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Entry version 72 (16 Oct 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

GAR domain-containing protein

Gene

vab-10

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GAR domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vab-10Imported
ORF Names:CELE_ZK1151.1Imported, ZK1151.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
ZK1151.1g ; CE36463 ; WBGene00006876 ; vab-10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
G5ECG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006876 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5ECG5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5ECG5, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5ECG5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 142Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini179 – 286Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini817 – 874SH3InterPro annotationAdd BLAST58
Domaini4184 – 4256GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4284 – 4410DisorderedSequence analysisAdd BLAST127

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili23 – 43Sequence analysisAdd BLAST21
Coiled coili782 – 802Sequence analysisAdd BLAST21
Coiled coili1029 – 1049Sequence analysisAdd BLAST21
Coiled coili1182 – 1202Sequence analysisAdd BLAST21
Coiled coili1406 – 1426Sequence analysisAdd BLAST21
Coiled coili1649 – 1669Sequence analysisAdd BLAST21
Coiled coili1705 – 1725Sequence analysisAdd BLAST21
Coiled coili1796 – 1816Sequence analysisAdd BLAST21
Coiled coili1850 – 1877Sequence analysisAdd BLAST28
Coiled coili1942 – 1962Sequence analysisAdd BLAST21
Coiled coili2094 – 2114Sequence analysisAdd BLAST21
Coiled coili2210 – 2237Sequence analysisAdd BLAST28
Coiled coili2415 – 2435Sequence analysisAdd BLAST21
Coiled coili2481 – 2504Sequence analysisAdd BLAST24
Coiled coili2804 – 2824Sequence analysisAdd BLAST21
Coiled coili2885 – 2905Sequence analysisAdd BLAST21
Coiled coili3000 – 3020Sequence analysisAdd BLAST21
Coiled coili3044 – 3064Sequence analysisAdd BLAST21
Coiled coili3072 – 3092Sequence analysisAdd BLAST21
Coiled coili3245 – 3265Sequence analysisAdd BLAST21
Coiled coili3686 – 3706Sequence analysisAdd BLAST21
Coiled coili3740 – 3760Sequence analysisAdd BLAST21
Coiled coili3903 – 3923Sequence analysisAdd BLAST21
Coiled coili3964 – 3998Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4351 – 4376PolarSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164812

Database of Orthologous Groups

More...
OrthoDBi
24858at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF02187 GAS2, 1 hit
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00243 GAS2, 1 hit
SM00150 SPEC, 24 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

G5ECG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGERYRSHH AVDPSDAQEK EVLDHYELNR EKYNDERDNV QKKTFTKWVN
60 70 80 90 100
KHLSKTDHKI DDLFVDLRDG YALIALLEAL TGERIQKENG YTRFHRIQNV
110 120 130 140 150
QYCLDFLKKK NIKLVNIRPE DIVEGNGKLT LGLIWTIILN FQVSVIRQRL
160 170 180 190 200
LLESSQHEQM SAKHTTTNSQ VSLHGSDATS ARDALLQWAR RVTAGYPRVN
210 220 230 240 250
VNNFSSSWRD GLAFNAILHR YRSSAIDWNK ISSDSVSNTE RLNNAFAAAD
260 270 280 290 300
REFGVERLLD AEDVDTNNPD EKSIITYVSS LYNALPHEPE MSRLQKVQEE
310 320 330 340 350
YIEEAYEWRE WVVRAIQLVD DRHLQGTASE LIYELQRFRE DDLPPREEQK
360 370 380 390 400
RRLTLVYEHL EKVMRSTELF AIPHELSAPE LQRVWNELQN SIDRRFDVLE
410 420 430 440 450
RHRIQEGNSN DLLSRLARGI GITNEKLDLI LKRIEDVEAR VDTSPPAAVE
460 470 480 490 500
RTVSEIVDDL NALESPIARF FEDVEELKSM QHPEANDFYK QVYGLHQRRT
510 520 530 540 550
TYLDRLTNQI LVRLGVRTDS LHKENQQRLE NMRKTSFSRV EECIEWVRVR
560 570 580 590 600
MEKLTTMEFL EDLETLEHVF EQHKFDNRDI QDFRQNVDEC IARQAEVSAE
610 620 630 640 650
DTYEYCELLR VLESEYQQLR DLSAGRMLDL DSLIAFVRAA QLELIWVSER
660 670 680 690 700
ESIEVTRNWS DIKQLDLPML TNYYKQLLHE MELREKQYND VHNQGAALLN
710 720 730 740 750
QGHPAIRVIE VYLRQMQSQW DWLLALSKCL EEHLRDALNL KSFMEEASDA
760 770 780 790 800
EAWIQEQSVR LENNYNRTDF SLEEGERFLR ELDEIKEILN KYHQVLMALT
810 820 830 840 850
ERCASISPLW QRGERIPHPI KVTALCDYSD ENVTIKAGDD VYLLDNSDLI
860 870 880 890 900
KWTIRDISGA EGQVPSVVFR IPPTDARLTA LLNRLLQQFE KLKKLWDKKH
910 920 930 940 950
RMVRFNMVLN TMRTIQGWDL DTFNSIDPDQ RDAIMKALND DANKLLSELD
960 970 980 990 1000
PNDPLALRLR EELRRTNEHF WNLLNASQKP PEPDWASQYD QKMAELLKKL
1010 1020 1030 1040 1050
EEAWRELNDA VGKPISRSPE DLERVIHAHK RFEDALQALD SDVANVKELF
1060 1070 1080 1090 1100
RQLPNPTPTQ RVNHDRLNGL WDDLWDLSRM YVERIKVLES VLNGMVEVAD
1110 1120 1130 1140 1150
IVRQHEITLN SFDDLPAALD KLRGHHSQLL EINMVLKVSK LGAQNEHFSQ
1160 1170 1180 1190 1200
QQTVIDQLNR NVALLRQHVS RTRINEGHHP DVDAIEDEVQ KLNVRWENVN
1210 1220 1230 1240 1250
SQIASRLLAV ESALQIQMVY RSEYETEMSW LDTVEETINR LRKPEELRPE
1260 1270 1280 1290 1300
QYQQQLDMLI AEYTNLQEHT QAIEHVNKEG GRFIHEAKIF DAKLGQYSDG
1310 1320 1330 1340 1350
IVGIHGPGIK SEFRRTKPQP KNGSQIVTEE LELLNRRFAQ LSSLILERRN
1360 1370 1380 1390 1400
TMQVLIQNWK RQKQENVTQV VSFREAEVSG MMTDLTRFRQ EIFTTHLTFN
1410 1420 1430 1440 1450
SNPESIDAAT KNVQNVKQSL DSWRDRIKER LDEIDRLCTE EGDSLTPEQY
1460 1470 1480 1490 1500
SALREMRRQL ADEYDTVLRT VEGIHTRLNI LSALLIEFSS VTSSMQSWMT
1510 1520 1530 1540 1550
DRTRLAGDIR HKSGDPMRID EARFEAKSLM DEVIREESRL KTIGASVLKI
1560 1570 1580 1590 1600
EQEISAMRDD VRASGSTDDV GISVDEVYET RRRVEDDYMQ LLRQCQDLIS
1610 1620 1630 1640 1650
FQNRLHAMND EHSEQARRAD EWLQMLQNDV EDVDQDPRFQ RDEDRIQRIE
1660 1670 1680 1690 1700
ELNRMAAGGS SQLDDAEQAS RRLLTALEGT NVANDVRARH EELANLRRGK
1710 1720 1730 1740 1750
HQKVIDRLSQ NMMEAASRKA EAEGVKQAVE NLRQWSEQTA QRTRQPVQLP
1760 1770 1780 1790 1800
LTELDLHEAR KDEQVLHGEI ENRLALIEEL EKKAADVGDH ASLAELQECK
1810 1820 1830 1840 1850
MKLKRSNSDL KGLRDNIFDA INGLQTVNSE GETLSRAVDS AGAKIRSARL
1860 1870 1880 1890 1900
PEAQSEVEAL QDQADNLERI TNNLCNIPNV TRTEPVIQKS KDLRKRVDSC
1910 1920 1930 1940 1950
AQELDARMGK LAELESLDAE FDGAKNKLSS FIGAFDDELK GLEKVSIDKE
1960 1970 1980 1990 2000
KLAEQRRQTQ DLVDKHSEGN AILDDVEAIA QKVTAEDPSK TGSAQKSVGE
2010 2020 2030 2040 2050
LGARLQRQAS ELKARGDKIN KLDSKATSFA ESEAAVLGYI EKQKDQLSTG
2060 2070 2080 2090 2100
