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Entry version 60 (18 Sep 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Transcription factor fos-1

Gene

fos-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3' (PubMed:23437011).1 Publication
Isoform a: Plays a role the development of the reproductive system, controlling events including anchor cell (AC) fusion and invasion (PubMed:15960981, PubMed:17488621). Regulates downstream transcriptional targets, including zmp-1, cdh-3, him-4 and mig10b, to promote the removal of the gonadal basement membrane during AC invasion (PubMed:15960981, PubMed:24553288). Regulates aff-1 expression to promote AC fusion (PubMed:17488621). With jun-1 regulates egl-1 and lin-12 expression to allow uterine cell specification and development (PubMed:17942488).4 Publications
Isoform b: Required for ovulation (PubMed:19570917). Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917). Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 (PubMed:23437011).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-2871796 FCERI mediated MAPK activation
R-CEL-450341 Activation of the AP-1 family of transcription factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor fos-1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fos-1Imported
Synonyms:evl-5Imported
ORF Names:F29G9.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F29G9.4a ; CE27375 ; WBGene00001345 ; fos-1
F29G9.4b ; CE39151 ; WBGene00001345 ; fos-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Isoform a: Animals are sterile and display a protruding vulva phenotype (PubMed:17942488). Animals have uterine defects lacking both a uterine lumen and a utse-like process; subsequently fail to develop a differentiated uterus. Furthermore, uterine seam cell genes egl-13 and lin-11 are not expressed during late larval development (PubMed:17942488). At the L3 developmental stage, AC display either failed or delayed invasion leading to the defective removal of the gonadal basement-membrane (PubMed:15960981, PubMed:17488621). AC do not fuse (PubMed:17488621). AC specific expression of lin-3 is increased, but zmp-1, him-4 and aff-1 expression is undetectable and cdh-3 expression is reduced (PubMed:15960981, PubMed:17488621). RNAi-mediated knockdown of both isoforms results in sterility, a protruding vulva and exploded through the vulva phenotypes (PubMed:17942488, PubMed:19570917). Animals have an undifferentiated uterus and lack uterine egl-13 expression (PubMed:17942488). Animals also display an endomitotic oocytes phenotype, which is due to improper distal spermathecal valve dilation and reduced plc-1 expression in the spermatheca (PubMed:19570917). Animals have no mig-10b expression in AC (PubMed:24553288). RNAi-mediated knockdown of isoform b results in an everted/protruded vulval phenotype in adults (PubMed:23437011).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi440T → A: Decreased phosphorylation by kgb-1. Loss of phosphorylation by kgb-1; when associated with A-452 and A-454. 1 Publication1
Mutagenesisi452T → A: Loss of phosphorylation by kgb-1; when associated with A-440 and A-454. 1 Publication1
Mutagenesisi454T → A: Loss of phosphorylation by kgb-1; when associated with A-440 and A-452. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004328551 – 467Transcription factor fos-1CuratedAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei440Phosphothreonine1 Publication1
Modified residuei452Phosphothreonine1 Publication1
Modified residuei454Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated by kgb-1. Phosphorylation at Thr-440 increases sensitivity to heavy metal stress. Phosphorylation inhibits homodimer formation, and promotes association with target promoters.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5ECG2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G5ECG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in anchor cells (PubMed:15960981). Isoform a is expressed in somatic gonad cells that neighbor anchor cells (PubMed:15960981, PubMed:19570917). Isoform b is expressed in vulval cells, the uterine cells that neighbor anchor cells and the spermatheca (PubMed:15960981, PubMed:19570917).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform a: Detected before the L2 molt stage (PubMed:15960981). Expressed throughout ventral uterine intermediate precursor cells (PubMed:17942488).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001345 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:23437011). Heterodimer; with jun-1 (PubMed:17942488).

Interacts with kgb-1 and hda-1 (PubMed:23437011).

1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5ECG2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F29G9.4b

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 226bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni165 – 205Basic motifPROSITE-ProRule annotationAdd BLAST41
Regioni212 – 219Leucine-zipperPROSITE-ProRule annotation8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1414 Eukaryota
ENOG4111CH5 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5ECG2

KEGG Orthology (KO)

More...
KOi
K09031

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSPMVQY

Database of Orthologous Groups

More...
OrthoDBi
1737689at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000837 AP-1
IPR004827 bZIP

The PANTHER Classification System

More...
PANTHERi
PTHR23351 PTHR23351, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00170 bZIP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.1 Publication
Isoform bImported (identifier: G5ECG2-1) [UniParc]FASTAAdd to basket
Also known as: a1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFEQPSSTTN TTTSSGSGSD SNHYFELGPR NPINQAHPTS VIVPPRQHHH
60 70 80 90 100
QIHQQQTDNS PLTPCTPYYP SNAYGLPLFF GTDFLQFQPS DIPSPLTPNI
110 120 130 140 150
SSPLTPHPFG PIPAIPTNQI YNRTFTDFYS TAASSPMVQY STVKKSSAGR
160 170 180 190 200
KPKEEDNMED DDDDKRLKRR QRNKEAAARC RQRRIDLMKE LQDQVNDFKN
210 220 230 240 250
SNDKKMAECN NIRNKLNSLK NYLETHDCKL SREERTHEIN RLIIPPSTVP
260 270 280 290 300
PSQPYLQHSL RVHPPRADSV PYSIRSGHSS SSSEQHSPVE DYKPSIDQLL
310 320 330 340 350
LPPISCIQNI KDRNINSMPP PALPASTSAA GIHVITSIPV SHANSLHGRS
360 370 380 390 400
ENVFAEPERK IPKIELDQTL TSLTMPDDVE RPSALPTLSR IVENQPITTP
410 420 430 440 450
SRPFRLGGEY QNQTPQSTGN GLFGGPPGPF DLLSSNTGLT PSGQPTMNFV
460
STPTPIQPHP DADLRPL
Length:467
Mass (Da):51,899
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3127084AD2284E1F
GO
Isoform aImported (identifier: G5ECG2-2) [UniParc]FASTAAdd to basket
Also known as: b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Show »
Length:331
Mass (Da):36,963
Checksum:i6645293F87445683
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0576141 – 136Missing in isoform a. Add BLAST136

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY835432 mRNA Translation: AAX37359.1
AY835433 mRNA Translation: AAX37360.1
FO080494 Genomic DNA Translation: CCD64133.1
FO080494 Genomic DNA Translation: CCD64134.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T31799

NCBI Reference Sequences

More...
RefSeqi
NP_001033480.1, NM_001038391.3 [G5ECG2-2]
NP_001033481.1, NM_001038392.3 [G5ECG2-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F29G9.4a.1; F29G9.4a.1; WBGene00001345 [G5ECG2-2]
F29G9.4b.1; F29G9.4b.1; WBGene00001345 [G5ECG2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F29G9.4

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY835432 mRNA Translation: AAX37359.1
AY835433 mRNA Translation: AAX37360.1
FO080494 Genomic DNA Translation: CCD64133.1
FO080494 Genomic DNA Translation: CCD64134.1
PIRiT31799
RefSeqiNP_001033480.1, NM_001038391.3 [G5ECG2-2]
NP_001033481.1, NM_001038392.3 [G5ECG2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5ECG2, 3 interactors
STRINGi6239.F29G9.4b

PTM databases

iPTMnetiG5ECG2

Proteomic databases

PaxDbiG5ECG2

Genome annotation databases

EnsemblMetazoaiF29G9.4a.1; F29G9.4a.1; WBGene00001345 [G5ECG2-2]
F29G9.4b.1; F29G9.4b.1; WBGene00001345 [G5ECG2-1]
GeneIDi178987
KEGGicel:CELE_F29G9.4

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178987
WormBaseiF29G9.4a ; CE27375 ; WBGene00001345 ; fos-1
F29G9.4b ; CE39151 ; WBGene00001345 ; fos-1

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
InParanoidiG5ECG2
KOiK09031
OMAiSSPMVQY
OrthoDBi1737689at2759

Enzyme and pathway databases

ReactomeiR-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-2871796 FCERI mediated MAPK activation
R-CEL-450341 Activation of the AP-1 family of transcription factors

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5ECG2

Gene expression databases

BgeeiWBGene00001345 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOS1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ECG2
Secondary accession number(s): G5EDK8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: December 14, 2011
Last modified: September 18, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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