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Entry version 61 (16 Oct 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Protein let-418

Gene

let-418

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate (PubMed:11076750, PubMed:21060680). This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1 (PubMed:17466968). Contributes to negative regulation of lag-2 which is expressed in the gut during larval development (PubMed:21060680). Has a broad role in development (PubMed:21060680). In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide genes in response to fungal infection (PubMed:30036395).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri256 – 303PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri317 – 365PHD-type 2PROSITE-ProRule annotationAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi627 – 634ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3214815 HDACs deacetylate histones
R-CEL-4551638 SUMOylation of chromatin organization proteins
R-CEL-8943724 Regulation of PTEN gene transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein let-418Imported
Alternative name(s):
Lethal protein 418
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:let-418Imported
Synonyms:evl-111 Publication
ORF Names:F26F12.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F26F12.7 ; CE17716 ; WBGene00002637 ; let-418

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Larval arrest, protruding vulva, sterile progeny.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004190061 – 1829Protein let-418Add BLAST1829

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EBZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EBZ4

PeptideAtlas

More...
PeptideAtlasi
G5EBZ4

PRoteomics IDEntifications database

More...
PRIDEi
G5EBZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryos and larva.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in all interphase nuclei throughout development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002637 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MEC (MEP-1-containing complex) complex that contains let-418, mep-1 and hda-1 (PubMed:21060680).

Component of a NURD complex that contains let-418, hda-1, lin-40 and lin-53 (PubMed:21060680).

Interacts with lin-1 (PubMed:17466968).

Interacts with pie-1 (PubMed:12507426).

Interacts with akir-1 (PubMed:30036395).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
mep-1Q215022EBI-3831970,EBI-319858

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
44019, 2 interactors

Protein interaction database and analysis system

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IntActi
G5EBZ4, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F26F12.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EBZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini401 – 458Chromo 1PROSITE-ProRule annotationAdd BLAST58
Domaini489 – 550Chromo 2PROSITE-ProRule annotationAdd BLAST62
Domaini614 – 798Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST185
Domaini930 – 1093Helicase C-terminalPROSITE-ProRule annotationAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi749 – 752DEAH boxSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi574 – 578Poly-LysSequence analysis5
Compositional biasi1143 – 1216Glu-richSequence analysisAdd BLAST74
Compositional biasi1249 – 1253Poly-AspSequence analysis5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 303PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri317 – 365PHD-type 2PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0383 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169383

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5EBZ4

KEGG Orthology (KO)

