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Protein
Submitted name:

Cathepsin H

Gene

CTSH

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPSiI29.003

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin HImported
Submitted name:
Pro-cathepsin H preproproteinImported
Gene namesi
Name:CTSHImported
ORF Names:GW7_10432Imported
OrganismiHeterocephalus glaber (Naked mole rat)Imported
Taxonomic identifieri10181 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeHeterocephalus
Proteomesi
  • UP000006813 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_500736173323 – 334UniRule annotationAdd BLAST312

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 89Inhibitor_I29InterPro annotationAdd BLAST56
Domaini115 – 331Pept_C1InterPro annotationAdd BLAST217

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

InParanoidiG5B3N9
KOiK01366

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

G5B3N9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRATLSLLCA TWLLVFPGLP AAELQLSTLE NFHFKSWMMQ HQKEYSTKEY
60 70 80 90 100
HHRQQIFASN WRKINAHNKG NHTFKMALNQ FSDMSFDEIK RKYLWSEPQN
110 120 130 140 150
CSATKSNYFR GTGPYPTSVD WRKKGNFVSA VKNQGACGSC WTFSTTGALE
160 170 180 190 200
SAVAIASGKM LSLAEQQLVD CAQDFNNHGC QGGLPSQAFE YILYNKGIMG
210 220 230 240 250
EDTYPYEGKD GHCRFQPQKA IAFVKDIVNI TLNDEEAMVE AVALYNPVSF
260 270 280 290 300
AYEVTEDFMS YKRGIYSSTS CHKTPDKVNH AVLAVGYGVD HGVPYWIVKN
310 320 330
SWGTQWGNNG YFLIERGKNM CGLAACASYP IPQV
Length:334
Mass (Da):37,617
Last modified:December 14, 2011 - v1
Checksum:i77ED52DD7DB6D1D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH168282 Genomic DNA Translation: EHB03900.1
GEBF01007427 Transcribed RNA Translation: JAN96205.1
RefSeqiXP_004874861.1, XM_004874804.1

Genome annotation databases

GeneIDi101700582
KEGGihgl:101700582

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH168282 Genomic DNA Translation: EHB03900.1
GEBF01007427 Transcribed RNA Translation: JAN96205.1
RefSeqiXP_004874861.1, XM_004874804.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI29.003

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101700582
KEGGihgl:101700582

Organism-specific databases

CTDi1512

Phylogenomic databases

InParanoidiG5B3N9
KOiK01366

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG5B3N9_HETGA
AccessioniPrimary (citable) accession number: G5B3N9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 12, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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