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Entry version 75 (29 Sep 2021)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Lysosomal-trafficking regulator

Gene

Lyst

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lysosomal-trafficking regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LystImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107448, Lyst

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000019726

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5E8Q0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
G5E8Q0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G5E8Q0

PeptideAtlas

More...
PeptideAtlasi
G5E8Q0

PRoteomics IDEntifications database

More...
PRIDEi
G5E8Q0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
343305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019726, Expressed in granulocyte and 156 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5E8Q0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2995 – 3101BEACH-type PHInterPro annotationAdd BLAST107
Domaini3106 – 3408BEACHInterPro annotationAdd BLAST303
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3598 – 3632WDPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 180DisorderedSequence analysisAdd BLAST33
Regioni198 – 217DisorderedSequence analysisAdd BLAST20
Regioni1169 – 1196DisorderedSequence analysisAdd BLAST28
Regioni1213 – 1240DisorderedSequence analysisAdd BLAST28
Regioni1485 – 1520DisorderedSequence analysisAdd BLAST36
Regioni2176 – 2220DisorderedSequence analysisAdd BLAST45
Regioni2555 – 2580DisorderedSequence analysisAdd BLAST26
Regioni2658 – 2680DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili350 – 370Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 173Polar residuesSequence analysisAdd BLAST15
Compositional biasi1214 – 1233Acidic residuesSequence analysisAdd BLAST20
Compositional biasi1485 – 1517Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi2186 – 2216Basic and acidic residuesSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156359

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000213_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFNQHRI

Database of Orthologous Groups

More...
OrthoDBi
101142at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5E8Q0

TreeFam database of animal gene trees

More...
TreeFami
TF313658

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06071, Beach, 1 hit
cd01201, PH_BEACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1540.10, 1 hit
2.130.10.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR030464, LYST
IPR023362, PH-BEACH_dom
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13743:SF86, PTHR13743:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02138, Beach, 1 hit
PF14844, PH_BEACH, 1 hit
PF00400, WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026, Beach, 1 hit
SM00320, WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G5E8Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTDSNSLAR EFLIDVNQLC NAVVQRAEAR EEEEEETHMA TLGQYLVHGR
60 70 80 90 100
GFLLLTKLNS IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPL
110 120 130 140 150
SSDIILTKEK NSSLQKSTQG KLYLEGSAPS GQVSAKVNLF RKIRRQRKST
160 170 180 190 200
HRYSVRDARK TQLSTSDSEG NSDEKSTVVS KHRRLHALPR FLTQSPKEGH
210 220 230 240 250
LVAKPDPSAT KEQVLSDTMS VENSREVILR QDSNGDILSE PAALSILSNM
260 270 280 290 300
NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LALSVVPTLT EFLAGFGDCC
310 320 330 340 350
NQSDTLEGQL VSAGWTEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR
360 370 380 390 400
KNLTELLRAA LKIRACLEKQ PEPFSPRQKK TLQEVQEGFV FSKYRHRALL
410 420 430 440 450
LPELLEGVLQ LLISCLQSAA SNPFYFSQAM DLVQEFIQHQ GFNLFETAVL
460 470 480 490 500
QMEWLLSRDG VPSEAAEHLK ALINSVIKIM STVKKVKSEQ LHHSMCTRKR
510 520 530 540 550
HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD VQYPERCCCI
560 570 580 590 600
AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIVPLLHAFK
610 620 630 640 650
LPALKAFQQH ILNVLSKLLL DQLGGAELSP RIKKAACNIC TVDSDQLAKL
660 670 680 690 700
GETLQGTLCG AGPTSGLPSP SYRFQGILPS SGSEDLLWKW DALEAYQSFV
710 720 730 740 750
FQEDRLHNIQ IANHICNLIQ KGNVVVQWKL YNYIFNPVLQ RGVELVHHCQ
760 770 780 790 800
QLSIPSAQTH MCSQLKQYLP QEVLQIYLKT LPVLLKSRVI RDLFLSCNGV
810 820 830 840 850
NQIIELNYLD GIRSHSLKAF ETLIVSLGEQ QKDAAVLDVD GLDIQQELPS
860 870 880 890 900
LSVGPSLHKQ QASSDSPCSL RKFYASLREP DPKKRKTIHQ DVHINTINLF
910 920 930 940 950
LCVAFLCVSK EADSDRESAN ESEDTSGYDS TASEPLSHML PCLSLENVVL
960 970 980 990 1000
PSPECLHHAA DIWSMCRWIY MLNSVFQKQF HRLGGFQVCH ELIFMIIQKL
1010 1020 1030 1040 1050
FRSHTEDQGR RQGEMSRNEN QELIRISYPE LTLKGDVSSA TAPDLGFLRK
1060 1070 1080 1090 1100
SADSVRGFQS QPVLPTSAEQ IVATESVPGE RKAFMSQQSE TSLQSIRLLE
1110 1120 1130 1140 1150
SLLAICLHSA RACQQKMELE LPSQGLSVEN ILCELREHLS QSKVAETELA
1160 1170 1180 1190 1200
KPLFDALLRV ALGNHSADLG PGDAVTEKSH PSEEELLSQP GDFSEEAEDS
1210 1220 1230 1240 1250
QCCSLKLLGE EEGYEADSES NPEDVDTQDD GVELNPEAEG FSGSIVSNNL
1260 1270 1280 1290 1300
LENLTHGEII YPEICMLGLN LLSASKAKLD VLAHVFESFL KIVRQKEKNI
1310 1320 1330 1340 1350
SLLIQQGTVK ILLGGFLNIL TQTNSDFQAC QRVLVDLLVS LMSSRTCSED
1360 1370 1380 1390 1400
LTLLLRIFLE KSPCTEILLL GIHKIVESDF TMSPSQCLTF PFLHTPSLSN
1410 1420 1430 1440 1450
GVLSQKPPGI LNSKALGLLR RARISRGKKE ADRESFPYRL LSSWHIAPIH
1460 1470 1480 1490 1500
LPLLGQNCWP HLSEGFSVSL WFNVEYIHES ESAAERGKRV KKRNKPSVLE
1510 1520 1530 1540 1550
DSSFEGAEGD RPEVTESINP GDRLIEDGCI HLISLGSKAL MIQVWADPHS
1560 1570 1580 1590 1600
GTFIFRVCMD SNDDTKAVSL AQVESQENIF FPSKWQHLVL TYIQHPQGKK
1610 1620 1630 1640 1650
NVHGEISIWV SGQRKTDVIL DFVLPRKTSL SSDSNKTFCM IGHCLTSQEE
1660 1670 1680 1690 1700
SLQLAGKWDL GNLLLFNGAK IGSQEAFFLY ACGPNYTSIM PCKYGQPVID
1710 1720 1730 1740 1750
YSKYINKDIL RCDEIRDLFM TKKEVDVGLL IESLSVVYTT CCPAQYTIYE
1760 1770 1780 1790 1800
PVIRLKGQVK TQPSQRPFSS KEAQSILLEP SQLKGLQPTE CKAIQGILHE
1810 1820 1830 1840 1850
IGGAGTFVFL FARVVELSSC EETQALALRV ILSLIKYSQQ RTQELENCNG
1860 1870 1880 1890 1900
LSMIHQVLVK QKCIVGFHIL KTLLEGCCGE EVIHVSEHGE FKLDVESHAI
1910 1920 1930 1940 1950
IQDVKLLQEL LLDWKIWNKA EQGVWETLLA ALEVLIRVEH HQQQFNIKQL
1960 1970 1980 1990 2000
LNAHVVHHFL LTCQVLQEHR EGQLTSMPRE VCRSFVKIIA EVLGSPPDLE
2010 2020 2030 2040 2050
LLTVIFNFLL AVHPPTNTYV CHNPTNFYFS LHIDGKIFQE KVQSLAYLRH
2060 2070 2080 2090 2100
SSSGGQAFPS PGFLVISPSA FTAAPPEGTS SSNIVPQRMA AQMVRSRSLP
2110 2120 2130 2140 2150
AFPTYLPLIR AQKLAASLGF SVDKLQNIAD ANPEKQNLLG RPYALKTSKE
2160 2170 2180 2190 2200
EAFISSCESA KTVCEMEALL GAHASANGVS RGSPRFPRAR VDHKDVGTEP
2210 2220 2230 2240 2250
RSDDDSPGDE SYPRRPDNLK GLASFQRSQS TVASLGLAFP SQNGSAVASR
2260 2270 2280 2290 2300
WPSLVDRNAD DWENFTFSPA YEASYNRATS THSVIEDCLI PICCGLYELL
2310 2320 2330 2340 2350
SGVLLVLPDA MLEDVMDRII QADILLVLVN HPSPAIQQGV IKLLHAYINR
2360 2370 2380 2390 2400
ASKEQKDKFL KNRGFSLLAN QLYLHRGTQE LLECFVEMFF GRPIGLDEEF
2410 2420 2430 2440 2450
DLEEVKHMEL FQKWSVIPVL GLIETSLYDN VLLHNALLLL LQVLNSCSKV
2460 2470 2480 2490 2500
ADMLLDNGLL YVLCNTVAAL NGLEKNIPVN EYKLLACDIQ QLFIAVTIHA
2510 2520 2530 2540 2550
CSSSGTQYFR VIEDLIVLLG YLHNSKNKRT QNMALALQLR VLQAALEFIR
2560 2570 2580 2590 2600
STANHDSESP VHSPSAHRHS VPPKRRSIAG SRKFPLAQTE SLLMKMRSVA
2610 2620 2630 2640 2650
SDELHSMMQR RMSQEHPSQA SEAELAQRLQ RLTILAVNRI IYQELNSDII
2660 2670 2680 2690 2700
DILRTPENTS QSKTSVSQTE ISEEDMHHEQ PSVYNPFQKE MLTYLLDGFK
2710 2720 2730 2740 2750
VCIGSSKTSV SKQQWTKILG SCKETLRDQL GRLLAHILSP THTVQERKQI
2760 2770 2780 2790 2800
LEIVHEPAHQ DILRDCLSPS PQHGAKLVLY LSELIHNHQD ELSEEEMDTA
2810 2820 2830 2840 2850
ELLMNALKLC GHKCIPPSAP SKPELIKIIR EEQKKYESEE SVSKGSWQKT
2860 2870 2880 2890 2900
VNNNQQSLFQ RLDFKSKDIS KIAADITQAV SLSQGIERKK VIQHIRGMYK
2910 2920 2930 2940 2950
VDLSASRHWQ ECIQQLTHDR AVWYDPIYYP TSWQLDPTEG PNRERRRLQR
2960 2970 2980 2990 3000
CYLTIPNKYL LRDRQKSEGV LRPPLSYLFE DKTHSSFSST VKDKAASESI
3010 3020 3030 3040 3050
RVNRRCISVA PSRETAGELL LGKCGMYFVE DNASDAVESS SLQGELEPAS
3060 3070 3080 3090 3100
FSWTYEEIKE VHRRWWQLRD NAVEIFLTNG RTLLLAFDNN KVRDDVYQSI
3110 3120 3130 3140 3150
LTNNLPNLLE YGNITALTNL WYSGQITNFE YLTHLNKHAG RSFNDLMQYP
3160 3170 3180 3190 3200
VFPFILSDYV SETLDLNDPS IYRNLSKPIA VQYKEKEDRY VDTYKYLEEE
3210 3220 3230 3240 3250
YRKGAREDDP MPPVQPYHYG SHYSNSGTVL HFLVRMPPFT KMFLAYQDQS
3260 3270 3280 3290 3300
FDIPDRTFHS TNTTWRLSSF ESMTDVKELI PEFFYLPEFL VNREGFDFGV
3310 3320 3330 3340 3350
RQNGERVNHV NLPPWARNDP RLFILIHRQA LESDHVSQNI CHWIDLVFGY
3360 3370 3380 3390 3400
KQKGKASVQA INVFHPATYF GMDVSAVEDP VQRRALETMI KTYGQTPRQL
3410 3420 3430 3440 3450
FHTAHASRPG AKLNIEGELP AAVGLLVQFA FRETREPVKE VTHPSPLSWI
3460 3470 3480 3490 3500
KGLKWGEYVG SPSAPVPVVC FSQPHGERFG SLQALPTRAI CGLSRNFCLL
3510 3520 3530 3540 3550
MTYNKEQGVR SMNNTNIQWS AILSWGYADN ILRLKSKQSE PPINFIQSSQ
3560 3570 3580 3590 3600
QHQVTSCAWV PDSCQLFTGS KCGVITAYTN RLTSSTPSEI EMESQMHLYG
3610 3620 3630 3640 3650
HTEEITGLCV CKPYSVMISV SRDGTCIVWD LNRLCYVQSL AGHKSPVTAV
3660 3670 3680 3690 3700
SASETSGDIA TVCDSAGGGS DLRLWTVNGD LVGHVHCREI ICSVAFSNQP
3710 3720 3730 3740 3750
EGVSINVIAG GLENGIVRLW STWDLKPVRE ITFPKSNKPI ISLTFSCDGH
3760 3770 3780
HLYTANSEGT VIAWCRKDQQ RVKLPMFYSF LSSYAAG
Length:3,787
Mass (Da):425,324
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3B7A9AFAFBB98A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97412LYST_MOUSE
Lysosomal-trafficking regulator
Lyst Bg, Chs1
3,788Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8W6Q6A0A2R8W6Q6_MOUSE
Lysosomal-trafficking regulator
Lyst
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_034878.2, NM_010748.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110559; ENSMUSP00000106188; ENSMUSG00000019726

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17101

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17101

UCSC genome browser

More...
UCSCi
uc007pmj.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_034878.2, NM_010748.2

3D structure databases

SMRiG5E8Q0
ModBaseiSearch...

Proteomic databases

EPDiG5E8Q0
jPOSTiG5E8Q0
MaxQBiG5E8Q0
PeptideAtlasiG5E8Q0
PRIDEiG5E8Q0
ProteomicsDBi343305

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34697, 21 antibodies

The DNASU plasmid repository

More...
DNASUi
17101

Genome annotation databases

EnsembliENSMUST00000110559; ENSMUSP00000106188; ENSMUSG00000019726
GeneIDi17101
KEGGimmu:17101
UCSCiuc007pmj.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1130
MGIiMGI:107448, Lyst
VEuPathDBiHostDB:ENSMUSG00000019726

Phylogenomic databases

GeneTreeiENSGT00940000156359
HOGENOMiCLU_000213_1_0_1
OMAiKFNQHRI
OrthoDBi101142at2759
PhylomeDBiG5E8Q0
TreeFamiTF313658

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
17101, 4 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Lyst, mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000019726, Expressed in granulocyte and 156 other tissues

Family and domain databases

CDDicd06071, Beach, 1 hit
cd01201, PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR030464, LYST
IPR023362, PH-BEACH_dom
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR13743:SF86, PTHR13743:SF86, 1 hit
PfamiView protein in Pfam
PF02138, Beach, 1 hit
PF14844, PH_BEACH, 1 hit
PF00400, WD40, 1 hit
SMARTiView protein in SMART
SM01026, Beach, 1 hit
SM00320, WD40, 4 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5E8Q0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E8Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 29, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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