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Entry version 79 (10 Feb 2021)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Dystrophia myotonica WD repeat-containing protein

Gene

DMWD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dystrophia myotonica WD repeat-containing proteinImported
Submitted name:
Dystrophia myotonica-containing WD repeat motif, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMWDImported
ORF Names:hCG_2039154Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2936, DMWD

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000185800.11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185800

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G5E9A7

PRoteomics IDEntifications database

More...
PRIDEi
G5E9A7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33882

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185800, Expressed in stomach and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5E9A7, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

G5E9A7
With#Exp.IntAct
ABLIM2 - isoform 8 [Q6H8Q1-8]3EBI-10976677,EBI-16436655
ACBD4 - isoform 3 [Q8NC06-3]3EBI-10976677,EBI-12811089
ACD [A0A590TQL1]3EBI-10976677,EBI-23197871
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-10976677,EBI-10173507
AGO2 [Q9UKV8]3EBI-10976677,EBI-528269
ANKRD23 [Q86SG2]3EBI-10976677,EBI-5661893
APLN [D3DTF8]3EBI-10976677,EBI-22002556
ARHGEF38 - isoform 1 [Q9NXL2-1]3EBI-10976677,EBI-18172597
ASB13 [Q8WXK3]3EBI-10976677,EBI-707573
ASB3 - isoform 3 [Q9Y575-3]3EBI-10976677,EBI-14199987
ASB9 [Q96DX5]3EBI-10976677,EBI-745641
ASB9 - isoform 3 [Q96DX5-3]3EBI-10976677,EBI-25843552
ASCL4 [Q6XD76]3EBI-10976677,EBI-10254793
ATP5IF1 [Q9UII2]3EBI-10976677,EBI-718459
BAG6 - isoform 2 [P46379-2]3EBI-10976677,EBI-10988864
BAK1 [Q16611]3EBI-10976677,EBI-519866
BATF [Q16520]3EBI-10976677,EBI-749503
BEX3 [Q00994]3EBI-10976677,EBI-741753
BEX5 [Q5H9J7]3EBI-10976677,EBI-10243741
BRK1 [Q8WUW1]3EBI-10976677,EBI-2837444
BTN3A1 [O00481]3EBI-10976677,EBI-2809309
C12orf74 [Q32Q52]3EBI-10976677,EBI-12891828
C22orf39 [Q6P5X5]3EBI-10976677,EBI-7317823
C8orf48 [Q96LL4]3EBI-10976677,EBI-751596
CBX2 - isoform 2 [Q14781-2]3EBI-10976677,EBI-11974585
CDC23 [Q9UJX2]3EBI-10976677,EBI-396137
CDKN1A [P38936]3EBI-10976677,EBI-375077
CDS2 [O95674]3EBI-10976677,EBI-3913685
CENPV [Q7Z7K6]3EBI-10976677,EBI-1210604
CEP41 - isoform 2 [Q9BYV8-2]3EBI-10976677,EBI-25843412
CEP70 - isoform 3 [Q8NHQ1-3]3EBI-10976677,EBI-11526150
CHMP7 [Q8WUX9]3EBI-10976677,EBI-749253
CNPY3 [Q9BT09]3EBI-10976677,EBI-2835965
COA7 [Q96BR5]3EBI-10976677,EBI-6269632
CRACR2A [Q9BSW2]3EBI-10976677,EBI-739773
