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UniProtKB - G5E8K5 (ANK3_MOUSE)

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Protein

Ankyrin-3

Gene

Ank3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg2+ levels, and thereby contributes to the regulation of renal Mg2+ reabsorption (PubMed:23903368).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • axon guidance Source: MGI
  • axonogenesis Source: BHF-UCL
  • cellular response to magnesium ion Source: UniProtKB
  • establishment of protein localization Source: MGI
  • Golgi to plasma membrane protein transport Source: MGI
  • magnesium ion homeostasis Source: UniProtKB
  • maintenance of protein location in plasma membrane Source: MGI
  • membrane assembly Source: BHF-UCL
  • mitotic cytokinesis Source: MGI
  • negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
  • neuromuscular junction development Source: BHF-UCL
  • neuronal action potential Source: BHF-UCL
  • plasma membrane organization Source: MGI
  • positive regulation of action potential Source: BHF-UCL
  • positive regulation of cation channel activity Source: BHF-UCL
  • positive regulation of cell communication by electrical coupling Source: BHF-UCL
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
  • positive regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • positive regulation of membrane potential Source: BHF-UCL
  • positive regulation of protein targeting to membrane Source: BHF-UCL
  • positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • positive regulation of sodium ion transport Source: BHF-UCL
  • protein localization to axon Source: MGI
  • protein localization to plasma membrane Source: BHF-UCL
  • regulation of potassium ion transport Source: BHF-UCL
  • signal transduction Source: InterPro
  • synapse organization Source: MGI
View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin-3
Short name:
ANK-3
Alternative name(s):
Ankyrin-G
Gene namesi
Name:Ank3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88026 Ank3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Lysosome, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004197821 – 1961Ankyrin-3Add BLAST1961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei830PhosphoserineCombined sources1
Modified residuei844PhosphoserineBy similarity1
Modified residuei850PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei914PhosphoserineBy similarity1
Modified residuei917PhosphoserineBy similarity1
Modified residuei923PhosphoserineCombined sources1
Modified residuei958PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1451PhosphoserineCombined sources1
Modified residuei1462PhosphoserineCombined sources1
Modified residuei1470PhosphoserineCombined sources1
Modified residuei1473PhosphoserineCombined sources1
Modified residuei1795PhosphoserineCombined sources1
Modified residuei1813PhosphoserineBy similarity1
Modified residuei1883PhosphoserineBy similarity1
Isoform 6 (identifier: G5E8K5-6)
Modified residuei732PhosphoserineCombined sources1
Isoform 2 (identifier: G5E8K5-2)
Modified residuei830PhosphoserineCombined sources1
Modified residuei1560PhosphoserineCombined sources1
Isoform 3 (identifier: G5E8K5-3)
Modified residuei830PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiG5E8K5
PaxDbiG5E8K5
PRIDEiG5E8K5

PTM databases

iPTMnetiG5E8K5
PhosphoSitePlusiG5E8K5
SwissPalmiG5E8K5

Expressioni

Tissue specificityi

Expressed in many epithelial tissues, muscles and axons. Expressed in kidney, brain, skin, lung, liver, intestine, pancreas, heart and testis (at protein level). In testis, expressed in Leydig cells, but very weakly or not at all in Sertoli cells or seminiferous tubules. Expressed in macrophages (at protein level).3 Publications

Developmental stagei

In an in vitro model of myogenesis, not detected in proliferating myoblasts. Hardly detectable during the first days of differentiation. Expression greatly increases in mature myotubes.1 Publication

Inductioni

Up-regulated by high dietary Mg2+ levels.1 Publication

Gene expression databases

BgeeiENSMUSG00000069601
ExpressionAtlasiG5E8K5 baseline and differential
GenevisibleiG5E8K5 MM

Interactioni

Subunit structurei

May be a constituent of a NFASC/NRCAM/ankyrin G complex. Interacts with RHBG (By similarity). Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres. Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs). Interacts with PLEC and FLNC (By similarity). Interacts with KCNA1; this inhibits channel activity (PubMed:23903368).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi198102, 5 interactors
IntActiG5E8K5, 9 interactors
MINTiG5E8K5
STRINGi10090.ENSMUSP00000090090

