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Entry version 74 (10 Apr 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

HCF1 related

Gene

hcf-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription factor binding Source: WormBase

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HCF1 relatedImported
Submitted name:
Host cell factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hcf-1Imported
ORF Names:C46A5.9Imported, CELE_C46A5.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C46A5.9 ; CE26914 ; WBGene00001827 ; hcf-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001827 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C46A5.9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini379 – 625Fibronectin type-IIIInterPro annotationAdd BLAST247
Domaini641 – 739Fibronectin type-IIIInterPro annotationAdd BLAST99

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4152 Eukaryota
ENOG410Y5AC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166952

KEGG Orthology (KO)

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KOi
K14966

Identification of Orthologs from Complete Genome Data

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OMAi
TAEWTTL

Database of Orthologous Groups

More...
OrthoDBi
416932at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR037854 HCFC1
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller

The PANTHER Classification System

More...
PANTHERi
PTHR23244:SF339 PTHR23244:SF339, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EC23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDVGLEAT NYSRGDESRS EEQEKNVVRW RIVQQSTGPN PKPRHGHRAV
60 70 80 90 100
VLKELIVIFG GGNEGMIDEL HAYNTQKREW TAPQCCGDVP TPAAAFGAIS
110 120 130 140 150
LGNKIYRFGG MTEYGKYTND LYELQSTRWE WRRLNPRVHS NGHLPCPRIG
160 170 180 190 200
HSFVVSQKSQ KAYVFGGLSN DLNDPKRNVP HYLDDLYVIN LSGPQHLIWE
210 220 230 240 250
KLNATGPGPI SRESHTAVIY EKDSISRMVV YGGMNGVRLG DLWYLNLNTL
260 270 280 290 300
HWTEIKFDDP RTGIPPMPRS LHSSVLIGDK MFVYGGWVPL LEHASTEQQT
310 320 330 340 350
EKEWKCTSSL GCWNITEDRW VPLHLYCSDE DTIPRGRAGH CAAAVGDRMY
360 370 380 390 400
IWSGRDGYRK AWSNQVCCRD MWLLDTILPE QPGKVQLGRA GFNSLEISWP
410 420 430 440 450
IVQGASGYFL QIGFGDAKEQ SVSPIKRATT SPRKQPSIVP PSQKETEQSP
460 470 480 490 500
KKPQGTAPSI ISTQGTTYTA PADPKPATDE GGLPQDLFED TEKNETASPK
510 520 530 540 550
RSNDAQSADS STCEQKKTDE SGLEEDSEKD QKPSDAGETD EMKEENGDDD
560 570 580 590 600
LPWFDVGIID KATINVTHYF NDRQQSLEKQ LNDLIDHNAF KCVNDSVFTT
610 620 630 640 650
EDKIPLINGQ SYRFRVSAIN GLGKGAWSET ASCKTCVPGY PSAPSSIRIT
660 670 680 690 700
KSHEGAQLTW EPPSNTNISG KIIEYSVYLA VKNQSANSAD SQLAFMRVYC
710 720 730 740 750
GPQADCQVLQ SNLGTAFVDQ TNKPAIIFRI AARNEKGYGP ATQVRWLQDQ
760 770 780
QKIPVRTNYP NNSGFIYQQH GGQQKRARFD HQ
Length:782
Mass (Da):87,359
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DF7775CA82B8309
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072907 mRNA Translation: AAD12580.1
BX284604 Genomic DNA Translation: CCD66593.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T29816
T43277

NCBI Reference Sequences

More...
RefSeqi
NP_501279.1, NM_068878.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.17455

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C46A5.9; C46A5.9; WBGene00001827

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C46A5.9

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072907 mRNA Translation: AAD12580.1
BX284604 Genomic DNA Translation: CCD66593.1
PIRiT29816
T43277
RefSeqiNP_501279.1, NM_068878.4
UniGeneiCel.17455

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi6239.C46A5.9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC46A5.9; C46A5.9; WBGene00001827
GeneIDi177560
KEGGicel:CELE_C46A5.9

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177560
WormBaseiC46A5.9 ; CE26914 ; WBGene00001827 ; hcf-1

Phylogenomic databases

eggNOGiKOG4152 Eukaryota
ENOG410Y5AC LUCA
GeneTreeiENSGT00940000166952
KOiK14966
OMAiTAEWTTL
OrthoDBi416932at2759

Gene expression databases

BgeeiWBGene00001827 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.120.10.80, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR037854 HCFC1
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller
PANTHERiPTHR23244:SF339 PTHR23244:SF339, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EC23_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EC23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 10, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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