CREB5 - isoform 3 [Q02930-3]3EBI-10976677,EBI-10192698
CRLF3 [Q8IUI8]3EBI-10976677,EBI-2872414
CSTA [P01040]3EBI-10976677,EBI-724303
CTNNB1 [P35222]3EBI-10976677,EBI-491549
CTSC [P53634]3EBI-10976677,EBI-1047323
CXorf38 [Q8TB03]3EBI-10976677,EBI-12024320
DAXX [Q9UER7]3EBI-10976677,EBI-77321
DCAF8 - isoform 2 [Q5TAQ9-2]3EBI-10976677,EBI-25842815
DKFZp547K2416 [Q8NDP9]3EBI-10976677,EBI-25842538
DNTTIP1 [Q9H147]3EBI-10976677,EBI-2795449
DPF1 - isoform 2 [Q92782-2]3EBI-10976677,EBI-23669343
EED - isoform 2 [O75530-2]3EBI-10976677,EBI-11132357
EIF3F [O00303]3EBI-10976677,EBI-711990
EPS8L2 [Q9H6S3]3EBI-10976677,EBI-3940939
FABP7 [O15540]3EBI-10976677,EBI-10697159
FAM221A [A4D161]3EBI-10976677,EBI-11960181
FAM221B - isoform 3 [A6H8Z2-3]3EBI-10976677,EBI-25843965
FAM98C [Q17RN3]3EBI-10976677,EBI-5461838
FAM9A [Q8IZU1]3EBI-10976677,EBI-8468186
FANCG [O15287]3EBI-10976677,EBI-81610
FHL5 [Q5TD97]3EBI-10976677,EBI-750641
FNTB [P49356]3EBI-10976677,EBI-602349
FOXR1 [Q6PIV2]3EBI-10976677,EBI-10253815
FZD4 [Q9ULV1]3EBI-10976677,EBI-2466380
GATA1 - isoform 2 [P15976-2]3EBI-10976677,EBI-9090198
GFOD1 [Q9NXC2]3EBI-10976677,EBI-8799578
GMCL2 [Q8NEA9]3EBI-10976677,EBI-745707
GPR141 [Q7Z602]3EBI-10976677,EBI-21649723
GPX7 [Q96SL4]3EBI-10976677,EBI-749411
GUSBP1 [Q15486]3EBI-10976677,EBI-712457
HAND1 [O96004]3EBI-10976677,EBI-11320290
hCG_2001421 [A8K0U2]3EBI-10976677,EBI-25843825
HOXA1 [P49639]3EBI-10976677,EBI-740785
HOXB7 [P09629]3EBI-10976677,EBI-1248457
HOXC4 [P09017]3EBI-10976677,EBI-3923226
ID3 [Q02535]3EBI-10976677,EBI-1387094
IGFBP1 [P08833]3EBI-10976677,EBI-13646303
IGFBP4 [P22692]3EBI-10976677,EBI-2831948
IL16 - isoform 2 [Q14005-2]3EBI-10976677,EBI-17178971
ILF3 [Q9NXX0]3EBI-10976677,EBI-743980
IMPA1 - isoform 3 [P29218-3]3EBI-10976677,EBI-12330251
INKA1 [Q96EL1]3EBI-10976677,EBI-10285157
IQGAP3 [Q86VI3]3EBI-10976677,EBI-1237354
ISCA2 [Q86U28]3EBI-10976677,EBI-10258659
KAT5 - isoform 1 [Q92993-2]3EBI-10976677,EBI-20795332
KCTD17 [Q8N5Z5]3EBI-10976677,EBI-743960
KLHL20 [Q9Y2M5]3EBI-10976677,EBI-714379
KRT33B [Q14525]3EBI-10976677,EBI-1049638
LAPTM4A [Q15012]3EBI-10976677,EBI-723416
LCE2A [Q5TA79]3EBI-10976677,EBI-10246607
LHX5 [Q9H2C1]3EBI-10976677,EBI-25835523
LHX8 [Q68G74]3EBI-10976677,EBI-8474075
LNX1 [Q8TBB1]3EBI-10976677,EBI-739832
LOC401296 [A2RU56]3EBI-10976677,EBI-9088215
LONRF2 [Q1L5Z9]3EBI-10976677,EBI-2510853
MALT1 - isoform 2 [Q9UDY8-2]3EBI-10976677,EBI-12056869
MEOX1 [P50221]3EBI-10976677,EBI-2864512
METTL15 - isoform 4 [A6NJ78-4]3EBI-10976677,EBI-10174029
MLH3 - isoform 2 [Q9UHC1-2]3EBI-10976677,EBI-9089845
MOGAT3 - isoform 3 [Q86VF5-3]3EBI-10976677,EBI-25840143
MPND [Q8N594]3EBI-10976677,EBI-2512452
MSX2 [P35548]3EBI-10976677,EBI-6447480
MTF2 - isoform 4 [Q9Y483-4]3EBI-10976677,EBI-10698053
MYLIP [Q8WY64]3EBI-10976677,EBI-6952711
MYNN [Q9NPC7]3EBI-10976677,EBI-3446748
NBL1 - isoform 2 [P41271-2]3EBI-10976677,EBI-12135485
NDUFA8 [P51970]3EBI-10976677,EBI-1237250
NFX1 [Q12986]3EBI-10976677,EBI-2130062
NR1D2 [Q14995]3EBI-10976677,EBI-6144053
NR1H2 [F1D8P7]3EBI-10976677,EBI-10177172
NR1H3 - isoform 3 [Q13133-3]3EBI-10976677,EBI-11952806
NSMCE2 [Q96MF7]3EBI-10976677,EBI-2557388
NSMF - isoform 6 [Q6X4W1-6]3EBI-10976677,EBI-25842707
NUFIP2 [Q7Z417]3EBI-10976677,EBI-1210753
OLIG3 [Q7RTU3]3EBI-10976677,EBI-10225049
OTUB1 [Q96FW1]3EBI-10976677,EBI-1058491
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-10976677,EBI-25830200
PALM [O75781]3EBI-10976677,EBI-6448827
PARP11 - isoform 4 [Q9NR21-5]3EBI-10976677,EBI-17159452
PARVG [Q9HBI0]3EBI-10976677,EBI-3921217
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-10976677,EBI-11022007
PCMT1 - isoform 2 [P22061-2]3EBI-10976677,EBI-12386584
PCMTD2 [Q9NV79]3EBI-10976677,EBI-6309018
PHF5A [Q7RTV0]3EBI-10976677,EBI-2555365
PIAS1 [O75925]3EBI-10976677,EBI-629434
PIK3R2 [O00459]3EBI-10976677,EBI-346930
PLEKHB1 - isoform 2 [Q9UF11-2]3EBI-10976677,EBI-12832742
PPARA [Q07869]3EBI-10976677,EBI-78615
PPTC7 [Q8NI37]3EBI-10976677,EBI-9089276
PRKAB2 [O43741]3EBI-10976677,EBI-1053424
PRR15 [Q8IV56]3EBI-10976677,EBI-8787485
PSMB10 [P40306]3EBI-10976677,EBI-603329
PXN [Q7Z7K5]3EBI-10976677,EBI-25841978
RAB3IP - isoform 7 [Q96QF0-7]3EBI-10976677,EBI-11984839
RASSF1 - isoform C [Q9NS23-4]3EBI-10976677,EBI-438710
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-10976677,EBI-12123390
RCHY1 - isoform 4 [Q96PM5-4]3EBI-10976677,EBI-21252376
REX1BD [Q96EN9]3EBI-10976677,EBI-745810
RGR - isoform 3 [P47804-3]3EBI-10976677,EBI-25834767
RGS17 [Q9UGC6]3EBI-10976677,EBI-3918154
RING1 [Q06587]3EBI-10976677,EBI-752313
RNF10 [Q8N5U6]3EBI-10976677,EBI-714023
RNF138 [Q8WVD3]3EBI-10976677,EBI-749039
RNF34 [Q969K3]3EBI-10976677,EBI-2340642
RPS4X [P62701]3EBI-10976677,EBI-354303
RUFY4 [Q6ZNE9]3EBI-10976677,EBI-10181525
RXRG [P48443]3EBI-10976677,EBI-712405
RYBP [Q8N488]3EBI-10976677,EBI-752324
SAMD3 - isoform 2 [Q8N6K7-2]3EBI-10976677,EBI-11528848
SDC2 [P34741]3EBI-10976677,EBI-1172957
SDCBP [O00560]3EBI-10976677,EBI-727004
SHFL - isoform 3 [Q9NUL5-3]3EBI-10976677,EBI-22000547
SHLD1 [Q8IYI0]3EBI-10976677,EBI-2560428
SMARCB1 [Q12824]3EBI-10976677,EBI-358419
SNW1 [Q13573]3EBI-10976677,EBI-632715
SOCS4 [Q8WXH5]3EBI-10976677,EBI-3942425
SPAG8 - isoform 2 [Q99932-2]3EBI-10976677,EBI-11959123
SPATA24 - isoform 2 [Q86W54-2]3EBI-10976677,EBI-12041693
SPATA3 [A0A024R4B0]3EBI-10976677,EBI-14123856
SPRED2 [Q7Z698]3EBI-10976677,EBI-7082156
SPRY4 [Q9C004]3EBI-10976677,EBI-354861
SPSB2 [Q99619]3EBI-10976677,EBI-2323209
SRGAP3 [Q8IXS7]3EBI-10976677,EBI-18616594
STAM2 [O75886]3EBI-10976677,EBI-373258
STK36 [Q9NRP7]3EBI-10976677,EBI-863797
STUB1 [Q9UNE7]3EBI-10976677,EBI-357085
TASOR2 [Q5VWN6]3EBI-10976677,EBI-745958
TERF1 - isoform 2 [P54274-2]3EBI-10976677,EBI-711018
TGM2 - isoform 2 [P21980-2]3EBI-10976677,EBI-25842075
TMEM61 [Q8N0U2]3EBI-10976677,EBI-25830583
TMUB2 - isoform 4 [Q71RG4-4]3EBI-10976677,EBI-25831574
TNIP3 [Q96KP6]3EBI-10976677,EBI-2509913
TP53BP1 [Q12888]3EBI-10976677,EBI-396540
TRIB3 [Q96RU7]3EBI-10976677,EBI-492476
TRIM65 [L8E9Q5]3EBI-10976677,EBI-25843781
TRIM69 - isoform 2 [Q86WT6-2]3EBI-10976677,EBI-11525489
TSC1 [Q86WV8]3EBI-10976677,EBI-12806590
TXN [P10599]3EBI-10976677,EBI-594644
UBE2V1 [Q13404]3EBI-10976677,EBI-1050671
UCHL3 [P15374]3EBI-10976677,EBI-954554
USP15 - isoform 2 [Q9Y4E8-2]3EBI-10976677,EBI-12041225
USP2 - isoform 3 [O75604-3]3EBI-10976677,EBI-10696113
USP54 - isoform 6 [Q70EL1-9]3EBI-10976677,EBI-11975223
VHL - isoform 2 [P40337-2]3EBI-10976677,EBI-12157263
VPS37A [Q8NEZ2]3EBI-10976677,EBI-2850578
VPS37A - isoform 2 [Q8NEZ2-2]3EBI-10976677,EBI-10270911
WDR83 [Q9BRX9]3EBI-10976677,EBI-7705033
WWOX - isoform 5 [Q9NZC7-5]3EBI-10976677,EBI-12040603
WWP2 [O00308]3EBI-10976677,EBI-743923
YAF2 - isoform 2 [Q8IY57-5]3EBI-10976677,EBI-12111538
YY1 [P25490]3EBI-10976677,EBI-765538
ZBTB24 - isoform 2 [O43167-2]3EBI-10976677,EBI-25842419
ZFP2 [Q6ZN57]3EBI-10976677,EBI-7236323
ZFPM2 [Q8WW38]3EBI-10976677,EBI-947213
ZKSCAN8 [Q15776]3EBI-10976677,EBI-2602314
ZNF124 [Q15973]3EBI-10976677,EBI-2555767
ZNF165 [P49910]3EBI-10976677,EBI-741694
ZNF180 - isoform 4 [Q9UJW8-4]3EBI-10976677,EBI-12055755
ZNF20 [P17024]3EBI-10976677,EBI-717634
ZNF24 [A0A024RC47]3EBI-10976677,EBI-25830832
ZNF286A [Q9HBT8]3EBI-10976677,EBI-10754950
ZNF345 [Q14585]3EBI-10976677,EBI-2818408
ZNF366 [Q8N895]3EBI-10976677,EBI-2813661
ZNF436 [Q9C0F3]3EBI-10976677,EBI-8489702
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-10976677,EBI-12010736
ZNF460 [Q14592]3EBI-10976677,EBI-2555738
ZNF488 - isoform 2 [Q96MN9-2]3EBI-10976677,EBI-25831733
ZNF497 [Q6ZNH5]3EBI-10976677,EBI-10486136
ZNF57 [Q68EA5]3EBI-10976677,EBI-8490788
ZNF581 [Q9P0T4]3EBI-10976677,EBI-745520
ZNF597 [Q96LX8]3EBI-10976677,EBI-9091553
ZNF641 - isoform 2 [Q96N77-2]3EBI-10976677,EBI-12939666
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-10976677,EBI-18036029
ZSCAN22 [P10073]3EBI-10976677,EBI-10178224
Q7L8T73EBI-10976677,EBI-25831943
Q7Z7833EBI-10976677,EBI-9088990
Q86V283EBI-10976677,EBI-10259496

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G5E9A7, 213 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini280 – 378WD_REPEATS_REGIONInterPro annotationAdd BLAST99
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati322 – 363WDPROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 92DisorderedSequence analysisAdd BLAST62
Regioni103 – 122DisorderedSequence analysisAdd BLAST20
Regioni384 – 419DisorderedSequence analysisAdd BLAST36
Regioni456 – 516DisorderedSequence analysisAdd BLAST61
Regioni532 – 573DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 89Pro-richSequence analysisAdd BLAST39
Compositional biasi532 – 546PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007686

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_005019_2_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320, WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G5E9A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGAEGGS GPGAAMGDCA EIKSQFRTRE GFYKLLPGDG AARRSGPASA
60 70 80 90 100
QTPVPPQPPQ PPPGPASASG PGAAGPASSP PPAGPGPGPA LPAVRLSLVR
110 120 130 140 150
LGEPDSAGAG EPPATPAGLG SGGDRVCFNL GRELYFYPGC CRRGSQRSID
160 170 180 190 200
LNKPIDKRIY KGTQPTCHDF NQFTAATETI SLLVGFSAGQ VQYLDLIKKD
210 220 230 240 250
TSKLFNEERL IDKTKVTYLK WLPESESLFL ASHASGHLYL YNVSHPCASA
260 270 280 290 300
PPQYSLLKQG EGFSVYAAKS KAPRNPLAKW AVGEGPLNEF AFSPDGRHLA
310 320 330 340 350
CVSQDGCLRV FHFDSMLLRG LMKSYFGGLL CVCWSPDGRY VVTGGEDDLV
360 370 380 390 400
TVWSFTEGRV VARGHGHKSW VNAVAFDPYT TRAEEAATAA GADGERSGEE
410 420 430 440 450
EEEEPEAAGT GSAGGAPLSP LPKAGSITYR FGSAGQDTQF CLWDLTEDVL
460 470 480 490 500
YPHPPLARTR TLPGTPGTTP PAASSSRGGE PGPGPLPRSL SRSNSLPHPA
510 520 530 540 550
GGGKAGGPGV AAEPGTPFSI GRFATLTLQE RRDRGAEKEH KRYHSLGNIS
560 570 580 590 600
RGGSGGSGSG GEKPSGPVPR SRLDPAKVLG TALCPRIHEV PLLEPLVCKK
610 620 630 640
IAQERLTVLL FLEDCIITAC QEGLICTWAR PGKAGISSQP GNSPSGTVV
Length:649
Mass (Da):67,702
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94CD9F81F5EBD13B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q09019DMWD_HUMAN
Dystrophia myotonica WD repeat-cont...
DMWD DM9
674Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMW3R4GMW3_HUMAN
Dystrophia myotonica WD repeat-cont...
DMWD
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGU4H0YGU4_HUMAN
Dystrophia myotonica WD repeat-cont...
DMWD
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMZ4R4GMZ4_HUMAN
Dystrophia myotonica WD repeat-cont...
DMWD
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN01R4GN01_HUMAN
Dystrophia myotonica WD repeat-cont...
DMWD
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011530 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57386.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377735; ENSP00000366964; ENSG00000185800

UCSC genome browser

More...
UCSCi
uc021uwc.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011530 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57386.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiG5E9A7, 213 interactors

Proteomic databases

MaxQBiG5E9A7
PRIDEiG5E9A7
ProteomicsDBi33882

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31398, 136 antibodies

Genome annotation databases

EnsembliENST00000377735; ENSP00000366964; ENSG00000185800
UCSCiuc021uwc.2, human

Organism-specific databases

HGNCiHGNC:2936, DMWD
OpenTargetsiENSG00000185800
VEuPathDBiHostDB:ENSG00000185800.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000007686
HOGENOMiCLU_005019_2_1_1

Gene expression databases

BgeeiENSG00000185800, Expressed in stomach and 202 other tissues
ExpressionAtlasiG5E9A7, baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00320, WD40, 4 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5E9A7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E9A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 10, 2021
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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