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Entry version 64 (26 Feb 2020)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Ankyrin repeat domain 12

Gene

Ankrd12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin repeat domain 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankrd12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914357 Ankrd12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034647 Expressed in retina and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G5E893 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039035

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5E893

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ47 Eukaryota
ENOG4110UQU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001632_0_0_1

KEGG Orthology (KO)

More...
KOi
K21436

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVSNEHK

Database of Orthologous Groups

More...
OrthoDBi
854133at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326440

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G5E893-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKSGFTKPV QSENSDSDSS MVERPYGRKS KDKIASYSKT SKIDRGDMGK
60 70 80 90 100
EMREKPSMKR KLPFTVSPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY
110 120 130 140 150
SEKEGPEKKK TKKEAGTKKS TPVSILFGYP LSERKQMALL MQMTARDNSP
160 170 180 190 200
DSTPSHPSQA TPAQKKTPSS SSRQKDKINK RNERGETPLH MAAIRGDVKQ
210 220 230 240 250
VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA GADVNTQGLD
260 270 280 290 300
DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL
310 320 330 340 350
KREVPLSGDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSF VCGSKILPSK
360 370 380 390 400
APLPSALDEY EFKDDDEEEI SKMIDDRHIL RKEQRRENES EAERSGLFAK
410 420 430 440 450
QEKTFYSKSF KTKKQKPSRV LCSSTESSDE EGLQNRKIST ACSVAESSHP
460 470 480 490 500
DMQAKKEYEY KQKGKVKRKL KNQNKNKENQ ELKQEKEGKE NSRIATLTVN
510 520 530 540 550
TALDCSEKYR EEGNFRKSFS PKDDTSLHLF HISTGKSPKH SCGLSEKQTP
560 570 580 590 600
LKQEHTKACI SPGSSEMSLQ PDLTRYDNAE PESSNVKSYK HKEKNKQQKD
610 620 630 640 650
FHIEFGEKSN AKIKDEDHNP AFENSDCTLK KMDKEGKTLK KHKLKHKEKD
660 670 680 690 700
KEKHKKEVEG EKEKYKNKDN AKELQRSIEF DREFWKENFF KSDETEDLFL
710 720 730 740 750
TMEHESIIEK KTKMEKNMKD DRSAKEKHVS KERNFKEERE KTKKENEKSL
760 770 780 790 800
REEKVKDPKE EKDSVSTEKE AECCSVGVSV SQEAAGLHSS EKEMDAEKQE
810 820 830 840 850
RHTKEREKSD RRFQTKEKEL DRNERKFSEK EKKIKHEHKS EREKLDFSDC
860 870 880 890 900
TDRVREKDKL YSHQTERCHK DSEKLKNTVR KTDDRERNRE KADRKHDREK
910 920 930 940 950
PERERYLAEN KEKHLEKRKQ SDSSEYSKSE KVRTKDRDRE GEKKEKLRDK
960 970 980 990 1000
ESVNVTNLKH LQEERKSSTG DSSGKTQHEK ALSLKERARD EPLKTPDGKE
1010 1020 1030 1040 1050
KDKKDIDRYK ERDKRKDKAQ LNTLIRLKSE TEKLKPKLSP ASKDTRPKEK
1060 1070 1080 1090 1100
RLVNDDLMQT SFERMLSLKD LEIEQWHRKH KEKIKQKEKE RLRNRTCLEL
1110 1120 1130 1140 1150
KVKDKEKTKH APTESKSKEL TRSRSSELTD VYSKEKQSKD VGSNRSQSVD
1160 1170 1180 1190 1200
NRNVLNLGKP SYISESGSNR SPRSEGERLG LSSRSVSMLS VASSEDSCHT
1210 1220 1230 1240 1250
VTTPRPLVEY DSDFMLEGSE SQLSFSQSPF LPNAKSPALY ERELEGLTEL
1260 1270 1280 1290 1300
PDRLKPPYTN RLPVCHLRSS SVEDVKLITN EVRPAVEIRR CSMPSVICEP
1310 1320 1330 1340 1350
IKHFQVSEES SQGNLAVPRE TCLSPKPEVS SAVPERGLSH VSDLHPNCTG
1360 1370 1380 1390 1400
SPTRSANSSY ISSDVNVIKS ATLVGTLIDS SMHLEPSNQV GVIPSKSWET