Structurei

3D structure databases

ProteinModelPortaliG5E8K5
SMRiG5E8K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 85ANK 1Add BLAST30
Repeati89 – 118ANK 2Add BLAST30
Repeati122 – 151ANK 3Add BLAST30
Repeati155 – 184ANK 4Add BLAST30
Repeati186 – 213ANK 5Add BLAST28
Repeati217 – 246ANK 6Add BLAST30
Repeati250 – 279ANK 7Add BLAST30
Repeati283 – 312ANK 8Add BLAST30
Repeati316 – 345ANK 9Add BLAST30
Repeati349 – 378ANK 10Add BLAST30
Repeati382 – 411ANK 11Add BLAST30
Repeati415 – 444ANK 12Add BLAST30
Repeati448 – 477ANK 13Add BLAST30
Repeati481 – 510ANK 14Add BLAST30
Repeati514 – 543ANK 15Add BLAST30
Repeati547 – 576ANK 16Add BLAST30
Repeati580 – 609ANK 17Add BLAST30
Repeati613 – 642ANK 18Add BLAST30
Repeati646 – 675ANK 19Add BLAST30
Repeati679 – 708ANK 20Add BLAST30
Repeati712 – 741ANK 21Add BLAST30
Repeati745 – 774ANK 22Add BLAST30
Repeati778 – 807ANK 23Add BLAST30
Domaini985 – 1140ZU5 1PROSITE-ProRule annotationAdd BLAST156
Domaini1142 – 1289ZU5 2PROSITE-ProRule annotationAdd BLAST148
Domaini1478 – 1562DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1274 – 1408UPA domainBy similarityAdd BLAST135

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00840000129677
HOGENOMiHOG000012873
InParanoidiG5E8K5
KOiK10380
TreeFamiTF351263

