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Protein

Fucose-1-phosphate guanylyltransferase

Gene

Fpgt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:14686921). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (Probable).1 Publication1 Publication

Catalytic activityi

GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6787639 GDP-fucose biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Fucose-1-phosphate guanylyltransferaseImported (EC:2.7.7.301 Publication)
Alternative name(s):
GDP-L-fucose diphosphorylaseBy similarity
GDP-L-fucose pyrophosphorylase1 Publication
Gene namesi
Name:FpgtImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922790 Fpgt

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004363841 – 590Fucose-1-phosphate guanylyltransferaseAdd BLAST590

Proteomic databases

MaxQBiG5E8F4
PaxDbiG5E8F4
PRIDEiG5E8F4

PTM databases

PhosphoSitePlusiG5E8F4

Expressioni

Tissue specificityi

Expressed at highest levels in brain, moderately in testis, ovary and kidney, and weakly in liver, spleen, heart and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000053870 Expressed in 235 organ(s), highest expression level in islet of Langerhans

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068939

Structurei

3D structure databases

ProteinModelPortaliG5E8F4
SMRiG5E8F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE28 Eukaryota
ENOG410XT7S LUCA
GeneTreeiENSGT00780000122095
HOGENOMiHOG000067964
HOVERGENiHBG025123
InParanoidiG5E8F4
KOiK00976
OMAiDMIAYRE
OrthoDBiEOG091G0CO4
TreeFamiTF328750

Family and domain databases

InterProiView protein in InterPro
IPR012887 Fucokinase
IPR012120 Fucose-1-phosphate_GuaTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF07959 Fucokinase, 1 hit
PIRSFiPIRSF036640 FPGT, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit

Sequencei

Sequence statusi: Complete.

G5E8F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLREATLR KLRRFSELRG KPVAAGEFWD VVAITAADEK QELAYKQQLS
60 70 80 90 100
EKLKKRELPL GVQYHVFPDP AGTKIGNGGS TLCSLECLES LCGDKWNSLK
110 120 130 140 150
VLLIHSGGYS QRLPNASALG KIFTALPLGE PIYQMLELKL AMYVDFPSNM
160 170 180 190 200
RPGVLVTCAD DIELYSVGDS EYIAFDQPGF TALAHPSSLA VGTTHGVFVL
210 220 230 240 250
HSDSSLQHGD LEYRQCYQFL HKPTIENMHR FNAVHRQRSF GQQNLSGGDT
260 270 280 290 300
DCLPLHTEYV YTDSLFYMDH KSAKKLLDFY KSEGPLNCEI DAYGDFLQAL
310 320 330 340 350
GPGATAEYTR NTSHVTKEES QLLDMRQKIF HLLKGTPLNV VVLNNSRFYH
360 370 380 390 400
IGTLQEYLLH FTSDSALKTE LGLQSIAFSV SPSVPERSSG TACVIHSIVD
410 420 430 440 450
SGCCVAPGSV VEYSRLGPEV SIGENCIISS SVIAKTVVPA YSFLCSLSVK
460 470 480 490 500
INGHLKYSTM VFGMQDNLKN SVKTLEDIKA LQFFGVCFLS CLDIWNLKAT
510 520 530 540 550
EKLFSGNKMN LSLWTACIFP VCSSLSESAT ASLGMLSAVR NHSPFNLSDF
560 570 580 590
NLLSIQEMLV YKDVQDMLAY REHIFLEISS NKNQSDLEKS
Length:590
Mass (Da):65,362
Last modified:December 14, 2011 - v1
Checksum:iCBAC6708227668C9
GO

Sequence cautioni

The sequence BAC26043 differs from that shown. Reason: Frameshift at position 566.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231 – 233FNA → LIS in CAC81971 (PubMed:14686921).Curated3
Sequence conflicti238R → G in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti241G → A in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti270H → R in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti293Y → N in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti297L → I in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti517C → R in AAI10552 (PubMed:15489334).Curated1
Sequence conflicti517C → R in AAI10553 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276067 mRNA Translation: CAC81971.2
AK028640 mRNA Translation: BAC26043.1 Frameshift.
AC144762 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL11881.1
BC110551 mRNA Translation: AAI10552.1
BC110552 mRNA Translation: AAI10553.1
CCDSiCCDS38681.1
RefSeqiNP_083606.2, NM_029330.2
UniGeneiMm.35218

Genome annotation databases

EnsembliENSMUST00000066568; ENSMUSP00000068939; ENSMUSG00000053870
GeneIDi75540
KEGGimmu:75540
UCSCiuc008ruu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276067 mRNA Translation: CAC81971.2
AK028640 mRNA Translation: BAC26043.1 Frameshift.
AC144762 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL11881.1
BC110551 mRNA Translation: AAI10552.1
BC110552 mRNA Translation: AAI10553.1
CCDSiCCDS38681.1
RefSeqiNP_083606.2, NM_029330.2
UniGeneiMm.35218

3D structure databases

ProteinModelPortaliG5E8F4
SMRiG5E8F4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068939

PTM databases

PhosphoSitePlusiG5E8F4

Proteomic databases

MaxQBiG5E8F4
PaxDbiG5E8F4
PRIDEiG5E8F4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066568; ENSMUSP00000068939; ENSMUSG00000053870
GeneIDi75540
KEGGimmu:75540
UCSCiuc008ruu.1 mouse

Organism-specific databases

CTDi8790
MGIiMGI:1922790 Fpgt

Phylogenomic databases

eggNOGiENOG410IE28 Eukaryota
ENOG410XT7S LUCA
GeneTreeiENSGT00780000122095
HOGENOMiHOG000067964
HOVERGENiHBG025123
InParanoidiG5E8F4
KOiK00976
OMAiDMIAYRE
OrthoDBiEOG091G0CO4
TreeFamiTF328750

Enzyme and pathway databases

ReactomeiR-MMU-6787639 GDP-fucose biosynthesis

Miscellaneous databases

PROiPR:G5E8F4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053870 Expressed in 235 organ(s), highest expression level in islet of Langerhans

Family and domain databases

InterProiView protein in InterPro
IPR012887 Fucokinase
IPR012120 Fucose-1-phosphate_GuaTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF07959 Fucokinase, 1 hit
PIRSFiPIRSF036640 FPGT, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFPGT_MOUSE
AccessioniPrimary (citable) accession number: G5E8F4
Secondary accession number(s): Q2TB53, Q712G7, Q8C1A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 8, 2016
Last sequence update: December 14, 2011
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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