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Entry version 49 (10 Feb 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Peptidylprolyl isomerase

Gene

GW7_09546

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GW7_09546Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHeterocephalus glaber (Naked mole rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10181 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeHeterocephalus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006813 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10181.XP_004849615.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 290PPIase FKBP-typeInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 70DisorderedSequence analysisAdd BLAST30
Regioni293 – 354DisorderedSequence analysisAdd BLAST62
Regioni736 – 761DisorderedSequence analysisAdd BLAST26
Regioni929 – 1216DisorderedSequence analysisAdd BLAST288

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili567 – 608Sequence analysisAdd BLAST42
Coiled coili624 – 658Sequence analysisAdd BLAST35
Coiled coili817 – 837Sequence analysisAdd BLAST21
Coiled coili852 – 872Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 70PolarSequence analysisAdd BLAST25
Compositional biasi339 – 354PolarSequence analysisAdd BLAST16
Compositional biasi980 – 1001PolarSequence analysisAdd BLAST22
Compositional biasi1131 – 1158PolarSequence analysisAdd BLAST28
Compositional biasi1179 – 1194PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0552, Eukaryota
KOG4725, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5BWQ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
GNHATKE

Database of Orthologous Groups

More...
OrthoDBi
936280at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001179, PPIase_FKBP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00254, FKBP_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50059, FKBP_PPIASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5BWQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGAGDEDDT DFLSPRGGAR LASLFGLDQP AAGHGNEFFQ YTAPKQPKKG
60 70 80 90 100
QGTTATGNQA TPKPTPTTTD TSTVLVATAV HAYRYTNGQY VKQGKFGAAV
110 120 130 140 150
LGNHIAREYR ILLYISQQQP VTVARIHLNF ELTVQSNNYS TFYDDQRQNW
160 170 180 190 200
SIMFESEKAA VEFNKQVCIA KCNSTSALEA VLSQDLVVAE GSAVEVGDSL
210 220 230 240 250
EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKA WEDGMLGMKK
260 270 280 290 300
GGKRLLIIPP TCAAGSEGVI GWTQSPDSIL VFEVEVKRVK FGRDSGSDGH
310 320 330 340 350
SVSSRDSAAP SPIPGVDSHS AGPVVSPPTS VPFRSGEPAL RTKSNSLSEQ
360 370 380 390 400
LTINSSPDAV KAKLISRMAK MGQPMLPILP PQLDSNDSEM EDLNTLRGPG
410 420 430 440 450
QPLVTPPIQP SFQPAHPVLP QMTSQAPQSS VSGLHAPSAA LVQVASLDSH
460 470 480 490 500
SVVSGNAQSF QPYAGTQAYA YPQAASVTSQ LQPVRPLYPA PLSQPPHFQG
510 520 530 540 550
SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL QKHSAGNSML
560 570 580 590 600
IPSMSVTMET SLIMSNIQRI IQENERLKQE ILEKSSRIEE QNDKISELIE
610 620 630 640 650
RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA
660 670 680 690 700
QVSHLQLKMT MHQKKETELQ MQLTESLKEI DLLRGQVVKL QAELSELQET
710 720 730 740 750
SAQAQSKFKN EKQTRKQLEL KLTALEEELS DLRAEKESLE KNLSERKKKS
760 770 780 790 800
AQERSQAEEE IDEIRKSYQE ELDKLRQLLI KARVSTDQAA AEQLSQVQAE
810 820 830 840 850
LQTHWEAKCE HLLASAKDEH LQQYQEVCAE RDAYQQKLTY LQEKCLALQA
860 870 880 890 900
QVTSLIEQNE QHIKELENSK SQRSGVEVLD PSEKVKKIMN QVFQSLRGEF
910 920 930 940 950
ELEESYDGRT ILGTIMSTIK MVTLQLLNQQ EREQEESSSE EEEQPQRPSQ
960 970 980 990 1000
EQSGPATPRL SPAPLSRERQ EAPVVSSEQV VEEVASSPPQ TLATPQYGIQ
1010 1020 1030 1040 1050
RREEASSEAE MLSETKDGFL PPEAASIPAH RVLGPPTSIP PKPPGPITTD
1060 1070 1080 1090 1100
SECEETLAAS LMTAKPDNPL GKAHVGEIAP HGPLQESSGT LSLTPDPEKG
1110 1120 1130 1140 1150
DPPAMEPESP EGKPQPPELK GDEALASFPG PSEAPSSTES STAAGEAALR
1160 1170 1180 1190 1200
PSHNSQHSSL SGDKEEELFQ GATLKLPRPK AQPEEEDEDE VSMKGRPPPT
1210
PLFGDDDDDD DISWLG
Length:1,216
Mass (Da):133,332
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEB9DB631E870A3D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JH172220 Genomic DNA Translation: EHB13719.1

NCBI Reference Sequences

More...
RefSeqi
XP_004849615.1, XM_004849558.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
101710082

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hgl:101710082

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH172220 Genomic DNA Translation: EHB13719.1
RefSeqiXP_004849615.1, XM_004849558.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10181.XP_004849615.1

Genome annotation databases

GeneIDi101710082
KEGGihgl:101710082

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23307

Phylogenomic databases

eggNOGiKOG0552, Eukaryota
KOG4725, Eukaryota
InParanoidiG5BWQ8
OMAiGNHATKE
OrthoDBi936280at2759

Family and domain databases

InterProiView protein in InterPro
IPR001179, PPIase_FKBP_dom
PfamiView protein in Pfam
PF00254, FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059, FKBP_PPIASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5BWQ8_HETGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5BWQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 10, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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