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Entry version 71 (02 Dec 2020)
Sequence version 1 (14 Dec 2011)
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Protein

Bromodomain-containing protein 1

Gene

Brd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:21753189). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri214 – 264PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 301C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri325 – 389PHD-type 2PROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processErythrocyte maturation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214847, HATs acetylate histones
R-MMU-6804758, Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain-containing protein 11 Publication
Alternative name(s):
Bromodomain and PHD finger-containing protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brd11 PublicationImported
Synonyms:Brpf21 Publication, Kiaa41911 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924161, Brd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryos die at mid-gestation because of anemia and impaired fetal liver erythropoiesis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004496101 – 1058Bromodomain-containing protein 1Add BLAST1058

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei128PhosphoserineBy similarity1
Modified residuei368N6-acetyllysineBy similarity1
Modified residuei516N6-acetyllysineBy similarity1
Modified residuei519N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei803PhosphoserineBy similarity1
Modified residuei903N6-acetyllysineBy similarity1
Modified residuei1052PhosphoserineBy similarity1
Modified residuei1055PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
G5E8P1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G5E8P1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PZ26

PeptideAtlas

More...
PeptideAtlasi
G5E8P1

PRoteomics IDEntifications database

More...
PRIDEi
G5E8P1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G5E8P1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PZ26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022387, Expressed in zygote and 303 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5E8P1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of some HBO1 complexes composed of KAT7/HBO1, MEAF6, ING4 and BRD1/BRPF2 (PubMed:21753189).

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (By similarity).

Interacts (via PHD-type zinc finger domain) with unmodified histone H3 (By similarity).

Interacts (via PWWP domain) with dimethylated and trimethylated 'Lys-79' on histone H3 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-801, MOZ2 histone acetyltransferase complex
CPX-805, MORF2 histone acetyltransferase complex

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9PZ26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5E8P1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 649BromoPROSITE-ProRule annotationAdd BLAST71
Domaini929 – 1012PWWPPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 80Interaction with KAT7/HBO1 and histonesBy similarityAdd BLAST50

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 264PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 301C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri325 – 389PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0955, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003589_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PZ26

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGEHMQT

Database of Orthologous Groups

More...
OrthoDBi
566217at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05839, BR140_related, 1 hit
cd15702, ePHD_BRPF2, 1 hit
cd15677, PHD_BRPF2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035502, BR140-rel_PWWD
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR042004, BRPF2_ePHD
IPR042009, BRPF2_PHD
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR000313, PWWP_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 1 hit
PF10513, EPL1, 1 hit
PF00855, PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00249, PHD, 2 hits
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS50812, PWWP, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: G5E8P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRKGRCHRG SAARHPSSPC SIKHSPTRET LTYAQAQRMV EIEIEGRLHR
60 70 80 90 100
ISIFDPLEII LEDDLTAQEM SECNSNKENS ERPPVCLRTK RHKNNRVKKK
110 120 130 140 150
NEVLPSTHGT PASASALPEP KVRIVEYSPP SAPRRPPVYY KFIEKSAEEL
160 170 180 190 200
DNEVEYDMDE EDYAWLEIIN EKRKGDCVSA VSQNMFEFLM DRFEKESYCE
210 220 230 240 250
NQKQGEQQSL IDEDAVCCIC MDGECQNSNV ILFCDMCNLA VHQECYGVPY
260 270 280 290 300
IPEGQWLCRH CLQSRARPAD CVLCPNKGGA FKKTDDDRWG HVVCALWIPE
310 320 330 340 350
VGFANTVFIE PIDGVRNIPP ARWKLTCYLC KQKGVGACIQ CHKANCYTAF
360 370 380 390 400
HVTCAQKAGL YMKMEPVKEL TGGSATFSVR KTAYCDVHTP PGCTRRPLNI
410 420 430 440 450
YGDVEMKNGV CRKESSVKTV RSTSKVRKKA KKAKKTLAEP CAVLPTVCAP
460 470 480 490 500
YIPPQRLNRI ANQVAIQRKK QFVERAHSYW LLKRLSRNGA PLLRRLQSSL
510 520 530 540 550
QSQRNTQQRE NDEEMKAAKE KLKYWQRLRH DLERARLLIE LLRKREKLKR
560 570 580 590 600
EQVKVEQMAM ELRLTPLTVL LRSVLEQLQE KDPAKIFAQP VSLKEVPDYL
610 620 630 640 650
DHIKHPMDFA TMRKRLEAQG YKNLHAFEED FNLIVDNCMK YNAKDTVFYR
660 670 680 690 700
AAVRLRDQGG VVLRQARREV ESIGLEEASG MHLPERPIAA PRRPFSWEEV
710 720 730 740 750
DRLLDPANRA HMSLEEQLRE LLDKLDLTCS MKSSGSRSKR AKLLKKEIAL
760 770 780 790 800
LRNKLSQQHS QAPPTGAGTG GFEDEAAPLA PDTAEEVLPR LETLLQPRKR
810 820 830 840 850
SRSTCGDSEV EEESPGKRLD TGLTNGFGGA RSEQEPGGGP GRKAAPRRRC
860 870 880 890 900
ASESSICSSN SPLCDSSFST PKCGRGKPAL VRRHTLEDRS ELISCIENGN
910 920 930 940 950
YAKAARIAAE VGQSNMWIST DAAASVLEPL KVVWAKCSGY PSYPALIIDP
960 970 980 990 1000
KMPRVPGHHN GVTIPAPPLD VLKIGEHMQT KSEEKLFLVL FFDNKRSWQW
1010 1020 1030 1040 1050
LPKSKMVPLG VDETIDKLKM MEGRNSSIRK AVRIAFDRAM NHLSRVHGEP

