UniProtKB - G5E9Z4 (G5E9Z4_HUMAN)
Protein
Phosphatidylinositol 4-kinase type 2
Gene
PI4K2B
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H+UniRule annotationARBA annotationEC:2.7.1.67UniRule annotationARBA annotation
GO - Molecular functioni
- 1-phosphatidylinositol 4-kinase activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | KinaseUniRule annotationImported, Transferase |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-kinase type 2UniRule annotation (EC:2.7.1.67UniRule annotation) |
Gene namesi | Name:PI4K2BImported ORF Names:hCG_19614Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000281028.1 |
HGNCi | HGNC:18215, PI4K2B |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Peripheral membrane protein UniRule annotation
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembraneUniRule annotationARBA annotationPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000038210 |
Polymorphism and mutation databases
BioMutai | ENSG00000281028 |
Expressioni
Gene expression databases
Bgeei | ENSG00000281028, Expressed in intestine and 83 other tissues |
ExpressionAtlasi | G5E9Z4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 331 | PI3K/PI4KInterPro annotationAdd BLAST | 299 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000010434 |
HOGENOMi | CLU_032516_1_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR039756, Lsb6/PI4K2 IPR000403, PI3/4_kinase_cat_dom |
PANTHERi | PTHR12865, PTHR12865, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
G5E9Z4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAFLDDPEF ADIMLRAEQA IEVGIFPERI SQGSSGSYFV KDPKRKIIGV
60 70 80 90 100
FKPKSEEPYG QLNPKWTKYV HKVCCPCCFG RGCLIPNQGY LSEAGAYLVD
110 120 130 140 150
NKLHLSIVPK TKVVWLVSET FNYNAIDRAK SRGKKYALEK VPKVGRKFHR
160 170 180 190 200
IGLPPKIGSF QLFVEGYKEA EYWLRKFEAD PLPENIRKQF QSQFERLVIL
210 220 230 240 250
DYIIRNTDRG NDNWLVRYEK QKCEKEIDHK ESKWIDDEEF LIKIAAIDNG
260 270 280 290 300
LAFPFKHPDE WRAYPFHWAW LPQAKVPFSE EIRNLILPYI SDMNFVQDLC
310 320 330 340 350
EDLYELFKTD KGFDKATFES QMSVMRGQIL NLTQALRDGK SPFQLVQIPC
360 370 380
VIVERSQGGS QGRIVHLSNS FTQTVNCRKP FFSSW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8TCG2 | P4K2B_HUMAN | Phosphatidylinositol 4-kinase type ... | PI4K2B | 481 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104662 Genomic DNA No translation available. AC108218 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW92836.1 |
RefSeqi | XP_005248232.1, XM_005248175.4 |
Genome annotation databases
Ensembli | ENST00000512921; ENSP00000423373; ENSG00000038210 |
GeneIDi | 55300 |
UCSCi | uc011bxs.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104662 Genomic DNA No translation available. AC108218 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW92836.1 |
RefSeqi | XP_005248232.1, XM_005248175.4 |
3D structure databases
SMRi | G5E9Z4 |
ModBasei | Search... |
Polymorphism and mutation databases
BioMutai | ENSG00000281028 |
Proteomic databases
MaxQBi | G5E9Z4 |
PRIDEi | G5E9Z4 |
ProteomicsDBi | 34092 |
Protocols and materials databases
Antibodypediai | 1318, 159 antibodies |
Genome annotation databases
Ensembli | ENST00000512921; ENSP00000423373; ENSG00000038210 |
GeneIDi | 55300 |
UCSCi | uc011bxs.3, human |
Organism-specific databases
CTDi | 55300 |
EuPathDBi | HostDB:ENSG00000281028.1 |
HGNCi | HGNC:18215, PI4K2B |
OpenTargetsi | ENSG00000038210 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000010434 |
HOGENOMi | CLU_032516_1_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 55300, 7 hits in 844 CRISPR screens |
ChiTaRSi | PI4K2B, human |
GenomeRNAii | 55300 |
Gene expression databases
Bgeei | ENSG00000281028, Expressed in intestine and 83 other tissues |
ExpressionAtlasi | G5E9Z4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR039756, Lsb6/PI4K2 IPR000403, PI3/4_kinase_cat_dom |
PANTHERi | PTHR12865, PTHR12865, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E9Z4_HUMAN | |
Accessioni | G5E9Z4Primary (citable) accession number: G5E9Z4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |