UniProtKB - G5E8D6 (G5E8D6_MOUSE)
Protein
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2
Gene
Efemp2
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- elastic fiber assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: EGF-containing fibulin-like extracellular matrix protein 2Imported |
Gene namesi | Name:Efemp2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1891209, Efemp2 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 226 ↔ 236 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
MaxQBi | G5E8D6 |
PeptideAtlasi | G5E8D6 |
PRIDEi | G5E8D6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024909, Expressed in humerus cartilage element and 252 other tissues |
ExpressionAtlasi | G5E8D6, baseline and differential |
Family & Domainsi
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159437 |
OrthoDBi | 1174178at2759 |
TreeFami | TF317514 |
Family and domain databases
InterProi | View protein in InterPro IPR026823, cEGF IPR026824, Efemp2 IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24034:SF96, PTHR24034:SF96, 1 hit |
Pfami | View protein in Pfam PF12662, cEGF, 2 hits PF07645, EGF_CA, 3 hits |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
G5E8D6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGAVAETPD FCPPPPSLRM LPFASCLPGS LLLWAFLLLL LGAASPQDPE
60 70 80 90 100
EPDSYTECTD GYEWDADSQH CRDVNECLTI PEACKGEMKC INHYGGYLCL
110 120 130 140 150
PRSAAVISDL HGEGPPPPAA HAQQPNPCPQ GYEPDEQESC VDVDECTQAL
160 170 180 190 200
HDCRPSQDCH NLPGSYQCTC PDGYRKIGPE CVDIDECRYR YCQHRCVNLP
210 220 230 240 250
GSFRCQCEPG FQLGPNNRSC VDVNECDMGA PCEQRCFNSY GTFLCRCNQG
260 270 280 290 300
YELHRDGFSC SDIDECGYSS YLCQYRCVNE PGRFSCHCPQ GYQLLATRLC
310 320 330 340 350
QDIDECETGA HQCSEAQTCV NFHGGYRCVD TNRCVEPYVQ VSDNRCLCPA
360 370 380 390 400
SNPLCREQPS SIVHRYMSIT SERSVPADVF QIQATSVYPG AYNAFQIRSG
410 420 430 440 450
NTQGDFYIRQ INNVSAMLVL ARPVTGPREY VLDLEMVTMN SLMSYRASSV
460
LRLTVFVGAY TF
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9WVJ9 | FBLN4_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 Fbln4, Mbp1 | 443 | Annotation score: | ||
E9Q3N9 | E9Q3N9_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 402 | Annotation score: | ||
A0A494BAR1 | A0A494BAR1_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 404 | Annotation score: | ||
A0A494BBF0 | A0A494BBF0_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 455 | Annotation score: | ||
E9Q3F3 | E9Q3F3_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 280 | Annotation score: | ||
E9Q2T8 | E9Q2T8_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 191 | Annotation score: | ||
E9Q1U0 | E9Q1U0_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 128 | Annotation score: | ||
E9Q2A0 | E9Q2A0_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 153 | Annotation score: | ||
E9PYW6 | E9PYW6_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 82 | Annotation score: | ||
F6Z1C2 | F6Z1C2_MOUSE | EGF-containing fibulin-like extrace... | Efemp2 | 157 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC126029 Genomic DNA No translation available. |
RefSeqi | NP_001157824.1, NM_001164352.1 |
Genome annotation databases
Ensembli | ENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909 |
GeneIDi | 58859 |
UCSCi | uc012bgy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC126029 Genomic DNA No translation available. |
RefSeqi | NP_001157824.1, NM_001164352.1 |
3D structure databases
SMRi | G5E8D6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | G5E8D6 |
PeptideAtlasi | G5E8D6 |
PRIDEi | G5E8D6 |
Protocols and materials databases
Antibodypediai | 16033, 359 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000070118; ENSMUSP00000064719; ENSMUSG00000024909 |
GeneIDi | 58859 |
UCSCi | uc012bgy.1, mouse |
Organism-specific databases
CTDi | 30008 |
MGIi | MGI:1891209, Efemp2 |
Phylogenomic databases
GeneTreei | ENSGT00940000159437 |
OrthoDBi | 1174178at2759 |
TreeFami | TF317514 |
Miscellaneous databases
BioGRID-ORCSi | 58859, 5 hits in 17 CRISPR screens |
ChiTaRSi | Efemp2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024909, Expressed in humerus cartilage element and 252 other tissues |
ExpressionAtlasi | G5E8D6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026823, cEGF IPR026824, Efemp2 IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24034:SF96, PTHR24034:SF96, 1 hit |
Pfami | View protein in Pfam PF12662, cEGF, 2 hits PF07645, EGF_CA, 3 hits |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G5E8D6_MOUSE | |
Accessioni | G5E8D6Primary (citable) accession number: G5E8D6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | February 10, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |