVV AGGQTAARRS
160 170 180 190 200
NNHNNGTGWS VNDMFAANEK MNVVSTFKED LTQYTTVEVV GTDEDRARAE
210 220 230 240 250
RLAREIESNS SSKFMANLEN DDDERDLDKI TRQEDFENGN GRKRNNNSFN
260 270 280 290 300
QQQQQRRNPN IAPNGQPVNR RAEGLRGDRR NSGSSSANNS RYGAPAAAQQ
310 320 330 340 350
NYSQNQQQQQ GQKGYRRQNE ENDWQMAKGK GQNQGHDHSF RQQQKQMLDP
360 370 380 390 400
RPNNNVKPAD DKAQSATTAT AAAGGSRVTD LKNWGNEFSI ATAPKDQAPA
410 420 430 440 450
VPAGNSGSAW NRGPPSSLVA KGSSNESTPP PTTNGEEAET KKEEAPSTSV
460 470 480 490 500
DVAAAPVQNV QNDAEKHQED DNVSVTSEND SVITSKSSSF KFNINAPEFK
510 520 530 540 550
PRVAPATPTA TTPVQNEYHP QQQPHPAMMA PQQGPPAPGM GMVPPHMGGP
560 570 580 590 600
QNQGQPPMMM WQQTGQQQQG GGGYPQNHQF PIQHVPMQGV PGQMYGPGAA
610 620 630 640 650
TPVTVAQQPN QQHQVPTSAA GGQNHQLRDG EYREKQPLYM PYGPPQMVPV
660 670 680 690 700
TSQQFYHSQY QGQMQQAAPY QMKMMPQQAP QGAYQQRYQQ PQVYMMPPQG
710 720 730 740 750
QQQQPRYQGP PPPQQQQQQQ PQQQQFSGEQ SRPQSHPNSQ PTTPGPRGEL
760 770 780 790 800
PKMSGAPQNG NMQAESSSNA SHSGSTSSQS GQRSGSPPGA VPPPPPPQQQ
810 820 830 840 850
HQQQQHPPHH APPHVGAPPP QMMQQQQQHI QQYMVMQGPH QMHPQIPNYY
860 870 880 890 900
QQPQQVFYPM IMPQQMPMQQ NQHPQQSLMG ERSDQGFPTS GYFDYRTMPN
910 920 930 940 950
YQQQQQQQQQ QMHRQNSLPQ QFQGNQGVNP SGQQSGPPPP PPPSQQGTPR

DQQHSQSPP
Length:959
Mass (Da):106,041
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B1C79F10A91F97D
GO
Isoform bImported (identifier: G5ED29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.

Show »
Length:634
Mass (Da):69,515
Checksum:i8A3D8A7028C97057
GO
Isoform cImported (identifier: G5ED29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-930: GVNP → ALKV
     931-959: Missing.

Show »
Length:930
Mass (Da):103,101
Checksum:iE57F92684F577D0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4PH96D4PH96_CAEEL
LsmAD domain-containing protein
atx-2 CELE_D2045.1, D2045.1
1,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0588181 – 325Missing in isoform b. CuratedAdd BLAST325
Alternative sequenceiVSP_058819927 – 930GVNP → ALKV in isoform c. Curated4
Alternative sequenceiVSP_058820931 – 959Missing in isoform c. CuratedAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY571963 mRNA Translation: AAS78587.1
BX284603 Genomic DNA Translation: CAA84697.3
BX284603 Genomic DNA Translation: CAI46560.1
BX284603 Genomic DNA Translation: CAQ35032.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20369

NCBI Reference Sequences

More...
RefSeqi
NP_001021230.1, NM_001026059.2
NP_001021231.1, NM_001026060.2
NP_001122690.1, NM_001129218.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
D2045.1a.1; D2045.1a.1; WBGene00000231 [G5ED29-1]
D2045.1b.1; D2045.1b.1; WBGene00000231 [G5ED29-2]
D2045.1c.1; D2045.1c.1; WBGene00000231 [G5ED29-3]

UCSC genome browser

More...
UCSCi
D2045.1b.2, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571963 mRNA Translation: AAS78587.1
BX284603 Genomic DNA Translation: CAA84697.3
BX284603 Genomic DNA Translation: CAI46560.1
BX284603 Genomic DNA Translation: CAQ35032.1
PIRiT20369
RefSeqiNP_001021230.1, NM_001026059.2
NP_001021231.1, NM_001026060.2
NP_001122690.1, NM_001129218.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5ED29, 1 interactor
STRINGi6239.D2045.1d

Proteomic databases

EPDiG5ED29
PeptideAtlasiG5ED29

Genome annotation databases

EnsemblMetazoaiD2045.1a.1; D2045.1a.1; WBGene00000231 [G5ED29-1]
D2045.1b.1; D2045.1b.1; WBGene00000231 [G5ED29-2]
D2045.1c.1; D2045.1c.1; WBGene00000231 [G5ED29-3]
UCSCiD2045.1b.2, c. elegans

Organism-specific databases

WormBaseiD2045.1a ; CE37889 ; WBGene00000231 ; atx-2
D2045.1b ; CE37967 ; WBGene00000231 ; atx-2
D2045.1c ; CE42488 ; WBGene00000231 ; atx-2

Phylogenomic databases

eggNOGiKOG2375, Eukaryota
GeneTreeiENSGT00940000174882
OMAiQSNPRMM

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5ED29

Gene expression databases

BgeeiWBGene00000231, Expressed in multi-cellular organism and 6 other tissues
ExpressionAtlasiG5ED29, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009604, LsmAD_domain
IPR025852, SM_dom_ATX
PfamiView protein in Pfam
PF14438, SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272, LsmAD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATX2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ED29
Secondary accession number(s): B2D6K7, Q5FC83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: December 14, 2011
Last modified: June 2, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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