FPVPATKEGV KSQLLDLERM NKTGKEEQRR VDDARHSARE LAREASVEKE
2110 2120 2130 2140 2150
VQDMNQREKK LLDEWEDLAD QFDASESQKA AGKINSLVAE IADLDPIGRS
2160 2170 2180 2190 2200
RDELQKQKKE VVELAGDLGS AQTKMLELGA EWEAALGAGI VAQPVFEMNR
2210 2220 2230 2240 2250
AATDELNKLA ARAGKRLAQR EKKITETEDE IDKLHADADQ IVGALEAIAK
2260 2270 2280 2290 2300
DEALQGAPSQ LLDPKQVSEK VRQLKESLKP VGEKMDAFNT DCKLLIKTAG
2310 2320 2330 2340 2350
PESDTKELDS LLKKVGDAYS DVVGKVSDKE MSVDAAVQQQ GKVEDAYRAL
2360 2370 2380 2390 2400
LNWLEETEEM MENRKKPSAD AKVAKAQLHD YEVLMKHVED KKPSVDGFKA
2410 2420 2430 2440 2450
MIEKIVAEAS SDEEKKALGN KNAQIEDRYK DLLNSAVDRQ RKLLDAVDLA
2460 2470 2480 2490 2500
ERLQEVTIPL DSWLQSADKR LQALAKVPIT VEKAEEMIGE QEALQDELEH
2510 2520 2530 2540 2550
KSDDLKDVLE IAPMLASLVS VEDANSISGQ VNQLEARARA LDAGITNMRP
2560 2570 2580 2590 2600
LLESFLQQIQ DFTLDAEDMT QFVGETEVKL GELDELPIEP DDLVEQTNIL
2610 2620 2630 2640 2650
AEIAVSIADR DEMMANIFEV GKQLAIQGEP EEALIAQKKL DDLKFRYADL
2660 2670 2680 2690 2700
MTSADEKIAL LAKAIPLSEG FHEGFDTVMQ VLEDMDRDLQ TIDEEDPETQ
2710 2720 2730 2740 2750
AELIFLLEED ISQKMRPSVD ELTALSNQLQ VLCSADKADE LQTNTIAMNK
2760 2770 2780 2790 2800
LVNSVADRVA RRAERIEMAS KQSRAVLDDL QYLIEWFSAA RERILEGAPP
2810 2820 2830 2840 2850
SLDLEVLKSQ LKHQRITNEE ASANKVQFRN VAGEAKKVAR QLGMEGNEAN
2860 2870 2880 2890 2900
EKISDTVDEG KELVEEVMAL CADRTETLER ALALMEQLTS QFDELNKWLD
2910 2920 2930 2940 2950
QMDAELQASP SVTTATPAAE LREMHDHNEE LARMVAAYRP IIEGFKSDVG
2960 2970 2980 2990 3000
SLHEVLAEDQ APLLESVAGE LVQGYEEVRE AVRARGHAID NMMGATIGFG
3010 3020 3030 3040 3050
ERLETLVANL QGAADRLREN EGISADPSVL ESRLAENRSI VESLRDKQNA
3060 3070 3080 3090 3100
YDALKQTASE LLASAPEGDA AAGDVENKLN RLEKLWKEIE REAVDRGVLL
3110 3120 3130 3140 3150
EDVLDKAKHF WSELDSCQKA VDDLRNRLEL VEPATGHPEQ LADQQEIMAQ
3160 3170 3180 3190 3200
VASEMERARP RIEALSIAGK QLADYVPDDE KAVIENQVAN VRGGFSTITG
3210 3220 3230 3240 3250
LFAEKKRDLI AAMEEAMTFH GDLQELLKWL DMAEQKLLKM SPVEHAKHMT
3260 3270 3280 3290 3300
EIEQLLKELH TFKDEVHERG VAKEQVVATA LQLAADAPPH LAATVRQPVA
3310 3320 3330 3340 3350
DLNTRWSRLN AALAEREHKL ENLMLQMGKL ASTIAQLTAW MDKTRATLKD
3360 3370 3380 3390 3400
IAPPKNAVNL RDIEIAQCKL VVLSNDIHAH QDSVNAVNRA AQKYIQTSGA
3410 3420 3430 3440 3450
LDAETSDSLK SMNLKWEDIQ KVLESLAFDM EVAKKEAENV GGEVEKWQRW
3460 3470 3480 3490 3500
LEETESALLS TKPTGGLPET AEFQLDEFKA LKLDVEHNAS PLEAHLHATE
3510 3520 3530 3540 3550
QHLKEEPQDA DTWLSKTHGA MKTKWNKVKE LLVDREKKLQ VAYEQAVALE
3560 3570 3580 3590 3600
SALNDMEDWI IAAERKLTDQ PSISRLPDVI EKQLAEHESW MEEVAGRKMA
3610 3620 3630 3640 3650
MTKHQASGVH MQYYCEKKDA IPIKNRLVSL KHRVEKISGR TAERAKQLAV
3660 3670 3680 3690 3700
TRDEVATWQD GLHDLEHFIS DVLVKIAPEP NTTSSLEKLK AKLEEVKEAQ
3710 3720 3730 3740 3750
RDVTAKQTLF DVTRKRGIGL AERATRSEYK QISMTNEKMS KKWAEMLKKL
3760 3770 3780 3790 3800
RDRLREAEQA VLEGGAFEES MNDLESWVDD ELERYQKAEH EPVFADIDGV
3810 3820 3830 3840 3850
RALVDEESRR SAERKTKENG VKTVVKKADA LMASGVDEKD SIAQAKERLV
3860 3870 3880 3890 3900
EKWNQVEEAA RHRGNSIKEA EQAAEEFDAK THALLDWLAV EEQKLKASGL
3910 3920 3930 3940 3950
DEVEGVKQEM DEAKGRYQEC LKKGEEILSK CQPAAEPILR NWMRVVEARW
3960 3970 3980 3990 4000
KEVSEKVDER EFTLLEQEQK AKEQNEQIEK LAKFAAQKRE ELNRMIEQPP
4010 4020 4030 4040 4050
AQDLDTMEQN ICDFANLDSE LREQQPEVDA ACKSAKKGAR NPAAEMLSTE
4060 4070 4080 4090 4100
WKKLWLDAMG LQSSLDNQKA LLEEMKRLEG WKWEDWKERY VEWNDHAKAR
4110 4120 4130 4140 4150
VNDLFRRIDR LHTGNVPRQV FIDGIIGSNY VPNSTIVYSK FPTSRLEMAK
4160 4170 4180 4190 4200
VADRFDKGDG MINAKEFINA LRFDASNRNA KPQTDTEKIT HEIELQKKTC
4210 4220 4230 4240 4250
SCCTPYQIEK ISENHYRFGD THIKRMVRIL RSTVMVRVGG GWESLDEFLH
4260 4270 4280 4290 4300
KHDPCRAKGR LNINMFPEAR PIHALDSMRS FTKNRHGKQL PTTGTPGPIM
4310 4320 4330 4340 4350
KIREKTDRSV PMSGGLGGTA GYTVTTDSHR HTDARPSRIP RAPSDMSAGR
4360 4370 4380 4390 4400
LSRVGSVSNS KNSIVDSSTP SRPESRASSD AGDRQTRIPS LRARKGQRYI
4410
PQGPSSSSSK
Length:4,410
Mass (Da):502,632
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i324C6B88A26C0BBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EDD3G5EDD3_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,955Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECG8G5ECG8_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,323Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5ECP9G5ECP9_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,424Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFK7G5EFK7_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,322Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFW2G5EFW2_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,405Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EEC4G5EEC4_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
3,436Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFM4G5EFM4_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,944Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFD1G5EFD1_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
1,497Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYP3A0A1N7SYP3_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
5,059Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYR7A0A1N7SYR7_CAEEL
GAR domain-containing protein
vab-10 CELE_ZK1151.1, ZK1151.1
4,819Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAH04743.1

NCBI Reference Sequences

More...
RefSeqi
NP_001021859.1, NM_001026688.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK1151.1g.1; ZK1151.1g.1; WBGene00006876

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173058

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAH04743.1
RefSeqiNP_001021859.1, NM_001026688.3

3D structure databases

SMRiG5ECG5
ModBaseiSearch...

Protein-protein interaction databases

IntActiG5ECG5, 3 interactors

Proteomic databases

PeptideAtlasiG5ECG5

Genome annotation databases

EnsemblMetazoaiZK1151.1g.1; ZK1151.1g.1; WBGene00006876
GeneIDi173058

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173058
WormBaseiZK1151.1g ; CE36463 ; WBGene00006876 ; vab-10

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000164812
OrthoDBi24858at2759

Gene expression databases

BgeeiWBGene00006876 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiG5ECG5 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF02187 GAS2, 1 hit
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00243 GAS2, 1 hit
SM00150 SPEC, 24 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5ECG5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ECG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 16, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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