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Protein
Submitted name:

MCG118205, isoform CRA_c

Gene

Tpte

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyi

Protein namesi
Submitted name:
MCG118205, isoform CRA_cImported
Submitted name:
Transmembrane phosphatase with tensin homologyImported
Gene namesi
Name:TpteImported
ORF Names:mCG_118205Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2446460 Tpte

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei212 – 231HelicalSequence analysisAdd BLAST20
Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Transmembranei277 – 299HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000031481 Expressed in 39 organ(s), highest expression level in external ectoderm

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076435

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini348 – 524Phosphatase tensin-typeInterPro annotationAdd BLAST177
Domaini531 – 664C2 tensin-typeInterPro annotationAdd BLAST134

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili328 – 348Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
KOiK18079
OMAiTYVTDRV
OrthoDBiEOG091G09VG
TreeFamiTF354329

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G5E8H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGEKKSHLY LWMEHYGYDM PANIYKMYSQ PSRKTDDANK KVSVSASRTI
60 70 80 90 100
KLNGSTGYDT NEQITLITNG SSLSYPDEIK SASYADPIST KAYTNDSSVY
110 120 130 140 150
DPGGASSSTT LYELNSLSEV SKEIITQGES ALLRDKEATS ELKIPSTLQT
160 170 180 190 200
QTSMSTNTLS LSDLSSDYQE EQMNKCKLNQ MSKLYDDDER TDIQKSYWNV
210 220 230 240 250
VKKFVRILVS SVAFRIFGIF LVILDVFLVV VDLNVSEKKI YIPLDYRSIS
260 270 280 290 300
LAIALFFLVD VLLRVSVEGR RRYFSDVLNT LDAVVIGVTV VVAVIYALYD
310 320 330 340 350
KHFLRDIPRL AVLLRPLRLL ILIRILQLAH QKRQLERLTR KLVSGNKRRY
360 370 380 390 400
KKDGFDLDLT YVTERIIAMS FPSSGRESFY RNPIKEVVRF LDTKHPNHYQ
410 420 430 440 450
VYNLCSERAY DPKHFHYRVR RIMIDDHNVP TLEEMLLFSK EVNNWMAQDP
460 470 480 490 500
ENVVAIHCKG GKGRTGTMVC ACLIASEIVL NAKESLYFFG ERRTDKSNSS
510 520 530 540 550
KFQGIETPSQ NRYVKYFEKL KINYQLTLPP KKVLVIKRLV VYSIHGVGKG
560 570 580 590 600
DGSDLEVQII MWQETVFSFC NSRNCMIFHD PETDRAIINV FHCPALYDDV
610 620 630 640 650
KVKFLSPNLP KYYDDCPFFF WFHTSFIKNN RLYLPRNELD NTHKPKTWKI
660
YGEKFAVEVD FGEN
Length:664
Mass (Da):76,705
Last modified:December 14, 2011 - v1
Checksum:iB6921868B4E0EF53
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSB8A0A1B0GSB8_MOUSE
MCG118205, isoform CRA_a
Tpte mCG_118205
591Annotation score:
A0A1B0GS38A0A1B0GS38_MOUSE
Transmembrane phosphatase with tens...
Tpte
38Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121933 Genomic DNA No translation available.
AC140326 Genomic DNA No translation available.
CH466580 Genomic DNA Translation: EDL32898.1
RefSeqiNP_954866.2, NM_199257.2
UniGeneiMm.450553

Genome annotation databases

EnsembliENSMUST00000077194; ENSMUSP00000076435; ENSMUSG00000031481
GeneIDi234129
KEGGimmu:234129
UCSCiuc009lcy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121933 Genomic DNA No translation available.
AC140326 Genomic DNA No translation available.
CH466580 Genomic DNA Translation: EDL32898.1
RefSeqiNP_954866.2, NM_199257.2
UniGeneiMm.450553

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076435

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077194; ENSMUSP00000076435; ENSMUSG00000031481
GeneIDi234129
KEGGimmu:234129
UCSCiuc009lcy.1 mouse

Organism-specific databases

CTDi7179
MGIiMGI:2446460 Tpte

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
KOiK18079
OMAiTYVTDRV
OrthoDBiEOG091G09VG
TreeFamiTF354329

Enzyme and pathway databases

ReactomeiR-MMU-1660514 Synthesis of PIPs at the Golgi membrane

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031481 Expressed in 39 organ(s), highest expression level in external ectoderm

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5E8H5_MOUSE
AccessioniPrimary (citable) accession number: G5E8H5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 7, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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