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Entry version 80 (07 Apr 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Sorbin and SH3 domain-containing protein 1 homolog

Gene

sorb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for organization of sarcomeres in body wall muscles and for maintaining normal mitochondrial position in myocytes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • maintenance of mitochondrion location Source: UniProtKB
  • sarcomere organization Source: UniProtKB

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-182971, EGFR downregulation
R-CEL-432720, Lysosome Vesicle Biogenesis
R-CEL-432722, Golgi Associated Vesicle Biogenesis
R-CEL-437239, Recycling pathway of L1
R-CEL-6807004, Negative regulation of MET activity
R-CEL-8856825, Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
G5EC32

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorbin and SH3 domain-containing protein 1 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sorb-11 PublicationImported
ORF Names:Y45F10D.13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y45F10D.13a ; CE44448 ; WBGene00012891 ; sorb-1
Y45F10D.13c ; CE39436 ; WBGene00012891 ; sorb-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in no defects in brood size or locomotion compared to wild-type (PubMed:28978740). No defects in cytoneme length of distal tip cells (PubMed:28978740).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi461 – 1005Missing in gk769190; defects in sarcomere and mitochondrial organization. No motility defects. 1 PublicationAdd BLAST545

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004476681 – 1005Sorbin and SH3 domain-containing protein 1 homologAdd BLAST1005

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EC32

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EC32

PeptideAtlas

More...
PeptideAtlasi
G5EC32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body wall muscles, muscle arm attachment sites at the nerve ring, all non-striated muscles, and distal tip cells of the gonad (PubMed:28978740). Highly expressed in the origins and insertions of the vulval and anal depressor muscles and the spicule-associated and diagonal muscles of the male tail (PubMed:28978740). Expressed in small puncta throughout the uterus, stomatointestinal muscle and proximal gonadal sheath tissues (PubMed:28978740). Not expressed in the pharynx (PubMed:28978740).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from embryos to adults (PubMed:28978740). First expressed at the twofold stage of embryonic elongation (PubMed:28978740). Localizes to distal tip cells of the gonad from the late L4 stage to adulthood (PubMed:28978740).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00012891, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5EC32, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with deb-1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
G5EC32
With#Exp.IntAct
athp-1 [Q18605]4EBI-325337,EBI-331810
B0507.3 [B1Q247]6EBI-325337,EBI-2316099
C06A5.8 [O01481]8EBI-325337,EBI-2316191
C09G1.4 [Q17865]5EBI-325337,EBI-317562
ceh-17 [G5EC89]4EBI-325337,EBI-2316478
CELE_C06G3.6 [Q17746]7EBI-325337,EBI-313792
CELE_C17E4.10 [Q93231]5EBI-325337,EBI-326358
CELE_F41B4.1 [Q966J6]7EBI-325337,EBI-327612
CELE_F45B8.3 [O45522]3EBI-325337,EBI-326566
CELE_F52E10.4 [Q20670]4EBI-325337,EBI-2316655
CELE_T11B7.1 [Q22387]3EBI-325337,EBI-320525
cyk-1 [Q7JP75]6EBI-325337,EBI-2003118
ddl-2 [O18195]6EBI-325337,EBI-313368
eps-8 [G5ED33]15EBI-325337,EBI-2315916
exc-6 [Q9TYU9]4EBI-325337,EBI-2317613
F43B10.1 [Q17744]6EBI-325337,EBI-2315966
figl-1 [O16299]8EBI-325337,EBI-320880
grd-7 [Q3Y407]4EBI-325337,EBI-2317687
K10H10.4 [O45681]6EBI-325337,EBI-2316236
klp-3 [P45962]3EBI-325337,EBI-311892
lin-10 [O17583]6EBI-325337,EBI-313389
M57.1 [Q9TYX9]10EBI-325337,EBI-2315745
mab-10 [Q22002]4EBI-325337,EBI-2316177
mig-10 [P34400]7EBI-325337,EBI-2315872
nhl-1 [Q03601]7EBI-325337,EBI-314158
pat-12 [Q95QA6]13EBI-325337,EBI-327642
phm-2 [O62203]7EBI-325337,EBI-320780
sap-49 [Q09442]16EBI-325337,EBI-2316106
sas-5 [Q20010]3EBI-325337,EBI-327608
sli-1 [Q19019]6EBI-325337,EBI-315356
snn-1 [Q8MXU3]3EBI-325337,EBI-2316201
tag-343 [Q1XFY2]3EBI-325337,EBI-2316564
ttx-1 [Q9U2Z0]4EBI-325337,EBI-330989
unc-11 [Q9XZI6]3EBI-325337,EBI-311866
vab-3 [G5EDS1]14EBI-325337,EBI-319610
wsp-1 [Q17795]12EBI-325337,EBI-2316131
wsp-1 [Q8MQE6]5EBI-325337,EBI-2316008
wve-1 [Q9XVK6]6EBI-325337,EBI-312105
Y50D4A.4 [Q95Y58]4EBI-325337,EBI-2316345
zfp-3 [O02174]4EBI-325337,EBI-2315779

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-24971N

Protein interaction database and analysis system

More...
IntActi
G5EC32, 72 interactors

Molecular INTeraction database

More...
MINTi
G5EC32

STRING: functional protein association networks

More...
STRINGi
6239.Y45F10D.13a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EC32

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini499 – 567SoHoPROSITE-ProRule annotationAdd BLAST69
Domaini683 – 742SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini745 – 805SH3 2PROSITE-ProRule annotationAdd BLAST61
Domaini946 – 1005SH3 3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili610 – 642Sequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

SH3 domains 1 and 2 are required for its localization to the cell membrane of dense bodies.1 Publication

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4225, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000172418

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_291067_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EC32

Identification of Orthologs from Complete Genome Data

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OMAi
PARTEHW

Database of Orthologous Groups

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OrthoDBi
87641at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
G5EC32

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14604, SH3_9, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform aImported (identifier: G5EC32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMHHPHPFGS NLANSSEPQQ PSGQYLNPAA DAYNFDTFED SDKFSPKGNV
60 70 80 90 100
AALRNVIHGQ LDMKTPTGNS SRYQKPAPPP VDSTPSWAKN VKVYEPNGYV
110 120 130 140 150
DPHLNKHNMG RVLDGPVNPN KYFQGVPPAS YSQVKHNESK PPVPPSTKPP
160 170 180 190 200
HSAAQALQAQ VLQSSKAPSQ PQQSQKTSYR IPYDVALDPR HHLGEFDIDD
210 220 230 240 250
SASIISSCIS TFGESSEIAG FSAAAEQRHL YEQYRKKLME EKNELKEGSE
260 270 280 290 300
TPCVSLSEKV MTSSTENLKN GNNQQNQQPE PQPPSSSIFN SELTPFGHVA
310 320 330 340 350
PVAKQFEPTN FPPFSPEKES EIKRSIDLES SQLLVKSKSP APYSTSSTDH
360 370 380 390 400
YGTIRRKHKP VAIDLSKSSP NLASQSPSNL FFGASFEEKQ NRSPMTSTPS
410 420 430 440 450
YKEQGFKNDS LNDSLNQAFE IASSIETTKN AYEAPPTPKS ASHDRSISDT
460 470 480 490 500
YPVSSSTTST WPSHTTTPTT TTAAAPIAAV APQTYTEQQP MSTSMSSSVM
510 520 530 540 550
STNMDEPIVV GSHQQIPQQS PDSSPERNED MSQWYRKMFK QMHRKGEDGS
560 570 580 590 600
NEGKEQHFIN PSNVTDGIGR TTPTASNLGR SRENLSFNQH RPDHPSSYFD
610 620 630 640 650
SLEHGPNDQY NNQERVKQSN EEELLRLKAE KLAEELRKEK ERKHSFIPSS
660 670 680 690 700
APSLQNNMDR LNSLLYDFSS DIQEPAHRDY TPQPVMTATA VYKFEPRSAR
710 720 730 740 750
ELPLNRGDII RIIREVDGYW MEGERNGRSG IFPTSYVQIN TGNQGDSQKM
760 770 780 790 800
RAIYPFTARS DTELSLKRGE IITRRRQIDS NWLEGSNQIG IVGIFPASYV
810 820 830 840 850
EPIEQVEQHI PTIVPNRPKT PKIEDQVYNQ VYKPNETVIM QSNQGYYDKA
860 870 880 890 900
AVVPNNKVRF DLPSGSDSNL QMSLNPHQNQ FPPTHTQTST QQPSNYGMKK
910 920 930 940 950
IEYEREKVVE EVPPMHMDQY RKLNDEPKNP KKDTNILMNA ASLIPKGSEM
960 970 980 990 1000
YRAVYPYQPQ KEDELQLYTN DIIFVVEKCD DGWFIGTSLR TGDFGIFPGN

YVKRH
Length:1,005
Mass (Da):112,832
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EC17DAF276330BD
GO
Isoform cImported (identifier: G5EC32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-604: MHHPHPFGSN...PSSYFDSLEH → CDLPKKDVEF...KRSKSQPIMK

Show »
Length:473
Mass (Da):54,867
Checksum:iD20A611556410173
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A4V0IMT6A0A4V0IMT6_CAEEL
Sorbin and SH3 domain-containing pr...
sorb-1 CELE_Y45F10D.13, Y45F10D.13
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4V0IL10A0A4V0IL10_CAEEL
Sorbin and SH3 domain-containing pr...
sorb-1 CELE_Y45F10D.13, Y45F10D.13
1,007Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0602262 – 604MHHPH…DSLEH → CDLPKKDVEFKEIDAIYENM KIKNSQRQRSQNSLDLIRIT NNLDETTKSLNLYLQQIDAT WKRSKSQPIMK in isoform c. CuratedAdd BLAST603

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA16388.2
BX284604 Genomic DNA Translation: CBJ25342.1

Protein sequence database of the Protein Information Resource

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PIRi
T26940

NCBI Reference Sequences

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RefSeqi
NP_001041035.2, NM_001047570.3 [G5EC32-1]
NP_001255756.1, NM_001268827.1 [G5EC32-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y45F10D.13a.1; Y45F10D.13a.1; WBGene00012891 [G5EC32-1]
Y45F10D.13c.1; Y45F10D.13c.1; WBGene00012891 [G5EC32-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3565590

UCSC genome browser

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UCSCi
Y45F10D.13b, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA16388.2
BX284604 Genomic DNA Translation: CBJ25342.1
PIRiT26940
RefSeqiNP_001041035.2, NM_001047570.3 [G5EC32-1]
NP_001255756.1, NM_001268827.1 [G5EC32-2]

3D structure databases

SMRiG5EC32
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-24971N
IntActiG5EC32, 72 interactors
MINTiG5EC32
STRINGi6239.Y45F10D.13a

Proteomic databases

EPDiG5EC32
PaxDbiG5EC32
PeptideAtlasiG5EC32

Genome annotation databases

EnsemblMetazoaiY45F10D.13a.1; Y45F10D.13a.1; WBGene00012891 [G5EC32-1]
Y45F10D.13c.1; Y45F10D.13c.1; WBGene00012891 [G5EC32-2]
GeneIDi3565590
UCSCiY45F10D.13b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3565590
WormBaseiY45F10D.13a ; CE44448 ; WBGene00012891 ; sorb-1
Y45F10D.13c ; CE39436 ; WBGene00012891 ; sorb-1

Phylogenomic databases

eggNOGiKOG4225, Eukaryota
GeneTreeiENSGT00940000172418
HOGENOMiCLU_291067_0_0_1
InParanoidiG5EC32
OMAiPARTEHW
OrthoDBi87641at2759
PhylomeDBiG5EC32

Enzyme and pathway databases

ReactomeiR-CEL-182971, EGFR downregulation
R-CEL-432720, Lysosome Vesicle Biogenesis
R-CEL-432722, Golgi Associated Vesicle Biogenesis
R-CEL-437239, Recycling pathway of L1
R-CEL-6807004, Negative regulation of MET activity
R-CEL-8856825, Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828, Clathrin-mediated endocytosis
SignaLinkiG5EC32

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EC32

Gene expression databases

BgeeiWBGene00012891, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues
ExpressionAtlasiG5EC32, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
PfamiView protein in Pfam
PF14604, SH3_9, 3 hits
SMARTiView protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit
SUPFAMiSSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRBS1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EC32
Secondary accession number(s): O62482
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 31, 2019
Last sequence update: December 14, 2011
Last modified: April 7, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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