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KOi
K11643

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWERDDM

Database of Orthologous Groups

More...
OrthoDBi
47497at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
G5EBZ4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012957 CHD_C2
IPR012958 CHD_N
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR009462 DUF1086
IPR009463 DUF1087
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08074 CHDCT2, 1 hit
PF08073 CHDNT, 1 hit
PF00385 Chromo, 1 hit
PF06461 DUF1086, 1 hit
PF06465 DUF1087, 1 hit
PF00271 Helicase_C, 1 hit
PF00628 PHD, 2 hits
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM01146 DUF1086, 1 hit
SM01147 DUF1087, 1 hit
SM00490 HELICc, 1 hit
SM00249 PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EBZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTEEDPSLV DAEESMEEGS VTQDATEETE EEEEQEQGDE AGPSERKRSS
60 70 80 90 100
RKKGGKGGKK GSKKSAAAAS KVEIPDPYNS TSEEVCAAIG LTDVEFDYDE
110 120 130 140 150
EEFQGISNLK TFSSIIKPQI LEANPGTNVS KMYPMFQVKY KEYQDHMAAQ
160 170 180 190 200
GKPVQKQARG SKTPAVSTPV IPPRSAPTKT RSARRKRRDS DAPDSDQEFE
210 220 230 240 250
AFIKQQEQLE DDLVKDKEDA RIKRAAEREE KKKGALEAAR AAKKAKLEKG
260 270 280 290 300
EEAENNDYCE ECKQDGELLL CDTCPRAYHT VCIDENMEEP PEGDWSCAHC
310 320 330 340 350
IEHGPEVVKE EPAKQNDEFC KICKETENLL LCDSCVCSFH AYCIDPPLTE
360 370 380 390 400
VPKEETWSCP RCETVKPEHK IEKILCWRWK EIPYPEPLEA GKEASSDDAM
410 420 430 440 450
LKPPRKMEPR REREFFVKWK YLSYWQCSWV SEMLLEVHFR MLILLYWRKN
460 470 480 490 500
DSDAPPEFEE SVTSRHHSDN DPYKLRERFY QYGIKPEWMQ IHRIINHQSY
510 520 530 540 550
AKSQQDYLVK WKELSYDQAT WERDDSNIAN YEEAIIKYWQ HRESKLNEDI
560 570 580 590 600
PKNVQKMIAK HREAKGLPPK EDEKKKKKRE KIDIRKKYEV QPDYVTETGG
610 620 630 640 650
KLHPYQLEGL NWLRHCWSNG TDAILADEMG LGKTVQSLTF LYSLMKEGHC
660 670 680 690 700
KGPFLIAAPL STIINWEREA EQWCPDFYVV TYVGLRDARV VLREHEFSFV
710 720 730 740 750
EGAVRSGPKA SKMKTTENMK FHVLLTSYET INMDKTILSS IEWGALVVDE
760 770 780 790 800
AHRLKNNQSL FFKNLNEYTI HYRVLLTGTP LQNNLEELFH LLNFLSKERF
810 820 830 840 850
NQLEAFTAEF NEISKEDQIE KLHNLLGPHM LRRLKADVLT GMPSKSELIV
860 870 880 890 900
RVELSAMQKK WYKNILTRNF DALNVKNGGT QMSLMNVLME LKKCCNHPYL
910 920 930 940 950
FVKAELEAPK EKNGMYEGTA LIKNSGKFVL LQKMLRKLKD GGHRVLIFSQ
960 970 980 990 1000
MTRMLDIMED LCEYEGYRYE RIDGSIMGQM RQDAIDRYNA PGAQQFIFLL
1010 1020 1030 1040 1050
STRAGGLGIN LATADTVIIY DSDWNPHNDI QAFSRAHRLG QKHKVMIYRF
1060 1070 1080 1090 1100
VTKKSVEEKI TSVAKKKMLL NHLVVRAGLG GKEGKTMSKT ELDDVLRWGT
1110 1120 1130 1140 1150
EELFSEDLDA AEGEGSEKKG AAAQEIVWDD AAVDALLDRS NKEETPAGED
1160 1170 1180 1190 1200
GEEKAEWQNE YLSSFKVASY QTKETEGQEE EEEEETEVIK EDEKEPDPDY
1210 1220 1230 1240 1250
WEKLLKHHYE QDREIELQKL GKGKRVRKQI NYASENMGTD WSKQNQTQDD
1260 1270 1280 1290 1300
DDDNESYRGS DNGDGLNSDE DDYDEKKKRR RDEEKMPPLM AKVNGQVEIL
1310 1320 1330 1340 1350
GFNPRQRKAF YGAVMRWGMP PQDSHQSQWL VRDLRNKSEK VFRAYASLFM
1360 1370 1380 1390 1400
RHLCEPGADG HDTFNDGVPR EGLNRQHVLG RIGLLSLVRR KVQEFEQYNG
1410 1420 1430 1440 1450
QWSMPEIQDE VLAKAANGSA QGSSRSTPKP KEEPKEEPME KEDATETVNG
1460 1470 1480 1490 1500
ATSEPATDAE SEQNAPVDEP MDTDEAKEPK EEPIETEKPR AARPSFKFNI
1510 1520 1530 1540 1550
CDGGFTELHS LWANEEKVAR NGKEYEIWYR RHDYWLLAGV VVHGYGRFQA
1560 1570 1580 1590 1600
NFNDIINDPR FSVLNEPFKE VGAEATGSDI KAKFMQRRFK LIEQSLVIEE
1610 1620 1630 1640 1650
QLRRAAHANR HLQPDNVGPL AQRFADLENI AESQANIAKE SSAGNRNANA
1660 1670 1680 1690 1700
VLHKTLVQLD EILSDMKADV SRLPSTFTQL ATVTERLNMT ERQILSRLTT
1710 1720 1730 1740 1750
KDEDAIANRS VLPPPGPFVT PILRQQMDGI QPKFAALYSK FMSENGERME
1760 1770 1780 1790 1800
EDEPVEAEEE EGVKQEPDDE TQDSAEAPPV LSAEVNSDDS NDVPSTSAAA
1810 1820
AVSSETAADA EPASAEDQAP TDEPEPMET
Length:1,829
Mass (Da):209,151
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A887E990C63B661
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF308445 mRNA Translation: AAG29838.1
BX284605 Genomic DNA Translation: CCD62685.1

Protein sequence database of the Protein Information Resource

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PIRi
T34239

NCBI Reference Sequences

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RefSeqi
NP_504523.1, NM_072122.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F26F12.7.1; F26F12.7.1; WBGene00002637

Database of genes from NCBI RefSeq genomes

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GeneIDi
178970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F26F12.7

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308445 mRNA Translation: AAG29838.1
BX284605 Genomic DNA Translation: CCD62685.1
PIRiT34239
RefSeqiNP_504523.1, NM_072122.4

3D structure databases

SMRiG5EBZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi44019, 2 interactors
IntActiG5EBZ4, 2 interactors
STRINGi6239.F26F12.7

Proteomic databases

EPDiG5EBZ4
PaxDbiG5EBZ4
PeptideAtlasiG5EBZ4
PRIDEiG5EBZ4

Genome annotation databases

EnsemblMetazoaiF26F12.7.1; F26F12.7.1; WBGene00002637
GeneIDi178970
KEGGicel:CELE_F26F12.7

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178970
WormBaseiF26F12.7 ; CE17716 ; WBGene00002637 ; let-418

Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000169383
InParanoidiG5EBZ4
KOiK11643
OMAiTWERDDM
OrthoDBi47497at2759
PhylomeDBiG5EBZ4

Enzyme and pathway databases

ReactomeiR-CEL-3214815 HDACs deacetylate histones
R-CEL-4551638 SUMOylation of chromatin organization proteins
R-CEL-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

Protein Ontology

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PROi
PR:G5EBZ4

Gene expression databases

BgeeiWBGene00002637 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.30.40.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR012957 CHD_C2
IPR012958 CHD_N
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR009462 DUF1086
IPR009463 DUF1087
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF08074 CHDCT2, 1 hit
PF08073 CHDNT, 1 hit
PF00385 Chromo, 1 hit
PF06461 DUF1086, 1 hit
PF06465 DUF1087, 1 hit
PF00271 Helicase_C, 1 hit
PF00628 PHD, 2 hits
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM01146 DUF1086, 1 hit
SM01147 DUF1087, 1 hit
SM00490 HELICc, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLE418_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EBZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: December 14, 2011
Last modified: October 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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