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Entry version 53 (16 Oct 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

DEP domain-containing protein

Gene

CELE_T08A11.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DEP domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CELE_T08A11.1Imported, T08A11.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
T08A11.1 ; CE16370 ; WBGene00011604

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
G5EBK0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
G5EBK0

PeptideAtlas

More...
PeptideAtlasi
G5EBK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011604 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
G5EBK0, 1 interactor

STRING: functional protein association networks

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STRINGi
6239.T08A11.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1492 – 1579DEPInterPro annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni770 – 911DisorderedSequence analysisAdd BLAST142
Regioni1031 – 1066DisorderedSequence analysisAdd BLAST36
Regioni1226 – 1264DisorderedSequence analysisAdd BLAST39
Regioni1747 – 1774DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 23PolarSequence analysisAdd BLAST23
Compositional biasi779 – 803PolyampholyteSequence analysisAdd BLAST25
Compositional biasi813 – 831Pro-richSequence analysisAdd BLAST19
Compositional biasi832 – 847PolyampholyteSequence analysisAdd BLAST16
Compositional biasi883 – 911PolarSequence analysisAdd BLAST29
Compositional biasi1031 – 1047PolarSequence analysisAdd BLAST17
Compositional biasi1232 – 1254PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1747 – 1769PolarSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3572 Eukaryota
ENOG410XQVG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016559

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EBK0

KEGG Orthology (KO)

More...
KOi
K20404

Identification of Orthologs from Complete Genome Data

More...
OMAi
DWKSLIR

Database of Orthologous Groups

More...
OrthoDBi
45642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EBK0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR027244 IML1

The PANTHER Classification System

More...
PANTHERi
PTHR13179 PTHR13179, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12257 IML1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EBK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFEIAGPSS SNNSSQRRAT TEPPPENELQ LGLHEAQKMT WNAKVVYHTI
60 70 80 90 100
DKCPHCDPMI FMNFPKKKQL KLYLNFRTIV CPENAEISKL GNSFAWEIKF
110 120 130 140 150
NSAGFLKNCF GKISTPPFSI LFSFLGIFMM LHFEIQSFCN FDLFYFSFSN
160 170 180 190 200
NFDQLPAVSC RKIGFLVIDN NKVFFRAKKP EIIENKIVEI LSKIWPVLIY
210 220 230 240 250
YSKKSNSFDF PKIIHIFQSK KPSCLKEDEH MAVLVHDKTL AFMKPCYITV
260 270 280 290 300
SKTDETGDHE LSFRIETTIL SEAKKTNSAA SIHRSGPSSN RNSRVYDEAA
310 320 330 340 350
RQAVLAELDK DEDVVEKKKS SVMIGKPEDV TCTLSLAKGA PGLITNRIDF
360 370 380 390 400
LKQNDIVKCT LETVDTVSLD NVQLTFREQY MSRADMYRYR SCLIGRMTYV
410 420 430 440 450
EEPKRYMNIN TRISDMWRKG SLVRSGYVTD KTRVVFRSSS STVLIFIQMC
460 470 480 490 500
SEMNQLDPQG DLYLEKCIKG FLTELFLKWK EQSCTHYVSI ILCSRWYAIG
510 520 530 540 550
GVDDAAKRFM KGACDHRGRY YQDFYRLLFQ NEHYEDWADK QLKEINVGCS
560 570 580 590 600
KYSSQIQEKL KEMLPQVQFE VSTAADGNFL QVVNMSMNSF SMYHSDRRFE
610 620 630 640 650
TTGQQIIFVT PGNGVLHVDR DLVSLTKQRV IDMGISLDMV CLGEQPLHAV
660 670 680 690 700
PLFVFHPIVG QMDKKCEYFI PHWMNYSYYQ MARRSAISVQ FRPRIQLPAA
710 720 730 740 750
VLSAPKKMIM GSTGTFRCFP QSVEKYGGDY DAKKLSNVCA KIQLLPKEEA
760 770 780 790 800
NDIDAVVRDA PEAGRRQLRE ILGLSPDKVK PNSDDKTKTS VRERKETDGE
810 820 830 840 850
PSEDNNTQKA APIASNPPPP PPLPPPPPSV EKKKLEPQDR DIAGSKIIKK
860 870 880 890 900
NSESSTYGGS VRPVSAAKDI EKPAPQRSLP PLVPNAGGSS WNNQNRPESP
910 920 930 940 950
RSASYESMKM PPSSIGGSIE IGSSALTKLR ATSPSRRGTI DGSTTTLANN
960 970 980 990 1000
DLTAVWKRQN GQLINPFRPE DFAVQVTANR RRWIHVFPVD SSGKSKLAHH
1010 1020 1030 1040 1050
FVSGQSIVHI VGAPDEQKKI VAQIGSVDTV SISKSPEQQS SSLTRSRRGA
1060 1070 1080 1090 1100
NMEDDRKHSS KSNSAGNASK KYKVWAWGST GEEKWNVDME IGTDWKSLVR
1110 1120 1130 1140 1150
SALLPITTDF FPDGQTLQTQ FRMNEYSIEV TNKSLEDYRN GLYEQDECAI
1160 1170 1180 1190 1200
IGTPFDSLEM SNSHHSDVQT TLQTQVKDQR YRRIRDRNEK PTMAQLVYEQ
1210 1220 1230 1240 1250
LILQRLQRGY QIVLLDKSLV EVSCEAAKKP SSSRPDLSRK QVTKSEKERV
1260 1270 1280 1290 1300
GSGGSERSRS NPRTIQNPEI VLSFNKFYHK LALEKDVVRI TLFRPKAEKS
1310 1320 1330 1340 1350
DEVAGFPGWC ERPSMRNEEN LDEAIRPFKK NAHDDELNSR YFNTTYMYYF
1360 1370 1380 1390 1400
QVPDASTYEK SATKLRHHDL DKLNWSAFDS AFKNIFSDIL YTESMKCFSA
1410 1420 1430 1440 1450
SFLVVFHPTD ILKTKLIEKQ TEGKGIEFRD PKEFESPNEA WYSRLTKLLL
1460 1470 1480 1490 1500
LMNKLQYQGM VPDPNSLQDR QQKWKNKPQN YKAIVEDFKK TPYVGLKNTN
1510 1520 1530 1540 1550
EKQMSVAHPA NMFVVYDFAL WLRYNVEEIS KFEIAVNLIR RLADSKFIQV
1560 1570 1580 1590 1600
ITSKGKYGSE SSLNSKKMFK FKAEYGFQLC YISDPDFPEN SKVSRFMMVE
1610 1620 1630 1640 1650
YKNKICQEEE TECKWQLQGD IDMELAPPTP DSPLGEWTRI TYDHWFYPDT
1660 1670 1680 1690 1700
AFRITMKWVM GTGQTVADTV LSWFNKASKQ GMSLYPVPED PFALAQDTHS
1710 1720 1730 1740 1750
NPLRCPIRIQ LKEKVVAHSD EREFLLKILF RFGFIDIGCN VKHDFSSPRT
1760 1770 1780 1790 1800
DSSSSDHTKA LSSPSPTLQL EGDDGDLDDV TISMNYIHQA GGMFISLVLS
1810 1820 1830 1840 1850
ENPNRPPFFY WAWNHLLSNR YRGQCSEKFQ DYLLSEFRAV CSDKNDTLTQ
1860 1870
LYSDFKKEKL QKPRPATPPK FD
Length:1,872
Mass (Da):213,927
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06DF7364A8CC3BB5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA90776.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T24683

NCBI Reference Sequences

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RefSeqi
NP_497852.1, NM_065451.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T08A11.1.1; T08A11.1.1; WBGene00011604

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175548

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T08A11.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA90776.1
PIRiT24683
RefSeqiNP_497852.1, NM_065451.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5EBK0, 1 interactor
STRINGi6239.T08A11.1

Proteomic databases

EPDiG5EBK0
PaxDbiG5EBK0
PeptideAtlasiG5EBK0

Genome annotation databases

EnsemblMetazoaiT08A11.1.1; T08A11.1.1; WBGene00011604
GeneIDi175548
KEGGicel:CELE_T08A11.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175548
WormBaseiT08A11.1 ; CE16370 ; WBGene00011604

Phylogenomic databases

eggNOGiKOG3572 Eukaryota
ENOG410XQVG LUCA
GeneTreeiENSGT00390000016559
InParanoidiG5EBK0
KOiK20404
OMAiDWKSLIR
OrthoDBi45642at2759
PhylomeDBiG5EBK0

Gene expression databases

BgeeiWBGene00011604 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR000591 DEP_dom
IPR027244 IML1
PANTHERiPTHR13179 PTHR13179, 1 hit
PfamiView protein in Pfam
PF12257 IML1, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EBK0_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EBK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 16, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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