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Entry version 86 (29 Sep 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Gamma-aminobutyric acid type B receptor subunit 2

Gene

gbb-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity).

Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity).

Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity).

Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity).

Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity).

Along with gbb-1, may couple to the G(o) alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679).

As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior (PubMed:18614679).

Regulates locomotory behavior in response to GABA release by GABAergic motor neurons (PubMed:18614679, PubMed:21613582).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled GABA receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1296041, Activation of G protein gated Potassium channels
R-CEL-418594, G alpha (i) signalling events
R-CEL-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)
R-CEL-977444, GABA B receptor activation
R-CEL-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gbb-21 PublicationImported
ORF Names:ZK180.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
ZK180.1 ; CE43384 ; WBGene00022675 ; gbb-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 438ExtracellularCuratedAdd BLAST421
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei439 – 459Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini460 – 477CytoplasmicCuratedAdd BLAST18
Transmembranei478 – 498Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini499 – 506ExtracellularCurated8
Transmembranei507 – 527Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini528 – 556CytoplasmicCuratedAdd BLAST29
Transmembranei557 – 577Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini578 – 610ExtracellularCuratedAdd BLAST33
Transmembranei611 – 631Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini632 – 647CytoplasmicCuratedAdd BLAST16
Transmembranei648 – 668Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini669 – 676ExtracellularCurated8
Transmembranei677 – 697Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini698 – 842CytoplasmicCuratedAdd BLAST145

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Increased locomotion and body curvature (deeper bends) in response to induced GABA release of GABAergic motor neurons, which in wild-type animals results in acute body relaxation (PubMed:21613582). Double knockout with gbb-1 also results in increased sensitivity to Aldicarb and accelerated paralysis, but in addition results in irregular locomotory behavior characterized by increased speed of locomotion, decreased turning frequency, reduced rate of reversals, and an increased maximal distance covered in a 40 second interval (PubMed:18614679). Double knockout with the muscarinic acetylcholine receptor gar-2 results in a slight increase in sensitivity to Aldicarb and accelerated paralysis 50 minutes following exposure to Aldicarb as compared to the gar-2 and gbb-2 single mutants (PubMed:18614679). Double knockout with the GABA(A) receptor unc-49 results in body elongation defects in response to induced GABA release of GABAergic motor neurons (PubMed:21613582).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi484A → V: No change in protein function; when associated with A-572. 1 Publication1
Mutagenesisi572V → A: No change in protein function; when associated with V-484. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501067439818 – 842Gamma-aminobutyric acid type B receptor subunit 2CuratedAdd BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi274N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi279N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi327N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi366N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi605N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5ECB2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5ECB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cholinergic motor neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00022675, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a heterodimer with gbb-1.

1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1158, GABA-B receptor complex

STRING: functional protein association networks

More...
STRINGi
6239.ZK180.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni725 – 744DisorderedSequence analysisAdd BLAST20
Regioni791 – 842DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi725 – 739Polar residuesSequence analysisAdd BLAST15
Compositional biasi791 – 823Polar residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alpha-helical parts of the C-terminal intracellular region may mediate heterodimeric interaction with gbb-1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1055, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171994

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005240_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5ECB2

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQNMYHN

Database of Orthologous Groups

More...
OrthoDBi
590810at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5ECB2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR002455, GPCR3_GABA-B
IPR000337, GPCR_3
IPR017978, GPCR_3_C
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...
PANTHERi
PTHR10519, PTHR10519, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00248, GPCRMGR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00196, COPPER_BLUE, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

G5ECB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRWLSLLLF AVQAVGGYEA GEELSCKRRH GGIPLPLGVF TVQKEGFPDA
60 70 80 90 100
LPAIRTALSH VHSRSCILQG YRLEMIVKDT HCKTSQGMKA LFDLIASRPR
110 120 130 140 150
PVAILGGQCT EVNEPIAMAL KYWQIVQLSY AETHAKFASS DSHELFTTFF
160 170 180 190 200
RVVPGSRNTN MAKCKFVNHF GWKRVGTVKQ NDQPRYALPH EALTTRLEHG
210 220 230 240 250
FGVKIVHTAG VNWEQIETVG GELDELKERD VRIILVDVDE EMAATVLCAG
260 270 280 290 300
YHRGMYGDNY VWILPGYHSD KWLNQTHDNC TVEEMREAAK NHFSVEFALT
310 320 330 340 350
RRDVDTKIVG NTRAGDVWNE ITQLDPNNTW RGYLYDGLWT LAIALSHSMG
360 370 380 390 400
DNAEFSHHKM MEAIDNSSFQ GLTGKVKFAN NERLGLVDIK QWSDGQYVPF
410 420 430 440 450
AVYDGADDEF KIIDSTTKGW SPPLDSTITE RRREHISSIL FLAMSLLALI
460 470 480 490 500
GIFLALIFLL INFRYRNHRF IKMSSPNLNN IIIAGSICTF ASVIMLGLDT
510 520 530 540 550
RIVSPDVFVW LCYTKTWTLC IGFTLSFGAM FSKTWRVHSI FTNIRMDRKA
560 570 580 590 600
IKDSKLFIIL GILLFIDICV LVTWAFVSPF SYTVTELPHI PEDNIVIIPE
610 620 630 640 650
VEKCNSSHSG VFQAVLYAVK GVLMILGCFL AWETRHVNVP ALNDSKYIGT
660 670 680 690 700
SVYCCVVMSV LGLSTSVILQ ERVNEMFSLA SFFVIFSTTL TLCLVFVPKV
710 720 730 740 750
IELARNPVGN EPRAYRRGLM KSVVAKTSQP MSPQPRSDSS GDLIGKAESE
760 770 780 790 800
NKLRRRYLHQ KSTQLWDLVE KLRAQGDTRF LQQEWCLSSA SPSSQERETS
810 820 830 840
LLLRQPSSSN NREETSLTAA GPNGERSSDW PWVDPDEPST KL
Length:842
Mass (Da):94,861
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AE45E919FED1B39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU729335 mRNA Translation: ACE63491.1
BX284604 Genomic DNA Translation: CCD73081.1

NCBI Reference Sequences

More...
RefSeqi
NP_500579.3, NM_068178.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK180.1.1; ZK180.1.1; WBGene00022675

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
191240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK180.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU729335 mRNA Translation: ACE63491.1
BX284604 Genomic DNA Translation: CCD73081.1
RefSeqiNP_500579.3, NM_068178.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-1158, GABA-B receptor complex
STRINGi6239.ZK180.1

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Proteomic databases

EPDiG5ECB2
PaxDbiG5ECB2

Genome annotation databases

EnsemblMetazoaiZK180.1.1; ZK180.1.1; WBGene00022675
GeneIDi191240
KEGGicel:CELE_ZK180.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
191240
WormBaseiZK180.1 ; CE43384 ; WBGene00022675 ; gbb-2

Phylogenomic databases

eggNOGiKOG1055, Eukaryota
GeneTreeiENSGT00940000171994
HOGENOMiCLU_005240_1_1_1
InParanoidiG5ECB2
OMAiRQNMYHN
OrthoDBi590810at2759
PhylomeDBiG5ECB2

Enzyme and pathway databases

ReactomeiR-CEL-1296041, Activation of G protein gated Potassium channels
R-CEL-418594, G alpha (i) signalling events
R-CEL-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)
R-CEL-977444, GABA B receptor activation
R-CEL-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5ECB2

Gene expression databases

BgeeiWBGene00022675, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR002455, GPCR3_GABA-B
IPR000337, GPCR_3
IPR017978, GPCR_3_C
IPR028082, Peripla_BP_I
PANTHERiPTHR10519, PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PRINTSiPR00248, GPCRMGR
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00196, COPPER_BLUE, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGABR2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5ECB2
Secondary accession number(s): B7WN65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2017
Last sequence update: December 14, 2011
Last modified: September 29, 2021
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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