We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - G5E9G1 (G5E9G1_HUMAN)
Protein
Submitted name:
Transient receptor potential cation channel subfamily M member 3
Gene
TRPM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium activated cation channel activity Source: InterPro
GO - Biological processi
- detection of temperature stimulus Source: InterPro
- protein tetramerization Source: InterPro
- sensory perception of temperature stimulus Source: InterPro
Keywordsi
Molecular function | ReceptorImported |
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Transient receptor potential cation channel subfamily M member 3ImportedSubmitted name: Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_aImported |
Gene namesi | Name:TRPM3Imported ORF Names:hCG_2042991Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17992, TRPM3 |
VEuPathDBi | HostDB:ENSG00000083067 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 732 – 751 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 799 – 817 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 829 – 847 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 868 – 888 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 946 – 971 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000083067, Expressed in pigmented layer of retina and 162 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 265 | LSDAT_eukInterPro annotationAdd BLAST | 265 | |
Domaini | 738 – 980 | Ion_transInterPro annotationAdd BLAST | 243 | |
Domaini | 1074 – 1129 | TRPM_tetraInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1293 – 1312 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1445 – 1566 | DisorderedSequence analysisAdd BLAST | 122 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1077 – 1097 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1115 – 1135 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1293 – 1308 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1445 – 1464 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1470 – 1492 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157366 |
OrthoDBi | 738147at2759 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029583, TRPM3 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF7, PTHR13800:SF7, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
G5E9G1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF
60 70 80 90 100
GKGLIKAAMT TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP
110 120 130 140 150
WGIVENQEDL IGRDVVRPYQ TMSNPMSKLT VLNSMHSHFI LADNGTTGKY
160 170 180 190 200
GAEVKLRRQL EKHISLQKIN TRIGQGVPVV ALIVEGGPNV ISIVLEYLRD
210 220 230 240 250
TPPVPVVVCD GSGRASDILA FGHKYSEEGG LINESLRDQL LVTIQKTFTY
260 270 280 290 300
TRTQAQHLFI ILMECMKKKE LITVFRMGSE GHQDIDLAIL TALLKGANAS
310 320 330 340 350
APDQLSLALA WNRVDIARSQ IFIYGQQWPV GSLEQAMLDA LVLDRVDFVK
360 370 380 390 400
LLIENGVSMH RFLTISRLEE LYNTRHGPSN TLYHLVRDVK KREYPGFGWI
410 420 430 440 450
YFKGNLPPDY RISLIDIGLV IEYLMGGAYR CNYTRKRFRT LYHNLFGPKR
460 470 480 490 500
PKALKLLGME DDIPLRRGRK TTKKREEEVD IDLDDPEINH FPFPFHELMV
510 520 530 540 550
WAVLMKRQKM ALFFWQHGEE AMAKALVACK LCKAMAHEAS ENDMVDDISQ
560 570 580 590 600
ELNHNSRDFG QLAVELLDQS YKQDEQLAMK LLTYELKNWS NATCLQLAVA
610 620 630 640 650
AKHRDFIAHT CSQMLLTDMW MGRLRMRKNS GLKVILGILL PPSILSLEFK
660 670 680 690 700
NKDDMPYMSQ AQEIHLQEKE AEEPEKPTKE KEEEDMELTA MLGRNNGESS
710 720 730 740 750
RKKDEEEVQS KHRLIPLGRK IYEFYNAPIV KFWFYTLAYI GYLMLFNYIV
760 770 780 790 800
LVKMERWPST QEWIVISYIF TLGIEKMREI LMSEPGKLLQ KVKVWLQEYW
810 820 830 840 850
NVTDLIAILL FSVGMILRLQ DQPFRSDGRV IYCVNIIYWY IRLLDIFGVN
860 870 880 890 900
KYLGPYVMMI GKMMIDMMYF VIIMLVVLMS FGVARQAILF PNEEPSWKLA
910 920 930 940 950
KNIFYMPYWM IYGEVFADQI DPPCGQNETR EDGKIIQLPP CKTGAWIVPA
960 970 980 990 1000
IMACYLLVAN ILLVNLLIAV FNNTFFEVKS ISNQVWKFQR YQLIMTFHER
1010 1020 1030 1040 1050
PVLPPPLIIF SHMTMIFQHL CCRWRKHESD PDERDYGLKL FITDDELKKV
1060 1070 1080 1090 1100
HDFEEQCIEE YFREKDDRFN SSNDERIRVT SERVENMSMR LEEVNEREHS
1110 1120 1130 1140 1150
MKASLQTVDI RLAQLEDLIG RMATALERLT GLERAESNKI RSRTSSDCTD
1160 1170 1180 1190 1200
AAYIVRQSSF NSQEGNTFKL QESIDPAGEE TMSPTSPTLM PRMRSHSFYS
1210 1220 1230 1240 1250
