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Entry version 72 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Laminin subunit gamma-2

Gene

Lamc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Laminin subunit gamma-2Imported
Submitted name:
Laminin, gamma 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lamc2Imported
ORF Names:mCG_22678Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99913 Lamc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509189422 – 1193Sequence analysisAdd BLAST1172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 65PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi104 ↔ 113PROSITE-ProRule annotation
Disulfide bondi157 ↔ 166PROSITE-ProRule annotation
Disulfide bondi464 ↔ 481PROSITE-ProRule annotation
Disulfide bondi484 ↔ 493PROSITE-ProRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi573 ↔ 585PROSITE-ProRule annotation
Disulfide bondi593 ↔ 602PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026479 Expressed in 109 organ(s), highest expression level in molar tooth

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 83Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini84 – 130Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini139 – 186Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini213 – 381Laminin IV type AInterPro annotationAdd BLAST169
Domaini462 – 516Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini517 – 572Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini573 – 615Laminin EGF-likeInterPro annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili614 – 634Sequence analysisAdd BLAST21
Coiled coili649 – 676Sequence analysisAdd BLAST28
Coiled coili684 – 704Sequence analysisAdd BLAST21
Coiled coili955 – 989Sequence analysisAdd BLAST35
Coiled coili1039 – 1066Sequence analysisAdd BLAST28
Coiled coili1142 – 1162Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP6C Eukaryota
ENOG4110QI9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160470

KEGG Orthology (KO)

More...
KOi
K06246

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQCFCYG

Database of Orthologous Groups

More...
OrthoDBi
156553at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 7 hits
SM00180 EGF_Lam, 7 hits
SM00281 LamB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 6 hits
PS51115 LAMININ_IVA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G5E874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPALWLSCCL GVALLLPAAQ ATSRREVCDC NGKSRQCVFD QELHRQTGSG
60 70 80 90 100
FRCLNCNDNT AGVHCERCRE GFYRHRDRDR CLPCNCHSKG SLSAGCDNSG
110 120 130 140 150
QCRCKPGVTG QRCDRCQPGF HMLTDAGCTR DQGQLDSKCD CDPAGISGPC
160 170 180 190 200
DSGRCVCKPA VTGERCDRCR PGYYHLDRAN PEGCTQCFCY GHSASCHASA
210 220 230 240 250
DFSVHKITST FSQDVDGWKA VQRNGAPAKL HWSQRHRDVF SSARRSDPVY
260 270 280 290 300
FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR QPSAYDVILE GAGLQIRAPL
310 320 330 340 350
MAPGKTLPCG ITKTYTFRLN EHPSSHWSPQ LSYFEYRRLL RNLTALLIRA
360 370 380 390 400
TYGEYSTGYI DNVTLVSARP VSGAPAPWVE RCVCPAGYKG QFCQECASGY
410 420 430 440 450
KRDSARLGPF GACVPCNCQG GGACDPDTGD CYSGDENPDI ECADCPIGFY
460 470 480 490 500
NDPHDPRSCK PCPCHNGFSC SVMPETEEVV CNNCPPGVTG ARCELCADGF
510 520 530 540 550
FGDPFGERGP VRPCQRCQCN NNVDPNASGN CDQLTGRCLK CIYNTAGVYC
560 570 580 590 600
DQCKAGYFGD PLAPNPADKC RACNCSPMGS EPGECRGDGS CVCKPGFGGL
610 620 630 640 650
NCDHAALTSC PACYNQVKIQ MDQFTQQLQS LEALVSKAQG GGGGGTVPSG
660 670 680 690 700
ELEGRMQQAE QALRDILREA QISEGAMRAL GFRLAKARSQ ENDYKTRLDD
710 720 730 740 750
LKMTAERIRA LGSQHQNRVQ DTSRLISQMR LSLAGSEASL QNTNIHSSEH
760 770 780 790 800
YVGPNGFKSL AQEATRLADS HAESANAMKQ LARETEDYSK QALSLARKAL
810 820 830 840 850
SGGGGSGVLD SSVVQGLMGK LEKTKSLSQQ LSREGTQADI EADRSYQHSL
860 870 880 890 900
RLLDSASQLQ GVSDLSFQVE AKRIRQKADS LSNLVTRQTD AFTRVRNNLG
910 920 930 940 950
NWEKETRQLL QTGKDRRQTS DQLLSRANLA KNRAQEALSM GNATFYEVEN
960 970 980 990 1000
ILKNLREFDL QVEDRKAEAE EAMKRLSSIS QKVADASDKT QQAETALGSA
1010 1020 1030 1040 1050
TADTQRAKNA AREALEISSE IEQEIGSLNL EANVTADGAL AMEKGLATLK
1060 1070 1080 1090 1100
SEMREMEGEL ARKELEFDTD KDTVQLVITE AQQADARATS AGVTIQDTLN
1110 1120 1130 1140 1150
TLDGILHLID QPGSVDEEGM MLLEQGLFQA KTQINSRLRP LMSDLEERVR
1160 1170 1180 1190
RQRNHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ
Length:1,193
Mass (Da):130,339
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i571E884B39010DBE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q61092LAMC2_MOUSE
Laminin subunit gamma-2
Lamc2
1,191Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9R086Q9R086_MOUSE
Laminin gamma2 chain
Lamc2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC099735 Genomic DNA No translation available.
AC159966 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39444.1

NCBI Reference Sequences

More...
RefSeqi
NP_032511.3, NM_008485.3
XP_011246228.1, XM_011247926.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027753; ENSMUSP00000027753; ENSMUSG00000026479
ENSMUST00000185356; ENSMUSP00000140514; ENSMUSG00000026479

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16782

UCSC genome browser

More...
UCSCi
uc007czr.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099735 Genomic DNA No translation available.
AC159966 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39444.1
RefSeqiNP_032511.3, NM_008485.3
XP_011246228.1, XM_011247926.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027753; ENSMUSP00000027753; ENSMUSG00000026479
ENSMUST00000185356; ENSMUSP00000140514; ENSMUSG00000026479
GeneIDi16782
KEGGimmu:16782
UCSCiuc007czr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3918
MGIiMGI:99913 Lamc2

Phylogenomic databases

eggNOGiENOG410IP6C Eukaryota
ENOG4110QI9 LUCA
GeneTreeiENSGT00940000160470
KOiK06246
OMAiTQCFCYG
OrthoDBi156553at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026479 Expressed in 109 organ(s), highest expression level in molar tooth

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 7 hits
SMARTiView protein in SMART
SM00181 EGF, 7 hits
SM00180 EGF_Lam, 7 hits
SM00281 LamB, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 6 hits
PS51115 LAMININ_IVA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5E874_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5E874
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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