UniProtKB - G5E968 (G5E968_HUMAN)
Protein
Submitted name:
Chromogranin A (Parathyroid secretory protein 1), isoform CRA_b
Gene
CHGA
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Chromogranin A (Parathyroid secretory protein 1), isoform CRA_bImportedSubmitted name: Chromogranin-AImported |
Gene namesi | Name:CHGAImported ORF Names:hCG_21274Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100604.12 |
HGNCi | HGNC:1929, CHGA |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- secretory granule Source: InterPro
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5014092027 | 19 – 306 | Sequence analysisAdd BLAST | 288 |
Keywords - PTMi
Disulfide bondARBA annotation, SulfationARBA annotationProteomic databases
PRIDEi | G5E968 |
ProteomicsDBi | 33848 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100604, Expressed in type B pancreatic cell and 169 other tissues |
ExpressionAtlasi | G5E968, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 88 – 287 | DisorderedSequence analysisAdd BLAST | 200 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 88 – 104 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 134 – 160 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 171 – 222 | PolyampholyteSequence analysisAdd BLAST | 52 | |
Compositional biasi | 262 – 287 | PolyampholyteSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the chromogranin/secretogranin protein family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154206 |
HOGENOMi | CLU_050861_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR001819, Chromogranin_AB IPR018054, Chromogranin_CS IPR001990, Granin |
PANTHERi | PTHR10583, PTHR10583, 2 hits |
Pfami | View protein in Pfam PF01271, Granin, 2 hits |
PRINTSi | PR00659, CHROMOGRANIN |
PROSITEi | View protein in PROSITE PS00422, GRANINS_1, 1 hit PS00423, GRANINS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G5E968-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM
60 70 80 90 100
PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF
110 120 130 140 150
EDELSEVLEN QSSQAELKGR SEALAVDGAG KPGAEEAQDP EGKGEQEHSQ
160 170 180 190 200
QKEEEEEMAV VPQGLFRGGK SGELEQEEER LSKEWEDSKR WSKMDQLAKE
210 220 230 240 250
LTAEKRLEGQ EEEEDNRDSS MKLSFRARAY GFRGPGPQLR RGWRPSSRED
260 270 280 290 300
SLEAGLPLQV RGYPEEKKEE EGSANRRPED QELESLSAIE AELEKVAHQL
QALRRG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP10645 | CMGA_HUMAN | Chromogranin-A | CHGA | 457 | Annotation score: | ||
G3V2Q7 | G3V2Q7_HUMAN | Chromogranin-A | CHGA | 38 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117192 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81506.1 |
RefSeqi | NP_001288619.1, NM_001301690.1 |
Genome annotation databases
Ensembli | ENST00000334654; ENSP00000334023; ENSG00000100604 ENST00000630996; ENSP00000486710; ENSG00000276781 |
GeneIDi | 1113 |
UCSCi | uc001ybd.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117192 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81506.1 |
RefSeqi | NP_001288619.1, NM_001301690.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | G5E968 |
ProteomicsDBi | 33848 |
Protocols and materials databases
Antibodypediai | 738, 2852 antibodies |
Genome annotation databases
Ensembli | ENST00000334654; ENSP00000334023; ENSG00000100604 ENST00000630996; ENSP00000486710; ENSG00000276781 |
GeneIDi | 1113 |
UCSCi | uc001ybd.6, human |
Organism-specific databases
CTDi | 1113 |
EuPathDBi | HostDB:ENSG00000100604.12 |
HGNCi | HGNC:1929, CHGA |
OpenTargetsi | ENSG00000100604 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154206 |
HOGENOMi | CLU_050861_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 1113, 169 hits in 842 CRISPR screens |
ChiTaRSi | CHGA, human |
GenomeRNAii | 1113 |
Gene expression databases
Bgeei | ENSG00000100604, Expressed in type B pancreatic cell and 169 other tissues |
ExpressionAtlasi | G5E968, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001819, Chromogranin_AB IPR018054, Chromogranin_CS IPR001990, Granin |
PANTHERi | PTHR10583, PTHR10583, 2 hits |
Pfami | View protein in Pfam PF01271, Granin, 2 hits |
PRINTSi | PR00659, CHROMOGRANIN |
PROSITEi | View protein in PROSITE PS00422, GRANINS_1, 1 hit PS00423, GRANINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E968_HUMAN | |
Accessioni | G5E968Primary (citable) accession number: G5E968 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |