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Entry version 77 (12 Aug 2020)
Sequence version 1 (14 Dec 2011)
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Protein

Synaptojanin

Gene

unc-26

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1660499, Synthesis of PIPs at the plasma membrane
R-CEL-1855183, Synthesis of IP2, IP, and Ins in the cytosol
R-CEL-1855204, Synthesis of IP3 and IP4 in the cytosol
R-CEL-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptojanin1 Publication (EC:3.1.3.36By similarity)
Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphataseBy similarity
Uncoordinated protein 26Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-26Imported
ORF Names:JC8.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
JC8.10a ; CE28239 ; WBGene00006763 ; unc-26
JC8.10b ; CE29050 ; WBGene00006763 ; unc-26
JC8.10c ; CE40972 ; WBGene00006763 ; unc-26
JC8.10d ; CE42707 ; WBGene00006763 ; unc-26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable but small with slow grow and uncoordinated movements (PubMed:10931870, PubMed:21029864). Synaptic vesicles at neuromuscular synapses are reduced, arranged linearly and are dissociated from the synaptic active zone (PubMed:10931870). Several defects in vesicle recycling including accumulation of endocytic pits at the neuromuscular junctions and accumulation of coated vesicles predominantly at synapses of neurons but also near the Golgi in cell bodies of neurons, muscles, hypodermis and gonadal sheath cells (PubMed:10931870). Accumulation of endosome-like compartments in cholinergic and GABA neurons and diffused snb-1/synaptobrevin distribution along the ventral nerve cord (PubMed:10931870). Neurotransmission defects characterized by reduced endogenous frequency of synaptic vesicle fusion, a reduced evoked current amplitude after one stimulation and a faster decline in evoked response caused by multiple responses (PubMed:14622579). Resistant to paralysis induced by Aldicar, an acetylcholinesterase inhibitor which causes acetylcholine accumulation (PubMed:14622579).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi378C → S: Normal synapse localization, locomotion and, endogenous and evoked excitatory postsynaptic currents; when associated with N-380. 1 Publication1
Mutagenesisi380D → N: Normal synapse localization, locomotion and, endogenous and evoked excitatory postsynaptic currents; when associated with S-378. 1 Publication1
Mutagenesisi722D → A: Probable loss of catalytic activity. Reduced locomotion and severe reduction in endogenous and evoked excitatory postsynaptic currents. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004382411 – 1119SynaptojaninCuratedAdd BLAST1119

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5ECL2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5ECL2

PeptideAtlas

More...
PeptideAtlasi
G5ECL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006763, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5ECL2, 11 interactors

STRING: functional protein association networks

More...
STRINGi
6239.JC8.10b

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 438SACPROSITE-ProRule annotationAdd BLAST320

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni532 – 826CatalyticSequence analysisAdd BLAST295

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1045 – 1116Pro-richPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Pro-rich domain is dispensable for endocytosis during the synaptic vesicle recycling, locomotion and for endogenous and evoked excitatory postsynaptic currents (EPSC) at neuromuscular junctions (PubMed:21029864, PubMed:25918845). May play a role together with the SAC domain in targeting unc-26 to synapses (PubMed:25918845).2 Publications
The SAC domain, but not is catalytic activity, is required for targeting unc-26 to synapses, for locomotion and for normal endogenous and evoked excitatory postsynaptic currents (EPSC) at neuromuscular junctions.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0566, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170400

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5ECL2

KEGG Orthology (KO)

More...
KOi
K20279

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVAIDCV

Database of Orthologous Groups

More...
OrthoDBi
359616at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5ECL2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015047, DUF1866
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR002013, SAC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08952, DUF1866, 1 hit
PF03372, Exo_endo_phos, 1 hit
PF02383, Syja_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01165, DUF1866, 1 hit
SM00128, IPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219, SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50275, SAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform bImported (identifier: G5ECL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVRGIRIWR RNDARFQPSI LVEKNGLDGS LLFQGGAIAT LDSDSTDVER
60 70 80 90 100
RSYQKIVDAY GILGVLAITK DEAVLVAVTG VLSVGQLYGA DILKITNVEF
110 120 130 140 150
ISLRTFGSVE NVDSRIIDLQ RLLSSQMFYF SSLQSYDLTR SAQHRDSHDC
160 170 180 190 200
SDARFFWNRS LHFSFQRYGI DTDNWLLKCM AGSVLVRVVY VGANTGRVAL
210 220 230 240 250
ISRLSCERVG TRFNVRGANY LGNVANFVET EQLLLFDEKE CSLLQIRGSI
260 270 280 290 300
PLFWEQPGVN VGSHKVKLRA FETSLPAYHR HLSQLQHRYG EFAIVNLLGR
310 320 330 340 350
KEGERVLGDA FKTQHKSSHF APLVDFIDFD YHAQMKISKE AIVQLKKKMS
360 370 380 390 400
PHMTKHGFFY SMGKEIVKRQ TGVIRTNCLD CLDRTNAVQT AIGLQMSHDQ
410 420 430 440 450
VAFLNLNAGK VNVEQRVEEI LRDLWQKNGD QCSTIYAGTG ALDGKSKLKD
460 470 480 490 500
ASRSLARTIQ NNLMDGAKQE SFDLFLTGAA YDPRLFDRAC NILPPSLIQE
510 520 530 540 550
SYYYHEYADA VSQLVERSPE IAEPQSIKIF VGTWNVNGGK NIHNVAFRNE
560 570 580 590 600
SSLSHWIFAN SMTRLVSVED EQLADIVAIG VEELVDLNAS NMVKASTTNQ
610 620 630 640 650
RMWCESIRKT LSEKAPFVLI GSEQLVGVCL FLFARPRVSP YLKDFAVASV
660 670 680 690 700
KTGMGGATGN KGSVAFRIVV FSTSICFICS HFAAGQNEIR DRNEDFATTL
710 720 730 740 750
KKIRFPLGRE IDSHDVIFWL GDFNYRINLS GDEVKNAVRN GDYAKLVEND
760 770 780 790 800
QLTQQKALGQ TFVGFNEGQL TFAPTYKYDT FSDDYDTSEK CRAPAWTDRI
810 820 830 840 850
LWKDQRKKGK TQLLSYDRSE LKTSDHRPVG AVFKVETFKV GGRKCVELIE
860 870 880 890 900
DVVESMGPPD GTIIVSIAGK PRFPPQMFPP IHEKLKELGA QVQLSKFDDG
910 920 930 940 950
DLWIVLNSGE MALAALSMDG LKIGGTDQIN VKLKSPDWAY ALKPHLSDFD
960 970 980 990 1000
LESFEVTAEE EALLGGTDGA VFEFADEDED AISVSSLTLT GSAPDRPRPP
1010 1020 1030 1040 1050
SARSEAISVA KLEWPTEQPN VLSTSMPTRA SSASLANSSW YEHVPPLAPP
1060 1070 1080 1090 1100
QSNNNKSPPQ ACLFNPFTQS APSPAPPPST IPLPPTRGAS VGPGPPAVPV
1110
RKAPPPPPRP VIPPRPKNM
Length:1,119
Mass (Da):124,209
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37004D0B646EF394
GO
Isoform aImported (identifier: G5ECL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     501-506: Missing.

Show »
Length:1,113
Mass (Da):123,366
Checksum:i917978E4A8C73587
GO
Isoform cImported (identifier: G5ECL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-502: ESY → GLF
     503-1119: Missing.

Show »
Length:502
Mass (Da):56,470
Checksum:i70501DDC47C581CF
GO
Isoform dImported (identifier: G5ECL2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-508: EYA → GKL
     509-1119: Missing.

Show »
Length:508
Mass (Da):57,293
Checksum:iB7FD10D25246C2D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058629500 – 502ESY → GLF in isoform c. Curated3
Alternative sequenceiVSP_058630501 – 506Missing in isoform a. Curated6
Alternative sequenceiVSP_058631503 – 1119Missing in isoform c. CuratedAdd BLAST617
Alternative sequenceiVSP_058632506 – 508EYA → GKL in isoform d. Curated3
Alternative sequenceiVSP_058633509 – 1119Missing in isoform d. CuratedAdd BLAST611

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF283322 mRNA Translation: AAG18574.1
AF283323 mRNA Translation: AAG18575.1
AF283324 mRNA Translation: AAG18576.1
BX284604 Genomic DNA Translation: CAB05234.2
BX284604 Genomic DNA Translation: CAC70096.1
BX284604 Genomic DNA Translation: CAQ58127.1
BX284604 Genomic DNA Translation: CAN86614.1

Protein sequence database of the Protein Information Resource

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PIRi
C88883

NCBI Reference Sequences

More...
RefSeqi
NP_001023265.1, NM_001028094.2 [G5ECL2-2]
NP_001023266.1, NM_001028095.3 [G5ECL2-1]
NP_001122785.1, NM_001129313.2 [G5ECL2-3]
NP_001129862.1, NM_001136390.2 [G5ECL2-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
JC8.10a.1; JC8.10a.1; WBGene00006763 [G5ECL2-2]
JC8.10b.1; JC8.10b.1; WBGene00006763 [G5ECL2-1]
JC8.10c.1; JC8.10c.1; WBGene00006763 [G5ECL2-3]
JC8.10c.2; JC8.10c.2; WBGene00006763 [G5ECL2-3]
JC8.10d.1; JC8.10d.1; WBGene00006763 [G5ECL2-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_JC8.10

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283322 mRNA Translation: AAG18574.1
AF283323 mRNA Translation: AAG18575.1
AF283324 mRNA Translation: AAG18576.1
BX284604 Genomic DNA Translation: CAB05234.2
BX284604 Genomic DNA Translation: CAC70096.1
BX284604 Genomic DNA Translation: CAQ58127.1
BX284604 Genomic DNA Translation: CAN86614.1
PIRiC88883
RefSeqiNP_001023265.1, NM_001028094.2 [G5ECL2-2]
NP_001023266.1, NM_001028095.3 [G5ECL2-1]
NP_001122785.1, NM_001129313.2 [G5ECL2-3]
NP_001129862.1, NM_001136390.2 [G5ECL2-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5ECL2, 11 interactors
STRINGi6239.JC8.10b

Proteomic databases

EPDiG5ECL2
PaxDbiG5ECL2
PeptideAtlasiG5ECL2

Genome annotation databases

EnsemblMetazoaiJC8.10a.1; JC8.10a.1; WBGene00006763 [G5ECL2-2]
JC8.10b.1; JC8.10b.1; WBGene00006763 [G5ECL2-1]
JC8.10c.1; JC8.10c.1; WBGene00006763 [G5ECL2-3]
JC8.10c.2; JC8.10c.2; WBGene00006763 [G5ECL2-3]
JC8.10d.1; JC8.10d.1; WBGene00006763 [G5ECL2-4]
GeneIDi178284
KEGGicel:CELE_JC8.10

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178284
WormBaseiJC8.10a ; CE28239 ; WBGene00006763 ; unc-26
JC8.10b ; CE29050 ; WBGene00006763 ; unc-26
JC8.10c ; CE40972 ; WBGene00006763 ; unc-26
JC8.10d ; CE42707 ; WBGene00006763 ; unc-26

Phylogenomic databases

eggNOGiKOG0566, Eukaryota
GeneTreeiENSGT00940000170400
InParanoidiG5ECL2
KOiK20279
OMAiDVAIDCV
OrthoDBi359616at2759
PhylomeDBiG5ECL2

Enzyme and pathway databases

ReactomeiR-CEL-1660499, Synthesis of PIPs at the plasma membrane
R-CEL-1855183, Synthesis of IP2, IP, and Ins in the cytosol
R-CEL-1855204, Synthesis of IP3 and IP4 in the cytosol
R-CEL-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5ECL2

Gene expression databases

BgeeiWBGene00006763, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

Gene3Di3.30.70.330, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR015047, DUF1866
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR002013, SAC_dom
PfamiView protein in Pfam
PF08952, DUF1866, 1 hit
PF03372, Exo_endo_phos, 1 hit
PF02383, Syja_N, 1 hit
SMARTiView protein in SMART
SM01165, DUF1866, 1 hit
SM00128, IPPc, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50275, SAC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYNJ_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ECL2
Secondary accession number(s): B3CJ53, G5EDR8, G5EEJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: December 14, 2011
Last modified: August 12, 2020
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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