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Protein
Submitted name:

MCG5959, isoform CRA_a

Gene

Kcnk16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • potassium channel activity Source: MGI
  • potassium ion leak channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1299361 TWIK-related alkaline pH activated K+ channel (TALK)
R-MMU-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Submitted name:
MCG5959, isoform CRA_aImported
Submitted name:
Potassium channel, subfamily K, member 16Imported
Gene namesi
Name:Kcnk16Imported
ORF Names:mCG_5959Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1921821 Kcnk16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalSequence analysisAdd BLAST24
Transmembranei95 – 114HelicalSequence analysisAdd BLAST20
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22
Transmembranei167 – 191HelicalSequence analysisAdd BLAST25
Transmembranei203 – 221HelicalSequence analysisAdd BLAST19
Transmembranei236 – 258HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineUniRule annotation1

Expressioni

Gene expression databases

BgeeiENSMUSG00000023387 Expressed in 15 organ(s), highest expression level in islet of Langerhans

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024155

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 147Ion_trans_2InterPro annotationAdd BLAST60
Domaini181 – 253Ion_trans_2InterPro annotationAdd BLAST73

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
KOiK04924
OMAiGWSYGEG
OrthoDBiEOG091G0E3R
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01095 TASKCHANNEL

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G5E845-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRAGVCGCW GGQVLPLLLA YICYLLLGAT IFQLLEKQAE AQSRDQFQLE
60 70 80 90 100
KLRFLENYTC LDQQALEQFV QVILEAWVKG VNPKGNSTNP SNWDFGSSFF
110 120 130 140 150
FAGTVVTTIG YGNLAPSTEA GQVFCVFYAL MGIPLNVVFL NHLGTGLRAH
160 170 180 190 200
LTTLDRWEDH PRHSQLLQVL GLALFLTLGT LVILIFPPMF FSHVEGWSFR
210 220 230 240 250
EGFYFAFITL STIGFGDYVV GTDPSKHYIA VYRSLAAIWI LLGLAWLAVV
260 270 280 290
LSLGSLLLHR CSRLWQLIRG LDLKDGAAPD SEPRSQKIPI SA
Length:292
Mass (Da):32,462
Last modified:December 14, 2011 - v1
Checksum:i0D10067616077216
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDH8A0A286YDH8_MOUSE
Potassium channel, subfamily K, mem...
Kcnk16
162Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159106 Genomic DNA No translation available.
CH466613 Genomic DNA Translation: EDL01527.1
RefSeqiNP_083282.1, NM_029006.1
UniGeneiMm.105571

Genome annotation databases

EnsembliENSMUST00000024155; ENSMUSP00000024155; ENSMUSG00000023387
GeneIDi74571
KEGGimmu:74571
UCSCiuc011zgl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159106 Genomic DNA No translation available.
CH466613 Genomic DNA Translation: EDL01527.1
RefSeqiNP_083282.1, NM_029006.1
UniGeneiMm.105571

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024155

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024155; ENSMUSP00000024155; ENSMUSG00000023387
GeneIDi74571
KEGGimmu:74571
UCSCiuc011zgl.1 mouse

Organism-specific databases

CTDi83795
MGIiMGI:1921821 Kcnk16

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
KOiK04924
OMAiGWSYGEG
OrthoDBiEOG091G0E3R
TreeFamiTF313947

Enzyme and pathway databases

ReactomeiR-MMU-1299361 TWIK-related alkaline pH activated K+ channel (TALK)
R-MMU-5576886 Phase 4 - resting membrane potential

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023387 Expressed in 15 organ(s), highest expression level in islet of Langerhans

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01095 TASKCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiG5E845_MOUSE
AccessioniPrimary (citable) accession number: G5E845
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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