1410 1420 1430 1440 1450
PVDKLESLST NDFICPDSNI SDQDSSAQSF YNSENKMLRE QNTDCLPPHQ
1460 1470 1480 1490 1500
PELPGNSCAQ DPASFLSSPQ PCSFSNQPLA GADSVPKPVS LSYVVSQEPG
1510 1520 1530 1540 1550
VLQQKSAAQM ASSVLDSDNN FPEDVENTFV LADIQKTNSF LPAYSESTVQ
1560 1570 1580 1590 1600
EALPSFEKAN TLLVLPSEKD FNGSDTAQPN THYAFSKLTY KSSNSQEIEK
1610 1620 1630 1640 1650
GPDDTQIISH EKENKLQSLV LTQLSKCDSD LYEMNAGLPK GNLNEQDNPK
1660 1670 1680 1690 1700
HGLDSEKYSL STEDEESQQS TLSSVENHSQ QSAQPEMHKY DQLSKVELEE
1710 1720 1730 1740 1750
NAEDDKTENQ TPQRVTRNKA STVVNPSKPM LAGCALVAEK DNESSPRGRI
1760 1770 1780 1790 1800
RLTEEDDPQI HHPRKRKVSR VPQPVQVSPS LLQAKEKTQQ SLAAIVDSLK
1810 1820 1830 1840 1850
LDEIEPYSSE RANPYFEYLH IRKKIEEKRK LLCSVIPQAP QYYDEYVTFN
1860 1870 1880 1890 1900
GSYLLDGNPL SKICIPTITP PPSLSDPLKE LFRQQEVVRM KLRLQHSIER
1910 1920 1930 1940 1950
EKLIVSNEQE VLRVHYRAAR TLANQTLPFS ACTVLLDAEV YNVPLDSQSD
1960 1970 1980 1990 2000
DSKTSVRDRF NARQFMSWLQ DVDDKFDKLK TCLLMRQQHE AAALNAVQRL
2010 2020 2030 2040
EWQLKLQELD PATYKSLSIY EIQEFYVPLV DVNDDFELTP I
Length:2,041
Mass (Da):232,912
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A661D90FAFF67B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U569Q3U569_MOUSE
Ankyrin repeat domain 12
Ankrd12
441Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W3X3A0A3B2W3X3_MOUSE
Ankyrin repeat domain 12
Ankrd12
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W7I2A0A3B2W7I2_MOUSE
Ankyrin repeat domain 12
Ankrd12
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W470A0A3B2W470_MOUSE
Ankyrin repeat domain 12
Ankrd12
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WAN9A0A3B2WAN9_MOUSE
Ankyrin repeat domain 12
Ankrd12
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC119957 Genomic DNA No translation available.
AC121299 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001020743.1, NM_001025572.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038116; ENSMUSP00000039035; ENSMUSG00000034647

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106585

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:106585

UCSC genome browser

More...
UCSCi
uc008dgs.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119957 Genomic DNA No translation available.
AC121299 Genomic DNA No translation available.
RefSeqiNP_001020743.1, NM_001025572.1

3D structure databases

SMRiG5E893
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039035

Genome annotation databases

EnsembliENSMUST00000038116; ENSMUSP00000039035; ENSMUSG00000034647
GeneIDi106585
KEGGimmu:106585
UCSCiuc008dgs.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23253
MGIiMGI:1914357 Ankrd12

Phylogenomic databases

eggNOGiENOG410IJ47 Eukaryota
ENOG4110UQU LUCA
GeneTreeiENSGT00940000154742
HOGENOMiCLU_001632_0_0_1
KOiK21436
OMAiGVSNEHK
OrthoDBi854133at2759
TreeFamiTF326440

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ankrd12 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034647 Expressed in retina and 238 other tissues
ExpressionAtlasiG5E893 baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5E893_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E893
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 26, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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