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Protein

Monocarboxylate transporter 6

Gene

Slc16a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

  • monocarboxylic acid transmembrane transporter activity Source: GO_Central
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 6
Short name:
MCT 6
Alternative name(s):
Monocarboxylate transporter 5
Short name:
MCT 5
Solute carrier family 16 member 5
Gene namesi
Name:Slc16a5
Synonyms:Mct5, Mct6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443515 Slc16a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 53ExtracellularSequence analysisAdd BLAST19
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 80CytoplasmicSequence analysis6
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102ExtracellularSequence analysis1
Transmembranei103 – 122HelicalSequence analysisAdd BLAST20
Topological domaini123 – 138CytoplasmicSequence analysisAdd BLAST16
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 171ExtracellularSequence analysisAdd BLAST12
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 239CytoplasmicSequence analysisAdd BLAST47
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 274ExtracellularSequence analysisAdd BLAST14
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 306CytoplasmicSequence analysisAdd BLAST11
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 330ExtracellularSequence analysis3
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 368CytoplasmicSequence analysisAdd BLAST17
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 396ExtracellularSequence analysis7
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Topological domaini418 – 468CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158041 – 468Monocarboxylate transporter 6Add BLAST468

Proteomic databases

PaxDbiG5E8K6
PRIDEiG5E8K6

PTM databases

PhosphoSitePlusiG5E8K6

Expressioni

Gene expression databases

BgeeiENSMUSG00000045775 Expressed in 60 organ(s), highest expression level in thymus
ExpressionAtlasiG5E8K6 baseline and differential
GenevisibleiG5E8K6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090102

Structurei

3D structure databases

ProteinModelPortaliG5E8K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiG5E8K6
KOiK08182
OMAiHCCVCGA
OrthoDBiEOG091G05SW
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030760 MCT6
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF21 PTHR11360:SF21, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G5E8K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARALEQADG RWAWVVLLSS LVTQALTLGF PTCIGVFFTD LQRDFQASNS
60 70 80 90 100
ETSWFPSILG AMVHGGGPLC SILVKHFGCR VTMMLGGVLA SLGMVVSTFS
110 120 130 140 150
GSLTHLFLTA GVITGLGMCF SFQSSITVVG LYFVRRRPLA NALASMGLSM
160 170 180 190 200
GVTLWPLLAR YLLETLGWRG AFLIFGGILL HCCVCGALLR PVATNEVPEP
210 220 230 240 250
KEDPLLPPKI PTRSCLATCV STIRYHLAFD ILRHNMGFCI YVTGVTWMNL
260 270 280 290 300
GFALPHIFLV PYAMHHGVDD YWAAMLMSIV GFCNIFLRPM AGLLLAGRKS
310 320 330 340 350
LAAYRKYLFA VAILINGLTN LICTVSADFR VLLGYCLVYS LSMCGVGILV
360 370 380 390 400
FQVLMDIVPM DRFPSALGLF TILCGVTSLI SPPLAGLLLD KTNNFSYVFY
410 420 430 440 450
MSSGFLVSGS LILGVGFYAA EKKKLKQDGQ AKMENATSEM TPMHDLTSED
460
KDSAKKQPYP ESIYMTNV
Length:468
Mass (Da):51,018
Last modified:December 14, 2011 - v1
Checksum:i561A2AE11D3B60F0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQH7A0A0A0MQH7_MOUSE
Monocarboxylate transporter 6
Slc16a5
137Annotation score:
A0A0A0MQC4A0A0A0MQC4_MOUSE
Monocarboxylate transporter 6
Slc16a5
149Annotation score:

Sequence cautioni

The sequence CAM23020 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM23021 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM23022 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645470 Genomic DNA Translation: CAM23020.1 Sequence problems.
AL645470 Genomic DNA Translation: CAM23021.1 Sequence problems.
AL645470 Genomic DNA Translation: CAM23022.1 Sequence problems.
CH466558 Genomic DNA Translation: EDL34494.1
CCDSiCCDS36373.1
RefSeqiNP_001074403.1, NM_001080934.1
UniGeneiMm.25773

Genome annotation databases

EnsembliENSMUST00000092445; ENSMUSP00000090102; ENSMUSG00000045775
GeneIDi217316
KEGGimmu:217316
UCSCiuc007mhp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645470 Genomic DNA Translation: CAM23020.1 Sequence problems.
AL645470 Genomic DNA Translation: CAM23021.1 Sequence problems.
AL645470 Genomic DNA Translation: CAM23022.1 Sequence problems.
CH466558 Genomic DNA Translation: EDL34494.1
CCDSiCCDS36373.1
RefSeqiNP_001074403.1, NM_001080934.1
UniGeneiMm.25773

3D structure databases

ProteinModelPortaliG5E8K6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090102

PTM databases

PhosphoSitePlusiG5E8K6

Proteomic databases

PaxDbiG5E8K6
PRIDEiG5E8K6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092445; ENSMUSP00000090102; ENSMUSG00000045775
GeneIDi217316
KEGGimmu:217316
UCSCiuc007mhp.1 mouse

Organism-specific databases

CTDi9121
MGIiMGI:2443515 Slc16a5

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiG5E8K6
KOiK08182
OMAiHCCVCGA
OrthoDBiEOG091G05SW
TreeFamiTF313792

Miscellaneous databases

PROiPR:G5E8K6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045775 Expressed in 60 organ(s), highest expression level in thymus
ExpressionAtlasiG5E8K6 baseline and differential
GenevisibleiG5E8K6 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030760 MCT6
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF21 PTHR11360:SF21, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT6_MOUSE
AccessioniPrimary (citable) accession number: G5E8K6
Secondary accession number(s): A2A9X8, A2A9X9, A2A9Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: December 14, 2011
Last modified: November 7, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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