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Entry version 71 (16 Oct 2019)
Sequence version 1 (14 Dec 2011)
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8

Gene

egl-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion (PubMed:10571228). Plays a role in efficient egg laying and defecation (PubMed:10571227, PubMed:10571228, PubMed:24212673). Involved in axon regeneration after injury (PubMed:23072806). Plays a role in male mating behavior by regulating spicule insertion and sperm transfer (PubMed:15958491). By triggering Ca2+ transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch (PubMed:19730689). By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection (PubMed:19380113). During embryogenesis, may play a role in epidermal morphogenesis together with plc-1 (PubMed:18369461).By similarity8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei355PROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi356Calcium 1; catalyticBy similarity1
Metal bindingi385Calcium 1; catalyticBy similarity1
Metal bindingi387Calcium 1; catalyticBy similarity1
Active sitei403PROSITE-ProRule annotationBy similarity1
Metal bindingi437Calcium 1; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei489SubstrateBy similarity1
Binding sitei491SubstrateBy similarity1
Binding sitei787SubstrateBy similarity1
Binding sitei814SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-112043 PLC beta mediated events
R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-416476 G alpha (q) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 (EC:3.1.4.11By similarity)
Alternative name(s):
Egg-laying defective protein 8
Phosphoinositide phospholipase C-beta egl-8
Phospholipase C-beta egl-81 PublicationImported
Short name:
PLC-beta egl-81 PublicationBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:egl-8Imported
ORF Names:B0348.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
B0348.4a ; CE30588 ; WBGene00001177 ; egl-8
B0348.4b ; CE30589 ; WBGene00001177 ; egl-8
B0348.4c ; CE36909 ; WBGene00001177 ; egl-8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant worms are similar in size to the wild-type but animals are bloated with eggs due to defective egg laying with decreased body flexion and sluggish locomotion (PubMed:10571227, PubMed:10571228). They have defects in the posterior body contraction step of the defecation motor program and become sluggish in the presence of exogenous betaine (PubMed:24212673). Animals are resistant to aldicarb, a carbamate insecticide (PubMed:10571228). Simultaneous knockout of egl-8 and snf-3 results in uncoordinated, hypercontracted and paralyzed animals (PubMed:24212673). RNAi-mediated knockdown causes a defect in sperm transfer and a slight defect in spicule protrusion resulting in male infertility (PubMed:15958491). Ca2+ transient increase and avoidance behavior are defective in response to nose touch but not to benzaldehyde (PubMed:19730689). nlp-29 expression is abrogated following fungal infection by D.coniospora but not following physical injury (PubMed:19380113). Causes a 1.6 fold increase in embryonic arrest in a plc-1 (tm753) mutant background (PubMed:18369461).7 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45G → D in n2659; egg laying and defecation defects, and sluggish locomotion. Grows in the presence of aldicarb unlike the wild-type. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004258641 – 14311-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8Add BLAST1431

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EBH0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EBH0

PeptideAtlas

More...
PeptideAtlasi
G5EBH0

PRoteomics IDEntifications database

More...
PRIDEi
G5EBH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most or all neurons with high expression in the head and tail ganglia and low expression in the motor neurons of the ventral cord. Expressed in the intestine (at protein level) (PubMed:10571227, PubMed:10571228). In males, expressed in vas deferens, spicule protractor muscles, diagonal muscles and a male-specific neuron (PubMed:15958491).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001177 Expressed in 4 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5EBH0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
43612, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.B0348.4b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EBH0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini340 – 491PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST152
Domaini758 – 874PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini881 – 979C2PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1135 – 1166Sequence analysisAdd BLAST32
Coiled coili1288 – 1318Sequence analysisAdd BLAST31
Coiled coili1368 – 1402Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0169 Eukaryota
ENOG410XPSW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232046

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EBH0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EBH0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13361 PH_PLC_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1230.10, 2 hits
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR042531 PLC-beta_C_sf
IPR009535 PLC-beta_CS
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336 PTHR10336, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06631 DUF1154, 1 hit
PF09279 EF-hand_like, 1 hit
PF17787 PH_14, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000956 PLC-beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390 PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform b1 Publication (identifier: G5EBH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKEFQFNWK PTIIPELLHG SVFDRYDDES TCLELNAQVR IDENGFFLRW
60 70 80 90 100
LIEGKDAVVL DMGQIWEART GGLPKDGRIM FELEQRGASE TIAERTIWIT
110 120 130 140 150
HGQDLVNVQS FFLVAESVEL AKTCRAGIND ILKSSRIRHV CPTTQLMKYH
160 170 180 190 200
TWLTMNVNER RKIPIKLIIK TFSSGKPEKM VQKCLNDLGL GGDKYTPARV
210 220 230 240 250
INRSMGKKFR NFYKCSRGRK RKEREELDVD ILTFEKFQRL YNKICPRTEV
260 270 280 290 300
QELFVKLSGQ KEYLTKERLI NFLNEEQRDP RLNEILFPFF DSQRIVALLK
310 320 330 340 350
KHENDIKYQE DGKMSGDGFL RFLMSDENPP VFLDRIEMFM DMDQPLCHYY
360 370 380 390 400
INSSHNTYLT GRQYGGKSSS EIYRQVLLSG CRCIELDCWD GTGENKGEPI
410 420 430 440 450
ITHGKAMCTD VFFKDVLVQI RDTAFARSDF PVVLSFENHC SKSNQLKMAK
460 470 480 490 500
YCMDIFGDML LSKPFEDAPL DPGVSLPSPN RLRKKILIKN KRLKTDIERH
510 520 530 540 550
QLDQFLREGK LDEEDELNET PEVVGEDSVS PRSGGSGGTG APEEVDDDTS
560 570 580 590 600
DDDDDPSVQT SLNVMRTIPT VNTTSNNGSN RSARSSLDTP SPSGGSLMVP
610 620 630 640 650
DRATSTATSI KNAVLARSPN FSSLRQKLSF KRRQSPLAGD QRAHPEVEQP
660 670 680 690 700
VSSSSPATPS ISGPPPCATS SGSTSSITIT TTGCSTSSSG PSKHILGGEM
710 720 730 740 750
PAKENDEAHP ELKQNFIAKN LKGFGFSKKQ PVLTKEEEER IFAEYHYTGA
760 770 780 790 800
TTNIHPLLSS LVNYTHPVKF SGFDVAEANN LHFHMSSFSE STGLGYLKQS
810 820 830 840 850
APEFVNYNKR QSSRIYPKGA RVDSSNFLPQ IFWNAGCQMV SLNFQTPDVY
860 870 880 890 900
MQLNMGKFEY NGGSGYLLKP DFLRRPDRTF DPFSESPVDG VIAAHCSVRV
910 920 930 940 950
ISGQFLSDRK IGTYVEVEMY GLPTDTIRKE HKTKVIPGNG LNPVYNEDPF
960 970 980 990 1000
VFRKVVLPEL AVLRFAVYDE NGKQLGQRIL PLDGLQAGYR HISLRSDTNQ
1010 1020 1030 1040 1050
SFILSPVLFV QIVIKTYVPD ELSGLVDALA DPRAFLSEQK KRQEALAHMG
1060 1070 1080 1090 1100
VDDSDIPDVP NTRNMALRHV KQPPRQNGSS ADLLANNGQT GSARGDQTSS
1110 1120 1130 1140 1150
MASSTIRSPN EQPQPVAVDK FKVDPIEVDD LRRDKAFAKL LKRFQKELDD
1160 1170 1180 1190 1200
LRKKHQKQRD SIQKQQPARR RNSSIAWIQT NVDKLITNNR RSTKKEKGSR
1210 1220 1230 1240 1250
RSLTASVSSG CGSASGTVTV SVCSPSGASC SGYSTGGPST PVACNSDGTG
1260 1270 1280 1290 1300
SPATIGSPVP QDLVNNDRVR SLVNTQTGEW SAMVRRHDEE EFELKKVQLK
1310 1320 1330 1340 1350
EQFDLLRKLM SEAQKNQMLA LKLRLEAEGK DLKQTQTKKS MEDAKVIQLD
1360 1370 1380 1390 1400
KGIKTKAERD RRVKELNEKN LKMFVEERKR LAMKAQKHEE QLTKRHLDQL
1410 1420 1430
EQLDKDFHKA LDAEVGNYKE EQLAAQPTSV V
Length:1,431
Mass (Da):160,904
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02C827299787FF02
GO
Isoform a1 Publication (identifier: G5EBH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1178: Missing.

Show »
Length:1,419
Mass (Da):159,496
Checksum:i6067C4BCF6F1CDD4
GO
Isoform c1 Publication (identifier: G5EBH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-698: Missing.
     731-758: PVLTKEEEERIFAEYHYTGATTNIHPLL → ETNKISNFNIVFKGFLFLLILILLSQIP
     759-1431: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:592
Mass (Da):68,705
Checksum:i90CE13F3FB621D25
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3ARR2A0A0K3ARR2_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,265Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARQ7A0A0K3ARQ7_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARR7A0A0K3ARR7_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,391Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARS4A0A0K3ARS4_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AS74A0A0K3AS74_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,346Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AS85A0A0K3AS85_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,297Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AS90A0A0K3AS90_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,225Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AUL3A0A0K3AUL3_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AUL7A0A0K3AUL7_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,334Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AUM3A0A0K3AUM3_CAEEL
1-phosphatidylinositol 4,5-bisphosp...
egl-8 B0348.4, CELE_B0348.4
1,403Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147 – 149MKY → I in AAF01458 (PubMed:10571228).Curated3
Sequence conflicti638A → AA in AAF01458 (PubMed:10571228).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053882533 – 698Missing in isoform c. 1 PublicationAdd BLAST166
Alternative sequenceiVSP_053883731 – 758PVLTK…IHPLL → ETNKISNFNIVFKGFLFLLI LILLSQIP in isoform c. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_053884759 – 1431Missing in isoform c. 1 PublicationAdd BLAST673
Alternative sequenceiVSP_0538851167 – 1178Missing in isoform a. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF179426 mRNA Translation: AAF05701.1
AF188477 mRNA Translation: AAF01458.1
FO080176 Genomic DNA Translation: CCD61782.1
FO080176 Genomic DNA Translation: CCD61783.1
FO080176 Genomic DNA Translation: CCD61784.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37264

NCBI Reference Sequences

More...
RefSeqi
NP_001021346.1, NM_001026175.3 [G5EBH0-2]
NP_001021347.1, NM_001026176.2 [G5EBH0-1]
NP_001021348.1, NM_001026177.3 [G5EBH0-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0348.4a.1; B0348.4a.1; WBGene00001177 [G5EBH0-2]
B0348.4b.1; B0348.4b.1; WBGene00001177 [G5EBH0-1]
B0348.4c.1; B0348.4c.1; WBGene00001177 [G5EBH0-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178537

UCSC genome browser

More...
UCSCi
B0348.4a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179426 mRNA Translation: AAF05701.1
AF188477 mRNA Translation: AAF01458.1
FO080176 Genomic DNA Translation: CCD61782.1
FO080176 Genomic DNA Translation: CCD61783.1
FO080176 Genomic DNA Translation: CCD61784.1
PIRiT37264
RefSeqiNP_001021346.1, NM_001026175.3 [G5EBH0-2]
NP_001021347.1, NM_001026176.2 [G5EBH0-1]
NP_001021348.1, NM_001026177.3 [G5EBH0-3]

3D structure databases

SMRiG5EBH0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi43612, 1 interactor
STRINGi6239.B0348.4b

Proteomic databases

EPDiG5EBH0
PaxDbiG5EBH0
PeptideAtlasiG5EBH0
PRIDEiG5EBH0

Genome annotation databases

EnsemblMetazoaiB0348.4a.1; B0348.4a.1; WBGene00001177 [G5EBH0-2]
B0348.4b.1; B0348.4b.1; WBGene00001177 [G5EBH0-1]
B0348.4c.1; B0348.4c.1; WBGene00001177 [G5EBH0-3]
GeneIDi178537
UCSCiB0348.4a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178537
WormBaseiB0348.4a ; CE30588 ; WBGene00001177 ; egl-8
B0348.4b ; CE30589 ; WBGene00001177 ; egl-8
B0348.4c ; CE36909 ; WBGene00001177 ; egl-8

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00940000156426
HOGENOMiHOG000232046
InParanoidiG5EBH0
PhylomeDBiG5EBH0

Enzyme and pathway databases

ReactomeiR-CEL-112043 PLC beta mediated events
R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-416476 G alpha (q) signalling events

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5EBH0

Gene expression databases

BgeeiWBGene00001177 Expressed in 4 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiG5EBH0 baseline and differential

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di1.20.1230.10, 2 hits
2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR042531 PLC-beta_C_sf
IPR009535 PLC-beta_CS
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF06631 DUF1154, 1 hit
PF09279 EF-hand_like, 1 hit
PF17787 PH_14, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCB_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EBH0
Secondary accession number(s): Q6EZG7, Q95X30, Q9U6B9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: December 14, 2011
Last modified: October 16, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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