Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 66 (29 Sep 2021)
Sequence version 1 (14 Dec 2011)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

ERCC4 domain-containing protein

Gene

xpf-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5696395, Formation of Incision Complex in GG-NER
R-CEL-6782135, Dual incision in TC-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ERCC4 domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xpf-1Imported
ORF Names:C47D12.8Imported, CELE_C47D12.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C47D12.8 ; CE24855 ; WBGene00008140 ; xpf-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EBZ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EBZ1

PeptideAtlas

More...
PeptideAtlasi
G5EBZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008140, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C47D12.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini687 – 767ERCC4InterPro annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni656 – 681DisorderedSequence analysisAdd BLAST26
Regioni848 – 867DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili524 – 551Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0442, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002265_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EBZ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHKILQA

Database of Orthologous Groups

More...
OrthoDBi
324863at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EBZ1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732, ERCC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00891, ERCC4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52980, SSF52980, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EBZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METETDDSET SLNDSFGNKD GLELLEYERA TLAKTLPASV LFVVANGLGL
60 70 80 90 100
ERLFLEHLIL FSDRRLLALV LNTNEHDESY FVSKLKEHNV ECDPKVINSE
110 120 130 140 150
VSIKDRQSIY LEGGVQFCSS RVLLVDLLQN RIPTDRIAAI FVYRAHQTLN
160 170 180 190 200
AFQDSFILRL YREKKPDGTV KAFTDFPNSL SSLGQLQRLV DRLYIRHVEL
210 220 230 240 250
MPRFSSIIES ELNRYQLKTA IFSVDVPTPL RRVHRTIIEF IKVCVRDLRT
260 270 280 290 300
CSTSGKQTDE QNEEMIHVPW AATRLEKRLH DRRGHISEKQ QRLLNDVASL
310 320 330 340 350
REILQLSENM DVATVLSRLQ VLKNDRTVLE EHSGWLLSPS FNRIMEDLLT
360 370 380 390 400
IAGVTNGKAD YKKFATPAKW TVLSEILREI KMLPVEKKDR GNDSPSVLVI
410 420 430 440 450
TSSEDLSRQV TDVVRYGINK MKWMTWRQLG YKSTQEMPED EPLWDPDTIS
460 470 480 490 500
QLMRSSVDGE SKSEVIANVQ KTQKTTARAA QKRRKHAEEL SGFSSDHRVQ
510 520 530 540 550
TNLIQFGILQ YKRRKSGNEA STSQETTEWE VKEEMEEIEE ITKNIGDLEA
560 570 580 590 600
ELVVSTTRER ERYTLLKLLE TKKPRAIVLY TMSLQTLRQI EIYRSTNPNR
610 620 630 640 650
SLHVYWLQYT ESTEESRYLE SINRETMSFE LLIREQGTLL ISREFNVDRE
660 670 680 690 700
DAPRLKISTR DGGGARRDGA VDPRDQMDPE EELERPKIIV DMREFNSELP
710 720 730 740 750
TVLYTKGYNV VATTIEIGDY ILSPNIAIER KALDDLTQSL QSGRVFKQIE
760 770 780 790 800
QMLEHYDCTV LLIESNRKFE TKIVNGGPFQ GELSRHCREI RSIFCSLIWA
810 820 830 840 850
NPKMRCVWTI SPTNSAEFFS ELKLSAPEPD VDRAISLKAD QVECSSQELT
860 870 880 890 900
DSEASTSTKA KKGKKWKPNP TVIRTLTQIF GIKASEAHNL LANSSIKTLA
910 920 930
DLFSLNITAS HLSDFIPSTS ADFIKDLSTF NFGRK
Length:935
Mass (Da):107,217
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A8D3959447D33F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA93766.2

Protein sequence database of the Protein Information Resource

More...
PIRi
B88322
T18568
T19998

NCBI Reference Sequences

More...
RefSeqi
NP_496498.1, NM_064097.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C47D12.8.1; C47D12.8.1; WBGene00008140
C47D12.8.2; C47D12.8.2; WBGene00008140

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174793

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C47D12.8

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA93766.2
PIRiB88322
T18568
T19998
RefSeqiNP_496498.1, NM_064097.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C47D12.8

Proteomic databases

EPDiG5EBZ1
PaxDbiG5EBZ1
PeptideAtlasiG5EBZ1

Genome annotation databases

EnsemblMetazoaiC47D12.8.1; C47D12.8.1; WBGene00008140
C47D12.8.2; C47D12.8.2; WBGene00008140
GeneIDi174793
KEGGicel:CELE_C47D12.8

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174793
WormBaseiC47D12.8 ; CE24855 ; WBGene00008140 ; xpf-1

Phylogenomic databases

eggNOGiKOG0442, Eukaryota
GeneTreeiENSGT00390000004394
HOGENOMiCLU_002265_1_0_1
InParanoidiG5EBZ1
OMAiFHKILQA
OrthoDBi324863at2759
PhylomeDBiG5EBZ1

Enzyme and pathway databases

ReactomeiR-CEL-5696395, Formation of Incision Complex in GG-NER
R-CEL-6782135, Dual incision in TC-NER

Gene expression databases

BgeeiWBGene00008140, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
PfamiView protein in Pfam
PF02732, ERCC4, 1 hit
SMARTiView protein in SMART
SM00891, ERCC4, 1 hit
SUPFAMiSSF52980, SSF52980, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EBZ1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EBZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 29, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again