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Entry version 83 (07 Apr 2021)
Sequence version 1 (14 Dec 2011)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs adt-1

Gene

adt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle.

1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi388Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei389PROSITE-ProRule annotation1
Metal bindingi392Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi398Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.302

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs adt-1Curated (EC:3.4.24.-By similarity)
Short name:
ADAMTS adt-1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adt-11 PublicationImported
ORF Names:C02B4.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C02B4.1 ; CE31872 ; WBGene00000082 ; adt-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000044090022 – 163Sequence analysisAdd BLAST142
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000440951164 – 1461A disintegrin and metalloproteinase with thrombospondin motifs adt-1Sequence analysisAdd BLAST1298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi212N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi405 ↔ 410PROSITE-ProRule annotation
Disulfide bondi719 ↔ 751PROSITE-ProRule annotation
Disulfide bondi723 ↔ 758PROSITE-ProRule annotation
Disulfide bondi735 ↔ 741PROSITE-ProRule annotation
Disulfide bondi816 ↔ 846PROSITE-ProRule annotation
Disulfide bondi820 ↔ 851PROSITE-ProRule annotation
Disulfide bondi831 ↔ 836PROSITE-ProRule annotation
Disulfide bondi862 ↔ 892PROSITE-ProRule annotation
Disulfide bondi866 ↔ 897PROSITE-ProRule annotation
Disulfide bondi877 ↔ 882PROSITE-ProRule annotation
Disulfide bondi1047 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1082PROSITE-ProRule annotation
Disulfide bondi1062 ↔ 1067PROSITE-ProRule annotation
Disulfide bondi1160 ↔ 1194PROSITE-ProRule annotation
Disulfide bondi1162 ↔ 1199PROSITE-ProRule annotation
Disulfide bondi1173 ↔ 1184PROSITE-ProRule annotation
Disulfide bondi1215 ↔ 1253PROSITE-ProRule annotation
Disulfide bondi1219 ↔ 1259PROSITE-ProRule annotation
Disulfide bondi1231 ↔ 1243PROSITE-ProRule annotation
Disulfide bondi1277 ↔ 1314PROSITE-ProRule annotation
Disulfide bondi1281 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1292 ↔ 1304PROSITE-ProRule annotation
Disulfide bondi1336 ↔ 1372PROSITE-ProRule annotation
Disulfide bondi1340 ↔ 1377PROSITE-ProRule annotation
Disulfide bondi1351 ↔ 1362PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5ECS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5ECS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In hermaphrodites, expressed in the vulva, head ganglia, ventral nerve cord and amphid neurons. Expressed in the rays of the male tail.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000082, Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C02B4.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5ECS8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini233 – 435Peptidase M12BPROSITE-ProRule annotationAdd BLAST203
Domaini464 – 546DisintegrinCuratedAdd BLAST83
Domaini708 – 759TSP type-1 1PROSITE-ProRule annotationAdd BLAST52
Domaini761 – 802TSP type-1 2PROSITE-ProRule annotationAdd BLAST42
Domaini804 – 852TSP type-1 3PROSITE-ProRule annotationAdd BLAST49
Domaini853 – 898TSP type-1 4PROSITE-ProRule annotationAdd BLAST46
Domaini903 – 952TSP type-1 5PROSITE-ProRule annotationAdd BLAST50
Domaini955 – 1000TSP type-1 6Sequence analysisAdd BLAST46
Domaini1035 – 1083TSP type-1 7PROSITE-ProRule annotationAdd BLAST49
Domaini1087 – 1133TSP type-1 8PROSITE-ProRule annotationAdd BLAST47
Domaini1148 – 1200TSP type-1 9PROSITE-ProRule annotationAdd BLAST53
Domaini1203 – 1260TSP type-1 10PROSITE-ProRule annotationAdd BLAST58
Domaini1265 – 1321TSP type-1 11PROSITE-ProRule annotationAdd BLAST57
Domaini1324 – 1378TSP type-1 12PROSITE-ProRule annotationAdd BLAST55
Domaini1382 – 1435TSP type-1 13PROSITE-ProRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi190 – 197Cysteine switchBy similarity8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004934_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5ECS8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQETEYH

Database of Orthologous Groups

More...
OrthoDBi
211122at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5ECS8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 12 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50092, TSP1, 12 hits
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G5ECS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPFYIVITF LLSTVFRISQ SVHHHLNEEE LKQVFGVSNK HDVPEYSLIE
60 70 80 90 100
ATRHPLKNGN LKMKFTAWND TYHLNLRKNS RIVSPHIISV VRHGDDDVTT
110 120 130 140 150
YAGLRDYEQC HYQGEVKSHG NMKAAISDCG ALMGSIVMED HFLVLQTLPK
160 170 180 190 200
RVHHLQKERH LVYKRSAGLL TNAESKIREE ITRLQEEQES FCDTSEQLDD
210 220 230 240 250
PAMTIPAHLH FNYTIPTSAQ LDSSFIFPNM DPITLEIGLF LDSKLFEHFE
260 270 280 290 300
REYIQDAEQH LLEFSLALIN NVHVLYQQDT LTPNLDIVIV RYEMWRTQPS
310 320 330 340 350
ALSTGVHKNG QAQSLLDAFC RYQAHMNPGT DLTDMNHYDH GVLLTGYDIY
360 370 380 390 400
HTTTSVAGVA PVARMCDPLF ACSLVEGLHL GRSFVLAHEM GHNMGMVHDG
410 420 430 440 450
VQNQCNKGCC LMSAVNGAGK TTWSDCSVRE FNAFLLQLDE SGRGNCLRDA
460 470 480 490 500
SPGLISTNHL SDLRLPGQRF TADQQCSYFW GRDYKVEIPN GKAMDDICRI
510 520 530 540 550
LWCGNSGSTI STAHPALEGS WCGANKWCHK GQCTHWTFGL TPVPIDGEWS
560 570 580 590 600
EWGGAEKGCP IQQCAVSGSI TVQGQHRDCV NPAPNNGGKT CEGANIRGIV
610 620 630 640 650
CGATSSNCLG FTREEFGNKI CSSIKYDPHK PDQQLTGEGF EHSTQPCRVW
660 670 680 690 700
CHLIGSELIR NKGQFPDGTP CGFDAYCVGG QCLALSCDNK ALVEQPEDCP
710 720 730 740 750
RIEGRSVHQW EEWSSWSECS VSCGLGGREV RERKCSSGRK CQGVSEESRP
760 770 780 790 800
CEGVLRDCEE FGEWKEWGSC SEKCALGVQK RFRPCLTDQC SSKHLQEERP
810 820 830 840 850
CDNEGCWTNW DEWSSCSQSC GGGRRYRIRK CLDDKCDGDD LEKESCNTQK
860 870 880 890 900
CISQSWGDWL PCSVSCGIGF QIRERLCDGE LCATANKQAR TCNQQQCPSA
910 920 930 940 950
FSLSVWSEWG EWTTCSATCG EGLQSRERSC RRGSCTEDDA SQTRRCVNGP
960 970 980 990 1000
CEHSYLTWSE WTTCETCSSF DSRKRIAKCD GTTENCQDKI DEETCDIACL
1010 1020 1030 1040 1050
REKHSFGPIS PRRPKLITSN DLRKAFGRPL LPIESIHSEK WSEWGPCSVT
1060 1070 1080 1090 1100
CGSGRRVRTR GCQEASCPEQ HIQTEECNLN SCLELFIWSD WSSCSKSCGQ
1110 1120 1130 1140 1150
DGIQTRQKLC LFNNAECSSY AESRRCKDLP SCSSISSGRT ISENGFDAPR
1160 1170 1180 1190 1200
WSEWSSWSAC SCFSLTSTRR RFCQVVDPTV QGFCAGAILE QIPCAPGSCS
1210 1220 1230 1240 1250
PSAGGWSLWS EWSSCSKDCG DTGHQIRNRM CSEPIPSNRG AYCSGYSFDQ
1260 1270 1280 1290 1300
RPCVMDNVCS DEKVDGGWTD WTAWSECTDY CRNGHRSRTR FCANPKPSQG
1310 1320 1330 1340 1350
GAQCTGSDFE LNPCFDPARC HLRDGGWSTW SDWTPCSASC GFGVQTRDRS
1360 1370 1380 1390 1400
CSSPEPKGGQ SCSGLAHQTS LCDLPACDHE SDGEWSAWNE WSGCMGNCGI
1410 1420 1430 1440 1450
GTRTRVRACV SPPVSDGGQP CFGRSSEITE CRQSPSTALC SSFITSSHLA
1460
DGYFIDTDQQ Q
Length:1,461
Mass (Da):162,616
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CFDC1C07C1F493A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q22580Q22580_CAEEL
Peptidase M12B domain-containing pr...
adt-1 C02B4.1, CELE_C02B4.1
1,458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB066246 mRNA Translation: BAC05514.1
BX284606 Genomic DNA Translation: CAA90293.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T18856

NCBI Reference Sequences

More...
RefSeqi
NP_510116.2, NM_077715.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C02B4.1.1; C02B4.1.1; WBGene00000082

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C02B4.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB066246 mRNA Translation: BAC05514.1
BX284606 Genomic DNA Translation: CAA90293.2
PIRiT18856
RefSeqiNP_510116.2, NM_077715.4

3D structure databases

SMRiG5ECS8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C02B4.1

Protein family/group databases

MEROPSiM12.302

Proteomic databases

EPDiG5ECS8
PaxDbiG5ECS8

Genome annotation databases

EnsemblMetazoaiC02B4.1.1; C02B4.1.1; WBGene00000082
GeneIDi181412
KEGGicel:CELE_C02B4.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181412
WormBaseiC02B4.1 ; CE31872 ; WBGene00000082 ; adt-1

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
HOGENOMiCLU_004934_0_0_1
InParanoidiG5ECS8
OMAiSQETEYH
OrthoDBi211122at2759
PhylomeDBiG5ECS8

Enzyme and pathway databases

ReactomeiR-CEL-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

Protein Ontology

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PROi
PR:G5ECS8

Gene expression databases

BgeeiWBGene00000082, Expressed in material anatomical entity and 4 other tissues

Family and domain databases

Gene3Di2.20.100.10, 12 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 12 hits
SMARTiView protein in SMART
SM00209, TSP1, 13 hits
SUPFAMiSSF82895, SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50092, TSP1, 12 hits
PS00142, ZINC_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADT1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ECS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: December 14, 2011
Last modified: April 7, 2021
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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