Family and domain databases

CDDicd00204 ANK, 7 hits
cd08803 Death_ank3, 1 hit
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR037971 Ank3_Death
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PF00531 Death, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: G5E8K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEEPKEKPA KPAHRKRKGK KSDANASYLR AARAGHLEKA LDYIKNGVDV 
        60         70         80         90        100
NICNQNGLNA LHLASKEGHV EVVSELLQRE ANVDAATKKG NTALHIASLA 
       110        120        130        140        150
GQAEVVKVLV TNGANVNAQS QNGFTPLYMA AQENHLEVVR FLLDNGASQS 
       160        170        180        190        200
LATEDGFTPL AVALQQGHDQ VVSLLLENDT KGKVRLPALH IAARKDDTKA 
       210        220        230        240        250
AALLLQNDTN ADVESKSGFT PLHIAAHYGN INVATLLLNR AAAVDFTARN 
       260        270        280        290        300
DITPLHVASK RGNANMVKLL LDRGAKIDAK TRDGLTPLHC GARSGHEQVV 
       310        320        330        340        350
EMLLDRSAPI LSKTKNGLSP LHMATQGDHL NCVQLLLQHN VPVDDVTNDY 
       360        370        380        390        400
LTALHVAAHC GHYKVAKVLL DKKASPNAKA LNGFTPLHIA CKKNRIRVME 
       410        420        430        440        450
LLLKHGASIQ AVTESGLTPI HVAAFMGHVN IVSQLMHHGA SPNTTNVRGE 
       460        470        480        490        500
TALHMAARSG QAEVVRYLVQ DGAQVEAKAK DDQTPLHISA RLGKADIVQQ 
       510        520        530        540        550
LLQQGASPNA ATTSGYTPLH LAAREGHEDV AAFLLDHGAS LSITTKKGFT 
       560        570        580        590        600
PLHVAAKYGK LEVASLLLQK SASPDAAGKS GLTPLHVAAH YDNQKVALLL 
       610        620        630        640        650
LDQGASPHAA AKNGYTPLHI AAKKNQMDIA TSLLEYGADA NAVTRQGIAS 
       660        670        680        690        700
VHLAAQEGHV DMVSLLLSRN ANVNLSNKSG LTPLHLAAQE DRVNVAEVLV 
       710        720        730        740        750
NQGAHVDAQT KMGYTPLHVG CHYGNIKIVN FLLQHSAKVN AKTKNGYTAL 
       760        770        780        790        800
HQAAQQGHTH IINVLLQNNA SPNELTVNGN TALAIARRLG YISVVDTLKV 
       810        820        830        840        850
VTEEIMTTTT ITEKHKMNVP ETMNEVLDMS DDEVRKASAP EKLSDGEYIS 
       860        870        880        890        900
DGEEGDKCTW FKIPKVQEVL VKSEDAITGD TDKYLGPQDL KELGDDSLPA 
       910        920        930        940        950
EGYVGFSLGA RSASLRSFSS DRSYTLNRSS YARDSMMIEE LLVPSKEQHL 
       960        970        980        990       1000
TFTREFDSDS LRHYSWAADT LDNVNLVSSP VHSGFLVSFM VDARGGSMRG 
      1010       1020       1030       1040       1050
SRHHGMRIII PPRKCTAPTR ITCRLVKRHK LANPPPMVEG EGLASRLVEM 
      1060       1070       1080       1090       1100
GPAGAQFLGP VIVEIPHFGS MRGKERELIV LRSENGETWK EHQFDSKNED 
      1110       1120       1130       1140       1150
LAELLNGMDE ELDSPEELGT KRICRIITKD FPQYFAVVSR IKQESNQIGP 
      1160       1170       1180       1190       1200
EGGILSSTTV PLVQASFPEG ALTKRIRVGL QAQPVPEETV KKILGNKATF 
      1210       1220       1230       1240       1250
SPIVTVEPRR RKFHKPITMT IPVPPPSGEG VSNGYKGDAT PNLRLLCSIT 
      1260       1270       1280       1290       1300
GGTSPAQWED ITGTTPLTFI KDCVSFTTNV SARFWLADCH QVLETVGLAS 
      1310       1320       1330       1340       1350
QLYRELICVP YMAKFVVFAK TNDPVESSLR CFCMTDDRVD KTLEQQENFE 
      1360       1370       1380       1390       1400
EVARSKDIEV LEGKPIYVDC YGNLAPLTKG GQQLVFNFYS FKENRLPFSI 
      1410       1420       1430       1440       1450
KIRDTSQEPC GRLSFLKEPK TTKGLPQTAV CNLNITLPAH KKAEKADRRQ 
      1460       1470       1480       1490       1500
SFASLALRKR YSYLTEPSMS PQSPCERTDI RMAIVADHLG LSWTELAREL 
      1510       1520       1530       1540       1550
NFSVDEINQI RVENPNSLIS QSFMLLKKWV TRDGKNATTD ALTSVLTKIN 
      1560       1570       1580       1590       1600
RIDIVTLLEG PIFDYGNISG TRSFADENNV FHDPVDGHPS FQVELETPMG 
      1610       1620       1630       1640       1650
LYCTPPNPFQ QDDHFSDISS IESPFRTPSR LSDGLVPSQG NIEHPTGGPP 
      1660       1670       1680       1690       1700
VVTAEDTSLE DSKMDDSVTV TDPADPLDVD ESQLKDLCQS ECAQCWASVP 
      1710       1720       1730       1740       1750
GIPNDGRQAE PLRPQTRKVG MSSEQQEKGK SGPDEEVTED KVKSLFEDIQ 
      1760       1770       1780       1790       1800
LEEVEAEEMT EDQGQAMLNR VQRAELAMSS LAGWQNETPS GSLESPAQAR 
      1810       1820       1830       1840       1850
RLTGGLLDRL DDSSDQARDS ITSYLTGEPG KIEANGNHTA EVIPEAKAKP 
      1860       1870       1880       1890       1900
YFPESQNDIG KQSIKENLKP KTHGCGRTEE PVSPLTAYQK SLEETSKLVI 
      1910       1920       1930       1940       1950
EDAPKPCVPV GMKKMTRTTA DGKARLNLQE EEGSTRSEPK QGEGYKVKTK 
      1960 
KEIRNVEKKT H
Length:1,961
Mass (Da):214,062
Last modified:December 14, 2011 - v1
Checksum:i58F91B5BF87867CE
GO
Isoform 2 (identifier: G5E8K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     834-873: VRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVKS → G
     1588-1783: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,726
Mass (Da):188,256
Checksum:i330058F77E15E49F
GO
Isoform 3 (identifier: G5E8K5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     834-873: VRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVKS → G

Show »
Length:1,922
Mass (Da):209,669
Checksum:i7A4B65429B20B8F2
GO
Isoform 4 (identifier: G5E8K5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-867: Missing.
     868-872: EVLVK → MALPH

Note: No experimental confirmation available.
Show »
Length:1,094
Mass (Da):121,205
Checksum:i5D9DA021B66D5BC2
GO
Isoform 5 (identifier: G5E8K5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-867: Missing.
     868-872: EVLVK → MALPH
     1941-1941: Missing.