VNMKDKGGIE KLESIFKERS LSLHRATSSH SVAKEPKAPA APANTLAIVP
1260 1270 1280 1290 1300
DSRRPSSCID IYVSAMDELH CDIDPLDNSV NILGLGEPSF STPVPSTAPS
1310 1320 1330 1340 1350
SSAYATLAPT DRPPSRSIDF EDITSMDTRS FSSDYTHLPE CQNPWDSEPP
1360 1370 1380 1390 1400
MYHTIERSKS SRYLATTPFL LEEAPIVKSH SFMFSPSRSY YANFGVPVKT
1410 1420 1430 1440 1450
AEYTSITDCI DTRCVNAPQA IADRAAFPGG LGDKVEDLTC CHPEREAELS
1460 1470 1480 1490 1500
HPSSDSEENE AKGRRATIAI SSQEGDNSER TLSNNITVPK IERANSYSAE
1510 1520 1530 1540 1550
EPSAPYAHTR KSFSISDKLD RQRNTASLRN PFQRSKSSKP EGRGDSLSMR
1560
RLSRTSAFQS FESKHN
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9HCF6 | TRPM3_HUMAN | Transient receptor potential cation... | TRPM3 KIAA1616, LTRPC3 | 1,732 | Annotation score: | ||
E9PBI7 | E9PBI7_HUMAN | Transient receptor potential cation... | TRPM3 | 1,579 | Annotation score: | ||
A2A3F7 | A2A3F7_HUMAN | Transient receptor potential cation... | TRPM3 | 1,711 | Annotation score: | ||
A2A3F4 | A2A3F4_HUMAN | Transient receptor potential cation... | TRPM3 | 1,569 | Annotation score: | ||
H7BYP1 | H7BYP1_HUMAN | Transient receptor potential cation... | TRPM3 hCG_2042991 | 1,556 | Annotation score: | ||
A2A3F3 | A2A3F3_HUMAN | Transient receptor potential cation... | TRPM3 | 1,566 | Annotation score: | ||
A0A7I2V4E8 | A0A7I2V4E8_HUMAN | Transient receptor potential cation... | TRPM3 | 1,690 | Annotation score: | ||
A0A7I2V4C9 | A0A7I2V4C9_HUMAN | Transient receptor potential cation... | TRPM3 | 1,184 | Annotation score: | ||
H0Y3D4 | H0Y3D4_HUMAN | Transient receptor potential cation... | TRPM3 | 123 | Annotation score: | ||
Q4VXD4 | Q4VXD4_HUMAN | Transient receptor potential cation... | TRPM3 | 275 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL159990 Genomic DNA No translation available. AL160273 Genomic DNA No translation available. AL161913 Genomic DNA No translation available. AL356318 Genomic DNA No translation available. AL358786 Genomic DNA No translation available. AL391819 Genomic DNA No translation available. AL442645 Genomic DNA No translation available. AL592438 Genomic DNA No translation available. KF458923 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62505.1 |
RefSeqi | NP_079247.5, NM_024971.5 |
Genome annotation databases
Ensembli | ENST00000377105; ENSP00000366309; ENSG00000083067 ENST00000408909; ENSP00000386127; ENSG00000083067 |
GeneIDi | 80036 |
UCSCi | uc004ahx.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL159990 Genomic DNA No translation available. AL160273 Genomic DNA No translation available. AL161913 Genomic DNA No translation available. AL356318 Genomic DNA No translation available. AL358786 Genomic DNA No translation available. AL391819 Genomic DNA No translation available. AL442645 Genomic DNA No translation available. AL592438 Genomic DNA No translation available. KF458923 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62505.1 |
RefSeqi | NP_079247.5, NM_024971.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 33927 |
Protocols and materials databases
Antibodypediai | 12418, 163 antibodies from 19 providers |
DNASUi | 80036 |
Genome annotation databases
Ensembli | ENST00000377105; ENSP00000366309; ENSG00000083067 ENST00000408909; ENSP00000386127; ENSG00000083067 |
GeneIDi | 80036 |
UCSCi | uc004ahx.5, human |
Organism-specific databases
CTDi | 80036 |
HGNCi | HGNC:17992, TRPM3 |
OpenTargetsi | ENSG00000083067 |
VEuPathDBi | HostDB:ENSG00000083067 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157366 |
OrthoDBi | 738147at2759 |
Miscellaneous databases
BioGRID-ORCSi | 80036, 3 hits in 1039 CRISPR screens |
ChiTaRSi | TRPM3, human |
GenomeRNAii | 80036 |
Gene expression databases
Bgeei | ENSG00000083067, Expressed in pigmented layer of retina and 162 other tissues |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029583, TRPM3 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF7, PTHR13800:SF7, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E9G1_HUMAN | |
Accessioni | G5E9G1Primary (citable) accession number: G5E9G1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | January 19, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |