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Protein

Claudin

Gene

Cldn20

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:Cldn20Imported
ORF Names:mCG_52371Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3646757 Cldn20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 105HelicalUniRule annotationAdd BLAST24
Transmembranei117 – 139HelicalUniRule annotationAdd BLAST23
Transmembranei163 – 186HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501509191424 – 219ClaudinSequence analysisAdd BLAST196

Expressioni

Gene expression databases

BgeeiENSMUSG00000091530 Expressed in 18 organ(s), highest expression level in embryonic stem cell

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126169

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJXC Eukaryota
ENOG410XTF5 LUCA
GeneTreeiENSGT00760000118928
KOiK06087
OMAiCTLKYSI
OrthoDBiEOG091G0MX2
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

G5E8X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAGLQLLA FILAVSGVSG VLAATLLPNW KVNAYAGPNI VTAVVQVQGL
60 70 80 90 100
WVDCTWYSTG MFSCTLKYSI LSLPVHVQTA RATMVLACVL SAWGICTSIA
110 120 130 140 150
GMNCTHLGGD THTKSKISFA GGVCFITAGI SGLIPTVWYT KEIIANFLDL
160 170 180 190 200
TIPESHKYEP GGALYIGFIS AMLLLISGVI FCTSYIQKNQ EPWIYPPKQK
210
LSTTWQPKNR RAHNLKDYM
Length:219
Mass (Da):23,754
Last modified:December 14, 2011 - v1
Checksum:i9C643DB341D6E39F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122350 Genomic DNA No translation available.
CH466633 Genomic DNA Translation: EDL01645.1
RefSeqiNP_001095030.1, NM_001101560.1
UniGeneiMm.469914

Genome annotation databases

EnsembliENSMUST00000168560; ENSMUSP00000126169; ENSMUSG00000091530
GeneIDi621628
KEGGimmu:621628
UCSCiuc012ajf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122350 Genomic DNA No translation available.
CH466633 Genomic DNA Translation: EDL01645.1
RefSeqiNP_001095030.1, NM_001101560.1
UniGeneiMm.469914

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126169

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168560; ENSMUSP00000126169; ENSMUSG00000091530
GeneIDi621628
KEGGimmu:621628
UCSCiuc012ajf.1 mouse

Organism-specific databases

CTDi49861
MGIiMGI:3646757 Cldn20

Phylogenomic databases

eggNOGiENOG410IJXC Eukaryota
ENOG410XTF5 LUCA
GeneTreeiENSGT00760000118928
KOiK06087
OMAiCTLKYSI
OrthoDBiEOG091G0MX2
TreeFamiTF331936

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091530 Expressed in 18 organ(s), highest expression level in embryonic stem cell

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5E8X0_MOUSE
AccessioniPrimary (citable) accession number: G5E8X0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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