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Protein
Submitted name:

Rap guanine nucleotide exchange factor

Gene

pxf-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • Rap guanyl-nucleotide exchange factor activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factorImported
Gene namesi
Name:pxf-1Imported
ORF Names:CELE_T14G10.2Imported, T14G10.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT14G10.2f ; CE46548 ; WBGene00004254 ; pxf-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiWBGene00004254 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliG5ECE2
SMRiG5ECE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 289Cyclic nucleotide-bindingInterPro annotationAdd BLAST66
Domaini355 – 469N-terminal Ras-GEFInterPro annotationAdd BLAST115
Domaini474 – 544PDZInterPro annotationAdd BLAST71
Domaini659 – 746Ras-associatingInterPro annotationAdd BLAST88
Domaini771 – 1001Ras-GEFInterPro annotationAdd BLAST231

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili760 – 780Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00880000137870

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 3 hits
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

G5ECE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVIDYPTEP QSNGMSPRTP PRGIHHSGEP VHQKTPRKSA PNMSVDSIAM
60 70 80 90 100
PPPPVPPRPL RLPQTAAKGP APLPPRGLPR TYPLDFPVDI PTTSSSSSNT
110 120 130 140 150
SYNDQHRSQV YLNGLSADED TLVRVKHRRE KSNSVGGQAQ NGISTARRLR
160 170 180 190 200
GRSTASSTTT EGETASNEGA DSDEDEGSMP SQESSSGGFM DLRDSVRECL
210 220 230 240 250
EKEPSERNSE DLAVLLDFMQ HMSAFAALPM SIKRQLCLKM VFAVVNDAGT
260 270 280 290 300
VVLAHNEKLD SWSVIVNGCV EVVKPSGERV EYKLGDSFGA EPTPATQIHI
310 320 330 340 350
GEMRTMVDDC EFVLVEHRDF CSIMSTIGDH IEKDRDGLTG EVVSEVERRT
360 370 380 390 400
VGTHCGQVLI KGKPDKLIHH LVDERDHNVD PHYVDDFLLT YRVFIRDPTT
410 420 430 440 450
IFEKLMLWFA DSIYRDKVAR LVLLWVNNHF NDFETNDEMW NLLERFEGAL
460 470 480 490 500
ERDGMHSQLS LLNIACSVKA KPRQVILTRR KDDKMMMRLV GGQESGNSVY
510 520 530 540 550
VAEVFPDTSA AREGVKRADE MLEVNQQSAK YLSAKKAEDL LTGSLSLTLM
560 570 580 590 600
LKNNVLGYKE TIGKIEHNKP KNGTSRSGAG IPMVIPVHKT SITGKKSSTT
610 620 630 640 650
SSKSGMMEKL MTILKSSKED SMDFTDEAKI SSADLRPSRS NPDITSISQY
660 670 680 690 700
YGPVRSECPE HVLKIYRNDQ TFKYLPVYKE TSAQNVVQLA LQEFNMTAEG
710 720 730 740 750
SPEWSLCECT VTIDGVIKQR RLPPQMENLA ERIALNSRYY LKNNSRSEPL
760 770 780 790 800
VPDELAPELL KEAQTQLLSL NAQVVAAQLT LQDFSVFSAI EPTEFLDNLF
810 820 830 840 850
KLDSKYGSPK LEEFEQLFNR EMWWVATEIC TERHVQKRAK LIKKFIKVAR
860 870 880 890 900
YCRDLRNFNS MFAIMSGLDK PAVRRLHSSW ERVSSKYIRM LDEIHQLVDP
910 920 930 940 950
SRNMSKYRQH LAEVAQEPPV VPIYPVIKKD LTFAHDGNAT YSEKLINFEK
960 970 980 990 1000
LRLIAKSIRG VMKLSSAPYE IASMAERSGG VVMDALLHMN SFENSNVATM
1010 1020 1030 1040 1050
RKGMSGKQNQ PRKKVYEQAL MVRKVKSYLE GLHVVDNEME LDSMSYDIEP
1060 1070 1080 1090 1100
QVQTAHRGAN SSSTANIRRV PSPTPSSLSS QSAGSADQSS RHRLLFNGTG
1110 1120 1130 1140 1150
SISSAGGGSK FGVESPQAVQ KMLSLVQNSK VKGAPPQITS PSTSARSSLQ
1160 1170 1180
RNMPRVTGRQ ATSSAQGPVQ LNEETSTVTT YYQSDVLI
Length:1,188
Mass (Da):132,464
Last modified:December 14, 2011 - v1
Checksum:i2F003803D3A19664
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EDB9RPGF_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 ra-gef, T14G10.2
1,470Annotation score:
G5ECB8G5ECB8_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,146Annotation score:
G5EEE0G5EEE0_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,305Annotation score:
F5GUA2F5GUA2_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
85Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD31119.1
RefSeqiNP_001255468.1, NM_001268539.1
UniGeneiCel.18293

Genome annotation databases

EnsemblMetazoaiT14G10.2f; T14G10.2f; WBGene00004254
GeneIDi177894

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD31119.1
RefSeqiNP_001255468.1, NM_001268539.1
UniGeneiCel.18293

3D structure databases

ProteinModelPortaliG5ECE2
SMRiG5ECE2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT14G10.2f; T14G10.2f; WBGene00004254
GeneIDi177894

Organism-specific databases

CTDi177894
WormBaseiT14G10.2f ; CE46548 ; WBGene00004254 ; pxf-1

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00880000137870

Gene expression databases

BgeeiWBGene00004254 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 3 hits
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5ECE2_CAEEL
AccessioniPrimary (citable) accession number: G5ECE2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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