UniProtKB - G5E9C7 (G5E9C7_HUMAN)
Protein
Submitted name:
Dual-specificity mitogen-activated protein kinase kinase 2
Gene
MAP2K2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- protein kinase activity Source: InterPro
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Dual-specificity mitogen-activated protein kinase kinase 2ImportedSubmitted name: Mitogen-activated protein kinase kinase 2, isoform CRA_bImported |
Gene namesi | Name:MAP2K2Imported ORF Names:hCG_23544Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126934.13 |
HGNCi | HGNC:6842, MAP2K2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126934, Expressed in testis and 245 other tissues |
ExpressionAtlasi | G5E9C7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 272 | Protein kinaseInterPro annotationAdd BLAST | 272 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 189 – 213 | DisorderedSequence analysisAdd BLAST | 25 |
Phylogenomic databases
GeneTreei | ENSGT00940000153487 |
HOGENOMi | CLU_000288_63_23_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G5E9C7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARKLIHLEI KPAIRNQIIR ELQVLHECNS PYIVGFYGAF YSDGEISICM
60 70 80 90 100
EHMDGGSLDQ VLKEAKRIPE EILGKVSIAV LRGLAYLREK HQIMHRDVKP
110 120 130 140 150
SNILVNSRGE IKLCDFGVSG QLIDSMANSF VGTRSYMAPE RLQGTHYSVQ
160 170 180 190 200
SDIWSMGLSL VELAVGRYPI PPPDAKELEA IFGRPVVDGE EGEPHSISPR
210 220 230 240 250
PRPPGRPVSG HGMDSRPAMA IFELLDYIVN EPPPKLPNGV FTPDFQEFVN
260 270 280 290 300
KCLIKNPAER ADLKMLTNHT FIKRSEVEEV DFAGWLCKTL RLNQPGTPTR
TAV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP36507 | MP2K2_HUMAN | Dual specificity mitogen-activated ... | MAP2K2 MEK2, MKK2, PRKMK2 | 400 | Annotation score: | ||
M0R1B6 | M0R1B6_HUMAN | Dual-specificity mitogen-activated ... | MAP2K2 | 104 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016586 Genomic DNA No translation available. KF511270 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69263.1 |
Genome annotation databases
Ensembli | ENST00000394867; ENSP00000378336; ENSG00000126934 |
UCSCi | uc060rua.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016586 Genomic DNA No translation available. KF511270 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69263.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | G5E9C7 |
PRIDEi | G5E9C7 |
ProteomicsDBi | 33901 |
Protocols and materials databases
Antibodypediai | 3543, 1338 antibodies |
Genome annotation databases
Ensembli | ENST00000394867; ENSP00000378336; ENSG00000126934 |
UCSCi | uc060rua.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126934.13 |
HGNCi | HGNC:6842, MAP2K2 |
OpenTargetsi | ENSG00000126934 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153487 |
HOGENOMi | CLU_000288_63_23_1 |
Miscellaneous databases
ChiTaRSi | MAP2K2, human |
Gene expression databases
Bgeei | ENSG00000126934, Expressed in testis and 245 other tissues |
ExpressionAtlasi | G5E9C7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E9C7_HUMAN | |
Accessioni | G5E9C7Primary (citable) accession number: G5E9C7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | October 7, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |