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UniProtKB - G5E9Q4 (G5E9Q4_HUMAN)
Protein
Submitted name:
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Gene
PRKRA
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- double-stranded RNA binding Source: InterPro
- enzyme activator activity Source: InterPro
- kinase activity Source: UniProtKB-KW
GO - Biological processi
- production of siRNA involved in RNA interference Source: InterPro
Keywordsi
Molecular function | KinaseImported, RNA-bindingPROSITE-ProRule annotation, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Interferon-inducible double-stranded RNA-dependent protein kinase activator ASubmitted name: Protein kinase, interferon-inducible double stranded RNA dependent activator, isoform CRA_dImported |
Gene namesi | Name:PRKRAImported ORF Names:hCG_43233Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9438, PRKRA |
VEuPathDBi | HostDB:ENSG00000180228 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180228, Expressed in sperm and 242 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 101 | DRBMInterPro annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 |
Phylogenomic databases
GeneTreei | ENSGT00940000157618 |
OMAi | KKIAKHR |
Family and domain databases
CDDi | cd19889, DSRM_PRKRA_rpt1, 1 hit |
InterProi | View protein in InterPro IPR014720, dsRBD_dom IPR033363, PRKRA IPR044465, PRKRA_DSRM_1 |
PANTHERi | PTHR46205:SF2, PTHR46205:SF2, 1 hit |
Pfami | View protein in Pfam PF00035, dsrm, 1 hit |
SMARTi | View protein in SMART SM00358, DSRM, 1 hit |
PROSITEi | View protein in PROSITE PS50137, DS_RBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All
G5E9Q4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP
60 70 80 90 100
VYECERSDVQ IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK
ANASI
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75569 | PRKRA_HUMAN | Interferon-inducible double-strande... | PRKRA PACT, RAX, HSD-14, HSD14 | 313 | Annotation score: | ||
B4DJC7 | B4DJC7_HUMAN | Interferon-inducible double-strande... | PRKRA | 200 | Annotation score: | ||
A0A7I2V3J2 | A0A7I2V3J2_HUMAN | Interferon-inducible double-strande... | PRKRA | 229 | Annotation score: | ||
A0A7I2V2I8 | A0A7I2V2I8_HUMAN | Interferon-inducible double-strande... | PRKRA | 228 | Annotation score: | ||
A0A7I2V5C2 | A0A7I2V5C2_HUMAN | Interferon-inducible double-strande... | PRKRA | 106 | Annotation score: | ||
A0A7I2V5H3 | A0A7I2V5H3_HUMAN | Interferon-inducible double-strande... | PRKRA | 191 | Annotation score: | ||
A0A7I2V3L6 | A0A7I2V3L6_HUMAN | Interferon-inducible double-strande... | PRKRA | 106 | Annotation score: | ||
C9JMM3 | C9JMM3_HUMAN | Interferon-inducible double-strande... | PRKRA | 127 | Annotation score: | ||
F8WEG8 | F8WEG8_HUMAN | Interferon-inducible double-strande... | PRKRA | 95 | Annotation score: | ||
A0A7I2V2P4 | A0A7I2V2P4_HUMAN | Interferon-inducible double-strande... | PRKRA | 94 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009948 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11037.1 |
Genome annotation databases
Ensembli | ENST00000424699.5; ENSP00000408029.1; ENSG00000180228.14 ENST00000677253.1; ENSP00000503466.1; ENSG00000180228.14 |
UCSCi | uc061qbw.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009948 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11037.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 34010 |
Genome annotation databases
Ensembli | ENST00000424699.5; ENSP00000408029.1; ENSG00000180228.14 ENST00000677253.1; ENSP00000503466.1; ENSG00000180228.14 |
UCSCi | uc061qbw.1, human |
Organism-specific databases
HGNCi | HGNC:9438, PRKRA |
OpenTargetsi | ENSG00000180228 |
VEuPathDBi | HostDB:ENSG00000180228 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157618 |
OMAi | KKIAKHR |
Miscellaneous databases
ChiTaRSi | PRKRA, human |
Gene expression databases
Bgeei | ENSG00000180228, Expressed in sperm and 242 other tissues |
Family and domain databases
CDDi | cd19889, DSRM_PRKRA_rpt1, 1 hit |
InterProi | View protein in InterPro IPR014720, dsRBD_dom IPR033363, PRKRA IPR044465, PRKRA_DSRM_1 |
PANTHERi | PTHR46205:SF2, PTHR46205:SF2, 1 hit |
Pfami | View protein in Pfam PF00035, dsrm, 1 hit |
SMARTi | View protein in SMART SM00358, DSRM, 1 hit |
PROSITEi | View protein in PROSITE PS50137, DS_RBD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E9Q4_HUMAN | |
Accessioni | G5E9Q4Primary (citable) accession number: G5E9Q4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |