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Protein

Fucose-1-phosphate guanylyltransferase

Gene

Fpgt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:14686921). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (Probable).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6787639 GDP-fucose biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fucose-1-phosphate guanylyltransferaseImported (EC:2.7.7.301 Publication)
Alternative name(s):
GDP-L-fucose diphosphorylaseBy similarity
GDP-L-fucose pyrophosphorylase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FpgtImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922790 Fpgt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004363841 – 590Fucose-1-phosphate guanylyltransferaseAdd BLAST590

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G5E8F4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5E8F4

PRoteomics IDEntifications database

More...
PRIDEi
G5E8F4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
G5E8F4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in brain, moderately in testis, ovary and kidney, and weakly in liver, spleen, heart and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053870 Expressed in 235 organ(s), highest expression level in islet of Langerhans

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068939

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
G5E8F4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5E8F4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE28 Eukaryota
ENOG410XT7S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00780000122095

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000067964

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG025123

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5E8F4

KEGG Orthology (KO)

More...
KOi
K00976

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMIAYRE

Database of Orthologous Groups

More...
OrthoDBi
324025at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328750

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012887 Fucokinase
IPR012120 Fucose-1-phosphate_GuaTrfase
IPR011004 Trimer_LpxA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07959 Fucokinase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036640 FPGT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51161 SSF51161, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5E8F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLREATLR KLRRFSELRG KPVAAGEFWD VVAITAADEK QELAYKQQLS
60 70 80 90 100
EKLKKRELPL GVQYHVFPDP AGTKIGNGGS TLCSLECLES LCGDKWNSLK
110 120 130 140 150
VLLIHSGGYS QRLPNASALG KIFTALPLGE PIYQMLELKL AMYVDFPSNM
160 170 180 190 200
RPGVLVTCAD DIELYSVGDS EYIAFDQPGF TALAHPSSLA VGTTHGVFVL
210 220 230 240 250
HSDSSLQHGD LEYRQCYQFL HKPTIENMHR FNAVHRQRSF GQQNLSGGDT
260 270 280 290 300
DCLPLHTEYV YTDSLFYMDH KSAKKLLDFY KSEGPLNCEI DAYGDFLQAL
310 320 330 340 350
GPGATAEYTR NTSHVTKEES QLLDMRQKIF HLLKGTPLNV VVLNNSRFYH
360 370 380 390 400
IGTLQEYLLH FTSDSALKTE LGLQSIAFSV SPSVPERSSG TACVIHSIVD
410 420 430 440 450
SGCCVAPGSV VEYSRLGPEV SIGENCIISS SVIAKTVVPA YSFLCSLSVK
460 470 480 490 500
INGHLKYSTM VFGMQDNLKN SVKTLEDIKA LQFFGVCFLS CLDIWNLKAT
510 520 530 540 550
EKLFSGNKMN LSLWTACIFP VCSSLSESAT ASLGMLSAVR NHSPFNLSDF
560 570 580 590
NLLSIQEMLV YKDVQDMLAY REHIFLEISS NKNQSDLEKS
Length:590
Mass (Da):65,362
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBAC6708227668C9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC26043 differs from that shown. Reason: Frameshift at position 566.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231 – 233FNA → LIS in CAC81971 (PubMed:14686921).Curated3
Sequence conflicti238R → G in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti241G → A in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti270H → R in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti293Y → N in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti297L → I in CAC81971 (PubMed:14686921).Curated1
Sequence conflicti517C → R in AAI10552 (PubMed:15489334).Curated1
Sequence conflicti517C → R in AAI10553 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ276067 mRNA Translation: CAC81971.2
AK028640 mRNA Translation: BAC26043.1 Frameshift.
AC144762 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL11881.1
BC110551 mRNA Translation: AAI10552.1
BC110552 mRNA Translation: AAI10553.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38681.1

NCBI Reference Sequences

More...
RefSeqi
NP_083606.2, NM_029330.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.35218

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000066568; ENSMUSP00000068939; ENSMUSG00000053870

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
75540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:75540

UCSC genome browser

More...
UCSCi
uc008ruu.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276067 mRNA Translation: CAC81971.2
AK028640 mRNA Translation: BAC26043.1 Frameshift.
AC144762 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL11881.1
BC110551 mRNA Translation: AAI10552.1
BC110552 mRNA Translation: AAI10553.1
CCDSiCCDS38681.1
RefSeqiNP_083606.2, NM_029330.2
UniGeneiMm.35218

3D structure databases

ProteinModelPortaliG5E8F4
SMRiG5E8F4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068939

PTM databases

PhosphoSitePlusiG5E8F4

Proteomic databases

MaxQBiG5E8F4
PaxDbiG5E8F4
PRIDEiG5E8F4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066568; ENSMUSP00000068939; ENSMUSG00000053870
GeneIDi75540
KEGGimmu:75540
UCSCiuc008ruu.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8790
MGIiMGI:1922790 Fpgt

Phylogenomic databases

eggNOGiENOG410IE28 Eukaryota
ENOG410XT7S LUCA
GeneTreeiENSGT00780000122095
HOGENOMiHOG000067964
HOVERGENiHBG025123
InParanoidiG5E8F4
KOiK00976
OMAiDMIAYRE
OrthoDBi324025at2759
TreeFamiTF328750

Enzyme and pathway databases

ReactomeiR-MMU-6787639 GDP-fucose biosynthesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G5E8F4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053870 Expressed in 235 organ(s), highest expression level in islet of Langerhans

Family and domain databases

InterProiView protein in InterPro
IPR012887 Fucokinase
IPR012120 Fucose-1-phosphate_GuaTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF07959 Fucokinase, 1 hit
PIRSFiPIRSF036640 FPGT, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFPGT_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E8F4
Secondary accession number(s): Q2TB53, Q712G7, Q8C1A2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 8, 2016
Last sequence update: December 14, 2011
Last modified: January 16, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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