Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Rap guanine nucleotide exchange factor

Gene

pxf-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • Rap guanyl-nucleotide exchange factor activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factorImported
Gene namesi
Name:pxf-1Imported
ORF Names:CELE_T14G10.2Imported, T14G10.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT14G10.2g ; CE46409 ; WBGene00004254 ; pxf-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiG5ECB8
PeptideAtlasiG5ECB8

Expressioni

Gene expression databases

BgeeiWBGene00004254 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliG5ECB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 247Cyclic nucleotide-bindingInterPro annotationAdd BLAST66
Domaini313 – 427N-terminal Ras-GEFInterPro annotationAdd BLAST115
Domaini432 – 502PDZInterPro annotationAdd BLAST71
Domaini617 – 704Ras-associatingInterPro annotationAdd BLAST88
Domaini729 – 959Ras-GEFInterPro annotationAdd BLAST231

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili718 – 738Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00880000137870

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 3 hits
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

G5ECB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVDSIAMPP PPVPPRPLRL PQTAAKGPAP LPPRGLPRTY PLDFPVDIPT
60 70 80 90 100
TSSSSSNTSY NDQHRSQVYL NGLSADEDTL VRVKHRREKS NSVGGQAQNG
110 120 130 140 150
ISTARRLRGR STASSTTTEG ETASNEGADS DEDEGSMPSQ ESSSGGFMDL
160 170 180 190 200
RDSVRECLEK EPSERNSEDL AVLLDFMQHM SAFAALPMSI KRQLCLKMVF
210 220 230 240 250
AVVNDAGTVV LAHNEKLDSW SVIVNGCVEV VKPSGERVEY KLGDSFGAEP
260 270 280 290 300
TPATQIHIGE MRTMVDDCEF VLVEHRDFCS IMSTIGDHIE KDRDGLTGEV
310 320 330 340 350
VSEVERRTVG THCGQVLIKG KPDKLIHHLV DERDHNVDPH YVDDFLLTYR
360 370 380 390 400
VFIRDPTTIF EKLMLWFADS IYRDKVARLV LLWVNNHFND FETNDEMWNL
410 420 430 440 450
LERFEGALER DGMHSQLSLL NIACSVKAKP RQVILTRRKD DKMMMRLVGG
460 470 480 490 500
QESGNSVYVA EVFPDTSAAR EGVKRADEML EVNQQSAKYL SAKKAEDLLT
510 520 530 540 550
GSLSLTLMLK NNVLGYKETI GKIEHNKPKN GTSRSGAGIP MVIPVHKTSI
560 570 580 590 600
TGKKSSTTSS KSGMMEKLMT ILKSSKEDSM DFTDEAKISS ADLRPSRSNP
610 620 630 640 650
DITSISQYYG PVRSECPEHV LKIYRNDQTF KYLPVYKETS AQNVVQLALQ
660 670 680 690 700
EFNMTAEGSP EWSLCECTVT IDGVIKQRRL PPQMENLAER IALNSRYYLK
710 720 730 740 750
NNSRSEPLVP DELAPELLKE AQTQLLSLNA QVVAAQLTLQ DFSVFSAIEP
760 770 780 790 800
TEFLDNLFKL DSKYGSPKLE EFEQLFNREM WWVATEICTE RHVQKRAKLI
810 820 830 840 850
KKFIKVARYC RDLRNFNSMF AIMSGLDKPA VRRLHSSWER VSSKYIRMLD
860 870 880 890 900
EIHQLVDPSR NMSKYRQHLA EVAQEPPVVP IYPVIKKDLT FAHDGNATYS
910 920 930 940 950
EKLINFEKLR LIAKSIRGVM KLSSAPYEIA SMAERSGGVV MDALLHMNSF
960 970 980 990 1000
ENSNVATMRK GMSGKQNQPR KKVYEQALMV RKVKSYLEGL HVVDNEMELD
1010 1020 1030 1040 1050
SMSYDIEPQV QTAHRGANSS STANIRRVPS PTPSSLSSQS AGSADQSSRH
1060 1070 1080 1090 1100
RLLFNGTGSI SSAGGGSKFG VESPQAVQKM LSLVQNSKVK GAPPQITSPS
1110 1120 1130 1140
TSARSSLQRN MPRVTGRQAT SSAQGPVQLN EETSTVTTYY QSDVLI
Length:1,146
Mass (Da):127,836
Last modified:December 14, 2011 - v1
Checksum:i2BD28CEF1C6BE838
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EDB9RPGF_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 ra-gef, T14G10.2
1,470Annotation score:
G5ECE2G5ECE2_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,188Annotation score:
G5EEE0G5EEE0_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
1,305Annotation score:
F5GUA2F5GUA2_CAEEL
Rap guanine nucleotide exchange fac...
pxf-1 CELE_T14G10.2, T14G10.2
85Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD31120.1
RefSeqiNP_001255469.1, NM_001268540.1
UniGeneiCel.18293

Genome annotation databases

EnsemblMetazoaiT14G10.2g; T14G10.2g; WBGene00004254
GeneIDi177894

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD31120.1
RefSeqiNP_001255469.1, NM_001268540.1
UniGeneiCel.18293

3D structure databases

ProteinModelPortaliG5ECB8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiG5ECB8
PeptideAtlasiG5ECB8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT14G10.2g; T14G10.2g; WBGene00004254
GeneIDi177894

Organism-specific databases

CTDi177894
WormBaseiT14G10.2g ; CE46409 ; WBGene00004254 ; pxf-1

Phylogenomic databases

eggNOGiKOG3542 Eukaryota
ENOG410XS6B LUCA
GeneTreeiENSGT00880000137870

Gene expression databases

BgeeiWBGene00004254 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR014710 RmlC-like_jellyroll
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 3 hits
SSF50156 SSF50156, 1 hit
SSF51206 SSF51206, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5ECB8_CAEEL
AccessioniPrimary (citable) accession number: G5ECB8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again