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Entry version 76 (18 Sep 2019)
Sequence version 1 (14 Dec 2011)
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Protein

DNA topoisomerase-like protein cin-4

Gene

cin-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution.1 Publication

Caution

Lacks the conserved ATP binding sites, the conserved active site tyrosine at position 404, the conserved isoleucine at position 455 important for DNA bending, and the conserved magnesium binding site at position 143, and therefore probably lacks topoisomerase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-4615885 SUMOylation of DNA replication proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase-like protein cin-4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cin-4Imported
ORF Names:ZK1127.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
ZK1127.7 ; CE42594 ; WBGene00022854 ; cin-4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown leads to impaired removal of the cohesin component scc-1 from kinetochores on mitotic metaphase chromosomes.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi304E → G in av59; no effect on viability observed at 15, 24 and 25 degrees Celsius. 1 Publication1
Mutagenesisi304E → G in mr127; temperature sensitive mutant. At the nonpermissive temperature, failure in proper hcp-3 localization on mitotic chromosomes indicating unresolved kinetochores, aberrant localization of the cohesin component scc-1 to mitotic chromosomes and centrosomes, defects in centromere resolution and in proper chromosome segregation during anaphase. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004427301 – 842DNA topoisomerase-like protein cin-4Add BLAST842

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5ECQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5ECQ8

PeptideAtlas

More...
PeptideAtlasi
G5ECQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00022854 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZK1127.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5ECQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUD5 Eukaryota
KOG0355 Eukaryota
COG0187 LUCA
COG0188 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5ECQ8

KEGG Orthology (KO)

More...
KOi
K03164

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPSGQFG

Database of Orthologous Groups

More...
OrthoDBi
117851at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5ECQ8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00187 TOP4c, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.268.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00521 DNA_topoisoIV, 1 hit
PF16898 TOPRIM_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56719 SSF56719, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00177 TOPOISOMERASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5ECQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEDRNVFT SIDKKGGGSK QMDDLNQKCP KRKTSKLKGI PKLEDANDAG
60 70 80 90 100
TKNSQQCTLI LTEGDSAKTL AVSGLSVVGR DKYGVFPFRR KLLNVCDLNV
110 120 130 140 150
NQIADSAEVN AIIKILGLQY TKKYETEDDF KTLRYGKLLI MANHDSDGSQ
160 170 180 190 200
FKGLLLNFFH RFWPALFKRD FVEDFITPIA KATEGKEEVS FYSLPEYSEW
210 220 230 240 250
RMNTDNWKSY TIKYYNGLGT LTSKEAKKCF SDMVRHRIRF KYNGADDDKA
260 270 280 290 300
VNMAFSKKKI EARTDYLMKL MQDKNQRKQQ GLAEECLYNK ETRFVTLKDF
310 320 330 340 350
FNYEIVCSWN LHSIPCLVDG LKPGQRKVLF ACFKRANKRE VKVAQLAGAV
360 370 380 390 400
AEISAYHHGE QSLMGTIVNL AQDYVGSHNI NLLLPIGQFG TRLQGGKDSA
410 420 430 440 450
SARSIFAQLS QVTRTLFPAH DDNVLRFLYE ENQRIEPEWY CPIIPMVLVN
460 470 480 490 500
GAQGTGTGWS TNIPNYNPRE LVKNIKRLIA GEPQKALAPW YKNFRGKIIQ
510 520 530 540 550
IDPSRFACYG EVSVLDDNTI EITELPIKQW TQDYKEKVLE GLMESSDKKS
560 570 580 590 600
PVIVDYKEYH TDTTVKFVVK LSPGKLRELE RGQDLHQVFK LQAVINTTCM
610 620 630 640 650
VLFDAAGWLR TYTSPEAITQ EFYDSRQEKY VQRKEYLLGV LQAQSKRLTN
660 670 680 690 700
QARFILATIN NKIVLENKKK TAIVDVLIKM KFDADPVKKW KEDQKLKELR
710 720 730 740 750
ESGEIELDED DLAAVAVEEG EDISSAAKAV ETKLSDYDYL VGLALIKLSE
760 770 780 790 800
EEKNKLIKES EEKMAEVRVL EKKTWQDLWI TDLDNFMSEL TSRRLARKLS
810 820 830 840
LRRTATRWYA MICQRRVTWS SMKESISIRT MTVWSVRMSS RS
Length:842
Mass (Da):96,658
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BE8B7EFE5125578
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU191083 mRNA Translation: ABW69249.1
BX284602 Genomic DNA Translation: CCD73727.1

NCBI Reference Sequences

More...
RefSeqi
NP_495440.4, NM_063039.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK1127.7.1; ZK1127.7.1; WBGene00022854

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
191525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK1127.7

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU191083 mRNA Translation: ABW69249.1
BX284602 Genomic DNA Translation: CCD73727.1
RefSeqiNP_495440.4, NM_063039.5

3D structure databases

SMRiG5ECQ8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.ZK1127.7

Proteomic databases

EPDiG5ECQ8
PaxDbiG5ECQ8
PeptideAtlasiG5ECQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1127.7.1; ZK1127.7.1; WBGene00022854
GeneIDi191525
KEGGicel:CELE_ZK1127.7

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
191525
WormBaseiZK1127.7 ; CE42594 ; WBGene00022854 ; cin-4

Phylogenomic databases

eggNOGiENOG410IUD5 Eukaryota
KOG0355 Eukaryota
COG0187 LUCA
COG0188 LUCA
GeneTreeiENSGT00940000168342
InParanoidiG5ECQ8
KOiK03164
OMAiEPSGQFG
OrthoDBi117851at2759
PhylomeDBiG5ECQ8

Enzyme and pathway databases

ReactomeiR-CEL-4615885 SUMOylation of DNA replication proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5ECQ8

Gene expression databases

BgeeiWBGene00022854 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd00187 TOP4c, 1 hit
Gene3Di1.10.268.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit
InterProiView protein in InterPro
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
PfamiView protein in Pfam
PF00521 DNA_topoisoIV, 1 hit
PF16898 TOPRIM_C, 1 hit
SMARTiView protein in SMART
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit
SUPFAMiSSF56719 SSF56719, 1 hit
PROSITEiView protein in PROSITE
PS00177 TOPOISOMERASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIN4_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ECQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2017
Last sequence update: December 14, 2011
Last modified: September 18, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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