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Protein
Submitted name:

E3 ubiquitin-protein ligase TTC3

Gene

Ttc3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase TTC3Imported
Submitted name:
Tetratricopeptide repeat domain 3, isoform CRA_bImported
Gene namesi
Name:Ttc3Imported
ORF Names:mCG_19601Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1276539 Ttc3

Expressioni

Gene expression databases

BgeeiENSMUSG00000040785 Expressed in 340 organ(s), highest expression level in central nervous system

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 332TPR_REGIONInterPro annotationAdd BLAST102
Repeati231 – 264TPRPROSITE-ProRule annotationAdd BLAST34
Repeati265 – 298TPRPROSITE-ProRule annotationAdd BLAST34
Domaini536 – 609TPR_REGIONInterPro annotationAdd BLAST74
Repeati576 – 609TPRPROSITE-ProRule annotationAdd BLAST34
Domaini1931 – 1970RING-typeInterPro annotationAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili336 – 356Sequence analysisAdd BLAST21
Coiled coili766 – 786Sequence analysisAdd BLAST21
Coiled coili1476 – 1496Sequence analysisAdd BLAST21
Coiled coili1501 – 1528Sequence analysisAdd BLAST28
Coiled coili1533 – 1567Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JR26 Eukaryota
ENOG41103HK LUCA
GeneTreeiENSGT00530000063254
KOiK15712
OMAiCCYQKCH
OrthoDBiEOG091G00EM
TreeFamiTF333981

Family and domain databases

Gene3Di1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 25 potential isoforms that are computationally mapped.Show allAlign All

G5E8T2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDFAEGGLS LADDILLEDY PYEDDCICTP DFTTDDYVRV TQLYYEGVGM
60 70 80 90 100
QYKDYAQSEK NLEYDICNIW CSKPLSILQD YCDAIKLYIF WPLLFQHQHS
110 120 130 140 150
SIISRLHPCV EAIRSRAAEI SLKKLQHLEL MEDIVDLAKK VANDSFLIEG
160 170 180 190 200
LLKIGYKIEN KILAMEDALN WIKYTGDVTI LPKLGSVDNC WPMLSIFFTE
210 220 230 240 250
YKYHITRVVT ENCNLLEEFR RHSCMQCVKQ GELMKMRGNE EFSKEKFEIA
260 270 280 290 300
VIYYTRAIEY RPENHLLYGN RALCFLRMGQ FRNALSDGKR AIVLKNTWPK
310 320 330 340 350
GHYRYCDALC MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI
360 370 380 390 400
EDLQGRTSNK NPIKAFYESR AYIPRNSSAP AFRTSLNFVE TERGFRKTKY
410 420 430 440 450
KMANGGDQNQ KVADEALKGD DCDCHPEFLP PPSQPPRHKG KQKSRNNESE
460 470 480 490 500
KPSSNSEVSL QVDLKSILEK QFSKSSRAAH QDFANIMKML RSLIQDGYTA
510 520 530 540 550
LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAVSLLGIG
560 570 580 590 600
RPEELSEAEN QFKRIIEHYP NEGLDCLAYC GIGKVYLKKN RFLEALNHFE
610 620 630 640 650
KAKTLISRLP GILTWPTSNV IIEESKPEKV KVMLEKFVEE CKFPPVPDAV
660 670 680 690 700
CCYQKCRGYS KIQIYLTDPD FKGFIRISCC QYCKVEFHMN CWKKLKTTTF
710 720 730 740 750
NDKIDKDFLQ GICLTPDCEG IISKIIIYSS GGQVKCEFEH KVIKEKVPSR
760 770 780 790 800
PVLKQKCSSL EKLRLKEDKK LKRKIQKQEA KKLAQERMEE DLRESNPPKN
810 820 830 840 850
EEPEETSDSA QRCQFLDDRI LQCIKQNADK IKSVVLNTST LLKELLSWKV
860 870 880 890 900
LSTEDYTTCF SSKNFVHEAV DYVIGHLIQE KNRVKTRIFL HVLSELKELD
910 920 930 940 950
PKLAPWIQRL NSFGLDAIGP FFTRYGASLK ELDFHVVTVL WDEKYGHKLG
960 970 980 990 1000
SIEGKQLDYF FEPASAMEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR
1010 1020 1030 1040 1050
CTVLRKQDSD EMPFGCIKVK NKGKKKKPKD SKPMLVGSGA ASVAPSSEAV
1060 1070 1080 1090 1100
TPEDHSRRNS DSAGPFAVPD HLRQDVEEFE ALYDQHSSEY VVRNKKLWDI
1110 1120 1130 1140 1150
NPKQKCSTLY DYFSQLLEEH GPLDMSDRMF SEEYEFFPEE TRQILEKAGG
1160 1170 1180 1190 1200
LKSFLLGCPR FVVIDNCIAL KKVASRLKKK RKKKNMKAKV EDISKTGEYL
1210 1220 1230 1240 1250
RVKLPLNPTA REFQPDVKSE ALSEDVKSIP GPADSSTLAA EDLKAQLDSD
1260 1270 1280 1290 1300
SSSGSASEDS RLEVASPDSP TPLCEDASPS PTPAPEEAKP TYWAQSHLVT
1310 1320 1330 1340 1350
GFCTYLPFQG FGITQRPAYI NMVPSLSQFT SIYTPLANIS SEYPMQRSMP
1360 1370 1380 1390 1400
VVPSFVASNR ADENAAAYFE SPNLNTEHDS GDHMASETQI LEDTLGVCVR
1410 1420 1430 1440 1450
SQGSAADADP ALSEPEGNSE HSGSSDSLWE ASLENVSGTT DAPAAPSVAI
1460 1470 1480 1490 1500
QVSRSMVHQE VNTEPYEPFE TQQGDLSQKE KECHLLREQL KVACENCEQI
1510 1520 1530 1540 1550
ELRSSQEIKD LEEKLQRHTE ENKISKTELD WFLQDLDREI KKWQQEKKEI
1560 1570 1580 1590 1600
QERLKALKKK IKKVINTSEM PAQKNDGFDK ECEPHPDQSL GFSSALTDEK
1610 1620 1630 1640 1650
TKVEESVRKG KELYEESHQR AVAAEVSVLE NWKEREVCKL QGVASQSEAY
1660 1670 1680 1690 1700
LKSLKLMSSD SATYPDVEYD ILSWESFLST VREEIESKKS QFEEHIKAIK
1710 1720 1730 1740 1750
NGSRLSDLSS VQLSEVSFPG CSTIHPQFLS ESSGHEDPGL VACVDSMTGA
1760 1770 1780 1790 1800
VLNDPYMDSA SGCPEEVPEL SLGSPTHQPE VTQQLELKGA SQVSPSEQSP
1810 1820 1830 1840 1850
EADEKLSGQA TRSSQSPKKP SNSIIEHLSV IFPCYTSTEL AGFIKKVRNK
1860 1870 1880 1890 1900
TKNSFSGLTI EEIVEKVTEH IVDEQKKKKP NPGKDKKTSE AHSAASVAKS
1910 1920 1930 1940 1950
SQSPPLAAAG PSARTKGQKK DDVPAPDGNS CEICHEIFKS KNMRVLKCGH
1960 1970
KFHKGCFKQW LKGQSTCPTC GSSDLLSEE
Length:1,979
Mass (Da):223,909
Last modified:December 14, 2011 - v1
Checksum:iE690ED4F28566235
GO

Computationally mapped potential isoform sequencesi

There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O88196TTC3_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3 Kiaa4119
1,979Annotation score:
D3Z485D3Z485_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
622Annotation score:
A0A0R4J1T2A0A0R4J1T2_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
776Annotation score:
D3Z502D3Z502_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
128Annotation score:
D3Z2K0D3Z2K0_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
382Annotation score:
D6RDD2D6RDD2_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
1,162Annotation score:
D6RD03D6RD03_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
1,179Annotation score:
D6RHT6D6RHT6_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
1,135Annotation score:
D6RFU5D6RFU5_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
1,197Annotation score:
A0A338P6W3A0A338P6W3_MOUSE
E3 ubiquitin-protein ligase TTC3
Ttc3
1,624Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC173208 Genomic DNA No translation available.
CH466602 Genomic DNA Translation: EDL03730.1
RefSeqiNP_033467.2, NM_009441.2
XP_011244415.1, XM_011246113.2
UniGeneiMm.213408

Genome annotation databases

EnsembliENSMUST00000117648; ENSMUSP00000112801; ENSMUSG00000040785
ENSMUST00000232395; ENSMUSP00000156023; ENSMUSG00000040785
ENSMUST00000232660; ENSMUSP00000156151; ENSMUSG00000040785
GeneIDi22129
KEGGimmu:22129
UCSCiuc008aav.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC173208 Genomic DNA No translation available.
CH466602 Genomic DNA Translation: EDL03730.1
RefSeqiNP_033467.2, NM_009441.2
XP_011244415.1, XM_011246113.2
UniGeneiMm.213408

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117648; ENSMUSP00000112801; ENSMUSG00000040785
ENSMUST00000232395; ENSMUSP00000156023; ENSMUSG00000040785
ENSMUST00000232660; ENSMUSP00000156151; ENSMUSG00000040785
GeneIDi22129
KEGGimmu:22129
UCSCiuc008aav.1 mouse

Organism-specific databases

CTDi7267
MGIiMGI:1276539 Ttc3

Phylogenomic databases

eggNOGiENOG410JR26 Eukaryota
ENOG41103HK LUCA
GeneTreeiENSGT00530000063254
KOiK15712
OMAiCCYQKCH
OrthoDBiEOG091G00EM
TreeFamiTF333981

Miscellaneous databases

ChiTaRSiTtc3 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040785 Expressed in 340 organ(s), highest expression level in central nervous system

Family and domain databases

Gene3Di1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5E8T2_MOUSE
AccessioniPrimary (citable) accession number: G5E8T2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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