ASDLSDID
Length:1,058
Mass (Da):119,714
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E44EA93A80325B0
GO
Isoform 2 (identifier: G5E8P1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-786: E → EGANSPPKLE...QLGTKTFLSV

Show »
Length:1,189
Mass (Da):133,373
Checksum:iF82ACBEDAACE8953
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060568786E → EGANSPPKLEPSDALPLPSN SETNSEPPTLNPVELHPEQS KLFKRVTFDNESHSTCTQSA LVSGHPPEPTLASSGDVPAA AASAVAEPSSDVNRRTSVLF CKSKSVSPPKSAKNTETQPT SPQLGTKTFLSV in isoform 2. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC117700 Genomic DNA No translation available.
AC158976 Genomic DNA No translation available.
AK220233 mRNA Translation: BAD90158.1
AK086982 mRNA Translation: BAC39779.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27730.2 [G5E8P1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001028446.2, NM_001033274.3 [G5E8P1-2]
XP_006520898.1, XM_006520835.2 [G5E8P1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000109380; ENSMUSP00000105006; ENSMUSG00000022387 [G5E8P1-1]
ENSMUST00000109381; ENSMUSP00000105007; ENSMUSG00000022387 [G5E8P1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
223770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:223770

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117700 Genomic DNA No translation available.
AC158976 Genomic DNA No translation available.
AK220233 mRNA Translation: BAD90158.1
AK086982 mRNA Translation: BAC39779.1
CCDSiCCDS27730.2 [G5E8P1-2]
RefSeqiNP_001028446.2, NM_001033274.3 [G5E8P1-2]
XP_006520898.1, XM_006520835.2 [G5E8P1-1]

3D structure databases

SMRiG5E8P1
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-801, MOZ2 histone acetyltransferase complex
CPX-805, MORF2 histone acetyltransferase complex

PTM databases

iPTMnetiG5E8P1
PhosphoSitePlusiE9PZ26

Proteomic databases

jPOSTiG5E8P1
MaxQBiG5E8P1
PaxDbiE9PZ26
PeptideAtlasiG5E8P1
PRIDEiG5E8P1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
251, 165 antibodies

Genome annotation databases

EnsembliENSMUST00000109380; ENSMUSP00000105006; ENSMUSG00000022387 [G5E8P1-1]
ENSMUST00000109381; ENSMUSP00000105007; ENSMUSG00000022387 [G5E8P1-2]
GeneIDi223770
KEGGimmu:223770

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23774
MGIiMGI:1924161, Brd1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0955, Eukaryota
GeneTreeiENSGT00940000157236
HOGENOMiCLU_003589_1_0_1
InParanoidiE9PZ26
OMAiVGEHMQT
OrthoDBi566217at2759
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-MMU-3214847, HATs acetylate histones
R-MMU-6804758, Regulation of TP53 Activity through Acetylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
223770, 5 hits in 15 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Brd1, mouse
RNActiE9PZ26, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000022387, Expressed in zygote and 303 other tissues
ExpressionAtlasiG5E8P1, baseline and differential

Family and domain databases

CDDicd05839, BR140_related, 1 hit
cd15702, ePHD_BRPF2, 1 hit
cd15677, PHD_BRPF2, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502, BR140-rel_PWWD
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR042004, BRPF2_ePHD
IPR042009, BRPF2_PHD
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR000313, PWWP_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF10513, EPL1, 1 hit
PF00855, PWWP, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00249, PHD, 2 hits
SM00293, PWWP, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS50812, PWWP, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E8P1
Secondary accession number(s): E9PZ26, Q571F6, Q8BU83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 22, 2020
Last sequence update: December 14, 2011
Last modified: December 2, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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