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Entry version 54 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein

Adhesion G protein-coupled receptor F5

Gene

Adgrf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that plays a critical role in lung surfactant homeostasis (PubMed:23590306, PubMed:23922714, PubMed:23684610). May play a role in controlling adipocyte function (PubMed:22971422).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5683826 Surfactant metabolism

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.032

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor F5
Alternative name(s):
G-protein coupled receptor 116
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgrf5
Synonyms:Gpr116
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2182928 Adgrf5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1019ExtracellularCuratedAdd BLAST998
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1020 – 1040HelicalSequence analysisAdd BLAST21
Topological domaini1041 – 1055CytoplasmicCuratedAdd BLAST15
Transmembranei1056 – 1076HelicalSequence analysisAdd BLAST21
Topological domaini1077 – 1092ExtracellularCuratedAdd BLAST16
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Topological domaini1114 – 1130CytoplasmicCuratedAdd BLAST17
Transmembranei1131 – 1151HelicalSequence analysisAdd BLAST21
Topological domaini1152 – 1175ExtracellularCuratedAdd BLAST24
Transmembranei1176 – 1196HelicalSequence analysisAdd BLAST21
Topological domaini1197 – 1221CytoplasmicCuratedAdd BLAST25
Transmembranei1222 – 1242HelicalSequence analysisAdd BLAST21
Topological domaini1243 – 1250ExtracellularCurated8
Transmembranei1251 – 1271HelicalSequence analysisAdd BLAST21
Topological domaini1272 – 1348CytoplasmicCuratedAdd BLAST77

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice exhibit premature death, decreased body weight and respiratory distress associated with pulmonary alveolar proteinosis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043356422 – 1348Adhesion G protein-coupled receptor F5Add BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi291 ↔ 348PROSITE-ProRule annotation
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi389 ↔ 447PROSITE-ProRule annotation
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi490 ↔ 543PROSITE-ProRule annotation
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei818PhosphoserineBy similarity1
Modified residuei1302PhosphothreonineCombined sources1
Modified residuei1309PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved at multiple sites: one in the GPS domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin.By similarity
Highly glycosylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei51 – 52Cleavage; by furinBy similarity2
Sitei223 – 224CleavageBy similarity2
Sitei992 – 993CleavageBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
G5E8Q8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G5E8Q8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5E8Q8

PeptideAtlas

More...
PeptideAtlasi
G5E8Q8

PRoteomics IDEntifications database

More...
PRIDEi
G5E8Q8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G5E8Q8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
G5E8Q8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed and highly expressed in the lung. In the lung predominantly expressed in the alveolar type II epithelial cells.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056492 Expressed in 231 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5E8Q8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
G5E8Q8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Fragment generates by the processing enzyme furin remains attached to the extracellular N-terminal fragment. Interacts (via N-terminal extracellular domain) with SFTPD (PubMed:23922714).By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109229

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 271SEAPROSITE-ProRule annotationAdd BLAST109
Domaini268 – 366Ig-like 1PROSITE-ProRule annotationAdd BLAST99
Domaini367 – 464Ig-like 2PROSITE-ProRule annotationAdd BLAST98
Domaini469 – 559Ig-like 3PROSITE-ProRule annotationAdd BLAST91
Domaini950 – 1004GPSPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi52 – 55Poly-AlaSequence analysis4
Compositional biasi1284 – 1345Ser-richPROSITE-ProRule annotationAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154603

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
G5E8Q8

KEGG Orthology (KO)

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KOi
K08458

Database of Orthologous Groups

More...
OrthoDBi
611778at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008078 GPCR_2_Ig-hepta-like_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
PF01390 SEA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN
PR01695 IGHEPTARCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits
SSF82671 SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 3 hits
PS50024 SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

G5E8Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSPRTFTFY FLLLVICSSE AALSTPTEPI VQPSILQEHE LAGEELLRPK
60 70 80 90 100
RAAAAGDRVA EEYMVDIEIS FENVSFLESI RAHLNNLSFP IRGTEADILN
110 120 130 140 150
IAMTTVCTPA GNDLLCFCEK GYQWSEERCL HSLTCQDYDS ALPGGYCSCL
160 170 180 190 200
KGLPPQGPFC QLPEAFITLK LKVRLNIGFQ EDLKNTSSAL YRSYKTDLER
210 220 230 240 250
AFRAGYRTLP GFRSVTVTQF TKGSVVVNYV VRVTSAPLPG SIHKANEQVI
260 270 280 290 300
QNLNHTYKMD YNSFQGTPSN ETKFTVIPEF IFEGDNVTLE CETEFVTSNT
310 320 330 340 350
SWYYGEKRSD IQNSDKYSIH TTVINNISLI TRLTIYNFTQ HDAGMYGCNV
360 370 380 390 400
TLDIFEYGTV RKLDVTPIRI LAKEERKVVC DNHPISLNCC SENIANWSSI
410 420 430 440 450
EWKQEGKISI LGNPESDLES SCSTYTLKAD GTQCPSGSSG TTVIYTCEFV
460 470 480 490 500
SAYGARGSKN IAVTFTSVAN LTITRDPISV SEGQSFSITC LSDVSSFDEV
510 520 530 540 550
YWNTSAGIKI HPRFYTMRRY QDGAESVLMV KTSTREWNGT YHCIFRYKNS
560 570 580 590 600
YSIATKDVTV HPLPLVSDIM MDPLEASGLC TSSHQFKCCV EEDAGEEYAV
610 620 630 640 650
TFHVDSSSFP AEREVIGKQA CYTYSLPANL PRCPKDIAVF CHFTNAANSS
660 670 680 690 700
VRSPSMKLKL IPRENVTCQD PIIGIGDPGK VIQKLCQFSG VYGSPGQAIG
710 720 730 740 750
GTVTYKCVGT QWKEESRACI SAPINGLLQV AKALIKSPTQ DQKLPTYLRD
760 770 780 790 800
LSVSAGKEEQ DIRSSPGSLG AIISILDLLS TVPTQVNSEM MRDILATINV
810 820 830 840 850
ILDKSALNSW EKLLQQQSNQ SSQFLHSVER FSQALQLGDS TPPFLAHPNV
860 870 880 890 900
QMKSMVIKRG HPQIYQQQFI FKDSDLWGDV AIDECQLGNL QPDSSIVTVA
910 920 930 940 950
FPTLKAILAQ DVQRKTSSNS LVMTTTVSHN IVKPFRISMT FKNNHRSGGK
960 970 980 990 1000
PQCVFWNFSL ANNTGGWDSS GCSVEDDGRD NRDRVFCKCN HLTSFSILMS
1010 1020 1030 1040 1050
PDSPDPGSLL KILLDIISYI GLGFSIVSLA ACLVVEAMVW KSVTKNRTSY
1060 1070 1080 1090 1100
MRHICIVNIA FCLLIADIWF IVAGAIHDGR YPLNETACVA ATFFIHFFYL
1110 1120 1130 1140 1150
SVFFWMLTLG LMLFYRLIFI LHDASKSTQK AIAFSLGYGC PLIISSITVG
1160 1170 1180 1190 1200
VTQPQEVYMR KNACWLNWED TRALLAFAIP ALIIVVVNVS ITVVVITKIL
1210 1220 1230 1240 1250
RPSIGDKPGK QEKSSLFQIS KSIGVLTPLL GLTWGFGLAT VIQGSNAVFH
1260 1270 1280 1290 1300
IIFTLLNAFQ GLFILLFGCL WDQKVQEALL HKFSLSRWSS QHSKSTSIGS
1310 1320 1330 1340
STPVFSMSSP ISRRFNNLFG KTGTYNVSTP ETTSSSLENS SSAYSLLN
Length:1,348
Mass (Da):149,387
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC2CDA96C63B7018
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDT5A0A286YDT5_MOUSE
Adhesion G protein-coupled receptor...
Adgrf5
1,143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YD74A0A286YD74_MOUSE
Adhesion G protein-coupled receptor...
Adgrf5
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YE42A0A286YE42_MOUSE
Adhesion G protein-coupled receptor...
Adgrf5
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCD3A0A286YCD3_MOUSE
Adhesion G protein-coupled receptor...
Adgrf5
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC169504 Genomic DNA No translation available.
CT010585 Genomic DNA No translation available.
CT025700 Genomic DNA No translation available.
CH466559 Genomic DNA Translation: EDL23401.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37622.1

NCBI Reference Sequences

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RefSeqi
NP_001074647.1, NM_001081178.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000113599; ENSMUSP00000109229; ENSMUSG00000056492
ENSMUST00000226087; ENSMUSP00000153049; ENSMUSG00000056492

Database of genes from NCBI RefSeq genomes

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GeneIDi
224792

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:224792

UCSC genome browser

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UCSCi
uc008cpa.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC169504 Genomic DNA No translation available.
CT010585 Genomic DNA No translation available.
CT025700 Genomic DNA No translation available.
CH466559 Genomic DNA Translation: EDL23401.1
CCDSiCCDS37622.1
RefSeqiNP_001074647.1, NM_001081178.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109229

Protein family/group databases

MEROPSiP02.032

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiG5E8Q8
PhosphoSitePlusiG5E8Q8

Proteomic databases

jPOSTiG5E8Q8
MaxQBiG5E8Q8
PaxDbiG5E8Q8
PeptideAtlasiG5E8Q8
PRIDEiG5E8Q8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113599; ENSMUSP00000109229; ENSMUSG00000056492
ENSMUST00000226087; ENSMUSP00000153049; ENSMUSG00000056492
GeneIDi224792
KEGGimmu:224792
UCSCiuc008cpa.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221395
MGIiMGI:2182928 Adgrf5

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000154603
InParanoidiG5E8Q8
KOiK08458
OrthoDBi611778at2759
TreeFamiTF316380

Enzyme and pathway databases

ReactomeiR-MMU-5683826 Surfactant metabolism

Miscellaneous databases

Protein Ontology

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PROi
PR:G5E8Q8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000056492 Expressed in 231 organ(s), highest expression level in right lung
ExpressionAtlasiG5E8Q8 baseline and differential
GenevisibleiG5E8Q8 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008078 GPCR_2_Ig-hepta-like_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
PF01390 SEA, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01695 IGHEPTARCPTR
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 3 hits
PS50024 SEA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRF5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E8Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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