Show »
Length:1,093
Mass (Da):121,077
Checksum:i339712E963046146
GO
Isoform 6 (identifier: G5E8K5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-867: Missing.
     868-872: EVLVK → MALPH
     1588-1783: Missing.

Show »
Length:898
Mass (Da):99,791
Checksum:i97A7901C8A0DAD67
GO

Sequence cautioni

The sequence AAB58380 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB58381 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti717L → P in AAH21657 (PubMed:15489334).Curated1
Sequence conflicti1603C → W in AAB01607 (PubMed:7615634).Curated1
Sequence conflicti1603C → W in AAB01603 (PubMed:7615634).Curated1
Sequence conflicti1603C → W in AAB58381 (PubMed:15489334).Curated1
Sequence conflicti1652V → I in BAC29151 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0443551 – 867Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST867
Alternative sequenceiVSP_044356834 – 873VRKAS…VLVKS → G in isoform 2 and isoform 3. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_044357868 – 872EVLVK → MALPH in isoform 4, isoform 5 and isoform 6. 2 Publications5
Alternative sequenceiVSP_0443581588 – 1783Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST196
Alternative sequenceiVSP_0443591941Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40631 mRNA Translation: AAB01602.1
L40631 mRNA Translation: AAB01603.1
L40632 mRNA Translation: AAB01607.1
AK035681 mRNA Translation: BAC29151.1
AK162007 mRNA Translation: BAE36677.1
AC100427 Genomic DNA No translation available.
AC129018 Genomic DNA No translation available.
AC132435 Genomic DNA No translation available.
AC156836 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31985.1
CH466553 Genomic DNA Translation: EDL31989.1
CH466553 Genomic DNA Translation: EDL31990.1
BC021657 mRNA Translation: AAH21657.1
U89274 mRNA Translation: AAB58380.1 Different initiation.
U89275 mRNA Translation: AAB58381.1 Different initiation.
CCDSiCCDS23909.1 [G5E8K5-1]
CCDS23912.1 [G5E8K5-4]
CCDS35931.1 [G5E8K5-3]
CCDS59545.1 [G5E8K5-2]
CCDS59546.1 [G5E8K5-6]
RefSeqiNP_033800.2, NM_009670.4 [G5E8K5-6]
NP_666117.2, NM_146005.3 [G5E8K5-1]
NP_733788.2, NM_170687.3 [G5E8K5-4]
NP_733789.1, NM_170688.2
NP_733790.2, NM_170689.2
NP_733791.2, NM_170690.2
NP_733924.2, NM_170728.2 [G5E8K5-2]
NP_733925.2, NM_170729.2 [G5E8K5-3]
NP_733926.2, NM_170730.2
XP_006513202.1, XM_006513139.3 [G5E8K5-5]
UniGeneiMm.235960

Genome annotation databases

EnsembliENSMUST00000054167; ENSMUSP00000061698; ENSMUSG00000069601 [G5E8K5-3]
ENSMUST00000092433; ENSMUSP00000090089; ENSMUSG00000069601 [G5E8K5-4]
ENSMUST00000092434; ENSMUSP00000090090; ENSMUSG00000069601 [G5E8K5-1]
ENSMUST00000181974; ENSMUSP00000138285; ENSMUSG00000069601 [G5E8K5-6]
ENSMUST00000182029; ENSMUSP00000138337; ENSMUSG00000069601 [G5E8K5-5]
ENSMUST00000182155; ENSMUSP00000138347; ENSMUSG00000069601 [G5E8K5-2]
ENSMUST00000182884; ENSMUSP00000138326; ENSMUSG00000069601 [G5E8K5-1]
GeneIDi11735
KEGGimmu:11735
UCSCiuc007fmw.1 mouse [G5E8K5-1]
uc007fna.1 mouse [G5E8K5-2]
uc007fnb.1 mouse [G5E8K5-3]
uc007fnh.1 mouse [G5E8K5-6]
uc007fni.1 mouse [G5E8K5-5]
uc007fnk.1 mouse [G5E8K5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANK3_MOUSE
AccessioniPrimary (citable) accession number: G5E8K5
Secondary accession number(s): G5E8K4
, O08866, O08867, Q3TSJ8, Q4U205, Q4U206, Q4U256, Q4U260, Q61305, Q61306, Q61307, Q61308, Q61309, Q61310, Q8CBN3, Q8VC68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: December 14, 2011
Last modified: June 20, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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