UniProtKB - G5E9A7 (G5E9A7_HUMAN)
Protein
Submitted name:
Dystrophia myotonica WD repeat-containing protein
Gene
DMWD
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Dystrophia myotonica WD repeat-containing proteinImportedSubmitted name: Dystrophia myotonica-containing WD repeat motif, isoform CRA_aImported |
Gene namesi | Name:DMWDImported ORF Names:hCG_2039154Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185800.11 |
HGNCi | HGNC:2936, DMWD |
Expressioni
Gene expression databases
Bgeei | ENSG00000185800, Expressed in stomach and 202 other tissues |
ExpressionAtlasi | G5E9A7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 280 – 378 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 99 | |
Repeati | 322 – 363 | WDPROSITE-ProRule annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 92 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 103 – 122 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 384 – 419 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 456 – 516 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 532 – 573 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 89 | Pro-richSequence analysisAdd BLAST | 39 | |
Compositional biasi | 532 – 546 | PolyampholyteSequence analysisAdd BLAST | 15 |
Keywords - Domaini
WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000007686 |
HOGENOMi | CLU_005019_2_1_1 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
G5E9A7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGGAEGGS GPGAAMGDCA EIKSQFRTRE GFYKLLPGDG AARRSGPASA
60 70 80 90 100
QTPVPPQPPQ PPPGPASASG PGAAGPASSP PPAGPGPGPA LPAVRLSLVR
110 120 130 140 150
LGEPDSAGAG EPPATPAGLG SGGDRVCFNL GRELYFYPGC CRRGSQRSID
160 170 180 190 200
LNKPIDKRIY KGTQPTCHDF NQFTAATETI SLLVGFSAGQ VQYLDLIKKD
210 220 230 240 250
TSKLFNEERL IDKTKVTYLK WLPESESLFL ASHASGHLYL YNVSHPCASA
260 270 280 290 300
PPQYSLLKQG EGFSVYAAKS KAPRNPLAKW AVGEGPLNEF AFSPDGRHLA
310 320 330 340 350
CVSQDGCLRV FHFDSMLLRG LMKSYFGGLL CVCWSPDGRY VVTGGEDDLV
360 370 380 390 400
TVWSFTEGRV VARGHGHKSW VNAVAFDPYT TRAEEAATAA GADGERSGEE
410 420 430 440 450
EEEEPEAAGT GSAGGAPLSP LPKAGSITYR FGSAGQDTQF CLWDLTEDVL
460 470 480 490 500
YPHPPLARTR TLPGTPGTTP PAASSSRGGE PGPGPLPRSL SRSNSLPHPA
510 520 530 540 550
GGGKAGGPGV AAEPGTPFSI GRFATLTLQE RRDRGAEKEH KRYHSLGNIS
560 570 580 590 600
RGGSGGSGSG GEKPSGPVPR SRLDPAKVLG TALCPRIHEV PLLEPLVCKK
610 620 630 640
IAQERLTVLL FLEDCIITAC QEGLICTWAR PGKAGISSQP GNSPSGTVV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ09019 | DMWD_HUMAN | Dystrophia myotonica WD repeat-cont... | DMWD DM9 | 674 | Annotation score: | ||
R4GMW3 | R4GMW3_HUMAN | Dystrophia myotonica WD repeat-cont... | DMWD | 161 | Annotation score: | ||
H0YGU4 | H0YGU4_HUMAN | Dystrophia myotonica WD repeat-cont... | DMWD | 64 | Annotation score: | ||
R4GMZ4 | R4GMZ4_HUMAN | Dystrophia myotonica WD repeat-cont... | DMWD | 149 | Annotation score: | ||
R4GN01 | R4GN01_HUMAN | Dystrophia myotonica WD repeat-cont... | DMWD | 102 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011530 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57386.1 |
Genome annotation databases
Ensembli | ENST00000377735; ENSP00000366964; ENSG00000185800 |
UCSCi | uc021uwc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011530 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57386.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | G5E9A7, 3 interactors |
Proteomic databases
MaxQBi | G5E9A7 |
PRIDEi | G5E9A7 |
ProteomicsDBi | 33882 |
Protocols and materials databases
Antibodypediai | 31398, 136 antibodies |
Genome annotation databases
Ensembli | ENST00000377735; ENSP00000366964; ENSG00000185800 |
UCSCi | uc021uwc.2, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185800.11 |
HGNCi | HGNC:2936, DMWD |
OpenTargetsi | ENSG00000185800 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000007686 |
HOGENOMi | CLU_005019_2_1_1 |
Gene expression databases
Bgeei | ENSG00000185800, Expressed in stomach and 202 other tissues |
ExpressionAtlasi | G5E9A7, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E9A7_HUMAN | |
Accessioni | G5E9A7Primary (citable) accession number: G5E9A7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | October 7, 2020 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |